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Two Massachusetts scientists receive Nobel Prize in Medicine for discovery of microRNA

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Two Massachusetts scientists receive Nobel Prize in Medicine for discovery of microRNA


Two Massachusetts scientists have been recognized with the Nobel Prize in Physiology or Medicine for their role in the discovery of microRNA — key to the understanding of gene regulation and potential treatments of heart disease, cancer, neurodegenerative diseases and more.

Researchers Victor Ambros, a University of Massachusetts Medical School professor of natural science, and Gary Ruvkun, a Massachusetts General Hospital and Harvard Medical School investigator and professor of genetics, received the Nobel Prize on Monday.

“Gene regulation by microRNA, first revealed by Ambros and Ruvkun, has been at work for hundreds of millions of years,” the Nobel Committee for Physiology or Medicine stated in a release. “This mechanism has enabled the evolution of increasingly complex organisms.”

The committee stated the scientists’ work “revealed an entirely new dimension to gene regulation” that are “proving to be fundamentally important for how organisms develop and function.”

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In a press conference at MGH on Monday, Ruvkun called the study of recombinant DNA starting in the 70s a “revolution” and said as a young student and researcher he “just wanted to be part of that.”

In the late 1980s, Ambros and Ruvkun worked as postdoctoral fellows in the laboratory of Robert Horvitz, who was awarded the Nobel Prize in 2002. There they studied the 1 mm long roundworm, C. elegans, narrowing in on a mutation and gene function in the animals.

Ambros and Ruvkun continued the research after the fellowship at respectively at their Harvard University lab and Massachusetts General Hospital and Harvard Medical School lab. The pair compared findings, discovering the existence of microRNA in the worms, and published in 1993 in two articles in the journal Cell.

The discovery was met with “deafening silence from the scientific community,” the Nobel committee wrote, until 2000 when Ruvkun published new findings on microRNA in another gene, demonstrating their presence across the animal kingdom.

In the past two decades, “research into the potential of microRNAs for the diagnosis, prognosis and treatment of disease has expanded from the two original papers published by Ruvkun and Ambros in 1993 to 176,000 papers today,” MGH said in a statement.

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The “unexpectedly short” microRNA, Ambros said, help regulate how genes are controlled in cells. The microRNAs “block gene expression by binding to regulatory segments in their target messenger RNAs,” MGH said.

Current research has shown human and most other plant and animal genomes contain “more than 1,000 microRNAs, which control many protein-coding messenger RNAs and may be involved in a broad range of normal- and disease-related activities,” the hospital said.

Researchers are currently conducting clinical trials involving microRNA for medical conditions including heart disease, cancer and neurodegenerative diseases.

Ambros said he was “surprised and delighted” to hear about the Nobel Prize at a press conference in the UMass Chan Medical School in Worcester on Monday and emphasized that studies of laboratory organisms of this kind are “critical and key and fundamental to advancing understanding of biology.”

“I think the unexpectedness of biology is probably the most important principle, perhaps, for people to appreciate,” said Ambros. … “At any given moment, it feels like we know most of what we need to know — that is actually an illusion that we have to consciously disabuse ourselves of and leave ourselves open for the surprises.”

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The 2023 Nobel Prize in Physiology or Medicine was awarded to two researchers, Katalin Karikó and Drew Weissman, who helped develop mRNA vaccines to combat the COVID-19 pandemic.

Nobel prize announcements will continue with the physics prize on Tuesday, chemistry on Wednesday, literature on Thursday, Peace Prize on Friday and the Memorial Prize in Economic Sciences on Oct. 14.

Victor Ambros, left, 2024 Nobel Prize winner in physiology or medicine, and professor of natural science at the University of Massachusetts Medical School, hugs his wife Rosalind Lee following a news conference, Monday at the school in Worcester. (AP Photo/Steven Senne)
Nobel Committee chairman Thomas Perlmann, right, announces Americans Victor Ambros, left, and Gary Ruvkun, seen on a screen being awarded this year's Nobel Prize in Physiology or Medicine, during a press conference at the Karolinska Institute in Stockholm, Sweden, on Monday. (Christine Olsson/TT News Agency via AP)
Nobel Committee chairman Thomas Perlmann, right, announces Americans Victor Ambros, left, and Gary Ruvkun, seen on a screen being awarded this year’s Nobel Prize in Physiology or Medicine, during a press conference at the Karolinska Institute in Stockholm, Sweden, on Monday. (Christine Olsson/TT News Agency via AP)



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This Massachusetts shop is offering free coffee for patrons who come in dancing | CNN Business

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This Massachusetts shop is offering free coffee for patrons who come in dancing | CNN Business




CNN
 — 

A coffee shop in Middleborough, Massachusetts, went viral overnight for offering free coffee to customers who entered the shop while dancing.

A video of customers participating in the promotion was posted on Coffee Milano Café’s TikTok account on Monday and has since been viewed over 5 million times as of Wednesday afternoon.

The viral post highlights how businesses are finding new customers by amping up their online presence, moving away from traditional marketing methods that are not delivering the same reach anymore.

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Owner Josh Rashid told CNN that business picked up after the video was posted, attracting curious new customers while delighting cafe regulars.

“We’re a small little town here in Middleborough, and it’s fun. A couple of people were in the store when it happened, and they came in the next day and said, ‘Oh my gosh, I saw your video on my For You page,’” he said.

Inspired by a similar promotion by a pizza shop, Rashid posted a sign telling customers they would receive a free coffee if they danced for five seconds. The sign also informed them that they would be filmed and featured on the cafe’s social media.

Rashid told CNN that the cafe’s TikTok account gained over 10,000 followers since the video was posted, up from roughly 4,000 followers.

“Small businesses really need to be on these platforms where potential customers are searching,” said Kristyn Shay, social media director at SCORE, a nonprofit offering resources for small business owners. “It’s really an exciting time for small businesses to go viral on platforms like TikTok and be where younger potential customers are hanging out.”

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Rashid told CNN that the staff had only started creating short, playful videos using trending TikTok sounds four weeks ago when he decided to shake up their marketing strategy.

“We’re in a digital world and word of mouth is great, but at the same time, we’re glued to our phones,” he said. “It just shows us how powerful social media is, and as a business owner, we have to adapt and do what we can.”

Rashid said that the reaction to the cafe’s promotion was so positive that he plans to bring back the deal every month. But it comes with a catch.

He said he would not post an announcement or schedule an official date. Instead, he plans on leaving “Easter eggs” across the cafe’s social media for customers to find hints to future promotions.

“When you have a viral moment, it’s an indicator that you’re doing something right,” Shay said. “Maybe you tested a new strategy. Maybe that strategy was to be a little bit more silly and the audience responded to that.”

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And to those who worry about the cafe losing out on profits, Rashid says it’s not a problem.

“You’ve got to have some joy in this world, and if a little five second dance brings you joy, then it’s worth the free coffee.”



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Discolored water reported in 2 Massachusetts towns after long effort to get clean drinking water

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Discolored water reported in 2 Massachusetts towns after long effort to get clean drinking water


Residents in Holbrook and Randolph report muddy, discolored water

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Residents in Holbrook and Randolph report muddy, discolored water

02:13

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HOLBROOK – Residents in two Massachusetts communities are dealing with discolored water coming out of their pipes and they said it’s the latest issue in a years’ long process to get clean water.

Thick, muddy water

When John Davis woke up Tuesday morning in Holbrook, he found thick, muddy water flowing out of his tap. After a quick check of social media, it didn’t take long to figure out most of his neighbors were dealing with the same thing.  

“It was, just, black mud water came out of the tap,” said Davis. “I had a couple of friends that did their laundry. Ruined their laundry, they’ve been bleaching in the sink.” 

Davis has lived in Holbrook his entire life and said Tuesday’s dirty water debacle was just the latest in a years’ long effort to get clean drinking water. Each week for the last two years, Davis has been filling jugs up with clean spring water because the stuff coming out of his tap contains high levels of PFAS or “forever chemicals.” Davis said the town has advised residents not to cook with or drink their tap water. 

New treatment plant

The town is working to fix the issue by developing a so-called Tri-Town Water Treatment Plant out of Braintree. The town of Holbrook said Tuesday’s muddy water is the result of Monday night work on the project. 

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In a statement, the Holbrook Public Works Department said: 

“The Water Department is actively working to address the issue and appreciates your understanding during this time. Additionally, significant work was completed on Monday night on a major water transmission line that supplies the Holbrook’s Water Distribution System from the Randolph/Holbrook joint Water Treatment Plant. This work included the installation of two large junctions that will soon connect to new transmission lines from the Tri-Town Water Treatment Plant under construction in Braintree.” 

The statement went on to say the new plant should be completed by January of 2026. They added if anyone’s water was still discolored Wednesday night, to flush their system by letting their bathtub or shower run.

The neighboring town of Randolph also reported discolored water as a result of the construction. 

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Where are fires burning in Massachusetts? See map of where fire are burning

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Where are fires burning in Massachusetts? See map of where fire are burning


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The brush fires continue to burn in Massachusetts.

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A major brush fire erupted at Blue Hills Reservation on Monday night, and crews continued to battle the blaze Tuesday.

In Braintree, a brush fire was reported in the woods near Skyline Drive on Monday.

“Fire will continue to smolder deep underground until we have a soaking rain,” states the Braintree Fire Department’s Instagram page.

On top of the major brush fires this week, the alerts for fires kept coming in consistently from Nov. 19-20. Using Dataminr, there were 10 notifications reported in Massachusetts by noon on Nov. 20 and 14 fires reported on Nov. 19.

See map of where fires are burning in MA

The National Weather Service is continuing to warn residents that the state is at high risk for fires, issuing a special advisory on Wednesday.

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“The combination of prolonged dry weather and low relative humidities will contribute to elevated fire weather concerns Wednesday across Massachusetts. Obey fire bans, keep vehicles off dry grass and use extra caution if handling any potential ignition sources,” the agency said.

Brush fires/fire alerts today, Nov. 20

These alerts come from Dataminr.

  • Brush fire burns on 0 block of Mulberry St. in Groveland
  • Fire reported on 10 block of Overland St. Southbridge
  • Butternut Fire burns at 1,100 acres on East Mountain Rd. in Great Barrington
  • Fire reported on Great Neck Rd. South, Mashpee
  • Fire reported on 110 block of Townsend St. Worcester
  • Fire reported on Western Ave. Lynn
  • Fire reported on 200 block of Walnut Plain Rd. Rochester
  • Fire reported on 70 block of Wales St. Taunton
  • Brush fire prompts emergency response near Donald E Ross Elementary School on 20 block of Hayward St. in Braintree
  • Fire reported on Oakmont St. Webster

Brush fires/fires alerts on Nov. 19

  • Fire reported on 900 block of South St. Southbridge
  • Fire reported at intersection of Essex Street and Hampshire St. Lawrence
  • Fire reported on Methuen St. Lowell
  • Fire reported on 0 block of Shrewsbury St. Worcester
  • Fire reported on Azalea Rd. Winchester
  • Fire reported on Sycamore St. Westfield
  • Fire reported on 0 block of Wakefield Ave. Saugus
  • Fire reported on Rockland St. Abington
  • Fire reported on 300 block of Cherry St. Newton
  • Fire reported on 20 block of Virginia St. Dorchester
  • Fire reported on 200 block of Rockland St. Hanover
  • Three-alarm brush fire burns on 230 block of Topsfield Rd. in Wenham
  • Fire reported on 10 block of Colonial Ave. Lowell
  • Brush fire burns at Cedar Glen Golf Course on 60 block of Water St. in Saugus

Is this a bad season for brush fires in Massachusetts?

Yes.

The Carver Fire Department reported on Facebook that the average number of November brush fires in Massachusetts is 21.

“So far for November 2024 we are at 292 with over 700 acres burned” for the state, the department noted.

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State fire officials report that there were 175 wildfires that continued to be an issue across Massachusetts earlier this month on Nov. 9.

Mass.gov stated that there were 203 brush fires in Massachusetts during the month of October, which is an increase of about 1,200% over the average. Typically, there are only about 15 brush fires in October.

How bad is the drought in Massachusetts?

As of this week, the U.S. Drought Monitor recently showed that dry conditions in Massachusetts keep getting worse.

That’s because the state really hasn’t seen any significant rain since September, with precipitation totals in October being low.

The Massachusetts Executive Office of Energy and Environmental Affairs declared a Level 3 – Critical Drought for the central and northeast regions parts of Massachusetts late last week.

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The U.S. Drought Monitor currently classifies just over 66% of the state as being in a severe drought covering most of the Boston area, North shore, Central Massachusetts and Western Massachusetts. Other parts of the state are considered to be in a moderate drought, while the Cape and Islands are currently classified as abnormally dry.

Is there any rain on the way? If so, will it help?

The National Weather Service stated that a “slow-moving frontal system” will bring overcast skies and rain Thursday into Friday, “which could mix with wet snow at locations above 1,500 feet elevation.”

Meteorologist Candice Hrencecin of the National Weather Service branch in Norton told USA Today Network on Tuesday, Nov. 19, that “about an inch of rain” can be expected this Thursday into Friday.

But after Thursday, the weather is supposed to dry up again, she added.

Regarding whether the forecasted rain would stop the drought, Hrencecin said, “Definitely not,” but she added it would help quench any ongoing brush fires.

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