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Commentary: 7 million people have Alzheimer's. Why is the Trump administration derailing research?

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Commentary: 7 million people have Alzheimer's. Why is the Trump administration derailing research?

Dr. Charles DeCarli, co-director of the UC Davis Alzheimer’s Research Center, got the news in a call from a colleague on March 24.

“Your study was terminated.”

DeCarli had been conducting a six-year examination, funded by the National Institutes of Health, of brain and vascular conditions that can be risk factors for dementia. The study, involving hundreds of medical staff, 14 research sites, and 1,700 patients at 19 clinical locations in the U.S., was building toward a goal of 2,250 patients.

Steve Lopez

Steve Lopez is a California native who has been a Los Angeles Times columnist since 2001. He has won more than a dozen national journalism awards and is a four-time Pulitzer finalist.

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“This was the culmination of my career, the pinnacle of my research” over the last 38 years, DeCarli said.

The $53-million study, paid in annual allotments, was approved during President Trump’s first term. But in Term Two, the administration has taken a chain saw to universities, federal jobs and federal funding for scientific research, which has prompted talk of a brain drain, with scientists looking for work in other countries.

The termination letter from NIH informed DeCarli that his study, with its “artificial and non-scientific categories,” was on the chopping block because it “no longer effectuates agency priorities.” The UC Davis study was one of 14 such research projects notified in March that funding was being terminated.

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About 7 million U.S. residents aged 65 and older have Alzheimer’s, the nation’s seventh-leading cause of death. Given the cresting age wave, the number is expected to roughly double in the next 35 years. So it doesn’t make sense that a deeper understanding of a complex set of unremittingly cruel brain diseases that decimate the lives of victims, and their loved ones, is no longer a priority.

Mannie Rezende, suffering from Alzheimer's, walks with Rose Shalom at home in 2023.

Mannie Rezende, who was suffering from Alzheimer’s, walks with his wife Rose Shalom in June 2023. About 7 million U.S. residents age 65 and older have Alzheimer’s, the nation’s seventh-leading cause of death.

(Genaro Molina / Los Angeles Times)

DeCarli suspects he was targeted because of the name of his study:

“The Clinical Significance of Incidental White Matter Lesions on MRI Amongst a Diverse Population with Cognitive Complaints.”

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DEI — diversity, equity and inclusion — programs are on the administration’s hit list. But in this case, “diverse” was a reference to a spectrum of health and age, and educational and racial backgrounds of patients.

With the help of UC Davis lawyers, DeCarli appealed the decision, but he also had to begin shutting down the study in anticipation of a second rejection or a long appeal process.

The appeal was successful, and funding was restored on April 11, but DeCarli is still playing catch-up.

“There were big-time disruptions,” he told me.

Clinical partners, who each had to contact as many as 100 patients with news of the termination, had to reach out again to tell them the green light was back on.

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But for how long?

Nobody seems to know, said Russ Paulsen of UsAgainstAlzheimer’s, a nonprofit advocacy group. When I spoke to him on Wednesday, Paulsen had just watched a Senate hearing in which Appropriations Committee Chair Susan Collins (R-Maine), demanded that NIH cuts be restored.

Mannie Rezende, suffering from Alzheimer's, and wife Rose spend time with their dogs in 2023.

Mannie Rezende and wife Rose Shalom with their dogs Clara, foreground, and Teddy in 2023.

(Genaro Molina / Los Angeles Times)

“I think there is broadly bipartisan support” for continued research into Alzheimer’s, Paulsen said. And the official word at Health and Human Services is that the administration remains committed to “robust biomedical research” and “maintaining our global leadership in science and technology.”

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But that claim doesn’t square with the dismissal earlier this year of 1,000 NIH employees, or with news accounts of a plan to slash 30% of the Health and Human Services budget and 40% of the NIH budget.

“It’s hard to imagine somebody opposed to finding cures, and yet we have no explanation for why they’re proposing a 40% cut,” Paulsen said.

“We know that funds are flowing out the door far slower than they have in many years, and we know that researchers are submitting high-quality research and getting ‘answer pending’ or getting rejected,” he added. “And we know that existing multi-year grants are being canceled or payment is being delayed.”

In March, Rose Shalom of Sunland lost her husband, Mannie Rezende, who had slowly deteriorated from Alzheimer’s over several years. Shalom called the disruption of research egregious and immoral, and she said those who control the purse strings on research should “spend some time with someone with Alzheimer’s and their caregivers to understand the unique horror of this disease.”

I visited Rose and Mannie in 2023 at their home and at OPICA, the West L.A. adult day-care center where Mannie spent his days with a few dozen others on the same path.

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“As we are living longer, more and more people will be diagnosed with this disease,” Shalom said. “The emotional and financial toll on the patients and their caregivers is beyond description.”

There is, unfortunately, no cure on the immediate horizon. But DeCarli said there have been some encouraging advances, including medication that can help slow the progression of cognitive decline, and improved diagnostics that can lead to earlier intervention.

The U.S. is both a world leader and a collaborator in medical research, DeCarli said. The process is integrated, “with people working on different parts … of the same question, and true discovery sometimes comes from interacting” with each other.

The Trump administration seems to have a different agenda.

It includes:

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· Dismantling the U.S. role in solving medical mysteries.

· Dismissing hundreds of researchers studying the impact of global warming.

· Driving scientists to look for work in other countries.

Who knew there’d be so many backwater swamps, potholes and detours on the road to making America great again.

steve.lopez@latimes.com

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Owners of mobile home park destroyed in the Palisades fire say they’re finally clearing the debris

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Owners of mobile home park destroyed in the Palisades fire say they’re finally clearing the debris

Former residents of the Palisades Bowl Mobile Home Estates, a roughly 170-unit mobile home park completely destroyed in the Palisades fire, received a notice Dec. 23 from park owners saying debris removal would start as early as Jan. 2.

The Bowl is the largest of only a handful of properties in the Palisades still littered with debris nearly a year after the fire. It’s left the Bowl’s former residents, who described the park as a “slice of paradise,” stuck in limbo.

The email notice, which was reviewed by The Times, instructed residents to remove any burnt cars from their lots as quickly as possible, since contractors cannot dispose of vehicles without possessing the title. It followed months of near silence from the owners.

“The day before Christmas Eve … it triggers everybody and throws everybody upside down,” said Jon Brown, who lived in the Bowl for 10 years and now helps lead the fight for the residents’ right to return home. “Am I liable if I can’t get this done right now? Between Christmas and New Year’s? It’s just the most obnoxious, disgusting behavior.”

Brown is not optimistic the owners will follow through. “They’ve said things like this before over the years with a bunch of different things,” he said, “and then they find some reason not to do it.”

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Earlier this year, the Federal Emergency Management Agency denied requests from the city and the Bowl’s owners to include the park in the U.S. Army Corps of Engineers cleanup program, which FEMA said was focused on residential lots, not commercial properties. In a letter, FEMA argued it could not trust the owners of the Bowl to preserve the beachfront property as affordable housing.

A tattered flag waves in the wind at Asilomar View Park overlooking the Pacific Palisades Bowl Mobile Estates.

(Myung J. Chun/Los Angeles Times)

The Bowl, which began as a Methodist camp in the 1890s, was purchased by Edward Biggs, a Northern California real estate mogul, in 2005 and split between his first and second wives after his death in 2021. The family has a history of failing to perform routine maintenance and seeking to redevelop the park into a more lucrative resort community.

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After FEMA’s rejection, the owners failed to meet the City of L.A.’s debris removal deadlines. In October, the city’s Board of Building and Safety Commissioners declared the park a public nuisance alongside seven other properties, giving the city the authority to complete the debris removal itself and charge the owners the bill.

But the city has yet to find funds to front the work, which is expected to cost millions.

On Dec. 10, City Councilmember Traci Park filed a motion that would order the city to come up with a cost estimate for debris removal and identify funding sources within the city. It would also instruct the city attorney’s office to explore using criminal prosecution to address the uncleared properties.

The Department of Building and Safety did not immediately respond to requests for comment.

Despite the recent movement on debris removal, residents of the Palisades Bowl still have a long road ahead.

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Fire debris remains at Pacific Palisades Bowl Mobile Estates on Dec. 31, 2025.

On Wednesday, numerous burnt out vehicles still remained at the Pacific Palisades Bowl Mobile Estates. The owners instructed residents they must get them removed as quickly as possible.

(Myung J. Chun/Los Angeles Times)

In mobile home parks, tenants lease their spaces from the landowners but own the homes placed on the land. Before residents can start rebuilding, the Bowl’s owners need to replace or repair the foundations for the homes; fix any damage to the roads, utilities and retaining walls; and rebuild facilities like the community center and pool.

The owners have not responded to multiple requests for comment, but in February, Colby Biggs, Edward Biggs’ grandson, told CalMatters that “If we have to go invest $100 million to rebuild the park and we’re not able to recoup that in some fashion, then it’s not likely we will rebuild the park.”

Mobile home law experts and many residents doubt that the Biggs family would be able to convert the rent-controlled mobile home park into something else under existing law. The most realistic option, should the Biggs decide against rebuilding, would be to sell the park to another owner — or directly to the residents, a course of action the residents have been actively pursuing.

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The lack of communication and action from the owners has nonetheless left the Bowl’s eclectic former community of artists, teachers, surfers, first responders and retirees in limbo.

Many are running out of insurance money for temporary housing and remain unsure whether they’ll ever be able to move back.

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Video: Drones Detect Virus in Whale Blow in the Arctic

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Video: Drones Detect Virus in Whale Blow in the Arctic

new video loaded: Drones Detect Virus in Whale Blow in the Arctic

Scientists flew drones with petri dishes above several species of whales in northern seas to collect samples of whale blow, which they tested for four different viruses. For the first time in the Arctic, researchers found cetacean morbillivirus, a highly infectious and deadly virus for marine mammals.

By Jamie Leventhal and Alexa Robles-Gil

January 2, 2026

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Commentary: ‘Stop exercising, you’re killing yourself.’ Not really, but try more nurture, less torture in 2026

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Commentary: ‘Stop exercising, you’re killing yourself.’ Not really, but try more nurture, less torture in 2026

One day my left foot hurt for no good reason. I stood up to shake off the pain and tweaked my right Achilles tendon, so I headed for the medicine cabinet, bent over like an ape because of a stiff back.

Actually, I lied.

It wasn’t one day. It’s pretty much every day.

None of this is severe or serious, and I’m not complaining at the age of 72. I’m just wondering.

Are my exercise routines, which were meant to keep me from falling apart, slowing my demise, or accelerating it?

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What better time than the start of a new year to get an answer? In one poll, the top New Year’s resolution for 2026 is exercising more. Also among the top six resolutions are eating healthier, improving physical health and losing weight, so good luck to all you dreamers, and I hope you last longer than I have with similar resolutions.

Instead of a resolution, I have a goal, which is to find a sweet spot — if there is one — between exercise and pain.

Maybe I’m asking too much. I’ve had two partial knee replacements, I’ve got a torn posterior cruciate ligament, a scar tissue knob on a frayed Achilles tendon, a hideously pronated left foot, a right shoulder that feels like it needs an oil change, and a pacemaker that keeps on ticking.

But I decided to get some expert advice that might be useful for anyone who has entered this glorious phase of life in which it’s possible to pull a muscle while taking a nap, or pinch a nerve in your neck while brushing your teeth.

And I knew just whom to call.

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Cedars-Sinai orthopedic surgeon Robert Klapper hosts an ESPN radio show called “Weekend Warrior.” This lab-coated Renaissance man, a surfer and sculptor in his spare time, also weighs in regularly on the radio with “Klapper Vision” — clear-eyed takes on all manner of twisted, pulled and broken body parts suffered by elite athletes and banged-up buzzards like me.

On “Weekend Warrior,” Klapper might be talking about knee replacement surgery one minute, segue to Michelangelo’s rendering of the human form, and then insist that a sandwich is not a sandwich without peperoncini. It isn’t necessarily all connected, but it doesn’t matter.

When I emailed Klapper about my aches and pains, he responded immediately to say he’s written one book on hips, another on knees and a third one is in the works with the following title:

“Stop Exercising, You’re Killing Yourself.”

No, he’s not saying you should never get off the sofa. In a phone conversation and later at his office, Klapper said the subtitle is going to be, “Let Me Explain.” He’s making a point about what kind of exercise is harmful and what kind is helpful, particularly for people in my age group.

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Dr. Robert Klapper holds up his book about preventing hip surgery.

(Genaro Molina/Los Angeles Times)

My daily routine, I told him, involves a two-mile morning walk with my dog followed by 30 minutes of swimming laps or riding a stationary bike.

So far, so good.

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But I also play pickleball twice a week.

“Listen, I make a living from pickleball now,” Klapper said. “Exercise is wonderful, but it comes in two flavors.”

One is nurturing, which he calls “agercise” for my demographic.

The other is abusive, and one of Klapper’s examples is pickleball. With all its starts and stops, twists and turns, reaches and lunges, pickleball is busting the Medicare bank, with a few hundred million dollars’ worth of injuries each year.

I know. The game looks pretty low key, although it was recently banned in Carmel-by-the-Sea because of all the racket. I had no idea, when I first picked up a paddle, that there’d be so much ice and ibuprofen involved, not to mention the killer stares from retirees itching for a chance to drill you in the sternum with a hot laser.

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“This is a sport which has the adrenaline rushing in every 50-year-old, 60-year-old, 80-year-old,” Klapper told me in his office, which is the starting point in his joint replacement factory. The walls are covered with photos of star athletes and A-list Hollywood celebrities he’s operated on.

“I see these patients, but they’re not coming to me with acute injuries. They didn’t snap their Achilles tendon … like they do in tennis. They’re not snapping their ACL like they are in pickup basketball,” Klapper said. “They’re coming to me saying, ‘My shoulder is killing me, my knee is killing me.’ ”

Pickleball has obvious conditioning benefits for every age group. But it can also worsen arthritis and accelerate joint degeneration, Klapper said, particularly for addicts who play several times a week.

Not that he’s the first MD to suggest that as you age, walking, cycling and swimming are easier on your body than higher-impact activities. As one doctor said in an AARP article on joint care and the benefits of healthy eating, watching your weight and staying active, “the worst thing you can do with osteoarthritis after 50 is be sedentary.”

Still, I thought Klapper might tell me to stop pickling, but he didn’t.

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“Pickleball is more than a sport to you … and all of your compadres,” he said. “It’s mental. You need it because of the stress. The world’s falling apart.… I want you to play it, but I want you to do the nurturing exercises so you can do the abuse.”

There’s no fountain of youth, Klapper said, but the closest thing is a swimming pool.

OK, but I already swim three times a week.

A woman is seated in a chair next to a man seated on a table.

Dr. Robert Klapper meets with patient Kathleen Clark, who is recovering from knee surgery.

(Genaro Molina/Los Angeles Times)

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Klapper had different ideas.

“You need to be walking forward and backwards for half an hour,” he said. Do that three times a week, he told me, and ride a stationary bike three times.

Why the water walking?

“We as humans take over a million steps a year. Forget pickleball, just in … daily living,” Klapper said, so I’m well beyond 72 million steps.

“Think about that,” he said.

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Do I have to?

Water walking will develop muscles and joints without the stress of my full weight, and that could “optimize” my pickleball durability and general fitness, Klapper said. Buoyancy and the touch of water on skin are magic, he said, but there’s science involved too.

“It’s hard to move your arms and legs and your body through water, and yet it’s unloading the joint,” Klapper said. “And finally — and this is the real X factor — when you close your eyes and straighten your elbow and bend your elbow, straighten your knee and bend your knee … your brain knows where your limbs are in space.”

This is called proprioception, Klapper said. Receptors in your skin, muscles, ligaments and tendons send messages to your brain, leading to better balance, coordination and agility and potentially reducing risk of injury.

There are lots of exercises for sharpening proprioception, but the surfing doctor is partial to bodies of water. At my age, he said, my proprioception “batteries are running low,” but I can recharge them with a short break from pickleball and a focus on the pool.

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“You can’t guarantee anything in life and medicine,” Klapper said. “But I guarantee you, a month into it, you’re going to feel so much better than you do at this moment.”

It’s worth a try, and I’ll let you know how it goes.

In the pool and on the court.

steve.lopez@latimes.com

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