Science
Microplastics may be new risk factor for cardiovascular disease, researchers say
Add one more likely culprit to the long list of known cardiovascular risk factors including red meat, butter, smoking and stress: microplastics.
In a study released Wednesday in the New England Journal of Medicine, an international team of physicians and researchers showed that surgical patients who had a build-up of micro and nanoplastics in their arterial plaque had a 2.1 times greater risk of nonfatal heart attack, nonfatal stroke or death from any cause in the three years post surgery than those who did not.
It’s the first study to show these ubiquitous and pernicious fossil fuel-based particles are having a direct effect on human health, said study co-author, Antonio Ceriello, head of the diabetes department at IRCCS MultiMedica, a research hospital in Milan.
And it should serve as a caution to all people, governments and corporations that plastic is not just a nuisance and blight in the environment, but is also harming human health, he said.
As government officials, negotiators, environmental activists and corporate representatives get ready to gather next month in Ottawa to discuss a global ban on plastic pollution, many are hoping this study will help tip the scales to establish real and tangible regulations.
“This is a beginning … whereby people are going to see plastic is not just harmful to whales or sea turtles. It’s not just litter on a beach in some faraway country. It’s in them and it has the potential to cause harm. I think it’s going to change the narrative,” said Dr. Philip Landrigan, director of the Program for Global Public Health and the Common Good at Boston College.
He compared the awareness of the plastic crisis to climate change — in which people understood it in an abstract, theoretical way until wildfires burned their homes, sustained heatwaves killed their crops and flooding destroyed their communities.
“To my knowledge, this is the first report to link microplastics with human disease,” said Landrigan, who was not involved in the study but wrote an accompanying essay urging the global community to deliver on a “mandatory global cap on plastic production.”
Matt Seaholm, president and chief executive of the Plastics Industry Assn., suggested more research needs to be done.
“We encourage lawmakers to evaluate where those particles come from before using any type of microplastics or nanoplastics arguments for the justification or passage of any laws, because every study has shown that they are not coming from packaging or single-use items,” he said.
Studies have shown that the two biggest contributors of microplastics in the environment are car tires and synthetic clothing. However, as the plastic industry expands and the number of single-use plastic items grow, so, too does their contribution to environmental contamination and pollution. Around 151 million tons of single-use plastics were produced
from fossil fuels in 2021. That number is expected to rise another 19 million tons by 2027.
The research on arterial plaque was conducted by a team of 40 scientists — including surgeons, engineers, statisticians and pathologists — from more than a dozen institutions, including Harvard Medical School, Brigham and Women’s Hospital in Boston and Case Western Reserve School of Medicine in Cleveland.
The 257 patients who completed the study all had asymptomatic extracranial high-grade internal carotid artery stenosis — in other words, their carotid arteries were blocked with plaque. The patients underwent carotid endarterectomies, a procedure in which the artery is opened and the plaque is cleaned out. Patients who’d had previous heart failure, valvular defects, cancer or other causes of hypertension were disqualified.
The researchers then examined the plaque and found polyethylene micro- and nano- particles in 150 of the patients. Thirty patients had polyvinyl chloride particles in their plaque. Images from electron microscopy showed visible, jagged-edged “foreign bodies” along with the biological plaque in these patients.
Polythylene, or PET, is the plastic used to make soda and water bottles. Polyvinyl chloride, or PVC, is the plastic used in water pipes, packaging, medical devices, toothbrushes, children’s toys and window frames, to name a few.
The two patient populations were roughly the same in terms of age, sex, weight, smoking status, geographical location, blood pressure and heart rate.
The one glaring difference, the authors noted, was the two groups’ susceptibility to heart disease in the months following the surgery — an indication that the presence of microplastics may have played a role. Indeed, indicators of inflammation were higher in the plastic-exposed group. Nonfatal heart attack, nonfatal stroke, or death from any cause occurred in eight of the 107 patients who did not have microplastics in their plaque and 30 of the 150 patients with microplastics.
The authors stressed they could only show correlation, not causality. Additional research would be necessary to establish a clear connection.
Study co-author Leonardo Trasande, a pediatrician and public policy expert at New York University’s Grossman School of Medicine and Wagner School of Public Service, said it was equally possible that chemicals piggy-backing on the particles — such as bisphenol A, phthalates and/or other plasticizers and additives — could be the culprits. The paper also notes that lab contamination and patient behaviors that are unknown to the researchers could also influence their results.
“I can’t tell you it’s the microplastics and I can’t tell you it’s the chemicals. I couldn’t tell you because no study has measured both and they both coexist,” he said. “The fact is that plastics are horrible for human health and costly.”
He noted a recent study he authored that showed the disease burden of these chemicals costs the U.S. healthcare system roughly $250 billion a year.
Ceriello and his co-authors noted scores of animal studies that showed harmful effects of microplastics. He also said the authors were still unclear as to how patients were being exposed, whether through inhalation or ingestion.
Recent studies have found micro- and nanoplastics in water bottled in plastic, as well as in dust.
“This is very solid and should be taken very seriously at the highest level of government,” said Judith Enck, the director of Beyond Plastics and a former regional director at the U.S. Environmental Protection Agency. “This tracks with other studies that have found microplastics in various organs, human blood, placenta and breast milk so this is not all that surprising, but still stunning.”
Plastic has been found everywhere scientists have looked: From the deepest ocean trenches to the highest alpine peaks. Petroleum-based plastics do not biodegrade. Over time, they break down into smaller and smaller pieces — known as microplastics, microfibers and nanoplastics — and have been found in household dust, drinking water and human tissue and blood.
“Cardiologists need to inform their patients to avoid plastic packaging — which is very hard to do,” Enck said.
Tracey Woodruff, director of UC San Francisco’s Program on Reproductive Health and the Environment in the Department of Obstetrics, Gynecology and Reproductive Sciences, said physicians and clinicians need to begin talking to their patients about the harms of plastic. She authored an essay that looked at the harmful effects of endocrine disruptors in the same edition as the heart study.
She said advice from doctors to eat organic, unprocessed foods already reduces exposures to plastics. But more is needed, especially in the medical fields of reproduction, obstetrics and pediatrics, she said, where the evidence of harm from plastic chemicals and endocrine disruptors has been well established.
The mounting evidence, she said, is getting “hard to ignore.”
Science
Very little plastic being recycled in California as state efforts falter
California touts itself as a leader on the problem of plastic garbage, but recent developments suggest otherwise.
A new report issued by the state’s waste agency shows plastic yogurt containers, shampoo bottles and restaurant takeout trays are being recycled at rates only in the single digits.
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Polypropylene, labeled as #5 on packaging, is used for yogurt containers, margarine tubs and microwavable trays. Only 2% of it is getting recycled. Colored shampoo and detergent bottles, made from polyethylene, or #1 plastic, are getting recycled at a rate of just 5%.
Other plastics, including ones promoted as highly recyclable, such as clear polyethylene bottles, which hold some medications, or hard water bottles, are being recycled at just 16%.
No plastic in the report exceeds a recycling rate of 23%, with the majority reported in just the single digits.
Adding to this disquieting assessment, CalRecycle also just pulled back regulations that were supposed to finalize a landmark single-use plastic law known as Senate Bill 54 — a law designed to make the majority of packaging waste in the state recyclable or compostable by working with the plastic and packaging industries.
The report and delay have sparked a wide variety of reactions by those who have closely watched the law as it was written and implemented.
The proposed regulations were regarded as friendly to industry. As a result, some are hopeful that CalRecycle’s decision to pull them back for tweaking means the agency will make the law stronger. Others say the two developments just show the state has never really been serious about plastic recycling.
“California’s SB 54 … will NEVER increase the recycling rates of these items … because cartons and plastic packaging are fundamentally not technically or economically recyclable,” said Jan Dell, the founder of Orange County-based Last Beach Cleanup, an anti-plastic organization.
Industry representatives are also expressing disappointment, saying the more delays and changes the state makes, the harder it is “for California businesses to comply with the law and implement the resulting changes,” said John Myers, a spokesman for the California Chamber of Commerce, which represents companies that will be affected.
Reports on abysmally low rates of recycling for milk cartons and polystyrene have been widely shared and known. But the newest numbers were still a grim confirmation that there are few options for dealing with these materials.
According to one state analysis, 2.9 million tons of single-use plastic and 171.4 billion single-use plastic components were sold, offered for sale or distributed in California in 2023.
Single-use plastics and plastic waste more broadly are considered a growing environmental and health problem. In recent decades, plastic waste has overwhelmed waterways and oceans, sickening marine life and threatening human health.
Last spring, the Newsom administration was accused of neutering the regulations that CalRecycle had initially proposed to implement the law. The changes excluded all packaging material related to produce, meat, dairy products, dog food, toothpaste, condoms, shampoo and cereal boxes, among other products. These are all products that might fall under the purview of the U.S. Food and Drug Administration and the U.S. Department of Agriculture.
It also opened the door to “alternative” recycling, such as chemical recycling, which environmentalists say is polluting, and was banned in the language of the law.
The waste agency then submitted those draft regulations to the Office of Administrative Law, whose lawyers and staff review proposed regulations to ensure they are “clear, necessary, legally valid, and available to the public” before finalizing them. They were set to release their determination on Friday; CalRecycle pulled the regulations back before the office issued its determination.
Neither the law office nor governor’s office responded to requests for comment.
Melanie Turner, CalRecycle’s spokeswoman, said the agency withdrew its proposed regulations “to make changes … to improve clarity and support successful implementation of the law,” and its revisions were focused on areas that dealt with “food and agricultural commodities.”
California State Sen. Ben Allen (D-Santa Monica), author of the original legislation, called the delay “entirely avoidable” in a statement, but said it would allow CalRecycle an “opportunity to ensure the regulations truly follow the law as it was signed.”
He urged the waste agency and Newsom’s administration not to “allow broad, sweeping exemptions that would undermine the program and increase costs for ratepayers.”
Critics of the watered-down regulations, such as Anja Brandon, the director of plastics policy for the Ocean Conservancy, said she wasn’t surprised by the withdrawal.
The proposed regulations “would have gone beyond CalRecycle’s authority by creating a sweeping categorical exclusion for food and agricultural packaging — effectively a loophole that would have allowed producers to continue putting vast amounts of plastic packaging into the marketplace, completely undermining SB 54’s goals and success,” she said in a text message.
Turner said CalRecycle will conduct a 15-day comment period — although when that begins has not yet been divulged.
Science
Cancer survival rates soar nationwide, but L.A. doctors warn cultural and educational barriers leave some behind
The American Cancer Society’s 2026 Cancer Statistics report, released Tuesday, marks a major milestone for U.S. cancer survival rates. For the first time, the annual report shows that 70% of Americans diagnosed with cancer can expect to live at least five years, compared with just 49% in the mid-1970s.
The new findings, based on data from national cancer records and death statistics from 2015 to 2021, also show promising progress in survival rates for people with the deadliest, most advanced and hardest-to-treat cancers when compared with rates from the mid-1990s. The five-year survival rate for myeloma, for example, nearly doubled (from 32% to 62%). The survival rate for liver cancer tripled (from 7% to 22%), for late-stage lung cancer nearly doubled (from 20% to 37%), and for both melanoma and rectal cancer more than doubled (from 16% to 35% and from 8% to 18%, respectively).
For all cancers, the five-year survival rate more than doubled since the mid-1990s, rising from 17% to 35%.
This also signals a 34% drop in cancer mortality since 1991, translating to an estimated 4.8 million fewer cancer deaths between 1991 and 2023. These significant public health advances result from years of public investment in research, early detection and prevention, and improved cancer treatment, according to the report.
“This stunning victory is largely the result of decades of cancer research that provided clinicians with the tools to treat the disease more effectively, turning many cancers from a death sentence into a chronic disease,” said Rebecca Siegel, senior scientific director at the American Cancer Society and lead author of the report.
As more people survive cancer, there is also a growing focus on the quality of life after treatment. Patients, families and caregivers face physical, financial and emotional challenges. Dr. William Dahut, the American Cancer Society’s chief scientific officer, said that ongoing innovation must go hand in hand with better support services and policies, so all survivors — not just the privileged — can have “not only more days, but better days.”
Indeed, the report also shows that not everyone has benefited equally from the advances of the last few decades. American Indian and Alaska Native people now have the highest cancer death rates in the country, with deaths from kidney, liver, stomach and cervical cancers about double that of white Americans.
Additionally, Black women are more likely to die from breast and uterine cancers than non-Black women — and Black men have the highest cancer rates of any American demographic. The report connects these disparities in survival to long-standing issues such as income inequity and the effects of past discrimination, such as redlining, affecting where people live — forcing historically marginalized populations to be disproportionately exposed to environmental carcinogens.
Dr. René Javier Sotelo, a urologic oncologist at Keck Medicine of USC, notes that the fight against cancer in Southern California, amid long-standing disparities facing vulnerable communities, is very much about overcoming educational, cultural and socioeconomic barriers.
While access to care and insurance options in Los Angeles are relatively robust, many disparities persist because community members often lack crucial information about risk factors, screening and early warning signs. “We need to insist on the importance of education and screening,” Sotelo said. He emphasized that making resources, helplines and culturally tailored materials readily available to everyone is crucial.
He cites penile cancer as a stark example: rates are higher among Latino men in L.A., not necessarily due to lack of access, but because of gaps in awareness and education around HPV vaccination and hygiene.
Despite these persisting inequities, the dramatic nationwide improvement in cancer survival is unquestionably good news, bringing renewed hope to many individuals and families. However, the report also gives a clear warning: Proposed federal cuts to cancer research and health insurance could stop or even undo these important gains.
“We can’t stop now,” warned Shane Jacobson, the American Cancer Society’s chief executive.
“We need to understand that we are not yet there,” Sotelo concurred. ”Cancer is still an issue.”
Science
Clashing with the state, L.A. City moves to adopt lenient wildfire ‘Zone Zero’ regulations
As the state continues multiyear marathon discussions on rules for what residents in wildfire hazard zones must do to make the first five feet from their houses — an area dubbed “Zone Zero” — ember-resistant, the Los Angeles City Council voted Tuesday to start creating its own version of the regulations that is more lenient than most proposals currently favored in Sacramento.
Critics of Zone Zero, who are worried about the financial burden and labor required to comply as well as the detrimental impacts to urban ecosystems, have been particularly vocal in Los Angeles. However, wildfire safety advocates worry the measures endorsed by L.A.’s City Council will do little to prevent homes from burning.
“My motion is to get advice from local experts, from the Fire Department, to actually put something in place that makes sense, that’s rooted in science,” said City Councilmember John Lee, who put forth the motion. “Sacramento, unfortunately, doesn’t consult with the largest city in the state — the largest area that deals with wildfires — and so, this is our way of sending a message.”
Tony Andersen — executive officer of the state’s Board of Forestry and Fire Protection, which is in charge of creating the regulations — has repeatedly stressed the board’s commitment to incorporating L.A.’s feedback. Over the last year, the board hosted a contentious public meeting in Pasadena, walking tours with L.A. residents and numerous virtual workshops and hearings.
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Some L.A. residents are championing a proposed fire-safety rule, referred to as “Zone Zero,” requiring the clearance of flammable material within the first five feet of homes. Others are skeptical of its value.
With the state long past its original Jan. 1, 2023, deadline to complete the regulations, several cities around the state have taken the matter into their own hands and adopted regulations ahead of the state, including Berkeley and San Diego.
“With the lack of guidance from the State Board of Forestry and Fire Protection, the City is left in a precarious position as it strives to protect residents, property, and the landscape that creates the City of Los Angeles,” the L.A. City Council motion states.
However, unlike San Diego and Berkeley, whose regulations more or less match the strictest options the state Board of Forestry is considering, Los Angeles is pushing for a more lenient approach.
The statewide regulations, once adopted, are expected to override any local versions that are significantly more lenient.
The Zone Zero regulations apply only to rural areas where the California Department of Forestry and Fire Protection responds to fires and urban areas that Cal Fire has determined have “very high” fire hazard. In L.A., that includes significant portions of Silver Lake, Echo Park, Brentwood and Pacific Palisades.
Fire experts and L.A. residents are generally fine with many of the measures within the state’s Zone Zero draft regulations, such as the requirement that there be no wooden or combustible fences or outbuildings within the first five feet of a home. Then there are some measures already required under previous wildfire regulations — such as removing dead vegetation like twigs and leaves, from the ground, roof and gutters — that are not under debate.
However, other new measures introduced by the state have generated controversy, especially in Los Angeles. The disputes have mainly centered around what to do about trees and other living vegetation, like shrubs and grass.
The state is considering two options for trees: One would require residents to trim branches within five feet of a house’s walls and roof; the other does not. Both require keeping trees well-maintained and at least 10 feet from chimneys.
On vegetation, the state is considering options for Zone Zero ranging from banning virtually all vegetation beyond small potted plants to just maintaining the regulations already on the books, which allow nearly all healthy vegetation.
Lee’s motion instructs the Los Angeles Fire Department to create regulations in line with the most lenient options that allow healthy vegetation and do not require the removal of tree limbs within five feet of a house. It is unclear whether LAFD will complete the process before the Board of Forestry considers finalized statewide regulations, which it expects to do midyear.
The motion follows a pointed report from LAFD and the city’s Community Forest Advisory Committee that argued the Board of Forestry’s draft regulations stepped beyond the intentions of the 2020 law creating Zone Zero, would undermine the city’s biodiversity goals and could result in the loss of up to 18% of the urban tree canopy in some neighborhoods.
The board has not decided which approach it will adopt statewide, but fire safety advocates worry that the lenient options championed by L.A. do little to protect vulnerable homes from wildfire.
Recent studies into fire mechanics have generally found that the intense heat from wildfire can quickly dry out these plants, making them susceptible to ignition from embers, flames and radiant heat. And anything next to a house that can burn risks taking the house with it.
Another recent study that looked at five major wildfires in California from the last decade, not including the 2025 Eaton and Palisades fires, found that 20% of homes with significant vegetation in Zone Zero survived, compared to 37% of homes that had cleared the vegetation.
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