Science
I'm a woman in my 40s. Why do I feel terrible every time I have a drink?
This summer an old high school friend of mine decided to quit drinking entirely. She didn’t want to, but she felt she had no choice.
“All of a sudden my body decided that alcohol is poison,” she told me recently over a bitter grapefruit mocktail at an Italian restaurant. “I can have as little as one drink, and I have a hangover.”
Like me, my high school friend was never a heavy drinker. She enjoyed having a glass of wine with dinner and a craft cocktail or two at a bar or restaurant with friends. If she had several drinks in a night she would expect to feel sluggish in the morning, but one or two was never a problem. Then, sometime in her mid-40s, her ability to tolerate alcohol plummeted.
“It’s that feeling of regret,” she said when I asked her about her post-drinking symptoms. “Headache, fatigue, I don’t know how to name that feeling in your stomach.”
The last time she had a margarita she felt so terrible that she ended up canceling her plans the following evening.
It’s a story I’ve been hearing from a growing number of my female friends since we entered our mid-40s a few years ago. Molly finds drinking wreaks havoc with her digestive system and her sleep. Alexis loads up on water and Motrin even if all she’s had was a half-glass of wine. Naama, who still makes the world’s most delicious batch cocktails, stopped drinking a few years ago after getting the sweats and a splitting headache halfway through a vodka soda.
I’ve experienced it as well. After even one drink, I find myself waking up at 3 in the morning with a dull ache in my stomach, wishing I’d made a different choice. Now, each opportunity to grab a beer at a barbecue, enjoy a cocktail at a restaurant or sip a glass of wine at a dinner party requires a cost-benefit analysis: How much do I want a drink now versus but how much am I willing to pay for it later?
To understand why my friends and I are finding alcohol more difficult to tolerate as we age, I reached out to George F. Koob, director of the National Institute on Alcohol Abuse and Alcoholism.
Koob pointed to studies that show that women are more sensitive to the toxic effects of alcohol — developing alcohol-related liver disease and high blood pressure due to drinking at higher rates than men — but added that scientists are still working out why that seems to be the case.
“This is a new area of research,” he said.
While Koob wasn’t aware of studies that looked specifically at how a woman’s ability to metabolize alcohol changes in middle age, he said any changes may be due in part to the natural and inevitable fact that our lean muscle mass decreases and our body fat increases as we get older.
“You might drink the same amount of alcohol that you used to drink, but now that one drink is more like having one and a half or two drinks, because the alcohol is hanging out in the bloodstream.”
— George F. Koob, director of the National Institute on Alcohol Abuse and Alcoholism
Alcohol is drawn to water, Koob explained, and lean muscle mass has a higher percentage of water than fat does. Lean muscle mass, then, gives alcohol more space to dissipate throughout the body, making for less of it in the bloodstream, and a lower blood alcohol concentration. But as we age and lose lean muscle mass and gain fat, a higher concentration of alcohol winds up in our bloodstream. That makes for worse hangovers and extended recovery time.
“You might drink the same amount of alcohol that you used to drink, but now that one drink is more like having one and a half or two drinks, because the alcohol is hanging out in the bloodstream,” he said.
If it makes you feel any better, men also lose lean muscle mass and gain fat as they age, but men’s bodies have a higher concentration of water (55% to 65%) compared with women (45% to 50%) to begin with, so the effects may not be as obvious as they are for us.
Koob supports finding alternatives to drinking — “If you feel better when you don’t drink, then listen to your body,” he said. If you are going to drink, he offered that eating a snack beforehand can slow down the body’s absorption of alcohol and help blunt the irritation to the stomach that can cause the icky feeling I know so well. He also advised against using ibuprofen immediately after drinking, because it can also irritate the stomach. Drinking extra water will help dilute the alcohol, but ultimately, it’s the amount of alcohol you drink that will affect how you feel, not how much water you drink.
Because my friends and I are also firmly in the perimenopausal phase of our lives, I called up Dr. Monica Christmas, associate professor of obstetrics and gynecology at the University of Chicago and associate medical director of the Menopause Society, to see if our new challenges with alcohol might be related to hormonal changes as well.
The answer was a resounding yes.
She explained that alcohol triggers or exacerbates many of the symptoms of both menopause and “the menopause transition,” which can begin seven to 10 years before a woman’s period actually stops.
For example, 40% of women report mood instability during the menopause transition, which can include increased anxiety, depression, or not being motivated to do the things they once did.
“Alcohol exacerbates those things,” Dr. Christmas said. “So if you’re already experiencing mood instability, you’re only going to feel that much worse when you drink alcohol.”
I haven’t noticed my anxiety skyrocketing after having a drink or two, but my high school friend said that sounded familiar.
“There was an evil loop I was in, where I was like, I’m really anxious, maybe I’ll have another drink,” she said. “My husband was like, how’s that working out for you?”
To be clear, not all my friends feel this way. Some who have always consumed alcohol more regularly looked at me quizzically when I asked if they find it harder to drink these days. It’s possible they have developed a physiological tolerance to alcohol or may just be more used to hangovers, said MacKenzie Peltier, an assistant professor of psychiatry at Yale School of Medicine who studies sex differences in alcohol abuse disorders. It might also be that their experiences of the menopausal transition or aging are different. “But that’s complete speculation,” she said.
As for the rest of my friend group, we’re all handling this frankly unwelcome change in different ways. My high school friend has become a mocktail connoisseur. Molly hasn’t cut out alcohol completely, but she does do dry months to give her body a break. Alexis recently decided not to drink during the week anymore, but weekends are still up for debate. Naama is always on the hunt for a fancy nonalcoholic drink with low sugar content to sip at celebratory occasions.
“The only time I miss it is when we’re out with friends and the only option is Diet Coke,” she said. “And God forbid if that option is only Diet Pepsi. Then I’m really screwed.”
As for me, I’m trying to minimize the temptation to consume alcohol. Not only are pre-dinner cocktails expensive from a financial standpoint, they’re costly from a health perspective, too.
I do still love to have a drink at my Italian social club, however, and if that means a couple of rough nights a month in order to enjoy an Aperol Spritz or two — for me, that’s a trade-off I’m willing to make.
Science
Video: NASA Announces Artemis III Crew
new video loaded: NASA Announces Artemis III Crew
transcript
transcript
NASA Announces Artemis III Crew
NASA announced the crew of Artemis III mission, which will fly to low-Earth orbit to test rendezvous and docking maneuvers with one or two lunar landers.
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“I am excited to welcome you as the next crew in the Artemis journey to successfully return to the moon — this time to stay.” “I’m honored by the role that I’ve been given. I’m also very humbled by the task in front of us. But first and foremost, I’m grateful.” “So with that, the Artemis II crew, comrade, hands you the baton. You got the controls.” “As you know, we had a significant anomaly at our Launch Complex 36A on May 28. We’ve redoubled our efforts and are moving forward.”
By Alisa Shodiyev Kaff
June 9, 2026
Science
Santa Monica Mountains’ last steelhead trout survived the Palisades fire — and even had babies
Scientists feared the Santa Monica Mountains’ last remaining steelhead trout were dead, smothered by debris flows unleashed by the Palisades fire.
But the endangered fish surprised them: A team of biologists recently spotted 30 of the rare trout — and 21 babies — in Topanga Creek.
“There was a lot of happy dancing in the creek,” said Rosi Dagit, principal conservation biologist for the Resource Conservation District of the Santa Monica Mountains, which works with public and private landowners to conserve natural resources.
That’s because the steelhead here are endangered, at both the state and federal levels. Once, they swam in most streams of the Santa Monicas, but their numbers plummeted amid overfishing and coastal development. Increasingly frequent wildfire has further stressed their habitat. Topanga Creek, a biodiversity hot spot, is home to their last known population in the mountains that stretch from the Hollywood Hills to Point Mugu in Ventura County.
The trout that were spotted, including this one, are part of a distinct Southern California population that’s listed as endangered at the state and federal levels.
(RCDSMM Stream Team)
The California Department of Fish and Wildlife spearheaded a complex mission to rescue trout threatened by the Palisades fire that sparked in January 2025.
Time was of the essence. The fire hadn’t yet been fully contained. But rain was on the way, which would sweep massive amounts of sediment from the denuded hillsides into the water. Fish are often killed this way.
Crews stunned the fish with electricity, scooped them up in buckets, trucked them to a hatchery and ultimately moved them to Arroyo Hondo Creek in Santa Barbara County.
Within days, Topanga Creek was choked with mud. Some assumed the fish left behind were goners.
But in March, the conservation district’s team found four. The following month, when water conditions were clearer, they saw more.
“These fish continue to amaze me,” said Kyle Evans, environmental program manager for the state Department of Fish and Wildlife, who had seen the damage to the creek. “I had seen populations get wiped out in similar situations. So when I heard, I was thrilled.”
Evans surmises the fish that survived were in an area of the creek where less charred material and sediment were swept in.
“These fish likely hunkered down, were hiding under some rocks or places to try to get away from the main concentration of flow,” he said. “And luckily they weren’t buried.”
The ones that were spotted were fairly small, around 6 to 14 inches. Rainbow trout and steelhead trout are the same species, but with different lifestyles. If the fish remain in freshwater, they’ll be considered rainbows. However, they can migrate to the ocean and become steelhead, where they typically grow larger before returning to their natal waters to spawn.
Topanga Creek hasn’t fully recovered from the damage it sustained, but scientists say it’s looking better. Surveys last year were “so depressing,” Dagit said, with very few animals, and stretches that were essentially transformed into flat roads from all the sediment buildup. Some of the riparian canopy burned right down to the creek.
Then came 32 inches of rain over the last nine months, scouring out and moving sediment, creating deeper pools. Dagit said they recently found newt egg masses for the first time in years, as well as a few adult newts and many frogs. Plants that provide cover are starting to recover.
She provided photos comparing certain pools last year and this year, some dramatically transformed. In September 2025, the Shrine Pool could have been an overgrown hiking trail. This April, it was filled with shallow water.
The Shrine Pool in September 2025, left, and the same location in April 2026, right, with RCDSMM’s Isaac Yelchin donning a wetsuit.
(RCDSMM Stream Team)
Topanga Creek is home to another endangered fish, the small but hardy northern tidewater goby, often described as cute. Not long before the trout operation, Dagit led a rescue of hundreds of these fish too. Many were repatriated to the lagoon at the mouth of the creek in a moving ceremony last June.
There’s still the matter of what to do with the trout that were moved to Santa Barbara County last year. Evans would like to bring them home to the Santa Monicas at some point, but isn’t sure if it will happen. On one hand, they could bolster the small, genetically isolated surviving population. On the other, they might inadvertently bring in a disease or bacteria. There is some time to decide. Evans estimates the creek still needs to recover for two to three more years.
For now, the fish are functioning fine in their adopted creek. Experts worried the trauma wrought by the move would disrupt their spawning process, but they had babies that spring. This year, they spawned again.
Science
Pacifica pier cracks, another coastal casualty as seas continue to rise
The Pacifica Municipal Pier was shut down and taped off Thursday after city workers noticed cracks running through the landmark structure and concrete chunks falling into the ocean.
It’s just one of many coastal California structures that have recently crumbled under pressure from a rising and relentless ocean.
Officials from the small, beach city south of San Francisco said the pier was closed due to “cracking, separation, and displacement of the concrete walkway and structural elements.”
It will stay closed while structural engineers asses its safety.
Photos taken by city employees show a wide crack that runs from top to bottom and across the structure as well. Other photos show a large horizontal crack under the foundation of a small restaurant on the pier, the Chit Chat Cafe.
The cafe was also shut down.
This is not the first time the 53-year-old pier has shown signs of stress. In 2021, part of it was shut down after handrails along the edge collapsed. And in 2023, after a series of storms pummeled the Central California coast, damaging parts of the pier, the structure was partially closed for more than year.
Those same storms caused extensive damage in Aptos and Capitola, 70 miles south, where piers and waterfront infrastructure were swept away or damaged.
In 2024, a 150- to 180- foot section of the Santa Cruz wharf was ripped off by powerful waves.
At least 10 of the state’s dozens of coastal public piers were closed for part or all of 2024 due to structural damage sustained in winter storms since 2022. At least five others have longer-term upgrades planned to address structural issues.
“These things are costly to maintain,” said Zach Plopper, senior environmental director at Surfrider. “They are a part of our California coastal culture in many ways, but we’re going to need to reckon with, one, the state that they’re in, and two, the continuous and worsening threats they’re going to experience,”
He said most of the piers were constructed in the early 1900s, and they weren’t built to withstand decades of rough seas, storms and rising sea level.
“With this incoming El Niño, which is forecasted to be significant, and this marine heat wave we’re in the midst of, we’re kind of in uncharted waters as far as what this winter could bring in terms of storms and swells to the California coast, and we’re likely going to see a lot more damage,” he said. “Not just piers, but roads and other coastal infrastructure up and down the state.”
There was no storm in Pacifica earlier this week, so no single event could be blamed for the destruction.
However, a 2025 report from an outside engineering firm, GHD, found that several sections of the pier were in “poor” or “serious” condition, and they recommended closure before anticipated storms or events that could “subject the piles to high winds, swells and large waves.”
The firm found several areas of the pier where concrete was missing and rebar was exposed and corroding.
“The pier has continued to experience high winds and large waves in a harsh marine environment,” the engineers wrote in the report, noting that continuous exposure to seawater or marine spray was “detrimental” to the structure.
A 2023 city report estimated it would cost $19 million to repair.
That same year, a state law was enacted to require local governments along the California coast to plan for sea level rise in the coming decades.
Sea level has risen some 8 inches, on average, along the coast in the past 150 years, Plopper said, and researchers anticipate another foot in the next 25 years.
“We’re going to see profound shifts on our coastline, none that we have ever experienced before, and building static structures on the coast just doesn’t work all that well,” he said. “We’re going to have to make some really hard decisions.”
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