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Microplastics may be new risk factor for cardiovascular disease, researchers say

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Microplastics may be new risk factor for cardiovascular disease, researchers say

Add one more likely culprit to the long list of known cardiovascular risk factors including red meat, butter, smoking and stress: microplastics.

In a study released Wednesday in the New England Journal of Medicine, an international team of physicians and researchers showed that surgical patients who had a build-up of micro and nanoplastics in their arterial plaque had a 2.1 times greater risk of nonfatal heart attack, nonfatal stroke or death from any cause in the three years post surgery than those who did not.

It’s the first study to show these ubiquitous and pernicious fossil fuel-based particles are having a direct effect on human health, said study co-author, Antonio Ceriello, head of the diabetes department at IRCCS MultiMedica, a research hospital in Milan.

And it should serve as a caution to all people, governments and corporations that plastic is not just a nuisance and blight in the environment, but is also harming human health, he said.

As government officials, negotiators, environmental activists and corporate representatives get ready to gather next month in Ottawa to discuss a global ban on plastic pollution, many are hoping this study will help tip the scales to establish real and tangible regulations.

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“This is a beginning … whereby people are going to see plastic is not just harmful to whales or sea turtles. It’s not just litter on a beach in some faraway country. It’s in them and it has the potential to cause harm. I think it’s going to change the narrative,” said Dr. Philip Landrigan, director of the Program for Global Public Health and the Common Good at Boston College.

He compared the awareness of the plastic crisis to climate change — in which people understood it in an abstract, theoretical way until wildfires burned their homes, sustained heatwaves killed their crops and flooding destroyed their communities.

“To my knowledge, this is the first report to link microplastics with human disease,” said Landrigan, who was not involved in the study but wrote an accompanying essay urging the global community to deliver on a “mandatory global cap on plastic production.”

Matt Seaholm, president and chief executive of the Plastics Industry Assn., suggested more research needs to be done.

“We encourage lawmakers to evaluate where those particles come from before using any type of microplastics or nanoplastics arguments for the justification or passage of any laws, because every study has shown that they are not coming from packaging or single-use items,” he said.

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Studies have shown that the two biggest contributors of microplastics in the environment are car tires and synthetic clothing. However, as the plastic industry expands and the number of single-use plastic items grow, so, too does their contribution to environmental contamination and pollution. Around 151 million tons of single-use plastics were produced
from fossil fuels in 2021. That number is expected to rise another 19 million tons by 2027.

The research on arterial plaque was conducted by a team of 40 scientists — including surgeons, engineers, statisticians and pathologists — from more than a dozen institutions, including Harvard Medical School, Brigham and Women’s Hospital in Boston and Case Western Reserve School of Medicine in Cleveland.

The 257 patients who completed the study all had asymptomatic extracranial high-grade internal carotid artery stenosis — in other words, their carotid arteries were blocked with plaque. The patients underwent carotid endarterectomies, a procedure in which the artery is opened and the plaque is cleaned out. Patients who’d had previous heart failure, valvular defects, cancer or other causes of hypertension were disqualified.

The researchers then examined the plaque and found polyethylene micro- and nano- particles in 150 of the patients. Thirty patients had polyvinyl chloride particles in their plaque. Images from electron microscopy showed visible, jagged-edged “foreign bodies” along with the biological plaque in these patients.

Polythylene, or PET, is the plastic used to make soda and water bottles. Polyvinyl chloride, or PVC, is the plastic used in water pipes, packaging, medical devices, toothbrushes, children’s toys and window frames, to name a few.

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The two patient populations were roughly the same in terms of age, sex, weight, smoking status, geographical location, blood pressure and heart rate.

The one glaring difference, the authors noted, was the two groups’ susceptibility to heart disease in the months following the surgery — an indication that the presence of microplastics may have played a role. Indeed, indicators of inflammation were higher in the plastic-exposed group. Nonfatal heart attack, nonfatal stroke, or death from any cause occurred in eight of the 107 patients who did not have microplastics in their plaque and 30 of the 150 patients with microplastics.

The authors stressed they could only show correlation, not causality. Additional research would be necessary to establish a clear connection.

Study co-author Leonardo Trasande, a pediatrician and public policy expert at New York University’s Grossman School of Medicine and Wagner School of Public Service, said it was equally possible that chemicals piggy-backing on the particles — such as bisphenol A, phthalates and/or other plasticizers and additives — could be the culprits. The paper also notes that lab contamination and patient behaviors that are unknown to the researchers could also influence their results.

“I can’t tell you it’s the microplastics and I can’t tell you it’s the chemicals. I couldn’t tell you because no study has measured both and they both coexist,” he said. “The fact is that plastics are horrible for human health and costly.”

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He noted a recent study he authored that showed the disease burden of these chemicals costs the U.S. healthcare system roughly $250 billion a year.

Ceriello and his co-authors noted scores of animal studies that showed harmful effects of microplastics. He also said the authors were still unclear as to how patients were being exposed, whether through inhalation or ingestion.

Recent studies have found micro- and nanoplastics in water bottled in plastic, as well as in dust.

“This is very solid and should be taken very seriously at the highest level of government,” said Judith Enck, the director of Beyond Plastics and a former regional director at the U.S. Environmental Protection Agency. “This tracks with other studies that have found microplastics in various organs, human blood, placenta and breast milk so this is not all that surprising, but still stunning.”

Plastic has been found everywhere scientists have looked: From the deepest ocean trenches to the highest alpine peaks. Petroleum-based plastics do not biodegrade. Over time, they break down into smaller and smaller pieces — known as microplastics, microfibers and nanoplastics — and have been found in household dust, drinking water and human tissue and blood.

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“Cardiologists need to inform their patients to avoid plastic packaging — which is very hard to do,” Enck said.

Tracey Woodruff, director of UC San Francisco’s Program on Reproductive Health and the Environment in the Department of Obstetrics, Gynecology and Reproductive Sciences, said physicians and clinicians need to begin talking to their patients about the harms of plastic. She authored an essay that looked at the harmful effects of endocrine disruptors in the same edition as the heart study.

She said advice from doctors to eat organic, unprocessed foods already reduces exposures to plastics. But more is needed, especially in the medical fields of reproduction, obstetrics and pediatrics, she said, where the evidence of harm from plastic chemicals and endocrine disruptors has been well established.

The mounting evidence, she said, is getting “hard to ignore.”

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Cluster of farmworkers diagnosed with rare animal-borne disease in Ventura County

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Cluster of farmworkers diagnosed with rare animal-borne disease in Ventura County

A cluster of workers at Ventura County berry farms have been diagnosed with a rare disease often transmitted through sick animals’ urine, according to a public health advisory distributed to local doctors by county health officials Tuesday.

The bacterial infection, leptospirosis, has resulted in severe symptoms for some workers, including meningitis, an inflammation of the brain lining and spinal cord. Symptoms for mild cases included headaches and fevers.

The disease, which can be fatal, rarely spreads from human to human, according to the U.S. Centers for Disease Control and Prevention.

Ventura County Public Health has not given an official case count but said it had not identified any cases outside of the agriculture sector. The county’s agriculture commissioner was aware of 18 cases, the Ventura County Star reported.

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The health department said it was first contacted by a local physician in October, who reported an unusual trend in symptoms among hospital patients.

After launching an investigation, the department identified leptospirosis as a probable cause of the illness and found most patients worked on caneberry farms that utilize hoop houses — greenhouse structures to shelter the crops.

As the investigation to identify any additional cases and the exact sources of exposure continues, Ventura County Public Health has asked healthcare providers to consider a leptospirosis diagnosis for sick agricultural workers, particularly berry harvesters.

Rodents are a common source and transmitter of disease, though other mammals — including livestock, cats and dogs — can transmit it as well.

The disease is spread through bodily fluids, such as urine, and is often contracted through cuts and abrasions that contact contaminated water and soil, where the bacteria can survive for months.

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Humans can also contract the illness through contaminated food; however, the county health agency has found no known health risks to the general public, including through the contact or consumption of caneberries such as raspberries and blackberries.

Symptom onset typically occurs between two and 30 days after exposure, and symptoms can last for months if untreated, according to the CDC.

The illness often begins with mild symptoms, with fevers, chills, vomiting and headaches. Some cases can then enter a second, more severe phase that can result in kidney or liver failure.

Ventura County Public Health recommends agriculture and berry harvesters regularly rinse any cuts with soap and water and cover them with bandages. They also recommend wearing waterproof clothing and protection while working outdoors, including gloves and long-sleeve shirts and pants.

While there is no evidence of spread to the larger community, according to the department, residents should wash hands frequently and work to control rodents around their property if possible.

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Pet owners can consult a veterinarian about leptospirosis vaccinations and should keep pets away from ponds, lakes and other natural bodies of water.

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Political stress: Can you stay engaged without sacrificing your mental health?

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Political stress: Can you stay engaged without sacrificing your mental health?

It’s been two weeks since Donald Trump won the presidential election, but Stacey Lamirand’s brain hasn’t stopped churning.

“I still think about the election all the time,” said the 60-year-old Bay Area resident, who wanted a Kamala Harris victory so badly that she flew to Pennsylvania and knocked on voters’ doors in the final days of the campaign. “I honestly don’t know what to do about that.”

Neither do the psychologists and political scientists who have been tracking the country’s slide toward toxic levels of partisanship.

Fully 69% of U.S. adults found the presidential election a significant source of stress in their lives, the American Psychological Assn. said in its latest Stress in America report.

The distress was present across the political spectrum, with 80% of Republicans, 79% of Democrats and 73% of independents surveyed saying they were stressed about the country’s future.

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That’s unhealthy for the body politic — and for voters themselves. Stress can cause muscle tension, headaches, sleep problems and loss of appetite. Chronic stress can inflict more serious damage to the immune system and make people more vulnerable to heart attacks, strokes, diabetes, infertility, clinical anxiety, depression and other ailments.

In most circumstances, the sound medical advice is to disengage from the source of stress, therapists said. But when stress is coming from politics, that prescription pits the health of the individual against the health of the nation.

“I’m worried about people totally withdrawing from politics because it’s unpleasant,” said Aaron Weinschenk, a political scientist at the University of Wisconsin–Green Bay who studies political behavior and elections. “We don’t want them to do that. But we also don’t want them to feel sick.”

Modern life is full of stressors of all kinds: paying bills, pleasing difficult bosses, getting along with frenemies, caring for children or aging parents (or both).

The stress that stems from politics isn’t fundamentally different from other kinds of stress. What’s unique about it is the way it encompasses and enhances other sources of stress, said Brett Ford, a social psychologist at the University of Toronto who studies the link between emotions and political engagement.

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For instance, she said, elections have the potential to make everyday stressors like money and health concerns more difficult to manage as candidates debate policies that could raise the price of gas or cut off access to certain kinds of medical care.

Layered on top of that is the fact that political disagreements have morphed into moral conflicts that are perceived as pitting good against evil.

“When someone comes into power who is not on the same page as you morally, that can hit very deeply,” Ford said.

Partisanship and polarization have raised the stakes as well. Voters who feel a strong connection to a political party become more invested in its success. That can make a loss at the ballot box feel like a personal defeat, she said.

There’s also the fact that we have limited control over the outcome of an election. A patient with heart disease can improve their prognosis by taking medicine, changing their diet, getting more exercise or quitting smoking. But a person with political stress is largely at the mercy of others.

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“Politics is many forms of stress all rolled into one,” Ford said.

Weinschenk observed this firsthand the day after the election.

“I could feel it when I went into my classroom,” said the professor, whose research has found that people with political anxiety aren’t necessarily anxious in general. “I have a student who’s transgender and a couple of students who are gay. Their emotional state was so closed down.”

That’s almost to be expected in a place like Wisconsin, whose swing-state status caused residents to be bombarded with political messages. The more campaign ads a person is exposed to, the greater the risk of being diagnosed with anxiety, depression or another psychological ailment, according to a 2022 study in the journal PLOS One.

Political messages seem designed to keep voters “emotionally on edge,” said Vaile Wright, a licensed psychologist in Villa Park, Ill., and a member of the APA’s Stress in America team.

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“It encourages emotion to drive our decision-making behavior, as opposed to logic,” Wright said. “When we’re really emotionally stimulated, it makes it so much more challenging to have civil conversation. For politicians, I think that’s powerful, because emotions can be very easily manipulated.”

Making voters feel anxious is a tried-and-true way to grab their attention, said Christopher Ojeda, a political scientist at UC Merced who studies mental health and politics.

“Feelings of anxiety can be mobilizing, definitely,” he said. “That’s why politicians make fear appeals — they want people to get engaged.”

On the other hand, “feelings of depression are demobilizing and take you out of the political system,” said Ojeda, author of “The Sad Citizen: How Politics is Depressing and Why it Matters.”

“What [these feelings] can tell you is, ‘Things aren’t going the way I want them to. Maybe I need to step back,’” he said.

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Genessa Krasnow has been seeing a lot of that since the election.

The Seattle entrepreneur, who also campaigned for Harris, said it grates on her to see people laughing in restaurants “as if nothing had happened.” At a recent book club meeting, her fellow group members were willing to let her vent about politics for five minutes, but they weren’t interested in discussing ways they could counteract the incoming president.

“They’re in a state of disengagement,” said Krasnow, who is 56. She, meanwhile, is looking for new ways to reach young voters.

“I am exhausted. I am so sad,” she said. “But I don’t believe that disengaging is the answer.”

That’s the fundamental trade-off, Ojeda said, and there’s no one-size-fits-all solution.

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“Everyone has to make a decision about how much engagement they can tolerate without undermining their psychological well-being,” he said.

Lamirand took steps to protect her mental health by cutting social media ties with people whose values aren’t aligned with hers. But she will remain politically active and expects to volunteer for phone-banking duty soon.

“Doing something is the only thing that allows me to feel better,” Lamirand said. “It allows me to feel some level of control.”

Ideally, Ford said, people would not have to choose between being politically active and preserving their mental health. She is investigating ways to help people feel hopeful, inspired and compassionate about political challenges, since these emotions can motivate action without triggering stress and anxiety.

“We want to counteract this pattern where the more involved you are, the worse you are,” Ford said.

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The benefits would be felt across the political spectrum. In the APA survey, similar shares of Democrats, Republicans and independents agreed with statements like, “It causes me stress that politicians aren’t talking about the things that are most important to me,” and, “The political climate has caused strain between my family members and me.”

“Both sides are very invested in this country, and that is a good thing,” Wright said. “Antipathy and hopelessness really doesn’t serve us in the long run.”

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Video: SpaceX Unable to Recover Booster Stage During Sixth Test Flight

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Video: SpaceX Unable to Recover Booster Stage During Sixth Test Flight

President-elect Donald Trump joined Elon Musk in Texas and watched the launch from a nearby location on Tuesday. While the Starship’s giant booster stage was unable to repeat a “chopsticks” landing, the vehicle’s upper stage successfully splashed down in the Indian Ocean.

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