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University of Minnesota team working to unlock biological mysteries

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University of Minnesota team working to unlock biological mysteries


Lead researcher and Ph.D. candidate at the University of Minnesota, Judee Sharon, equates what she’s doing with test tubes and cells in a lab on campus to taking a car engine apart and learning as much as possible about the potential of each piece.

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“Even though biology research has existed for arguably 100 years, there is still so little we know,” says Sharon.

Through new research, Sharon and her team at the University of Minnesota have developed a platform for a new method of biocomputing they named “TRUMPET.” TRUMPET (Transcriptional RNA Universal Multi-Purpose gatE plaTform) uses biological enzymes as catalysts for DNA-based molecular computing. Their focus: a single strain of DNA, how enzymes attach, and produce a glow. The glow essentially turns a light on, pointing toward countless life-improving possibilities.

“That’s how we know the gate worked,” says Associate Professor Kare Adamala. “We want to do the same thing a computer does, but we want to do it with goo. We want to do it with biological parts. That’s an idea that’s been around for a couple of decades now. Hopefully, as this technology develops, we’ll be able to get as reliable as computer chips; we’ll be able to do some of those really complex computations using those biological molecules.”

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Initial ideas for the people TRUMPET could help include anyone with something in their bodies requiring computations. Think of someone who is diabetic and in need of an insulin pump or someone who has lost an eye or an arm. TRUMPET could someday help how an amputee operates their prosthetic.

Judee Sharon works in a lab at the University of Minnesota. (FOX 9)

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“It would be a good way to build prosthetic devices that can actually interface with a patient’s central nervous system. So, for example, you can imagine having an arm move, thinking about it like a natural arm,” says Adamala. “We are far from that now. We are early, but this is a way to get there.”

There’s also potential for environmental applications. How nice would it be to never have to worry about blue-green algae again?

“You know how you can’t go swim in it because you’ll get sick, but what if we were able to catch it much earlier?” asks Sharon. “And what if we were able to catch it when it was a few thousand cells instead of billions of cells that would cause an entire lake to be in the grip of algae blooms?”

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While the work analyzing fragments of cells thus far has been three years in the making, there’s still likely about a decade of work to be done. However, the potential, according to those doing the research, is limitless.

“Right now, we have some ideas on how to use it,” says Sharon, “but we are really hoping the next generation of scientists will be able to pull it into the future and imagine technology we can’t even fathom and dream of.”



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Minnesota Senate Minority Leader Mark Johnson says legislative session will have 'a lot going on'

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Minnesota Senate Minority Leader Mark Johnson says legislative session will have 'a lot going on'


EAST GRAND FORKS — As Minnesota lawmakers head into their legislative session, working to pass the next state budget likely will be the biggest item on their agenda, according to Senate Minority Leader Mark Johnson.

“Especially if we start off slow with these court cases, I’m not planning a vacation in June,” said Johnson, a Republican from East Grand Forks. “There are a lot of needs in this state — not just in my district but across the state — but given the issues with the budget right now … there’s going to be a lot going on down in St. Paul.”

The Legislature convenes Jan. 14 for its 94th session. The Minnesota Democratic-Farmer-Labor party has a one-seat majority in the Senate, and the House of Representatives is expected to be tied at 67. While a

power-sharing agreement — with both DFL and Republican chairs

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on all committees — has been discussed, two ongoing court cases mean unknowns remain on final majorities.

“We don’t know when those are going to be resolved,” Johnson said. “The House might be in a little bit of limbo trying to figure out who’s going to be leading.”

Two cases — one

regarding discarded ballots in a close representative race in Shakopee

and another challenging the residency of a Roseville representative — are working their way through Minnesota court.

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If a DFL-Republican tie does end up being the case on Jan. 14, there’s legal and constitutional ambiguity about whether co-speakers of the House could exist. A tie has only happened one other time in Minnesota, in 1979. At that time, the Independent Republican Party gained the speakership and the DFL chaired the rules, taxes and appropriations committees. It created

chaotic final days of the session.

There’s also the case of Sen. Nicole Mitchell, DFL-Woodbury, who has been

accused of burglary in Becker County court and has a jury trial scheduled for the end of January.

There have been calls for her resignation, but others have stressed that she hasn’t yet had her day in court.

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“So even before we get into the budget cycle, there are all these dynamics going on behind the scenes,” Johnson said. “That’s triggered some interesting conversations of a few Democrats in the Senate.”

Even disregarding the controversies, the Legislature will be tasked with creating and passing a budget for the next two-year biennium.

The last budget, passed in 2023, was only the

eighth budget in 40 years that was passed before the regular session’s

constitutional end date of the Monday after the third Saturday in May. This year, that date is May 19. If a budget isn’t passed by then, Gov. Tim Walz will have to call a special session; if a budget isn’t passed by June 30, the government will shut down. That last occurred in 2011.

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With the Minnesota Management and Budget Office

saying that the state has a structural imbalance

and as costs increase for long-term care and special education, Johnson said the Legislature needs to look at policy fixes.

“There are some policy things that we could be doing going forward that would really help out and fix what the Democrats have been doing over the last two years with that extreme policy,” he said. “Minnesotans are paying for (it) every single day and we can address and make this government more effective and efficient, and we can make it cheaper and better for people in Minnesota to live here.”

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Voigt covers government in Grand Forks and East Grand Forks.





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NEXT Weather: 10 p.m. forecast for Friday, Dec. 27, 2024

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NEXT Weather: 10 p.m. forecast for Friday, Dec. 27, 2024


NEXT Weather: 10 p.m. forecast for Friday, Dec. 27, 2024 – CBS Minnesota

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Things will stay pretty mild as we head into the weekend. Temps will remain in the upper 30s to low 40s. As we head into the near year our temps do drop. Chris Shaffer breaks down what you need to know.

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Houston takes home win streak into matchup with Minnesota Timberwolves

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Houston takes home win streak into matchup with Minnesota Timberwolves


Minnesota Timberwolves with a record of 15-14 and ranked ninth in the Western Conference match off against Houston Rockets with a record of 21-9 and ranked second in the Western Conference. The game is in Houston at 7 p.m. CST on Friday.

Houston aims to extend its three-game home winning streak.

The Rockets have gone 13-7 against Western Conference opponents. Houston ranks fifth in the NBA with 51.5 points in the paint led by Alperen Sengun averaging 12.5.

The Timberwolves have gone 12-9 against Western Conference opponents. Minnesota scores 109.1 points and has outscored opponents by 2.2 points per game.

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The Rockets are shooting 44.3 percent from the field this season, 1.4 percentage points lower than the 45.7 percent the Timberwolves allow to opponents.

The Timberwolves are shooting 45.7 percent from the field, 2.2 percent higher than the 43.5 percent the Rockets’ opponents have shot this season.

A top performer for the Rockets is Sengun who is scoring 18.3 points per game with 10.5 rebounds and 5.2 assists.

The Timberwolves’ Anthony Edwards is averaging 25.3 points, 5.6 rebounds and four assists.

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In the last ten games, the Rockets have held a record of 7-3, averaging 111.6 points, 49.3 rebounds, 21.1 assists, 6.9 steals and 5.7 blocks per game. The shooting average has been 44.6 percent from the field. Their opponents have averaged 107.7 points per game.

For the Timberwolves’ last ten games, they have had an average of 6-4, averaging 105.2 points, 45.0 rebounds, 27.0 assists, 10.2 steals and 4.5 blocks per game. They have been shooting 44.6 percent from the field. Their opponents have averaged 100.5 points.

Rockets’ Dillon Brooks has an ankle injury. Tari Eason is also on rest.

Timberwolves’ Daishen Nix and Luka Garza are out due to an ankle injuries. Joe Ingles is also injured.



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