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How to Get Heart Patients to Take Their Pills? Give Them Just One.

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How to Get Heart Patients to Take Their Pills? Give Them Just One.

Coronary heart illness kills extra folks than every other situation, however regardless of advances in remedy and prevention, sufferers typically don’t keep on with their medicine regimens. Now researchers could have discovered an answer: a so-called polypill that mixes three medication wanted to stop cardiovascular hassle.

In what is outwardly the most important and longest randomized managed trial of this strategy, sufferers who have been prescribed a polypill inside six months of a coronary heart assault have been extra prone to preserve taking their medication and had considerably fewer cardiovascular occasions, in contrast with these receiving the same old assortment of capsules.

The individuals additionally skilled one-third fewer cardiovascular deaths, though their total danger of demise from all causes was not considerably modified.

The research of greater than two thousand coronary heart sufferers, who have been adopted for 3 years, was printed Friday morning in The New England Journal of Drugs, because the findings have been introduced on the European Society of Cardiology Congress in Barcelona.

The research is the fruits of 15 years of labor by researchers led by Dr. Valentin Fuster, director of Mount Sinai Coronary heart at Mount Sinai Hospital in New York Metropolis, and basic director of the Nationwide Middle for Cardiovascular Analysis in Spain.

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“Mixture capsules are simpler for the doctor and for the affected person, and the info are fairly clear — it interprets right into a profit,” stated Dr. Thomas J. Wang, chair of the division of inside drugs at UT Southwestern Medical Middle, who was not concerned within the analysis however wrote an editorial accompanying the research.

“It’s simpler to take one capsule versus a number of capsules, and it’s simpler to take them as soon as a day than a number of instances a day.”

The supply of a polypill additionally seems to nudge physicians to put in writing prescriptions extra consistent with observe pointers, Dr. Wang added: “Below strange circumstances, physicians typically under-prescribe medicines that needs to be given.”

The polypill combines a blood-pressure medicine, a cholesterol-lowering drug and aspirin, which helps forestall blood clots. The concept was first floated twenty years in the past in a extra radical type: Advocates proposed giving a day by day polypill to everybody as soon as they turned 55, saying it could slash cardiovascular occasions globally by 80 p.c.

That notion was roundly criticized and rapidly laid to relaxation. However the advantages of a polypill for sufferers vulnerable to coronary heart issues have been examined in quite a few research since. Polypills are already out there to deal with different medical situations, comparable to H.I.V. and hepatitis C, Dr. Wang famous.

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The polypill used within the research has not been permitted by the Meals and Drug Administration and isn’t out there to sufferers in america proper now. Dr. Fuster stated the outcomes of the brand new trial can be submitted to the company shortly in an effort to acquire approval.

He referred to as the outcomes of the brand new research “hanging,” and stated the advantage of the polypill for prevention rivaled that of low-dose aspirin, which is now routinely prescribed to individuals who have already had a coronary heart assault or different cardiovascular occasion.

And since individuals grew to become much more prone to preserve taking the polypill over time, he stated, “The potential outcomes might be even higher with extra follow-up.” A number of research have proven that solely about half of sufferers, and even much less, take all their medicines as instructed.

The brand new research, a randomized managed scientific trial, enrolled just below 2,500 sufferers at 113 websites in Spain, Italy, France, Germany, Poland, the Czech Republic and Hungary.

All enrollees had survived a coronary heart assault inside the earlier six months. They have been both older than 75, or a minimum of 65 with different well being situations like diabetes or kidney illness. General, about 80 p.c had hypertension, practically 60 p.c had diabetes, and over half had a historical past of smoking.

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Virtually the entire sufferers have been white, and fewer than one-third have been girls. A overwhelming majority weren’t highschool graduates.

Half of the trial individuals acquired the polypill, whereas the opposite half acquired common care. There have been a number of sorts of polypills, and remedy was tailor-made to particular person sufferers.

The entire polypills contained 100 milligrams of aspirin, however docs may select between three doses of ramipril, a blood strain drug, and between two doses of atorvastatin, a cholesterol-lowering medicine.

Adherence to medicine was increased among the many polypill customers, and elevated over time, the researchers discovered. At six months, 70.6 p.c of the polypill group have been sticking to their regimens, in contrast with 62.7 p.c of these taking common assortment of capsules.

At 24 months, about three-quarters of the sufferers have been nonetheless taking a polypill, in contrast with 63.2 p.c of the sufferers taking the same old capsules.

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Over three years, 12.7 p.c of the sufferers taking an assortment of capsules skilled one other coronary heart assault or stroke, or died of a cardiac occasion or wanted pressing remedy to open a blocked artery, in contrast with 9.5 p.c of sufferers taking a polypill, for a relative discount in danger of 24 p.c.

There was no distinction between the 2 teams in total mortality, nevertheless, because the discount in cardiovascular deaths within the polypill group was offset by deaths from different causes.

Requested why the polypill was efficient, and why adherence to medicine was so poor, Dr. Fuster stated, “Folks neglect when there are a selection of capsules to be taken, they don’t take all of them or they take none.”

Though most sufferers keep on with remedy within the fast aftermath of a coronary heart assault, adherence drops off after the primary few months, he stated.

The polypill could also be cheaper to provide and distribute than a sequence of various capsules. The findings could assist make cardiovascular prevention remedy extra accessible, particularly to people in low-income and middle-income nations.

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Though the affected person cohort within the European research was very homogeneous, different research have checked out polypill use in minority and underserved populations.

Dr. Wang led a research of a polypill prescribed for major prevention of heart problems in a low-income, principally Black group of adults in Alabama. Adherence was very excessive, and the individuals noticed higher decreases in ldl cholesterol and blood strain than these receiving medicines of their common type.

A evaluation of eight research that included over 25,000 sufferers, additionally led by Dr. Wang, discovered considerably improved adherence to drug regimens with a polypill and important reductions in cardiovascular danger components.

General mortality declined amongst sufferers assigned to take polypills, as did severe cardiac occasions, significantly amongst those that have been at low danger to start with and had no earlier coronary heart illness.

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If you're living with a drug or mental health problem, here's where to look for help

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If you're living with a drug or mental health problem, here's where to look for help

Fatal overdoses in the U.S. fell for the first time in five years in 2023, according to preliminary estimates recently released by the Centers for Disease Control and Prevention, but UCLA researcher Joseph Friedman warns that the new findings should not be interpreted to mean that the nation’s drug and mental health crises are abating.

Friedman has analyzed “deaths of despair” that result from overdose, suicide and liver disease due to alcoholism and found that while death rates for white Americans have dipped, rates have risen in recent years among people of color in the U.S., especially among Native and Black Americans. Illegal opioids such as fentanyl have ravaged Black and low-income communities in Los Angeles.

While it’s difficult to pinpoint the exact reasons behind substance abuse or suicide, Friedman as well as other experts in addiction medicine and mental health say racial inequality, economic distress and historical trauma have aggravated those problems in marginalized communities.

If you or someone you know needs immediate help for a mental health, substance-use or suicidal crisis, call or text 988, or chat online by visiting the suicide and crisis line’s website. For mental health resources and referrals, call the Los Angeles County Department of Mental Health’s Help Line 24/7 at (800) 854-7771.

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Here are other organizations that offer information, counseling and support services:

Nakeya Fields, a licensed clinical social worker in Pasadena, founded the Black Mental Health Task Force, a coalition that brings together mental health professionals, clients, nonprofits, community organizations, educators and others in California to raise awareness about mental wellness. Her Therapeutic Play Foundation offers activities designed to improve resilience and coping skills through creative arts, play and sports. It provides individual, couples, group and family therapy for Black, Latinx, LGBTQ+ and other members of marginalized populations.

The American Indian Counseling Center, a division of the Los Angeles County Mental Health Department, offers crisis intervention, 24/7 intensive mental health services and counseling for all ages, as well as physician consultations for medications and referrals to culturally relevant support groups. Call (562) 402-0677 and ask to speak with the on-duty worker.

United American Indian Involvement’s behavioral health program provides outpatient substance use disorder treatment and mental health services to American Indians and Alaska Natives living throughout Los Angeles County. Visit the website or call (213) 202-3970.

Melanin and Mental Health offers an online network of Black and brown mental healthcare providers that is searchable by geographic area, issue type and treatment sought. It’s also possible to filter results by therapists’ racial background and specialty, as well as by insurance carrier.

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The Black Mental Health Alliance offers confidential referrals to culturally competent mental health professionals who are in its database of licensed therapists.

Painted Brain advocates for mental wellness in underserved L.A. communities by offering self-care, relaxation and therapeutic art and play sessions, support groups and trainings for mental health professionals. As part of its peer-led model, many of the staff have experienced mental health issues themselves. Its community center and art space is located at 5980 W. Pico Blvd. in Los Angeles.

The Los Angeles LGBT Center offers individual, couples, family, group therapy and psychiatric care, as well as support for people struggling with substance use. The center has locations in West Hollywood, at Mi Centro in East L.A., at its Trans Wellness Center near MacArthur Park and in South L.A.’s Leimert Park neighborhood.

The Community Health Project Los Angeles provides services to people who use drugs by way of a harm-reduction approach that emphasizes offering clean needles as well as education on how to respond to an overdose.

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Are 'deaths of despair' really more common for white Americans? A UCLA report says no

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Are 'deaths of despair' really more common for white Americans? A UCLA report says no

Nakeya Fields has seen how the stresses that come with being Black — racial injustice, financial strain, social isolation — can leave people feeling hopeless and push some into substance abuse.

It’s one of the reasons the Pasadena social worker started offering “therapeutic play” gatherings for Black mothers like herself and children.

“I’m trying to host more safe spaces for us to come and share that we’re suffering,” the 32-year-old said. “And honestly, the adults need play more than kids.”

Yet while Black and brown mental health practitioners such as Fields have labored to address these issues within their communities, a very different conversation has been occurring in the nation at large.

For years, discussions about America’s substance-abuse crisis have focused almost exclusively on the narrative that it is white, middle-age adults who face the greatest risk of dying from drug overdoses, alcoholic liver disease and suicide.

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The theory, which was presented by two Princeton economists in 2015 and based on data from 1999 to 2013, argued that despair was behind rising premature mortality rates among white Americans, especially those who were less educated.

Virtually overnight, the “deaths of despair” concept began to drive the national discourse over populist far-right politics; the rise of Donald Trump; and deepening political polarization over such topics as addiction treatment, law enforcement and immigration.

But after roughly a decade, researchers at UCLA and elsewhere have begun to dismantle this idea.

In a study published recently in the journal JAMA Psychiatry, authors found that deaths of despair rates for middle-age Black and Native Americans have surged past those of white Americans as the overdose crisis moves from being driven by prescription opioids to illegal drugs such as fentanyl and heroin.

While the opioid crisis did raise drug overdose deaths among white Americans for a time, it was an anomaly, said Joseph Friedman, a social medicine expert at UCLA’s David Geffen School of Medicine who was the lead author of the journal analysis. In fact, by 2022 the rate for white Americans had started to dip.

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“What’s really important is that now, with these three causes of death, the gap has closed, and it’s moving in the other direction,” Friedman said.

Sandra Mims, a community health worker with Community Health Project L.A., puts out boxes of Narcan — a naloxone nasal spray that reverses the effects of opioid overdose — at an event at MacArthur Park in Los Angeles on International Overdose Awareness Day.

(Mel Melcon / Los Angeles Times)

The analysis found that deaths of despair for Black Americans hit a rate of 103.81 per 100,000 people in 2022, compared with 102.63 for white Americans. The rate for Native American and Alaska Native populations was even higher at 241.7 per 100,000 people in 2022.

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The UCLA analysis doesn’t specify the midlife personal issues that might have led to addiction or suicide.

But the authors say that flaws in the methodology of the 2015 deaths of despair report skewed its conclusions about who was most at risk. Specifically, Friedman said that it failed to give enough consideration to long-standing racial inequities that Black Americans experience in income, educational attainment, incarceration and access to quality medical care, all of which can contribute to drug use and poor mental health outcomes. And statistics for Native Americans weren’t factored in at all.

“It was burned into the American psyche that it was white people in the rural U.S.,” Friedman said. “It was just a very small piece of the truth that was very interesting but was widely sold as something it wasn’t.”

Another recent worrying sign, Friedman says: Deaths of despair among Latinos are starting to catch up to those among Black and Native Americans.

Princeton professors Anne Case and her husband Angus Deaton, winner of the 2015 Nobel Prize in economic sciences, were thrust into the media spotlight when their deaths of despair findings were first published. Deaton told NPR that during a visit to the White House, even President Obama asked him about the phenomenon.

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Their 2020 book, “Deaths of Despair and the Future of Capitalism,” was described by publisher Princeton University Press as “a troubling portrait of the American dream in decline.”

“For the white working class, today’s America has become a land of broken families and few prospects. As the college educated become healthier and wealthier, adults without a degree are literally dying from pain and despair,” the publisher said.

Fields, who employs yoga and pottery in her therapy, said this framing was misleading and racially biased.

“I’m actually flabbergasted that somebody has a term called ‘deaths of despair,’” Fields said. “It’s ‘despair’ when white people experience this suffering. But when we experience it, it’s just what we have to deal with.”

Nakeya Fields

Nakeya Fields says it’s important to address mental wellness issues early, before people reach a crisis point and become another statistic.

(Jason Armond / Los Angeles Times)

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Both Friedman and Fields say their critiques are not intended to minimize deaths among white Americans.

Still, Friedman wonders: “How do we empower Black and Native American communities in a way that enables them to treat these problems?”

Racism must be considered when trying to make sense of the crisis in premature deaths, says Dr. Helena Hansen, head of UCLA’s Department of Psychiatry and a senior author on Friedman’s analysis. Hansen, who is Black and specializes in addiction psychiatry, also co-authored the book “Whiteout: How Racial Capitalism Changed the Color of Opioids in America.”

For years, pharmaceutical companies steered expensive prescription pain medications, such as the opioid Oxycontin, as well as the most effective medications for opioid-use disorder, to white Americans with good access to healthcare, she said.

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But at the same time, Black and brown Americans were unfairly subjected to law enforcement policies that prioritized incarceration for illegal drug use over increasing access to more humane medical strategies to help them, further harming already vulnerable communities, Hansen said.

“In our society, people with access to the new technologies and pharmaceuticals are more likely to be white,” Hansen says. “None of this is by accident. All of this is the direct result of careful racially and class-segmented marketing strategies by pharmaceutical companies.”

This two-tiered system arose because drug manufacturers, doctors and policymakers have for too long failed to see people from historically marginalized communities who live with addiction and mental health crises as worthy of the same sympathy and treatments that many white Americans receive, Hansen says.

Joseph Gone, a professor of anthropology at Harvard who has spent 25 years studying the intersection of colonialism, culture and mental health in Indigenous communities, agreed.

“Deaths of despair have been a reality for Indigenous communities since conquest and dispossession,” he said.

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“It’s amazing how much grief our people contend with from early deaths — there are not that many communities in America that bear it quite the way we do,” said Gone, who is a member of the Aaniiih-Gros Ventre tribal nation of north-central Montana. “Until we acknowledge and take responsibility for the casualties of colonization, which endure to this day through deaths of despair, it’s going to be very hard to turn this around.”

Gone, who has collaborated with Friedman on previous research, says the mental health crisis in tribal nations is aggravated by widespread joblessness and generational poverty, and a lack of healthcare resources to treat people in need of immediate or long-term treatment.

Just one traveling psychiatrist serves reservations spread across both Montana and Wyoming — a region covering more than 243,300 square miles — mostly to manage patients’ prescriptions, he says.

And “for all of Indian country, we’re talking about a very small number of in-patient psychiatric facilities,” Gone says.

General practitioners can serve as a first line of defense, but they are not necessarily equipped to address the ongoing life crises that can lead to excessive drug and alcohol use, Gone says.

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Fields says it’s important to address mental wellness issues early, before people reach a crisis point and become another statistic.

While her focus remains on Black women, she’s developed additional programming for adults, families and children, such as developmental screenings that measure for high stress levels. In June, Fields will co-present “Rap 4 Peace,” a conference and gala featuring hip-hop artists talking about mental health and reducing gun violence.

“This ‘tragedy of despair’ lives in us,” Fields says. “We breathe it. We go outside hoping that nobody will harm us or our children because they feel threatened by us. This is truly harmful to our bodies.”

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SpaceX plans to launch 90 rockets from Vandenberg Space Force Base by 2026. Could that harm the coast?

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SpaceX plans to launch 90 rockets from Vandenberg Space Force Base by 2026. Could that harm the coast?

SpaceX plans to launch 90 rockets into space from a Santa Barbara County military base by 2026, tripling the number of blasts rocking the coastal community — and raising concerns from neighbors and environmental groups about the effects on marine life.

Founded by billionaire Elon Musk, SpaceX has ramped up the number of rocket launches from Vandenberg Space Force Base in recent years, and it has made clear its desire to increase the frequency of blastoffs. But during a California Coastal Commission hearing Friday, U.S. Space Force officials outlined for the first time its own plans to multiply the number of launches from the base, from 37 in 2023 to more than 120 a year by 2026.

The overwhelming majority of those rocket liftoffs would be conducted by SpaceX, which has already done more launches from the base than the commission has approved.

Last year SpaceX breached an agreement with the commission that limited the number of launches to six, sending 28 rockets into space.

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It is seeking an agreement with the commission to do 36 launches a year, increasing to 90 in 2026.

The decision by the commission, which was created to protect the state’s coastal resources, will directly affect residents and marine life near the military base that hear and feel the rockets’ sonic booms.

It could also redirect the future of SpaceX, whose pursuit to redefine space exploration is already closely tied with U.S. military interests, given its work as a military contractor.

“The ultimate goal is for this to be more routine and not a huge deal,” said Space Force Col. Bryan Titus, operations vice commander at the base.

Formed in 2019, the U.S. Space Force has been looking to improve its ability to send rockets into space, Titus said, so SpaceX’s ability to launch with more frequency is a benefit to the U.S. military.

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SpaceX launched 96 rockets in 2023 from Vandenberg and three other facilities: Cape Canaveral Space Force Station in Florida, NASA’s Kennedy Space Center in Merritt Island, Fla., and SpaceX Starbase in Boca Chica, Texas.

Environmental groups argue that turning launches into a routine event could affect marine life.

“We’re concerned that more frequent launches will result in permanent changes,” said Ana Citrin, legal and policy director for the Gaviota Coast Conservancy.

Federal agencies, including the U.S. Fish and Wildlife Service and National Marine Fisheries Service, monitor the effects of the liftoffs on such animals as sea otters, bats, western snowy plovers, California least terns and California red-legged frogs.

Thus far, the monitoring has shown that some of the animals might react to the blastoff by flushing, or fleeing from their nests and homes, but they return soon after, according to U.S. Space Force officials. No long-term effects have been seen, they said.

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SpaceX did not respond to a request for comment.

Flushing or hunkering down after a blast are already signs of wildlife exhibiting signs of stress, said Duncan Leitch, a professor of integrative biology at UCLA.

Most animals can adapt to infrequent incidents, but exposure to more frequent stressful incidents can change their biology as well as their behavior, he said.

In the worst-case scenarios, he said, the ability of birds to communicate could be impeded, and migratory birds could avoid the area. Fish and other animals that use sound to communicate and navigate underwater — including whales — could be affected too.

“Over a longer period of time, there may be reductions in the population of fish as they move away from the sound, or they may be affected to the point that it affects their health,” Leitch said. “It would change the ecosystem as far as other animals that rely on the fish.

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“Having sounds that are well into the damaging, or painful, range of decibels now occurring [100] times a year, the animals might not have the ability to change their behavior or accommodate these types of sounds.”

Some environmental groups, including the Surfrider Foundation, are asking the commission to reject the increase.

SpaceX “intends to begin increasing very rapidly, so we’re very concerned about this,” said Mandy Sackett, senior California policy coordinator for the Surfrider Foundation.

More frequent launches could change the way wildlife in the area responds in the long term, environmental groups said.

Members of the California Coastal Commission are also asking whether SpaceX should be entitled to circumvent the permit process, as federal agencies are.

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Federal entities negotiate agreements with the commission but ultimately can move ahead even without commission approval. In such cases, the commission’s recourse would be through mediation or the courts.

Because SpaceX is a U.S. Space Force contractor, military officials argue that all launch operations at the base by the company are “federal activities.”

But U.S. Space Force officials said only 25% of the rockets launched into space by SpaceX are carrying payloads for the Department of the Defense.

The vast majority of the liftoffs are for the company’s private benefit, raising questions about why SpaceX can dispense with permits when 75% of its blasts from the base don’t involve the U.S. government.

“That is still pretty skewed for me,” Commissioner Mike Wilson said during a meeting Friday.

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Some commissioners — whose focus is usually on environmental protection, development and water issues during their monthly meetings — also brought up the war in Ukraine during Friday’s discussion.

“I question the national security public benefit of concentrating that much power, literally communication power, in one company that we’re enabling in this case,” Wilson said. “[SpaceX] has already showed that it will play in international conflicts at the will of one human being.”

Wilson was referring to reports that Musk’s company refused to allow Ukraine to use satellite internet service from Starlink, a subsidiary of SpaceX, to help it carry out an attack against Russia in September 2022.

“If the idea is that we’re supporting these permits on the side that we’re promoting national defense, and then a single company is able to dismantle our allies during armed conflict — that really doesn’t align,” Commissioner Justin Cummings said.

“I suspect that would violate our strategies around national defense.”

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Titus declined to address the question, saying it was “out of my lane,” but he said he would try to get answers to address the commissioners’ concerns.

Some commissioners on Friday also argued that SpaceX, not U.S. military officials, should be making the company’s case in front of the agency.

“When this comes back, I think it would be really important that a representative from SpaceX comes to the meeting,” Cummings said.

Cummings said it was “ridiculous” for SpaceX not to appear at the meeting, despite multiple efforts from the agency to have SpaceX officials speak.

“They obviously refuse to because they’ve never shown up,” he said.

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On Friday, Commission Chair Caryl Hart suggested an agreement might not be possible unless SpaceX changes its stance.

“From my perspective,” Hart said, “I think we’re going to continue to hit significant obstacles in achieving a federal consistency ruling without having SpaceX.”

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