Missouri heads to Norman on Saturday for a pivotal late-season matchup that carries real weight for both programs. Oklahoma enters the weekend as a touchdown favorite at home, backed by a 70% win probability in Dimers’ simulations, and the Sooners will try to lean on their defense to control the tempo in a game projected to stay low scoring. Missouri, meanwhile, comes in as a live underdog with a 55% chance to cover, and the Tigers have shown enough resilience this season to make this a far more competitive meeting than the odds might suggest.

With a projected final of 26–19 in favor of Oklahoma, the analytics point toward a tight, defense-driven contest—one where field position, turnovers, and red-zone execution could swing everything. Both teams remain firmly in the postseason conversation entering Week 13, and with the total sitting at just 42.5, every possession at Gaylord Family Oklahoma Memorial Stadium may feel magnified.

Missouri vs. Oklahoma betting preview

Explore the interactive widget below to discover the current spread, total, and moneyline betting odds and probabilities for the Missouri-Oklahoma matchup at Gaylord Family Oklahoma Memorial Stadium.

This prediction and best bet for Saturday’s college football matchup between Missouri and Oklahoma is from Dimers.com, a leader in sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

Key information on the Missouri vs. Oklahoma matchup, including where the game is and what time it kicks off.

• Teams: Missouri vs. Oklahoma
• Date: Saturday, November 22, 2025
• Kickoff: 12 p.m. EST
• Location: Gaylord Family Oklahoma Memorial Stadium
• NCAAF rankings: Updated AP Top 25
• College football news: Check the latest updates from the official NCAA football news site

Odds

Odds for the key markets in the Missouri-Oklahoma college football matchup.

• Spread: Missouri +7.5 (-112), Oklahoma -7.5 (-105)
• Moneyline: Missouri +240, Oklahoma -290
• Total: Over/Under 42.5 (-110/-110)

The odds and lines featured in this article are the best available from selected sports betting sites at the time of publication and are subject to change.

Promos

New users in Missouri can look forward to these offers from DraftKings, Bet365, BetMGM, and FanDuel all going live December 1st.

Expert prediction: Missouri vs. Oklahoma

Utilizing advanced data analysis and machine learning, the experts at Dimers have executed 10,000 simulations of Saturday’s Missouri vs. Oklahoma matchup.

According to Dimers’ renowned predictive analytics model, Oklahoma is more likely to beat Missouri at Gaylord Family Oklahoma Memorial Stadium. This prediction is based on the model giving Oklahoma a 70% chance of winning the game.

Furthermore, Dimers predicts that Missouri (+7.5) has a 55% chance of covering the spread, while the over/under total of 42.5 points has a 60% chance of staying under.

These predictions and probabilities are correct at the time of publication but are subject to potential changes.

Missouri vs. Oklahoma best bet

Our top pick for the Missouri vs. Oklahoma game on Saturday is to bet on Under 42.5 points (-110).

This betting advice is formulated through detailed modeling and valuable wagering intelligence, designed to bring you the best possible plays.

Score prediction for Missouri vs. Oklahoma

Dimers’ predicted final score for the Missouri vs. Oklahoma game on Saturday has Oklahoma winning 26-19.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

College football Week 13: Missouri vs. Oklahoma

Get ready for Saturday’s college football game between Missouri and Oklahoma at Gaylord Family Oklahoma Memorial Stadium, which is scheduled to start at 12 p.m. EST. We emphasize that all of the college football predictions and college football best bets in this preview are based on 10,000 data-driven simulations of the Missouri vs. Oklahoma matchup, and they are accurate at the time of publication to help you make better decisions when placing bets at online sportsbooks.

Please remember to gamble responsibly and seek trustworthy sources for accurate and up-to-date information when making online betting choices.

If you or a loved one has questions or needs to talk to a professional about gambling, call 1-800-GAMBLER or visit 1800gambler.net for more information.

KSHB 41 reporter Tod Palmer covers sports business and eastern Jackson County. Share your story idea with Tod.

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A new Missouri law will allow bars and restaurants to operate 24/7 and extend beer and liquor sales hours when FIFA World Cup 26 comes to North America next summer, but political subdivisions — think cities and counties — can opt out of the extended hours.

The Independence City Council unanimously voted Oct. 20 to allow establishments to stay open around the clock, but it opted out of extending hours for beer and liquor sales.

Instead, the usual 1:30 a.m. closing time, when alcohol-by-the-drink sales must end, will remain in place from June 11 to July 19, but other cities plan to let the 23-hour beer and liquor sales go into effect.

Kansas City, Missouri, which allows some bars to remain open until 3 a.m. anyway, plans to allow bars and restaurants to sell booze from 6 a.m. to 5 a.m., as allowed under the new Missouri law, which passed on May 9 and was signed into law July 10.

Liberty, Gladstone and Raymore also have discussed the issue and plan to allow the law to take effect, according to city officials in those municipalities.

“Keeping our local approach aligned with state guidance provides consistency for our residents, businesses and visitors,” the City of Raymore said in a statement. “We’ll work closely with our local establishments and public safety partners to ensure everything runs smoothly and responsibly during this highly anticipated event.”

Licensed businesses in cities that don’t take action to opt out won’t have to jump through additional hoops to take advantage of the round-the-clock operation and 23-hour booze sales changes.

“Licensees are not required to apply to the commission for approval and no special temporary license or permit shall be required of any licensee for the purposes of this temporary extension,” according to House Bill 1041.

It’s up to cities and counties to proactively take action if they want to opt out of 24/7 operations and 23-hour alcohol sales. The law automatically sunsets on July 20, 2026.

The Lee’s Summit City Council will consider an ordinance tonight — Tuesday, Nov. 18 — to opt out, while Belton — where city officials are leaning toward not opting out, a spokesperson told me — will begin discussions about the law next week.

Blue Springs, Grandview and Raytown are aware of the new law and are still discussing whether to opt out or not.

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The Missouri Lottery offers several draw games for those aiming to win big. Here’s a look at Nov. 17, 2025, results for each game:

Winning Powerball numbers from Nov. 17 drawing

07-33-50-57-66, Powerball: 23, Power Play: 5

Check Powerball payouts and previous drawings here.

Winning Pick 3 numbers from Nov. 17 drawing

Midday: 0-4-4

Midday Wild: 7

Evening: 7-8-0

Evening Wild: 6

Check Pick 3 payouts and previous drawings here.

Winning Pick 4 numbers from Nov. 17 drawing

Midday: 4-9-0-7

Midday Wild: 6

Evening: 2-8-7-5

Evening Wild: 4

Check Pick 4 payouts and previous drawings here.

Winning Cash4Life numbers from Nov. 17 drawing

13-16-23-31-37, Cash Ball: 01

Check Cash4Life payouts and previous drawings here.

Winning Cash Pop numbers from Nov. 17 drawing

Early Bird: 03

Morning: 05

Matinee: 12

Prime Time: 10

Night Owl: 11

Check Cash Pop payouts and previous drawings here.

Winning Show Me Cash numbers from Nov. 17 drawing

03-07-15-22-25

Check Show Me Cash payouts and previous drawings here.

Winning Powerball Double Play numbers from Nov. 17 drawing

11-18-23-59-69, Powerball: 05

Check Powerball Double Play payouts and previous drawings here.

Feeling lucky? Explore the latest lottery news & results

Are you a winner? Here’s how to claim your lottery prize

All Missouri Lottery retailers can redeem prizes up to $600. For prizes over $600, winners have the option to submit their claim by mail or in person at one of Missouri Lottery’s regional offices, by appointment only.

To claim by mail, complete a Missouri Lottery winner claim form, sign your winning ticket, and include a copy of your government-issued photo ID along with a completed IRS Form W-9. Ensure your name, address, telephone number and signature are on the back of your ticket. Claims should be mailed to:

Ticket Redemption

Missouri Lottery

P.O. Box 7777

Jefferson City, MO 65102-7777

For in-person claims, visit the Missouri Lottery Headquarters in Jefferson City or one of the regional offices in Kansas City, Springfield or St. Louis. Be sure to call ahead to verify hours and check if an appointment is required.

For additional instructions or to download the claim form, visit the Missouri Lottery prize claim page.

When are the Missouri Lottery drawings held?

• Powerball: 9:59 p.m. Monday, Wednesday and Saturday.
• Mega Millions: 10 p.m. Tuesday and Friday.
• Pick 3: 12:45 p.m. (Midday) and 8:59 p.m. (Evening) daily.
• Pick 4: 12:45 p.m. (Midday) and 8:59 p.m. (Evening) daily.
• Cash4Life: 8 p.m. daily.
• Cash Pop: 8 a.m. (Early Bird), 11 a.m. (Late Morning), 3 p.m. (Matinee), 7 p.m. (Prime Time) and 11 p.m. (Night Owl) daily.
• Show Me Cash: 8:59 p.m. daily.
• Lotto: 8:59 p.m. Wednesday and Saturday.
• Powerball Double Play: 9:59 p.m. Monday, Wednesday and Saturday.

This results page was generated automatically using information from TinBu and a template written and reviewed by a Missouri editor. You can send feedback using this form.