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Two Massachusetts scientists receive Nobel Prize in Medicine for discovery of microRNA

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Two Massachusetts scientists receive Nobel Prize in Medicine for discovery of microRNA


Two Massachusetts scientists have been recognized with the Nobel Prize in Physiology or Medicine for their role in the discovery of microRNA — key to the understanding of gene regulation and potential treatments of heart disease, cancer, neurodegenerative diseases and more.

Researchers Victor Ambros, a University of Massachusetts Medical School professor of natural science, and Gary Ruvkun, a Massachusetts General Hospital and Harvard Medical School investigator and professor of genetics, received the Nobel Prize on Monday.

“Gene regulation by microRNA, first revealed by Ambros and Ruvkun, has been at work for hundreds of millions of years,” the Nobel Committee for Physiology or Medicine stated in a release. “This mechanism has enabled the evolution of increasingly complex organisms.”

The committee stated the scientists’ work “revealed an entirely new dimension to gene regulation” that are “proving to be fundamentally important for how organisms develop and function.”

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In a press conference at MGH on Monday, Ruvkun called the study of recombinant DNA starting in the 70s a “revolution” and said as a young student and researcher he “just wanted to be part of that.”

In the late 1980s, Ambros and Ruvkun worked as postdoctoral fellows in the laboratory of Robert Horvitz, who was awarded the Nobel Prize in 2002. There they studied the 1 mm long roundworm, C. elegans, narrowing in on a mutation and gene function in the animals.

Ambros and Ruvkun continued the research after the fellowship at respectively at their Harvard University lab and Massachusetts General Hospital and Harvard Medical School lab. The pair compared findings, discovering the existence of microRNA in the worms, and published in 1993 in two articles in the journal Cell.

The discovery was met with “deafening silence from the scientific community,” the Nobel committee wrote, until 2000 when Ruvkun published new findings on microRNA in another gene, demonstrating their presence across the animal kingdom.

In the past two decades, “research into the potential of microRNAs for the diagnosis, prognosis and treatment of disease has expanded from the two original papers published by Ruvkun and Ambros in 1993 to 176,000 papers today,” MGH said in a statement.

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The “unexpectedly short” microRNA, Ambros said, help regulate how genes are controlled in cells. The microRNAs “block gene expression by binding to regulatory segments in their target messenger RNAs,” MGH said.

Current research has shown human and most other plant and animal genomes contain “more than 1,000 microRNAs, which control many protein-coding messenger RNAs and may be involved in a broad range of normal- and disease-related activities,” the hospital said.

Researchers are currently conducting clinical trials involving microRNA for medical conditions including heart disease, cancer and neurodegenerative diseases.

Ambros said he was “surprised and delighted” to hear about the Nobel Prize at a press conference in the UMass Chan Medical School in Worcester on Monday and emphasized that studies of laboratory organisms of this kind are “critical and key and fundamental to advancing understanding of biology.”

“I think the unexpectedness of biology is probably the most important principle, perhaps, for people to appreciate,” said Ambros. … “At any given moment, it feels like we know most of what we need to know — that is actually an illusion that we have to consciously disabuse ourselves of and leave ourselves open for the surprises.”

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The 2023 Nobel Prize in Physiology or Medicine was awarded to two researchers, Katalin Karikó and Drew Weissman, who helped develop mRNA vaccines to combat the COVID-19 pandemic.

Nobel prize announcements will continue with the physics prize on Tuesday, chemistry on Wednesday, literature on Thursday, Peace Prize on Friday and the Memorial Prize in Economic Sciences on Oct. 14.

Victor Ambros, left, 2024 Nobel Prize winner in physiology or medicine, and professor of natural science at the University of Massachusetts Medical School, hugs his wife Rosalind Lee following a news conference, Monday at the school in Worcester. (AP Photo/Steven Senne)
Nobel Committee chairman Thomas Perlmann, right, announces Americans Victor Ambros, left, and Gary Ruvkun, seen on a screen being awarded this year's Nobel Prize in Physiology or Medicine, during a press conference at the Karolinska Institute in Stockholm, Sweden, on Monday. (Christine Olsson/TT News Agency via AP)
Nobel Committee chairman Thomas Perlmann, right, announces Americans Victor Ambros, left, and Gary Ruvkun, seen on a screen being awarded this year’s Nobel Prize in Physiology or Medicine, during a press conference at the Karolinska Institute in Stockholm, Sweden, on Monday. (Christine Olsson/TT News Agency via AP)



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Massachusetts

2 of the top fishing charters in America are in Massachusetts, according to USA Today readers

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2 of the top fishing charters in America are in Massachusetts, according to USA Today readers


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Plan your next fishing adventure.

Guests on Reel Deal Fishing Charters in Truro. Reel Deal Fishing Charters

For those dreaming of catching a big one this summer, two of the best fishing charters in America are in Massachusetts, according to USA Today readers.


  • Your Boston Harbor Islands guide for the 2025 season

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The publication released a list of the 10 best fishing charters in America on Wednesday, part of its 2025 10Best Readers’ Choice Awards, and Fishbucket Sportfishing in Boston ranked No. 2 and Reel Deal Fishing Charters in Truro ranked No. 4.

“Whether you’re looking to polish your angling skills on calm inshore waters or head offshore in search of your next big catch, booking a fishing charter is a swell idea,” wrote USA Today.

Guests on Fishbucket Sportfishing set sail from downtown Boston on the 32-foot Fishbucket.

“For novice fishers, a jaunt along Boston Harbor provides ample insight into the sport, while more experienced anglers can go all-in on an offshore trip to search for massive tuna and even sharks,” wrote USA Today.

About Reel Deal Fishing Charters on Cape Cod, USA Today wrote, “For those wishing to spend a vacation day searching for native New England sea life, Reel Deal Fishing Charters is a top choice. Fish like striped bass and bluefin tuna can be found throughout the area.”

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For the 10Best Readers’ Choice Awards lists, USA Today travel experts select 20 nominees in topics from food to lodging, destinations to things to do. Then the publication asks readers to cast votes to determine the top 10.

The No. 1 fishing charter is Hubbard’s Marina in Madeira Beach, Florida.

Check out USA Today‘s list of the 10 best fishing charters in America.

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Kristi Palma

Culture writer

 

Kristi Palma is a culture writer for Boston.com, focusing on New England travel. She covers airlines, hotels, and things to do across Boston and New England. She is the author of Scenic Six, a weekly travel newsletter.





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Massachusetts mother of girl killed by alleged drunk driver in Franklin also dies: Norfolk DA

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Massachusetts mother of girl killed by alleged drunk driver in Franklin also dies: Norfolk DA


The mother of the 5-year-old girl struck and killed by an alleged drunk driver in Franklin over Memorial Day weekend has also died from injuries suffered in the head-on crash, according to authorities.

Norfolk District Attorney Michael Morrissey and Franklin Police Chief Thomas J. Lynch announced on Tuesday that Minaben Patel, 38, of Franklin, had died from the serious injuries she suffered in the crash.

Emergency Responders rushed Patel and her son, Kung, who had just turned 14 that day, May 24, from the scene to UMass Memorial Medical Center in Worcester for treatment. Her 5-year-old daughter, Krisha, died that night.

“The Norfolk District Attorney’s Office and the Franklin Police Department are saddened by the loss to Minaben’s family, and we extend our heartfelt condolences,” Morrissey and Lynch said in a joint statement on Tuesday.

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They did not provide an update on the condition of Patel’s son, while an autopsy was slated to be performed to determine the cause of her death.

Patel’s husband, Atulkumar Patel, was also rushed to UMass Memorial but was subsequently released from the medical center.

The father told a responding officer at the scene that the family had been en route to Blackstone for his son’s birthday celebration when suspect James Blanchard, 21, of Franklin, plowed into them in a pickup truck.

Blanchard allegedly told police that he drank two beers while at a landscaping job that afternoon before he opened a 1.75-liter bottle of Tito’s Vodka and “began drinking straight out of it,” on his way home from Plainville, according to an incident report.

Blanchard is being held on $250,000 cash bail after his arraignment at Wrentham District Court last Tuesday. A not guilty plea was entered on his behalf.

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He currently faces charges of motor vehicle homicide while driving negligently and under the influence of alcohol, three counts of operating under the influence of alcohol and causing serious bodily injury, negligent operation of a motor vehicle, operating a motor vehicle with an open container of alcohol, and a marked lanes violation.

The results of a breath test taken at the scene showed the man’s blood alcohol content at 0.189, more than double the legal limit of 0.08, according to the incident report.

A vigil is scheduled to be held in the area of the crash, 75 Grove St., in Franklin, on Thursday at 6 p.m., in remembrance of Minaben.

“Minaben’s family is again deeply thankful for all the love and support shared over the last week,” the vigil’s organizer, The SAFE Coalition, posted on Facebook Tuesday afternoon. “They invite the community to honor this amazing Mother, Wife, Family Member and friend.”

The gathering will come just five days after services were held in memory of her daughter.

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Krisha’s obituary states: “Our hearts are broken as we say goodbye to such a precious little soul. In her short time with us, she filled the world with laughter, wonder, and love. Her smile could brighten the darkest day, and her kind heart touched everyone she met. Though her time here was far too brief, her spirit will forever live on in the hearts of all who loved her. We will carry her memory with us always – like a beautiful, shining star in the sky. May she rest peacefully, wrapped in love and light.”

A memorial on Grove Street in Franklin marks the site of a deadly crash where a young girl was killed by an alleged drunk driver. Her mother has also died from injuries sustained in the same crash, according to the Norfolk DA’s office. (Lance Reynolds/Boston Herald, File)

 

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Fewer than half of Mass. residents approve of Gov. Maura Healey, new poll shows

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Fewer than half of Mass. residents approve of Gov. Maura Healey, new poll shows


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The poll showed that 49 percent of residents approve of Healey’s performance, while 45 percent don’t.

Massachusetts Governor Maura Healey speaks during a visit to the Cambridge Health Alliance Revere Care Center on Tuesday, May 27. (Brett Phelps for The Boston Globe)

Fewer than half of Massachusetts residents approve of Governor Maura Healey, and more people polled think she “does not deserve to be re-elected” than do, according to a new survey from University of New Hampshire.

Researchers polled 907 Massachusetts residents, a majority of whom are registered as unenrolled voters, according to the poll’s methodology.

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The poll showed that 49 percent of residents approve of Healey’s performance, while 45 percent don’t. That approval rating is down from 54 percent earlier this year, but up from a low of 42 percent in November.

A spokesperson for Healey deferred to the Massachusetts Democratic Party, which categorized the UNH poll as an “outlier.”

“Governor Healey will be re-elected because she is focused on the issues that matter most to voters in Massachusetts, lowering the cost of living, building more housing, improving transportation and education, and standing up to Donald Trump,” said MassDems Chair Steve Kerrigan. “What is undeniable is that Massachusetts voters overwhelmingly reject Donald Trump and his disastrous agenda.”

The poll also showed just one-third of voters approve of President Donald Trump, his handling of the economy, and his handling of foreign affairs. A majority of people polled also thought that Trump accepting the plane from Qatar was “inappropriate” and the U.S. isn’t supporting Ukraine enough.

Healey is facing two Republican challengers: Brian Shortsleeve, the former head of the MBTA, and Mike Kennealy, a Lexington Republican who served in former Gov. Charlie Baker’s administration. 

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Both candidates reacted to news of the polling numbers on X, with Shortsleeve writing “her numbers are devastating. Do you think it is the migrant crisis, utility bills, or out of control spending?”

MassGOP emailed supporters with one overall message: “Healey is “beatable” in 2026,” Executive Director John Milligan said.

“The UNH poll confirms what we all knew: Maura Healey is vulnerable and she does not deserve to be reelected. I am the only candidate who can defeat Maura Healey. Massachusetts is ready for change and I’m ready to deliver,” Kennealy said on X.

MassDems pointed to a University of Massachusetts poll from February that shows that Healey “maintains support” and a Democratic Governors Association that shows record high ratings in May.

“Try as they might, Mike Kennealy and Brian Shortsleeve cannot hide from their support for Trump’s policies,” Kerrigan said. “Voters will reject their brand of failed MAGA Republican politics.”

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Twenty-one percent of the respondents named the most important problem facing the state as housing, with 12 percent mentioning immigration and cost of living, according to UNH’s poll. The poll also showed that more than half of residents are also concerned about Sen. Ed Markey’s age. The senator is running for reelection next year at age 79.

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Molly Farrar is a general assignment reporter for Boston.com, focusing on education, politics, crime, and more.





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