Health
What Is Hantavirus, the Disease That Killed Gene Hackman’s Wife?
Betsy Arakawa, the wife of Gene Hackman, died from the effects of hantavirus, a rare disease often caused by contact with droppings from infected rodents.
Hantavirus does not spread among people in the cases found in the United States. It can be transmitted through rodent saliva. But it is most commonly transmitted by breathing in particles of dried deer mouse droppings or urine.
At first, hantavirus causes flulike symptoms, including fever, chills, body aches and headaches. But as the disease progresses, respiratory symptoms develop and patients can experience shortness of breath and then lung or heart failure.
Here is what to know about hantavirus.
What is hantavirus?
Hantavirus refers to a family of viruses that are carried by rodents. It is often transmitted to humans by inhaling particles from dried mouse droppings. In North America, Sin Nombre virus is the most common form of this virus, said Sabra L. Klein, a professor at the Johns Hopkins Bloomberg School of Public Health.
As of the end of 2022, 864 cases of hantavirus disease had been reported in the United States since surveys of such cases began in 1993, according to the Centers for Disease Control and Prevention. The “classic” case of hantavirus is contracted by someone who has visited a rural cabin that has a rodent infestation, said Emily Abdoler, a doctor and assistant professor of medicine at the University of Michigan Medical School.
Hantavirus has flulike symptoms at first.
Hantavirus can cause flulike symptoms that appear one to eight weeks after exposure to droppings from an infected rodent, according to Dr. Heather Jarrell, New Mexico’s chief medical examiner. Later, patients often experience shortness of breath and then lung or heart failure.
The mortality rate from the hantavirus strain in the southwestern United States is between 38 and 50 percent, Dr. Jarrell said. The strain in the region cannot be transmitted from person to person, she said.
New Mexico is no stranger to hantavirus.
In the United States, hantavirus is most commonly found in the Four Corners region — Utah, Colorado, Arizona and New Mexico — according to Dr. Abdoler.
New Mexico has recorded from one to seven hantavirus infections each year for the past five years, according to Dr. Erin Phipps, a veterinarian at the New Mexico Department of Health.
Most people get infected around their home or workplace, she said. On the property east of Santa Fe where Mr. Hackman and Ms. Arakawa lived, health officials found signs of rodent entry in some structures, although little risk of exposure to the virus in the main residence.
It is not clear when Ms. Arakawa began to feel ill, Dr. Jarrell said.
How do I prevent hantavirus?
Although there are antivirals that can help manage symptoms, there are no cures specifically for hantavirus, Ms. Klein of Johns Hopkins said. That’s why prevention is important.
If you live in an area where hantavirus-infected rodents are known to roam, clean any droppings with a wet paper towel. Do not use a vacuum or a broom, which can stir up the aerosols from the excrement.
Use gloves and a tightfitting N95 mask in a well-ventilated space. People should spray the area with a bleach solution or a commercial disinfectant and let it sit for five minutes. Then they should clean the area with paper towels, tossing them in a trash can that closes tightly, Dr. Phipps said.
Treatment of hantavirus in the intensive care unit may include intubation and oxygen therapy, fluid replacement and medications to support blood pressure. Sometimes antiviral drugs are used.
Health
Common nighttime noise exposure may trigger heart problems, study suggests
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Living near heavy traffic could negatively impact your heart health.
A European study, published in the journal Environmental Research, found that exposure to nighttime road traffic noise is linked to changes in the blood, leading to worsened cholesterol and cardiovascular risks.
The researchers considered data from the U.K. Biobank, Rotterdam Study, and Northern Finland Birth Cohort 1966, including more than 272,000 adults over the age of 30, according to a press release.
Nighttime road noise exposure was estimated at all participants’ homes based on national noise maps. Researchers also took blood samples to measure the participants’ metabolic biomarkers for disease, then mapped the link between nightly noise levels and existence of biomarkers.
Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers. (iStock)
The study found that people exposed to louder noise at night — especially sounds above 55 decibels — showed changes in 48 different substances in their blood. Twenty of these associations “remained robust” throughout all cohorts.
Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers, especially LDL “bad” cholesterol, IDL (intermediate-density lipoprotein) and unsaturated fatty acids.
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As noise levels increased, starting at around 50 decibels, cholesterol markers rose steadily, the release stated.
The authors concluded that this study “provides evidence that nighttime road traffic noise exposure from 50 dB upward is associated with alterations in blood cholesterol and lipid profiles in adults.”
Researchers noted a link between traffic noise and cardiometabolic disease. (iStock)
Study co-author Yiyan He, doctoral researcher at the University of Oulu in Finland, noted that in this type of research, small effect sizes are expected, and environmental exposures such as traffic noise are “typically modest.”
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“Despite this, we observed statistically robust and consistent associations across many biomarkers, especially those related to LDL and IDL lipoproteins,” she told Fox News Digital.
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“We also identified a clear exposure-response pattern starting at around 50 dB, suggesting that metabolic changes become more evident as noise levels increase.”
This aligns with public health guidance, as the World Health Organization recommends lower nighttime noise limits at around 40 to 45 dB, Yiyan He added.
“This finding may clarify the association between traffic noise and cardiometabolic diseases,” the researchers wrote. (iStock)
“The 55 dB level is often used as an interim benchmark associated with substantial noise annoyance and sleep disturbance,” she said. “In our study, we observed associations not only at 55 dB, but also indications of effects emerging at around 50 dB.”
The strength and consistency of the cholesterol-related associations were surprising, as these changes are usually “subtle.”
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“Instead, we found consistent associations across multiple large European cohorts, which strengthens confidence that the findings may reflect real biological patterns,” Yiyan He went on. “We were also interested to see that effects were minimal below ~50 dB, suggesting a possible threshold-like pattern.”
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The researcher noted that these findings were consistent across genders, education levels and obesity status.
The study was restricted to White Europeans, which posed a limitation. There was also a lack of information on the fasting status in the UK Biobank.
Changes in cholesterol levels were more severe than researchers expected. (iStock)
“Fasting can influence levels of certain metabolites, particularly fatty acids,” Yiyan He said. “However, based on UK Biobank documentation, fewer than 10% of participants were fasting for at least eight hours, and our main findings focused on cholesterol-related biomarkers, which are generally less sensitive to short-term fasting.”
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The researchers also lacked information on bedroom location, indoor noise exposure and time spent at home.
“These factors may introduce non-differential exposure misclassification,” Yiyan He said. “Additionally, noise exposure estimates were based on participants’ temporary residential addresses at the time of blood sampling, without considering the duration of residence.”
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“Many of these limitations would tend to bias results toward the null, so the consistent associations we observed remain noteworthy.”
Experts recommend taking measures to limit traffic noise at night. (iStock)
Based on this latest research, Yiyan He noted that nighttime noise is a “health-relevant exposure,” not just “an annoyance.”
“Our findings suggest that nighttime traffic noise may subtly but consistently affect metabolic health,” she said. “While the changes in cholesterol and lipid levels for any one individual are small, traffic noise affects a very large number of people, which means the potential public health impact could be substantial.”
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The researcher recommends taking measures like improving sound insulation, using noise-reducing strategies and placing bedrooms on the quieter side of the home when possible.
“Because sleep is a key pathway linking noise to health, protecting the nighttime sleep environment is especially important,” she added.
Health
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