Kidney transplants are not uncommon — the kidney is actually the most frequently transplanted organ in the U.S. — but a Chicago man recently received his in a highly unusual way.

John Nicholas, 28, was awake during the entire procedure, which was performed on May 24 at Northwestern Medicine Hospital. He was discharged the very next day.

Doctors administered a spinal anesthesia shot — similar to what is used for a Cesarean section — instead of general anesthesia, according to a press release from the hospital.

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“This is the first case at Northwestern Medicine where a patient was awake during an entire kidney transplant procedure and went home the next day, basically making this an outpatient procedure,” said Satish Nadig, M.D., PhD, transplant surgeon and director of the Northwestern Medicine Comprehensive Transplant Center, in the release. 

“Inside the operating room, it was an incredible experience being able to show a patient what their new kidney looked like before placing it inside the body,” he added. 

“It was incredibly simple and uneventful.”

This type of “awake transplant” could reduce surgical risks and shorten the length of the patient’s hospitalization, doctors say.

“It was an incredible experience, being able to show a patient what their new kidney looked like before placing it inside the body.”

It could also increase access to care for patients who are considered high-risk or have phobias surrounding general anesthesia.

Ideal candidate

Nicholas’ surgery took about two hours, according to the hospital.

He was considered an ideal patient for awake surgery due to his young age, his otherwise good health and his “eagerness to participate,” per the release.

John Nicholas is pictured awake during his kidney transplant in late May. (Northwestern Medicine)

“It was a pretty cool experience to know what was happening in real time and be aware of the magnitude of what they were doing,” said Nicholas in a statement to Northwestern. 

“At one point during surgery, I recall asking, ‘Should I be expecting the spinal anesthesia to kick in?’ They had already been doing a lot of work and I had been completely oblivious to that fact. Truly, no sensation whatsoever.”

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Although Nicholas did receive sedation for comfort, he said he was still aware of what was going on. 

“Especially when they called out my name and told me about certain milestones they had reached,” he noted.

Nicholas, center, is pictured after surgery with Dr. Vicente Garcia Tomas, his anesthesiologist, at left, and Dr. Nadig, transplant surgeon, at right.  (Northwestern Medicine)

Nicholas walked out of the hospital on May 25, the day after surgery.

With typical kidney transplants, the recipient remains in the hospital for two to three days.

Saved by a friend

Nicholas’ kidney issues began at age 16 when he was diagnosed with Crohn’s disease, the release stated.

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After a few years of managing the condition with medication, his kidney function worsened and he required a transplant.

Nicholas’ mother originally planned to donate her kidney, but a breast cancer diagnosis prevented her from doing so, the hospital relayed.

Nicholas, at left, is pictured with his donor and best friend, Pat Wise, after surgery. (Northwestern Medicine)

It was Nicholas’ best friend from elementary school, 29-year-old Pat Wise in Alexandria, Virginia, who ultimately donated the life-saving kidney.

‘Another tool in our toolbelt’

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, was not involved in the surgery but shared his input.

“My opinion is that in most cases, spinal anesthesia presents a reasonable alternative for those at high risk of general anesthesia complications,” Siegel told Fox News Digital. 

Nicholas is pictured awake with his care team during his kidney transplant surgery. (Northwestern Medicine)

“Having said that, general anesthesia would be preferred whenever possible for major surgery like this,” said Dr. Siegel, “because control of the airway and breathing is essential, and is much easier if the patient is asleep and on the ventilator.”

The doctors at Northwestern credit the patient for helping to advance the field of transplant medicine.

Nicholas, left, and donor Wise are pictured at a press conference after the surgery. (Northwestern Medicine)

“When John agreed to be the first known patient at Northwestern Medicine to undergo an awake kidney transplant and be discharged home the next day, he knew the benefits outweighed the risks, and … he’s now helping to move the field of transplantation forward,” said Vinayak Rohan, M.D., transplant surgeon at Northwestern Memorial Hospital, in the release. 

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“He is an extremely compliant patient who was in tune with his body and willing to push the envelope,” stressing that the patient had faith in the doctors and they, in turn, had faith in him.  

Nicholas, center, is pictured with his entire care team. “He’s now helping to move the field of transplantation forward,” a surgeon said about the patient. (Northwestern Medicine)

The hospital now plans to establish the AWAKE Program (Accelerated Surgery Without General Anesthesia in Kidney Transplantation) for patients who want or need to pursue surgery without general anesthesia.

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“It really opens up a whole new door and is another tool in our toolbelt for the field of transplantation,” Nadig added.

Fox News Digital reached out to Northwestern Medical for additional input.

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The Centers for Disease Control and Prevention has issued a fresh warning about an increased risk of dengue virus infections as a “record-breaking number” of cases are being reported in the Americas. 

From January 1 to June 24 of this year, more than 9.7 million dengue cases were recorded among countries in the Americas, which is more than double the 4.6 million infections recorded throughout 2023, according to the CDC. 

“Global incidence of dengue in 2024 has been the highest on record for this calendar year; many countries are reporting higher-than-usual dengue case numbers,” it also said. “In 2024, countries in the Americas have reported a record-breaking number of dengue cases, exceeding the highest number ever recorded in a single year.” 

The CDC describes the dengue virus as the “most common” mosquito-borne disease in the world. In the U.S., Florida has reported the most cases so far this year with 197, followed by New York with 134, Massachusetts with 50 and California with 40. 

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“Six U.S. territories and freely associated states are classified as areas with frequent or continuous dengue transmission: Puerto Rico, American Samoa, the U.S. Virgin Islands, the Federated States of Micronesia, the Republic of Marshall Islands, and the Republic of Palau,” the CDC adds. 

The health agency says one in every four dengue infections are symptomatic, with effects including fever and “nausea, vomiting, rash, muscle aches, joint pain, bone pain, pain behind the eyes, headache, or low white blood cell counts.” 

“Severe disease, with associated severe bleeding, shock or respiratory distress caused by plasma leakage, or end-organ impairment, develops in 1 in 20 people with symptomatic dengue,” according to the CDC. 

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Tiger mosquitoes are being blamed for the recent spread of the dengue virus in Europe. (iStock)

It said infants under the age of one, pregnant women and adults over the age of 65 carry an “increased risk of severe dengue” and that “transmission peaks during the warmer and wetter months in many tropical and subtropical regions.” 

There is not currently a medication to treat dengue, the CDC says. 

A worker is seen releasing smoke during a fumigation campaign against the Aedes aegypti or Aedes albopictus mosquito, which is the transmitter for the dengue virus, on June 24, in San Salvador, El Salvador.  (Aphotografia/Getty Images)

Infected people are advised to rest, take acetaminophen for pain and fever, stay hydrated and see a doctor. 

Fox News’ Melissa Rudy contributed to this report.