Missouri heads to Norman on Saturday for a pivotal late-season matchup that carries real weight for both programs. Oklahoma enters the weekend as a touchdown favorite at home, backed by a 70% win probability in Dimers’ simulations, and the Sooners will try to lean on their defense to control the tempo in a game projected to stay low scoring. Missouri, meanwhile, comes in as a live underdog with a 55% chance to cover, and the Tigers have shown enough resilience this season to make this a far more competitive meeting than the odds might suggest.
With a projected final of 26–19 in favor of Oklahoma, the analytics point toward a tight, defense-driven contest—one where field position, turnovers, and red-zone execution could swing everything. Both teams remain firmly in the postseason conversation entering Week 13, and with the total sitting at just 42.5, every possession at Gaylord Family Oklahoma Memorial Stadium may feel magnified.
Missouri vs. Oklahoma betting preview
Explore the interactive widget below to discover the current spread, total, and moneyline betting odds and probabilities for the Missouri-Oklahoma matchup at Gaylord Family Oklahoma Memorial Stadium.
This prediction and best bet for Saturday’s college football matchup between Missouri and Oklahoma is from Dimers.com, a leader in sports betting predictions.
Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.
Game details
Key information on the Missouri vs. Oklahoma matchup, including where the game is and what time it kicks off.
- Teams: Missouri vs. Oklahoma
- Date: Saturday, November 22, 2025
- Kickoff: 12 p.m. EST
- Location: Gaylord Family Oklahoma Memorial Stadium
- NCAAF rankings: Updated AP Top 25
- College football news: Check the latest updates from the official NCAA football news site
Odds
Odds for the key markets in the Missouri-Oklahoma college football matchup.
- Spread: Missouri +7.5 (-112), Oklahoma -7.5 (-105)
- Moneyline: Missouri +240, Oklahoma -290
- Total: Over/Under 42.5 (-110/-110)
The odds and lines featured in this article are the best available from selected sports betting sites at the time of publication and are subject to change.
Promos
New users in Missouri can look forward to these offers from DraftKings, Bet365, BetMGM, and FanDuel all going live December 1st.
Expert prediction: Missouri vs. Oklahoma
Utilizing advanced data analysis and machine learning, the experts at Dimers have executed 10,000 simulations of Saturday’s Missouri vs. Oklahoma matchup.
According to Dimers’ renowned predictive analytics model, Oklahoma is more likely to beat Missouri at Gaylord Family Oklahoma Memorial Stadium. This prediction is based on the model giving Oklahoma a 70% chance of winning the game.
Furthermore, Dimers predicts that Missouri (+7.5) has a 55% chance of covering the spread, while the over/under total of 42.5 points has a 60% chance of staying under.
These predictions and probabilities are correct at the time of publication but are subject to potential changes.
Missouri vs. Oklahoma best bet
Our top pick for the Missouri vs. Oklahoma game on Saturday is to bet on Under 42.5 points (-110).
This betting advice is formulated through detailed modeling and valuable wagering intelligence, designed to bring you the best possible plays.
Score prediction for Missouri vs. Oklahoma
Dimers’ predicted final score for the Missouri vs. Oklahoma game on Saturday has Oklahoma winning 26-19.
This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.
College football Week 13: Missouri vs. Oklahoma
Get ready for Saturday’s college football game between Missouri and Oklahoma at Gaylord Family Oklahoma Memorial Stadium, which is scheduled to start at 12 p.m. EST. We emphasize that all of the college football predictions and college football best bets in this preview are based on 10,000 data-driven simulations of the Missouri vs. Oklahoma matchup, and they are accurate at the time of publication to help you make better decisions when placing bets at online sportsbooks.
Please remember to gamble responsibly and seek trustworthy sources for accurate and up-to-date information when making online betting choices.
If you purchase a product or register for an account through a link on our site, we may receive compensation. By using this site, you consent to our User Agreement and agree that your clicks, interactions, and personal information may be collected, recorded, and/or stored by us and social media and other third-party partners in accordance with our Privacy Policy.
