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Berkeley startup wins government award to develop radiation and lead poisoning treatment

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Berkeley startup wins government award to develop radiation and lead poisoning treatment

Whether its lead from old buildings, arsenic from contaminated food or strontium fallout from a nuclear explosion, heavy metals that enter the body pose a serious health threat.

With chemical properties exceedingly similar to typical nutrients like iron and calcium, toxic metals look virtually the same to the body. So, it starts incorporating the toxic elements into the skeleton, liver and brain.

Saving a patient requires removing the sparse toxic metals from the body with more than surgical precision, while leaving the abundant life-sustaining nutrients intact.

For many toxic elements, doctors have few options.

Now, a startup spun out of UC Berkeley and the Department of Energy’s Lawrence Berkeley National Laboratory hopes to change that.

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Recently, HOPO Therapeutics won a nearly $10-million initial contract from the Biomedical Advanced Research and Development Authority of the U.S. Department of Health and Human Services. The research authority is tasked with developing defenses against major public health threats, such as a pandemic or a chemical weapons attack.

“This is a priority for [the authority] — the development of new products that can be used to address these types of threats,” said Julian Rees, chief executive of HOPO Therapeutics, who started working on the drug at Berkeley Lab. “So, it’s been really exciting for us to partner with BARDA.”

Since BARDA was created by Congress in 2006, it’s supported 61 drugs through the Food and Drug Administration’s approval process. The authority also played an essential role in Operation Warp Speed to develop the COVID-19 vaccine.

HOPO Therapeutics’ drugs are designed to chemically bond with toxic metals only. By bonding, the medicine transforms the reactive metals into benign molecules that have little interest in interacting with different compounds in the body. The body can then easily excrete the metals.

Currently, few of these types of drugs — called chelators, derived from the Greek word for claw — are approved by the FDA. Those select few that have been approved have a hard time distinguishing between toxic metals and essential nutrients.

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“HOPO chelators are extremely promising in that regard,” said Justin Wilson, a biochemistry professor at UC Santa Barbara who studies chelators and was not involved in HOPO Therapeutics work. “What the data show is that they have a very high selectivity for radioactive elements” over essential metals like zinc and calcium.

The HOPO chelators could potentially fill a crucial gap in lead poisoning treatment.

While the Centers for Disease Control and Prevention says a concentration of 3.5 micrograms of lead for every deciliter of blood constitutes lead poisoning, it doesn’t recommend treatment to remove lead until the concentration reaches over 45 micrograms, because of the adverse effects of existing treatments.

“So, there’s this huge window of people — primarily children — who have lead poisoning, but there’s no treatment available,” Rees said.

Lead poisoning can result in brain function impairment, fatigue, weight loss, paralysis and even death. It disproportionately affects children, whose bodies seek extra calcium — which lead can be mistaken as — to build bones.

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Current chelators designed to treat lead poisoning can also remove essential metals such as calcium and zinc. If the concentration of lead is too low, the drugs would remove too much natural metal before putting a sizable dent in the amount of lead in the body.

Treating radiation poisoning is harder. Lead is a single element, but there’s a whole suite of elements with radioactive forms.

For radioactive elements, “there’s no real common denominator. … They belong to all different kinds of chemical families,” said Ira Helfand, past president of the International Physicians for the Prevention of Nuclear War.

“People who are exposed to these … are in big trouble and are liable to radiation sickness, liable to cancer down the road if they survive post-exposure.”

In a complex and messy real-world nuclear or radioactive disaster, Helfand said, HOPO’s medicine could serve only as a small part of the armor against radiation.

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Much of the harm inflicted on victims of a nuclear strike — or nuclear plant catastrophe — comes from high-velocity radiation particles that pierce the body, damaging cells and their DNA. Only a small fraction of the injuries come from heavy metals that emit radiation from within the body.

And even then, some of the most abundant radioactive metals in nuclear fallout are particularly good at mimicking nutrients in the body, making it too difficult for the HOPO chelators to isolate them.

Instead, HOPO’s drug, which can target uranium and plutonium — elements found in nuclear weapons before they detonate — is better equipped to protect bomb makers, nuclear plant operators and victims of “dirty bombs,” conventional explosions that scatter radioactive material to harm bystanders.

Although state-of-the-art chelators approved by the FDA often need to be injected via an IV, HOPO drugs could be taken orally.

“If you think about the setting in which you want to apply this — where would you be getting exposed to radioactive elements? Typically some emergency situation,” Wilson said. “Having something on the field where you can take this as a pill very rapidly I think is a really big advantage.”

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HOPO Therapeutics said the initial contract could be extended to more than $226 million, should development go well. The next steps for the company include demonstrating that the drug could be easily manufactured in large quantities — not just small samples for the lab — and human trials to study potential negative side effects.

The company’s ultimate goal is FDA approval.

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Flu is hitting California early. Why doctors worry this year will be especially hard on kids

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Flu is hitting California early. Why doctors worry this year will be especially hard on kids

Fueled by a new viral strain, flu is hitting California early — and doctors are warning they expect the season may be particularly tough on young children.

Concentrations of flu detected in wastewater have surged in the San Francisco Bay Area, and the test positivity rate is rising in Los Angeles County and Orange County, according to state and county data. Hospitalizations and emergency room visits for flu are also rising in L.A. and Orange counties.

“We are at the point now where we’re starting to see a sharp rise in flu cases. This is a few weeks earlier than we usually experience, but very much akin to what was seen in the Southern Hemisphere’s experience with flu during their winter,” said Dr. Elizabeth Hudson, regional physician director of infectious diseases at Kaiser Permanente Southern California.

At Kaiser, flu cases are primarily being seen in clinics so far, but hospitalizations typically rise after Christmas. “We expect to see the same this year, too,” Hudson said.

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“The number of cases appears to be higher at an earlier time in the usual flu season than we’ve seen in years past,” she added.

Flu levels are high in San Francisco’s sewage as well as in wastewater across San José, Sunnyvale and Palo Alto, according to WastewaterSCAN and the Santa Clara County Public Health Department.

One area of concern this winter has been the rise of a relatively new flu subvariant, known as H3N2 Flu A subclade K, which appeared toward the end of summer. That was months after officials decided which strains this fall’s flu vaccine would target.

Subclade K “is causing an active, early flu season, with more cases occurring in some countries within the Northern Hemisphere,” the California Department of Public Health said.

It remains unclear whether subclade K will reduce the efficacy of this year’s flu shot. Data recently released in Britain showed this season’s vaccines were 70% to 75% effective against hospitalization for children from the flu, and 30% to 40% effective in adults, which is within expectations, the U.S. Centers for Disease Control and Prevention noted.

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This suggests “that influenza vaccination remains an effective tool in preventing influenza-related hospitalizations this season,” according to the agency.

However, the intended effectiveness of the flu vaccine against symptomatic disease caused by the new subvariant remains uncertain, the World Health Organization said.

Overall, flu rates in L.A. County remain relatively low, but are on the rise. Across California, flu hospitalizations are likewise low but increasing.

On a national level, severity indicators remain low, according to the CDC.

But the experience in other nations have led some experts to worry another severe flu season could be on deck for California.

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Australia’s flu season, which is seasonally opposite from California’s, came far earlier than usual, hit with record strength and was particularly hard on the nation’s children.

Japan, Taiwan and Britain have also reported early spikes to their flu seasons.

“Whether or not this season will be more severe, only time will tell,” Hudson said of California. “We know that we have a mutation … which may make the flu vaccine work less well. But the vaccine still offers excellent protection against hospitalization and death, even with the mutated strain in circulation.”

Based on what happened in the Southern Hemisphere — particularly in Australia — “we are expecting this season to have a disproportionate impact on children under the age of 10,” Hudson said.

Already, three flu-associated pediatric deaths have been reported nationally this season, including two Friday.

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During the flu season that ended in September, 280 children died from flu — the most since the swine flu pandemic season of 2009-10.

Overall, the 2024-25 season was considered the worst flu season since 2017-18, and hit adults hard as well. At least 38,000 people died from the flu last season, health authorities estimate.

Only a little more than half of the children who died from flu had an underlying medical condition, and 89% of those who died were not vaccinated, according to the CDC’s National Center for Immunization and Respiratory Diseases.

Among the children who died from flu last season, the most common complications experienced before death were shock or sepsis, pneumonia, acute respiratory distress syndrome, seizures and damage to the brain.

Early diagnosis of flu can help stave off the worst by giving those who are sick time to take antiviral medications like Tamiflu. Three out of five children who died from the flu during the 2024-25 season never received antiviral medication.

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Emergency warning signs of flu complications in children include trouble breathing; bluish lips or face; ribs pulling in with each breath; chest pain; severe muscle pain, in which a child may refuse to walk; dehydration, signs of which include no urine for eight hours or no tears when crying; seizures; fevers above 104 degrees that are not controlled by medication; fever or cough that improve but return or worsen; and any fever in newborns younger than 12 weeks.

Since the official start of the respiratory virus season Oct. 1, the CDC estimates there have been at least 1,900 flu-related deaths, 49,000 hospitalizations and 4.6 million illnesses nationwide.

Doctors have been urging everybody to get the flu vaccine — the CDC recommends it for everyone age 6 months and up.

But vaccination rates have been lagging. Among children age 6 months to 17 years, an estimated 40.8% had been vaccinated as of the first week of December, according to the National Immunization Survey. In the last season before the COVID-19 pandemic, flu vaccination rates were notably higher by this time of year, at 51.2%.

At the end of last flu season, only 49.8% of children and teens had been vaccinated, the survey estimated, down from the 62.4% who had gotten their shots by the end of the 2019-20 flu season.

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The decline in flu vaccinations has been seen locally, too. “Notably, fewer influenza vaccines have been administered this year compared to the same period last year,” the Orange County Health Care Agency said.

It takes about two weeks for protection to build, but getting vaccinated as soon as possible before travel or seeing friends and family “helps keep you and your loved ones safer,” the L.A. County Department of Public Health said in a statement to The Times.

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Why California’s milk cartons may lose their coveted recycling symbol

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Why California’s milk cartons may lose their coveted recycling symbol

California milk cartons may lose their coveted recycling symbol, the one with the chasing arrows, potentially threatening the existence of the ubiquitous beverage containers.

In a letter Dec. 15, Waste Management, one of the nation’s largest waste companies, told the state the company would no longer sort cartons out of the waste stream for recycling at its Sacramento facility. Instead, it will send the milk- and food-encrusted packaging to the landfill.

Marcus Nettz, Waste Management’s director of recycling for Northern California and Nevada, cited concerns from buyers and overseas regulators that cartons — even in small amounts — could contaminate valuable material, such as paper, leading them to reject the imports.

The company decision means the number of Californians with access to beverage carton recycling falls below the threshold in the state’s “Truth in Recycling” law, or Senate Bill 343.

And according to the law, that means the label has to come off.

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The recycling label is critical for product and packaging companies to keep selling cartons in California as the state’s single-use packaging law goes fully into effect. That law, Senate Bill 54, calls for all single-use packaging to be recyclable or compostable by 2032. If it isn’t, it can’t be sold or distributed in the state.

The labels also provide a feel-good marketing symbol suggesting to consumers the cartons won’t end up in a landfill when they’re discarded, or find their way into the ocean where plastic debris is a large and growing problem.

On Tuesday, the state agency in charge of waste, CalRecycle, acknowledged Waste Management’s change.

In updated guidelines for the Truth in Recycling law, recycling rates for carton material have fallen below the state threshold.

It’s a setback for carton manufacturers and their customers, including soup- and juice-makers. Their trade group, the National Carton Council, has been lobbying the state, providing evidence that Waste Management’s Sacramento Recycling and Transfer Station successfully combines cartons with mixed paper and ships it to Malaysia and other Asian countries including Vietnam, proving that there is a market. The Carton Council persuaded CalRecycle to reverse a decision it made earlier this year that beverage cartons did not meet the recycling requirements of the Truth in Recycling law.

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Brendon Holland, a spokesman for the trade group, said in an email that his organization is aware of Waste Management’s decision, but its understanding is that the company will now sort the cartons into their own dedicated waste stream “once a local end market is available.”

He added that even with “this temporary local adjustment,” food and beverage cartons are collected and sorted in most of California, and said this is just a “temporary end market adjustment — not a long-term shift away from historical momentum.”

In 2022, Malaysia and Vietnam banned imports of mixed paper bales — which include colored paper, newspapers, magazines and other paper products — from the U.S. because they were so often contaminated with non-paper products and plastic, such as beverage cartons. Waste Management told The Times on Dec. 5 that it has a “Certificate of Approval” by Malaysia’s customs agency to export “sorted paper material.” CalRecycle said it has no regulatory authority on “what materials may or may not be exported.”

Adding the Sacramento facility to the list of waste companies that were recycling cartons meant that the threshold required by the state had been met: More than 60% of the state’s counties had access to carton recycling.

At the time, CalRecycle’s decision to give the recycling stamp to beverage cartons was controversial. Many in the environmental, anti-plastic and no-waste sectors saw it as a sign that CalRecycle was doing the bidding of the plastic and packaging industry, as opposed to trying to rid the state of non-recyclable, polluting waste — which is not only required by law, but is something state Atty. Gen. Rob Bonta is investigating.

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Others said it was a sign that the Truth in Recycling law was working: Markets were being discovered and in some cases, created, to provide recycling.

“Recyclability isn’t static, it depends on a complicated system of sorting, transportation, processing, and, ultimately, manufacturers buying the recycled material to make a new product,” said Nick Lapis, director of advocacy for Californians Against Waste.

He said this new information, which will likely remove the recycling label from the cartons, also underscores the effectiveness of the law.

“By prohibiting recyclability claims on products that don’t get recycled, SB 343 doesn’t just protect consumers. It forces manufacturers to either use recyclable materials or come to the table to work with recyclers, local governments and policymakers to develop widespread sustainable and resilient markets,” he said.

Beverage and food cartons — despite their papery appearance — are composed of layers of paper, plastic and sometimes aluminum. The sandwiched blend extends product shelf life, making it attractive to food and beverage companies.

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But the companies and municipalities that receive cartons as waste say the packaging is problematic. They say recycling markets for the material are few and far between.

California, with its roughly 40 million residents, has some of the strictest waste laws in the nation. In 1989, the state passed legislation requiring cities, towns and municipalities to divert at least 50% of their residential waste away from landfills. The idea was to incentivize recycling and reuse. However an increasing number of products have since entered the commercial market and waste stream — such as single use plastics, polystyrene and beverage cartons — that have limited (if any) recycling potential, can’t be reused, and are growing in number every year.

Fines for municipalities that fail to achieve the required diversion rates can run $10,000 a day.

As a result, garbage haulers often look for creative ways to deal with the waste, including shipping trash products overseas or across the border. For years, China was the primary destination for California’s plastic, contaminated paper and other waste. But in 2018, China closed its doors to foreign garbage, so U.S. exporters began dumping their waste in smaller southeast Asian countries, including Malaysia and Vietnam.

They too have now tried to close the doors to foreign trash as reports of polluted waterways, chokingly toxic air, and illness grows — and as they struggle with inadequate infrastructure to deal with their own domestic waste.

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Jan Dell, the founder and CEO of Last Beach Cleanup, released a report with the Basel Action Network, an anti-plastic organization, earlier this month showing that the Sacramento facility and other California waste companies were sending bales of carton-contaminated paper to Malaysia, Vietnam and other Asian nations.

According to export data, public records searches and photographic evidence collected by Dell and her co-authors at the Basel Action Network, more than 117,000 tons or 4,126 shipping containers worth of mixed paper bales were sent by California waste companies to Malaysia between January and July of this year.

Dell said these exports violate international law. A spokesman for Waste Management said the material they were sending was not illegal — and that they had received approval from Malaysia.

However, the Dec. 15 letter suggests they were receiving more pushback from their export markets than they’d previously disclosed.

“While certain end users maintain … that paper mills are able to process and recycle cartons,” some of them “have also shared concerns … that the inclusion of cartons … may result in rejection,” wrote Nettz.

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Dell said she was “pleased” that Waste Management “stopped the illegal sortation of cartons into mixed paper bales. Now we ask them and other waste companies to stop illegally exporting mixed paper waste to countries that have banned it.”

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Video: Why Scientists Are Performing Brain Surgery on Monarchs

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Video: Why Scientists Are Performing Brain Surgery on Monarchs

new video loaded: Why Scientists Are Performing Brain Surgery on Monarchs

Scientists in Texas are studying monarch butterflies to understand how they navigate thousands of miles, possibly by sensing Earth’s magnetic field. Alexa Robles-Gil explains how researchers are examining the butterflies’ brains to find answers.

By Alexa Robles-Gil, Leila Medina, Joey Sendaydiego and Mark Felix

December 23, 2025

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