Iowa State football head coach Matt Campbell talks to the media during the program’s football media day at Stark Performance Center on Friday, August 2, 2024, in Ames, Iowa.© NIrmalendu Majumdar/Ames Tribune / USA TODAY NETWORK

 AMES — The excitement level spikes. The adrenaline flows more freely. Mistakes emerge that must be corrected.

 It’s finally game week for the Iowa State football team, and as the atmosphere changes, head coach Matt Campbell and his staff endeavor to ensure nothing else does in terms of his team’s preparedness and attention to detail.

 “That’s the whole mentality of this program,” Campbell said in advance of the Cyclones’ season-opener at 2:30 p.m. Saturday (FS1) against North Dakota at Jack Trice Stadium. “Your mindset day in and day out for the last six months should match what Tuesday practice in the fall looks like — week one, to week six, to week 12. The great teams that I’ve been around, they’ve had the same mindset every single day.”

 So there’s no mental shift for ISU as it transitions from fall camp to the regular season — except that now the players will be cheered on by 60,000-plus fans. 

 “The energy in the Jack — me personally, I love playing in Jack Trice (Stadium),” said junior defensive lineman Tyler Onyedim, one of six Cyclones whose 13 career starts all came last season. “It should be really fun, really exciting. I love the energy. Ready to go.”

 ISU and North Dakota have never met on the football field, but the Fighting Hawks’ rise though the FCS ranks over the past several years has been impressive. They reached the playoffs in 2023 and return skilled starters at key positions, but are less experienced on the offensive and defensive lines and at quarterback. And despite being prohibitive favorites this Saturday, Campbell and his staff know that danger and adversity often lurk in those on-paper mismatches in week one.

 Case in point: Last Saturday’s “week zero” game between No. 10 Florida State and Georgia Tech in Dublin, Ireland. The Yellow Jackets were double-digit underdogs, but upset the Seminoles, 24-21, on a last-second field goal.

 “Football’s hard to replicate,” Campbell said of the inevitable rust often evident early in the season. “Eleven-on-eleven, it’s really hard to replicate the environment and game day experience. So, man, how you tackle in the first game, how you handle the pressure of some of these guys in new roles — and all of a sudden, now there (are nearly) 70,000 people here and there’s this great environment and great experience. I think all of those things are unknown.”

 North Dakota’s biggest unknown is its quarterback, Simon Romfo. He beat out last season’s backup during fall camp, but nearly all of his college football statistics are sandwiched into mop-up duty in one game. The 5-11, 190-pound junior completed both his passes and rushed for two touchdowns in last season’s 49-10 win over Western Illinois. 

 “He’s a skilled guy,” Cyclones veteran defensive coordinator Jon Heacock said. “He’s athletic. He’s tough. And those guys present problems, too. They run the football, you know, quarterback runs. It’s stuff we’ve prepped for and studied all summer, and we’re just trying to figure out the balance to where it’s all gonna be.”

 Therein lies the uncertainty in week one of any season. That’s why Campbell hopes nothing changes in how his players approach each practice — even as the cheers and hoopla will soon surround each Saturday as “the lights come on.”

 “Now there’s a result,” Campbell said. “A tangible result to the time, the effort, the energy that you spend into it. Not all results will be great, and how you respond to it is defining of who you are and who you’ll become.”