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What to know about the new 'FLiRT' COVID variants

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What to know about the new 'FLiRT' COVID variants
  • According to the World Health Organization, the “FLiRT” variants of the SARS-CoV-2 coronavirus have been the dominant forms of the virus circulating globally this year.
  • “FLiRT” is an acronym for the locations of the mutations the variants share on the virus’ spike protein.
  • CDC data suggests COVID-related hospitalizations have trended downwards in recent weeks and the number of patients in emergency departments who have tested positive for COVID has been about flat for the past month.

The so-called FLiRT variants of SARS-CoV-2 coronavirus that cause COVID-19 have been the dominant forms of the virus circulating this year globally, according to the World Health Organization.

The moniker FLiRT is an acronym for the locations of the mutations the variants share on the virus’ spike protein. One of them, called KP.2, has become the most commonly circulating variant in the United States over the past month, according to the U.S. Centers for Disease Control and Prevention.

Here is what you need to know about FLiRT.

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HOW ARE THE FLIRT VARIANTS DIFFERENT FROM PREVIOUS VARIANTS?

The FLiRT variants, which also include KP.2’s “parental” lineage JN.1, have three key mutations on their spike protein that could help them evade antibodies, according to Johns Hopkins University.

ARE THE FLIRT VARIANTS MORE CONTAGIOUS OR LIKELY TO CAUSE MORE SEVERE ILLNESS?

Dr. Aaron Glatt, chief of infectious diseases at Mount Sinai South Nassau Hospital in Oceanside, New York, and a spokesperson for the Infectious Diseases Society of America said he has not seen evidence of an uptick in disease or hospitalizations, based on the data he tracks and experience with his own patients.

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U.S. experts and regulators will meet to discuss vaccine design on June 5, 2024, to address new COVID variants. (Reuters/Dado Ruvic/Illustration/File Photo)

“There have been some significant changes in the variants, but I think in recent times it’s not been as important, probably because of the immunity many, many people already have” from prior illness and vaccination.

CDC data suggests that COVID-related hospitalizations have trended downwards in recent weeks and the number of patients in emergency departments who have tested positive for COVID has been about flat for the past month.

Data suggests that COVID rates are also down year-over-year. The rate of COVID hospitalizations is less than half than a year earlier, and the amount of the antiviral Paxlovid currently being prescribed for COVID-19 is down around 60% from last year, according to analyst notes.

DO CURRENT VACCINES WORK AGAINST THE FLIRT VARIANTS?

The current vaccines should still have some benefit against the new variants, Glatt said.

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Since 2022, health regulators have asked vaccine makers to design new versions of the COVID-19 vaccines to better target circulating variants. Last month, Europe’s regulator said vaccine makers should target the JN.1 variant. U.S. experts and regulators will meet to discuss vaccine design on June 5 after having postponed the meeting from May 16 in order to have more time to “obtain surveillance data and other information.”

Makers of vaccines based on messenger RNA (mRNA) technology – Pfizer with partner BioNTech, and Moderna – say they are waiting for the June 5 meeting before settling on the design of their next vaccines.

Novavax, which makes a more traditional protein-based vaccine that takes longer to manufacture, has begun producing a shot targeting JN.1 consistent with recommendations from European regulators.

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How The Great British Bake Off Host Alison Hammond Lost 150 Lbs Naturally

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How The Great British Bake Off Host Alison Hammond Lost 150 Lbs Naturally


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Alison Hammond’s Weight Loss: How She Shed 150 Lbs | Woman’s World




















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One state leads country in human bird flu with nearly 40 confirmed cases

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One state leads country in human bird flu with nearly 40 confirmed cases

A child in California is presumed to have H5N1 bird flu, according to the San Francisco Department of Public Health (SFDPH).

As of Dec. 23, there had been 36 confirmed human cases of bird flu in the state, according to the California Department of Public Health (CDPH).

This represents more than half of the human cases in the country.

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The latest pediatric patient, who lives in San Francisco, experienced fever and conjunctivitis (pink eye) as a result of the infection.

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The unnamed patient was not hospitalized and has fully recovered, according to the SFDPH.

A child in California is presumed to have H5N1 bird flu, according to the San Francisco Department of Public Health. (iStock)

The child tested positive for bird flu at the SFDPH Public Health Laboratory. The U.S. Centers for Disease Control and Prevention (CDC) will perform additional tests to confirm the result.

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It is not yet known how the child was exposed to the virus and an investigation is ongoing.

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“I want to assure everyone in our city that the risk to the general public is low, and there is no current evidence that the virus can be transmitted between people,” said Dr. Grant Colfax, director of health, in the press release. 

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“We will continue to investigate this presumptive case, and I am urging all San Franciscans to avoid direct contact with sick or dead birds, especially wild birds and poultry. Also, please avoid unpasteurized dairy products.” 

Samuel Scarpino, director of AI and life sciences and professor of health sciences at Northeastern University in Boston, is calling for “decisive action” to protect individuals who may be in contact with infected livestock and also to alert the public about the risks associated with wild birds and infected backyard flocks. 

Chick bird flu test

An infectious diseases expert called for “decisive action” to alert the public about the risks associated with wild birds and infected backyard flocks.  (iStock)

“While I agree that the risk to the broader public remains low, we continue to see signs of escalating risk associated with this outbreak,” he told Fox News Digital.

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Experts have warned that the possibility of mutations in the virus could enable person-to-person transmission.

     

“While the H5N1 virus is currently thought to only transmit from animals to humans, multiple mutations that can enhance human-to-human transmission have been observed in the severely sick American,” Dr. Jacob Glanville, CEO of Centivax, a San Francisco biotechnology company, told Fox News Digital.

Split image of cows and bird flu vial

As of Jan. 10, there have been a total of 707 infected cattle in California, per reports from the California Department of Food and Agriculture. (iStock)

“This highlights the requirement for vigilance and preparation in the event that additional mutations create a human-transmissible pandemic strain.”

As of Jan. 10, there have been a total of 707 infected cattle in California, per reports from the California Department of Food and Agriculture (CDFA).

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In the last 30 days alone, the virus has been confirmed in 84 dairy farms in the state.

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Chronic Pain Afflicts Billions of People. It’s Time for a Revolution.

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Chronic Pain Afflicts Billions of People. It’s Time for a Revolution.

“In the beginning, everyone thought they were going to find this one breakthrough pain drug that would replace opioids,” Gereau said. Increasingly, though, it’s looking like chronic pain, like cancer, could end up having a range of genetic and cellular drivers that vary both by condition and by the particular makeup of the person experiencing it. “What we’re learning is that pain is not just one thing,” Gereau added. “It’s a thousand different things, all called ‘pain.’”

For patients, too, the landscape of chronic pain is wildly varied. Some people endure a miserable year of low-back pain, only to have it vanish for no clear reason. Others aren’t so lucky. A friend of a friend spent five years with extreme pain in his arm and face after roughhousing with his son. He had to stop working, couldn’t drive, couldn’t even ride in a car without a neck brace. His doctors prescribed endless medications: the maximum dose of gabapentin, plus duloxetine and others. At one point, he admitted himself to a psychiatric ward, because his pain was so bad that he’d become suicidal. There, he met other people who also became suicidal after years of living with terrible pain day in and day out.

The thing that makes chronic pain so awful is that it’s chronic: a grinding distress that never ends. For those with extreme pain, that’s easy to understand. But even less severe cases can be miserable. A pain rating of 3 or 4 out of 10 sounds mild, but having it almost all the time is grueling — and limiting. Unlike a broken arm, which gets better, or tendinitis, which hurts mostly in response to overuse, chronic pain makes your whole world shrink. It’s harder to work, and to exercise, and even to do the many smaller things that make life rewarding and rich.

It’s also lonely. When my arms first went crazy, I could barely function. But even after the worst had passed, I saw friends rarely; I still couldn’t drive more than a few minutes, or sit comfortably in a chair, and I felt guilty inviting people over when there wasn’t anything to do. As Christin Veasley, director and co-founder of the Chronic Pain Research Alliance, puts it: “With acute pain, medications, if you take them, they get you over a hump, and you go on your way. What people don’t realize is that when you have chronic pain, even if you’re also taking meds, you rarely feel like you were before. At best, they can reduce your pain, but usually don’t eliminate it.”

A cruel Catch-22 around chronic pain is that it often leads to anxiety and depression, both of which can make pain worse. That’s partly because focusing on a thing can reinforce it, but also because emotional states have physical effects. Both anxiety and depression are known to increase inflammation, which can also worsen pain. As a result, pain management often includes cognitive behavioral therapy, meditation practice or other coping skills. But while those tools are vital, it’s notoriously hard to reprogram our reactions. Our minds and bodies have evolved both to anticipate pain and to remember it, making it hard not to worry. And because chronic pain is so uncomfortable and isolating, it’s also depressing.

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