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Moderna says updated Covid-19 vaccine booster shows stronger antibody response against Omicron

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Moderna says updated Covid-19 vaccine booster shows stronger antibody response against Omicron

Bivalent boosters handle two viral strains in the identical vaccine. The up to date booster incorporates Moderna’s authentic vaccine, and a vaccine candidate that targets the Omicron variant.

The vaccine was usually well-tolerated, the corporate mentioned, with unwanted side effects much like booster doses of the present vaccine.

The 50-microgram bivalent booster, known as mRNA-1273.214, generated a stronger antibody response in opposition to Omicron than the unique Moderna vaccine. Omicron subvariants are driving nearly all the brand new Covid-19 instances in the US proper now.

Stéphane Bancel, chief government officer of Moderna, mentioned in a information launch “we anticipate extra sturdy safety in opposition to variants of concern with mRNA-1273.214, making it our lead candidate for a Fall 2022 booster.”
He mentioned the corporate will submit its preliminary knowledge and evaluation to regulators in order that the Omicron-containing bivalent booster will probably be out there in late summer season. The US Meals and Drug Administration’s vaccine advisers are set to satisfy June 28 to debate whether or not coronavirus vaccine compositions ought to be modified for fall 2022.

In April, Moderna introduced its first bivalent Covid-19 booster shot candidate — which mixed components of the present vaccine with updates primarily based on the Beta variant — induced larger antibody responses in opposition to all variants of concern, together with Omicron, when in comparison with the corporate’s authentic Covid-19 booster shot.

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Year in a word: Greenlash

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Year in a word: Greenlash

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(portmanteau noun) the backlash against environmental policies. Not to be confused with greenwashing, green hushing or green wishing

It seems it was only yesterday that green policies were on the march. If it wasn’t the US passing the biggest climate law in the country’s history, it was the EU legislating for the world’s first major carbon border tax or the UK pledging to end sales of new petrol and diesel cars by 2030. 

Green progress was especially notable in Europe. By 2022, the EU’s renewable power generation had boomed so much that solar and wind overtook gas for the first time. EU emissions plunged 8 per cent in 2023, the steepest annual fall in decades outside of 2020.

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But as climate promises were becoming a reality, inflation was spurring cost of living anxieties. Net zero-sceptic populist parties seized on these to denounce green policies as a costly elitist plot against working people. 

As 2023 turned into 2024, the green march began to stumble. Companies backed away from green targets. Germany watered down a contentious heat pump law that had helped to push the far-right AFD party’s poll numbers above 20 per cent. Brussels scrapped a plan to halve pesticide use. Green parties were hammered in June’s European parliament elections.  

In the UK, the former Conservative government pushed back the ban on new petrol and diesel cars to 2035. 

Yet the Conservatives still suffered a crushing election loss to the Labour party, which pledged to restore the 2030 target and is still committed to an ambitious decarbonisation agenda. 

That’s a reminder that the greenlash has limits, as does China’s remorseless charge towards green energy supremacy. But with an incoming Trump administration expected to reverse climate policies, and populism showing no sign of easing in Europe, it is clear that fraught green politics are by no means at an end.

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pilita.clark@ft.com

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Musk Vs MAGA War: Trump Camp In Bitter Fight Over Immigration, Foreign Worker Visas

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Musk Vs MAGA War: Trump Camp In Bitter Fight Over Immigration, Foreign Worker Visas

Putin Aide Suggests Punishing Europe Over Its ‘Bloodthirsty Policies’ Against Russia | Ukraine War

Former Russian President Dmitry Medvedev has called for decisive action against Europe, accusing it of “anti-Russian” policies and advocating political, economic, and hybrid measures to punish European nations aligned with the U.S. His remarks came after a Norwegian ship allegedly refused to rescue Russian sailors following the sinking of a Russian freighter, exacerbating tensions. Medvedev also suggested fostering internal instability within Europe and labeled its policies as deceitful, brainless, and bloodthirsty.

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Tech pullback drags Wall Street stocks lower

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Tech pullback drags Wall Street stocks lower

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US tech stocks slipped on Friday as investors pivoted away from companies that had led markets higher for much of this year.

The S&P 500, Wall Street’s main equity benchmark, fell 1.1 per cent on Friday, while the tech-heavy Nasdaq Composite dropped 1.5 per cent. Elon Musk’s electric-car maker Tesla was among the biggest laggards, falling 5 per cent, while chipmaker Nvidia dropped 2.1 per cent.

“I watch probably 30 different [market indicators] and they’re all down today,” said Jack Ablin, chief investment officer at Cresset Capital. “This was just widespread selling without much enthusiasm.”

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Tech stocks have rallied strongly this year, as investors bet artificial intelligence would drive demand for everything from servers to microchips. The gains accelerated after Donald Trump’s election victory in November on bets that the president-elect would usher in more business-friendly policies when his term begins next month.

However, the sector has been choppier in recent weeks as investors reassess their best-performing holdings at the end of the year. The Federal Reserve also sparked ructions last week when it forecast only two quarter-point rate cuts next year, compared with its September forecast of four, as officials fretted about growing risks that inflation becomes lodged well above the central bank’s 2 per cent target.

The hawkish projections have pushed up US long-term borrowing costs, with the 10-year Treasury yield rising to 4.63 per cent on Friday, compared with lows in September of about 3.6 per cent. Higher yields typically tarnish the appeal of holding shares in fast-growing companies.

Citigroup analysts on Friday said that while they still forecast the S&P 500 will rise about 10 per cent from current levels by the end of next year, they expect a “more volatile leg of the bull market ahead”.

The US bank noted this year’s gains in stock prices compared with corporate profits were “setting a high bar for fundamentals in the year ahead, and even the year after”. The S&P 500 trades at about 22.2 times expected earnings over the next year, compared with the average over the past decade of 18.1, according to FactSet data.

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Greg McBride, chief financial analyst at Bankrate.com, said that, “even with that volatile Friday, the market’s still higher than it was on Monday”.

He said: “Markets don’t go straight up, and a pullback often serves as a foundation for the next market advance.”

The S&P 500 is still up 25 per cent year-to-date even after Friday’s pullback, roughly on a par with the previous year’s gains.

The so-called Magnificent 7 Big Tech stocks — Apple, Microsoft, Meta, Amazon, Alphabet, Nvidia and Tesla — have been responsible for roughly half of the S&P 500’s total returns, including dividends, this year, said Howard Silverblatt at S&P Dow Jones Indices.

All of the Magnificent 7 shares declined modestly on Friday, however.

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Trading activity is typically lighter than usual during the holiday period, something that can exacerbate volatility.

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