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Commentary: 7 million people have Alzheimer's. Why is the Trump administration derailing research?

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Commentary: 7 million people have Alzheimer's. Why is the Trump administration derailing research?

Dr. Charles DeCarli, co-director of the UC Davis Alzheimer’s Research Center, got the news in a call from a colleague on March 24.

“Your study was terminated.”

DeCarli had been conducting a six-year examination, funded by the National Institutes of Health, of brain and vascular conditions that can be risk factors for dementia. The study, involving hundreds of medical staff, 14 research sites, and 1,700 patients at 19 clinical locations in the U.S., was building toward a goal of 2,250 patients.

Steve Lopez

Steve Lopez is a California native who has been a Los Angeles Times columnist since 2001. He has won more than a dozen national journalism awards and is a four-time Pulitzer finalist.

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“This was the culmination of my career, the pinnacle of my research” over the last 38 years, DeCarli said.

The $53-million study, paid in annual allotments, was approved during President Trump’s first term. But in Term Two, the administration has taken a chain saw to universities, federal jobs and federal funding for scientific research, which has prompted talk of a brain drain, with scientists looking for work in other countries.

The termination letter from NIH informed DeCarli that his study, with its “artificial and non-scientific categories,” was on the chopping block because it “no longer effectuates agency priorities.” The UC Davis study was one of 14 such research projects notified in March that funding was being terminated.

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About 7 million U.S. residents aged 65 and older have Alzheimer’s, the nation’s seventh-leading cause of death. Given the cresting age wave, the number is expected to roughly double in the next 35 years. So it doesn’t make sense that a deeper understanding of a complex set of unremittingly cruel brain diseases that decimate the lives of victims, and their loved ones, is no longer a priority.

Mannie Rezende, suffering from Alzheimer's, walks with Rose Shalom at home in 2023.

Mannie Rezende, who was suffering from Alzheimer’s, walks with his wife Rose Shalom in June 2023. About 7 million U.S. residents age 65 and older have Alzheimer’s, the nation’s seventh-leading cause of death.

(Genaro Molina / Los Angeles Times)

DeCarli suspects he was targeted because of the name of his study:

“The Clinical Significance of Incidental White Matter Lesions on MRI Amongst a Diverse Population with Cognitive Complaints.”

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DEI — diversity, equity and inclusion — programs are on the administration’s hit list. But in this case, “diverse” was a reference to a spectrum of health and age, and educational and racial backgrounds of patients.

With the help of UC Davis lawyers, DeCarli appealed the decision, but he also had to begin shutting down the study in anticipation of a second rejection or a long appeal process.

The appeal was successful, and funding was restored on April 11, but DeCarli is still playing catch-up.

“There were big-time disruptions,” he told me.

Clinical partners, who each had to contact as many as 100 patients with news of the termination, had to reach out again to tell them the green light was back on.

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But for how long?

Nobody seems to know, said Russ Paulsen of UsAgainstAlzheimer’s, a nonprofit advocacy group. When I spoke to him on Wednesday, Paulsen had just watched a Senate hearing in which Appropriations Committee Chair Susan Collins (R-Maine), demanded that NIH cuts be restored.

Mannie Rezende, suffering from Alzheimer's, and wife Rose spend time with their dogs in 2023.

Mannie Rezende and wife Rose Shalom with their dogs Clara, foreground, and Teddy in 2023.

(Genaro Molina / Los Angeles Times)

“I think there is broadly bipartisan support” for continued research into Alzheimer’s, Paulsen said. And the official word at Health and Human Services is that the administration remains committed to “robust biomedical research” and “maintaining our global leadership in science and technology.”

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But that claim doesn’t square with the dismissal earlier this year of 1,000 NIH employees, or with news accounts of a plan to slash 30% of the Health and Human Services budget and 40% of the NIH budget.

“It’s hard to imagine somebody opposed to finding cures, and yet we have no explanation for why they’re proposing a 40% cut,” Paulsen said.

“We know that funds are flowing out the door far slower than they have in many years, and we know that researchers are submitting high-quality research and getting ‘answer pending’ or getting rejected,” he added. “And we know that existing multi-year grants are being canceled or payment is being delayed.”

In March, Rose Shalom of Sunland lost her husband, Mannie Rezende, who had slowly deteriorated from Alzheimer’s over several years. Shalom called the disruption of research egregious and immoral, and she said those who control the purse strings on research should “spend some time with someone with Alzheimer’s and their caregivers to understand the unique horror of this disease.”

I visited Rose and Mannie in 2023 at their home and at OPICA, the West L.A. adult day-care center where Mannie spent his days with a few dozen others on the same path.

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“As we are living longer, more and more people will be diagnosed with this disease,” Shalom said. “The emotional and financial toll on the patients and their caregivers is beyond description.”

There is, unfortunately, no cure on the immediate horizon. But DeCarli said there have been some encouraging advances, including medication that can help slow the progression of cognitive decline, and improved diagnostics that can lead to earlier intervention.

The U.S. is both a world leader and a collaborator in medical research, DeCarli said. The process is integrated, “with people working on different parts … of the same question, and true discovery sometimes comes from interacting” with each other.

The Trump administration seems to have a different agenda.

It includes:

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· Dismantling the U.S. role in solving medical mysteries.

· Dismissing hundreds of researchers studying the impact of global warming.

· Driving scientists to look for work in other countries.

Who knew there’d be so many backwater swamps, potholes and detours on the road to making America great again.

steve.lopez@latimes.com

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For Oprah Winfrey, a croissant is now just a croissant — not a struggle

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For Oprah Winfrey, a croissant is now just a croissant — not a struggle

Yes, Oprah Winfrey has discussed her weight loss and weight gain and weight in general before — many, many times before. The difference this time around, she says, is how little food noise there is in her daily life, and how little shame. It’s so quiet, in fact, that she can eat a whole croissant and simply acknowledge she had breakfast.

“Food noise,” for those who don’t experience it, is a virtually nonstop mental conversation about food that, according to Tufts Medicine, rarely shuts up and instead drives a person “to eat when they’re not hungry, obsess over meals and feel shame or guilt about their eating habits.”

“This type of obsessive food-related thinking can override hunger cues and lead to patterns of overeating, undereating or emotional eating — especially for people who are overweight,” Tufts said.

Winfrey told People in an exclusive interview published Tuesday that in the past she would have been thinking, “‘How many calories in that croissant? How long is it going to take me to work it off? If I have the croissant, I won’t be able to have dinner.’ I’d still be thinking about that damn croissant!”

What has changed is her acceptance 2½ years ago that she has a disease, obesity, and that this time around there was something not called “willpower” to help her manage it.

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The talk show host has been using Mounjaro, one of the GLP-1 drugs, since 2023. The weight-loss version of Mounjaro is Zepbound, like Wegovy is the weight-loss version of Ozempic. Trulicity and Victroza are also GLP-1s, and a pill version of Wegovy was just approved by the FDA.

When she started using the injectable, Winfrey told People she welcomed the arrival of a tool to help her get away from the yo-yo path she’d been on for decades. After understanding the science behind it, she said, she was “absolutely done with the shaming from other people and particularly myself” after so many years of weathering public criticism about her weight.

“I have been blamed and shamed,” she said elsewhere in that 2023 interview, “and I blamed and shamed myself.”

Now, on the eve of 2026, Winfrey says her mental shift is complete. “I came to understand that overeating doesn’t cause obesity. Obesity causes overeating,” she told the outlet. “And that’s the most mind-blowing, freeing thing I’ve experienced as an adult.”

She isn’t even sharing her current weight with the public.

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Winfrey did take a break from the medication early in 2024, she said, and started to regain weight despite continuing to work out and eat healthy foods. So for Winfrey the obesity prescription will be renewed for a lifetime. C’est la vie seems to be her attitude.

“I’m not constantly punishing myself,” she said. “I hardly recognize the woman I’ve become. But she’s a happy woman.”

Winfrey has to take a carefully managed magnesium supplement and make sure she drinks enough water, she said. The shots are done weekly, except when she feels like she can go 10 or 12 days. But packing clothes for the Australian leg of her “Enough” book tour was an off-the-rack delight, not a trip down a shame spiral. She’s even totally into regular exercise.

Plus along with the “quiet strength” she has found in the absence of food noise, Winfrey has experienced another cool side effect: She pretty much couldn’t care less about drinking alcohol.

“I was a big fan of tequila. I literally had 17 shots one night,” she told People. “I haven’t had a drink in years. The fact that I no longer even have a desire for it is pretty amazing.”

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So back to that croissant. How did she feel after she scarfed it down?

“I felt nothing,” she said. “The only thing I thought was, ‘I need to clean up these crumbs.’”

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Owners of mobile home park destroyed in the Palisades fire say they’re finally clearing the debris

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Owners of mobile home park destroyed in the Palisades fire say they’re finally clearing the debris

Former residents of the Palisades Bowl Mobile Home Estates, a roughly 170-unit mobile home park completely destroyed in the Palisades fire, received a notice Dec. 23 from park owners saying debris removal would start as early as Jan. 2.

The Bowl is the largest of only a handful of properties in the Palisades still littered with debris nearly a year after the fire. It’s left the Bowl’s former residents, who described the park as a “slice of paradise,” stuck in limbo.

The email notice, which was reviewed by The Times, instructed residents to remove any burnt cars from their lots as quickly as possible, since contractors cannot dispose of vehicles without possessing the title. It followed months of near silence from the owners.

“The day before Christmas Eve … it triggers everybody and throws everybody upside down,” said Jon Brown, who lived in the Bowl for 10 years and now helps lead the fight for the residents’ right to return home. “Am I liable if I can’t get this done right now? Between Christmas and New Year’s? It’s just the most obnoxious, disgusting behavior.”

Brown is not optimistic the owners will follow through. “They’ve said things like this before over the years with a bunch of different things,” he said, “and then they find some reason not to do it.”

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Earlier this year, the Federal Emergency Management Agency denied requests from the city and the Bowl’s owners to include the park in the U.S. Army Corps of Engineers cleanup program, which FEMA said was focused on residential lots, not commercial properties. In a letter, FEMA argued it could not trust the owners of the Bowl to preserve the beachfront property as affordable housing.

A tattered flag waves in the wind at Asilomar View Park overlooking the Pacific Palisades Bowl Mobile Estates.

(Myung J. Chun/Los Angeles Times)

The Bowl, which began as a Methodist camp in the 1890s, was purchased by Edward Biggs, a Northern California real estate mogul, in 2005 and split between his first and second wives after his death in 2021. The family has a history of failing to perform routine maintenance and seeking to redevelop the park into a more lucrative resort community.

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After FEMA’s rejection, the owners failed to meet the City of L.A.’s debris removal deadlines. In October, the city’s Board of Building and Safety Commissioners declared the park a public nuisance alongside seven other properties, giving the city the authority to complete the debris removal itself and charge the owners the bill.

But the city has yet to find funds to front the work, which is expected to cost millions.

On Dec. 10, City Councilmember Traci Park filed a motion that would order the city to come up with a cost estimate for debris removal and identify funding sources within the city. It would also instruct the city attorney’s office to explore using criminal prosecution to address the uncleared properties.

The Department of Building and Safety did not immediately respond to requests for comment.

Despite the recent movement on debris removal, residents of the Palisades Bowl still have a long road ahead.

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Fire debris remains at Pacific Palisades Bowl Mobile Estates on Dec. 31, 2025.

On Wednesday, numerous burnt out vehicles still remained at the Pacific Palisades Bowl Mobile Estates. The owners instructed residents they must get them removed as quickly as possible.

(Myung J. Chun/Los Angeles Times)

In mobile home parks, tenants lease their spaces from the landowners but own the homes placed on the land. Before residents can start rebuilding, the Bowl’s owners need to replace or repair the foundations for the homes; fix any damage to the roads, utilities and retaining walls; and rebuild facilities like the community center and pool.

The owners have not responded to multiple requests for comment, but in February, Colby Biggs, Edward Biggs’ grandson, told CalMatters that “If we have to go invest $100 million to rebuild the park and we’re not able to recoup that in some fashion, then it’s not likely we will rebuild the park.”

Mobile home law experts and many residents doubt that the Biggs family would be able to convert the rent-controlled mobile home park into something else under existing law. The most realistic option, should the Biggs decide against rebuilding, would be to sell the park to another owner — or directly to the residents, a course of action the residents have been actively pursuing.

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The lack of communication and action from the owners has nonetheless left the Bowl’s eclectic former community of artists, teachers, surfers, first responders and retirees in limbo.

Many are running out of insurance money for temporary housing and remain unsure whether they’ll ever be able to move back.

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Video: Drones Detect Virus in Whale Blow in the Arctic

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Video: Drones Detect Virus in Whale Blow in the Arctic

new video loaded: Drones Detect Virus in Whale Blow in the Arctic

Scientists flew drones with petri dishes above several species of whales in northern seas to collect samples of whale blow, which they tested for four different viruses. For the first time in the Arctic, researchers found cetacean morbillivirus, a highly infectious and deadly virus for marine mammals.

By Jamie Leventhal and Alexa Robles-Gil

January 2, 2026

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