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Two Massachusetts scientists receive Nobel Prize in Medicine for discovery of microRNA

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Two Massachusetts scientists receive Nobel Prize in Medicine for discovery of microRNA


Two Massachusetts scientists have been recognized with the Nobel Prize in Physiology or Medicine for their role in the discovery of microRNA — key to the understanding of gene regulation and potential treatments of heart disease, cancer, neurodegenerative diseases and more.

Researchers Victor Ambros, a University of Massachusetts Medical School professor of natural science, and Gary Ruvkun, a Massachusetts General Hospital and Harvard Medical School investigator and professor of genetics, received the Nobel Prize on Monday.

“Gene regulation by microRNA, first revealed by Ambros and Ruvkun, has been at work for hundreds of millions of years,” the Nobel Committee for Physiology or Medicine stated in a release. “This mechanism has enabled the evolution of increasingly complex organisms.”

The committee stated the scientists’ work “revealed an entirely new dimension to gene regulation” that are “proving to be fundamentally important for how organisms develop and function.”

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In a press conference at MGH on Monday, Ruvkun called the study of recombinant DNA starting in the 70s a “revolution” and said as a young student and researcher he “just wanted to be part of that.”

In the late 1980s, Ambros and Ruvkun worked as postdoctoral fellows in the laboratory of Robert Horvitz, who was awarded the Nobel Prize in 2002. There they studied the 1 mm long roundworm, C. elegans, narrowing in on a mutation and gene function in the animals.

Ambros and Ruvkun continued the research after the fellowship at respectively at their Harvard University lab and Massachusetts General Hospital and Harvard Medical School lab. The pair compared findings, discovering the existence of microRNA in the worms, and published in 1993 in two articles in the journal Cell.

The discovery was met with “deafening silence from the scientific community,” the Nobel committee wrote, until 2000 when Ruvkun published new findings on microRNA in another gene, demonstrating their presence across the animal kingdom.

In the past two decades, “research into the potential of microRNAs for the diagnosis, prognosis and treatment of disease has expanded from the two original papers published by Ruvkun and Ambros in 1993 to 176,000 papers today,” MGH said in a statement.

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The “unexpectedly short” microRNA, Ambros said, help regulate how genes are controlled in cells. The microRNAs “block gene expression by binding to regulatory segments in their target messenger RNAs,” MGH said.

Current research has shown human and most other plant and animal genomes contain “more than 1,000 microRNAs, which control many protein-coding messenger RNAs and may be involved in a broad range of normal- and disease-related activities,” the hospital said.

Researchers are currently conducting clinical trials involving microRNA for medical conditions including heart disease, cancer and neurodegenerative diseases.

Ambros said he was “surprised and delighted” to hear about the Nobel Prize at a press conference in the UMass Chan Medical School in Worcester on Monday and emphasized that studies of laboratory organisms of this kind are “critical and key and fundamental to advancing understanding of biology.”

“I think the unexpectedness of biology is probably the most important principle, perhaps, for people to appreciate,” said Ambros. … “At any given moment, it feels like we know most of what we need to know — that is actually an illusion that we have to consciously disabuse ourselves of and leave ourselves open for the surprises.”

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The 2023 Nobel Prize in Physiology or Medicine was awarded to two researchers, Katalin Karikó and Drew Weissman, who helped develop mRNA vaccines to combat the COVID-19 pandemic.

Nobel prize announcements will continue with the physics prize on Tuesday, chemistry on Wednesday, literature on Thursday, Peace Prize on Friday and the Memorial Prize in Economic Sciences on Oct. 14.

Victor Ambros, left, 2024 Nobel Prize winner in physiology or medicine, and professor of natural science at the University of Massachusetts Medical School, hugs his wife Rosalind Lee following a news conference, Monday at the school in Worcester. (AP Photo/Steven Senne)
Nobel Committee chairman Thomas Perlmann, right, announces Americans Victor Ambros, left, and Gary Ruvkun, seen on a screen being awarded this year's Nobel Prize in Physiology or Medicine, during a press conference at the Karolinska Institute in Stockholm, Sweden, on Monday. (Christine Olsson/TT News Agency via AP)
Nobel Committee chairman Thomas Perlmann, right, announces Americans Victor Ambros, left, and Gary Ruvkun, seen on a screen being awarded this year’s Nobel Prize in Physiology or Medicine, during a press conference at the Karolinska Institute in Stockholm, Sweden, on Monday. (Christine Olsson/TT News Agency via AP)



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Lawmakers close door on Massachusetts online casino legalization

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Lawmakers close door on Massachusetts online casino legalization


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A House bill to green-light online casinos in Massachusetts failed to pass before the legislative session closed, but legislators voted to refer the bill for study to potentially bring back in 2027.

The legislative session closed for many states recently. For Massachusetts, that meant an end to hopes for 2026 legalization of online casinos. The state’s Joint Committee on Economic Development and Emerging Technologies voted to refer a House bill for study rather than advance it any further, delaying any potential for legalization until 2027.

Bill would have created up to nine Massachusetts online casinos

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As introduced by Rep. David Muradian, H4431 would carve out up to three skins for each of the state’s three land-based casinos. That would create up to nine real money online casino apps operating under the oversight of the Massachusetts Gaming Commission with a tax rate of 15% on adjusted gross revenue.

The bill also would have formally prohibited online sweepstakes operators that offer content simulating casino games online, lottery and sports betting. The DraftKings Casino promo code, among others, are available in nearby New Jersey.

While the joint committee did not advance the proposal, its pledge to study it in more detail ahead of 2027 provided some optimism. As Muradian told the State House News Service, H4431 exits the 2026 session with plenty of momentum and “will hopefully serve as a springboard to future economic growth” in Massachusetts.

Lawmakers discussed Muradian’s bill last fall before they agreed to extend its reporting deadline until March.

Massachusetts preparing for internet lottery launch

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Legal gaming expansion is already on the way for Massachusetts, which is preparing to go live with online lottery this year, powered by Aristrocrat Interactive. The iLottery service expects to offer online draw game tickets and instant-win games that resemble real money online slots.

While debating the online casino bill, Deb Goldberg, treasurer and lottery commissioner, emphasized that authorizing the launch of new online casinos would not be beneficial for the state or the lottery. In fact, she argued, legal casino apps would actually threaten the bottom line of potential revenue.

Massachusetts is surrounded by states with legal online casinos, with the likes of Connecticut, Pennsylvania and New Jersey nearby. What’s more, another New England state will soon join the crowd as Gov. Janet Mills allowed a bill to become law that legalized Maine online casinos.

Proponents of legal online casinos in Massachusetts have noted that those surrounding markets siphon potential revenue from the state while also pointing out that authorizing regulated iGaming would help curb black market operators and better protect state residents.

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Intense fire guts trucks behind Brockton bowling alley

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Intense fire guts trucks behind Brockton bowling alley


A fire ripped through several trucks behind a bowling alley in Brockton, Massachusetts, on Saturday afternoon, firefighters said.

Images shared on social media, including by City Councilor Winthrop Farwell Jr., showed heavy smoke billowing from the fire behind Westgate Lanes near Route 27.

The fire involving a group of tractor-trailers parked next to each other was reported just after 2 p.m., Brockton Fire Chief Brian Nardelli told reporters after the blaze was knocked down.

“It was extending from truck to truck,” Nardelli said, and spread to the woods behind where the trucks were parked.

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No one was hurt, including the firefighters, who “were able to kind of beat back the fire” in the brush, according to Nardelli.

Investigators hadn’t yet determined what started the fire as of Saturday afternoon, but the chief said he didn’t suspect foul play. The city’s fire marshal was at the scene.

Some trailers had been completely gutted by the blaze.

Unions of nearby fire departments noted on social media that they’ve been called to assist in Brockton.



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Battenfeld: Meet the most powerful politician in Massachusetts

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Battenfeld: Meet the most powerful politician in Massachusetts


A once-obscure Democratic state senator from sleepy Ashland, unelected by most voters, has emerged as the most powerful public official in Massachusetts, topping even Gov. Maura Healey in clout and impact.

Senate Majority Leader Karen Spilka tells the governor, the House speaker and even the mayor of Boston what to do and right now stands as the biggest obstacle to transparency in the Legislature.

Most voters don’t know her and certainly never voted for her, yet Spilka, who represents the 2nd Middlesex/Norfolk District, controls the agenda in the state and how taxpayer money is spent.

Spilka was reelected without opposition in 2024, getting just 68,762 votes — a tiny fraction of the population of Massachusetts.

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But she has managed to stay relatively scandal-free, unlike several of her Senate President predecessors who moved on.

While Spilka does not appear to have statewide ambitions, the position of Senate president has traditionally been a launching pad to lucrative lobbying careers.

And there really is no reason for Spilka to quit or run for governor, because she holds more power than any lobbyist or the current occupant of the Corner Office, Maura Healey.

When House lawmakers this week announced a breakthrough $4 million funding initiative to tackle Boston’s Mass and Cass drug issue, Spilka, who has feuded with Wu, was conspicuously absent, casting doubt about whether the funding will ever be approved.

Spilka and her fellow Democratic state senators stopped Wu’s commercial tax hike plan last year, angering the mayor and prompting her to challenge two senators who publicly blocked it. But Wu notably did not put up a challenger to Spilka.

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The Ashland senator is also engaged in a very nasty public dispute with Auditor Diana DiZoglio over the voter-approved audit of the Legislature.

DiZoglio has compared Spilka to a monarch, saying she “rules and reigns over Massachusetts, just like a Queen.”

Spilka, with a straight face, retorted that the Legislature’s actions are of course democratic — a ridiculous assertion considering the way she runs the Senate.

She also denied not wanting the Legislature to face the voter-approved audit which DiZoglion is leading.

“We have really worked hard to increase transparency,” she said.

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Spilka has often been in conflict with House Speaker Ron Mariano, and essentially nothing happens in the Legislature without Spilka’s approval. If Mariano were a Simpsons character, it would be Homer.

While staying away from scandal, Spilka is after all a creature of the Massachusetts Democratic hackerama, and has as bad a case of Trump derangement syndrome as any other liberal Democrat.

She raised eyebrows earlier this year by comparing President Donald Trump’s illegal immigration crackdown to the Holocaust.

“I’ve been open and honest that this moment, what is happening across our country, reminds me of what my family experienced in Poland in the 1930s leading up to World War II,” she said at the annual “Immigrant Day” celebration at the Statehouse.

“When people targeted my family with violence because they were Jewish. Like this government today, even targeting now because of people’s looks, their accents, the way they speak, and that is unacceptable.”

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