Health
The Fast-Changing Chemistry of New, Dangerous Drugs
Illicit labs are creating new synthetic drugs at breakneck speed. Dangerous, untested compounds are reaching users long before health agencies know they exist. Older drugs are regularly modified to create novel threats. Ecstasy is a prime example.
The party drug MDMA has been illegal since 1985. Its molecular structure can be drawn like this:
But what if you could add one atom to this molecule to change both the experience of taking the drug and its legal status?
You can. A single oxygen atom changes the molecule to methylone, which provides an Ecstasy-like euphoria.
This simple change had a profound consequence. When methylone reached the U.S. market in 2010 the drug could be sold legally in corner stores and smoke shops as “bath salts.”
But methylone wasn’t the end of the story. Illicit chemists now use methylone’s structure as a template for modern-day alchemy. New drug laws push them to invent new variants, which emerge in the illicit drug market with untested potencies and effects — a vicious cycle that has been impossible to contain.
These chemists are located in unregulated labs around the globe, from big enterprises in China and India that produce drugs and their precursor compounds in huge volumes, to single-person and small domestic operations that cut and package drugs for retail sale. Some of the most-used drugs, such as fentanyl, are mixed in Mexico and exported north.
Waves of Bath Salts
Methylone was an early example of a class of drugs known as synthetic cathinones, which continue to proliferate.
Beginning in 2010, emergency rooms began seeing agitated patients who were violent, paranoid and psychotic after ingesting synthetic cathinones sold as bath salts. Poison control centers received a few hundred calls about the drugs in 2010. The following year had over 6,000 calls.
When methylone was finally banned in 2011, unregulated chemists simply tweaked the molecule to evade the ban, creating new drug formulas. The Drug Enforcement Administration noted in 2019 that “as one synthetic cathinone is controlled, another unscheduled synthetic cathinone appears in the recreational drug market.”
Examining the drug on a molecular level shows how illicit chemists try to increase potency and heighten the effect in a user’s brain.
As cathinone molecules become more potent, they also become more addictive. “Because they hijack the dopamine system in the brain — the salience and reward system in the brain — they’re going to be extremely addictive,” said Dr. Michael Baumann, director of the Designer Drug Research Unit of the National Institute on Drug Abuse. “There’s a reason why chemists would design these.”
Experts confirmed that the molecules described in this article are well known among illicit chemists, who have moved on to newer structures. “These are not rudimentary chemists,” Dr. Baumann said. “They’re actually ahead of us.”
Nitazenes, the ‘Frankenstein Opioids’
Another class of drugs has been following a similar pattern. When China banned all variants of fentanyl in 2019, illicit chemists began to research non-fentanyl opioids and rediscovered nitazenes, drugs developed in the 1950s as alternatives to morphine but never approved for medical use. Chemists modify the molecules — which are more complex than cathinones — in similar ways to increase potency.
“This is trial and error,” said Dr. Alex Krotulski, director of the Center for Forensic Science Research and Education, of the efforts. “They’re pushing the envelope to make more and more potent drugs.”
By the end of 2024, at least 22 nitazene molecules had been identified. New variants are prized because of their inexpensive production costs, high potency and vague legal status, according to a 2023 paper.
Ohio’s attorney general was referring to nitazenes when he warned that “Frankenstein opioids are even more lethal than the drugs already responsible for so many overdose deaths.”
China banned nitazenes in July 2025, a move that may cause production to shift to other countries. In the meantime, illicit chemists searching through patents and research papers may stumble on another class of legal molecules to tweak and modify.
“It’s so much more dangerous today, the drugs are so much more potent,” said George W. Hime, assistant director of toxicology at the Miami-Dade Medical Examiner. “Someone out there is playing chemistry.”
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A decades-long effort to develop a vaccine against one of the world’s leading causes of severe digestive illness has reached a milestone, according to new research.
Scientists recently developed a technology targeting enterotoxigenic Escherichia coli (ETEC), a bacterium responsible for millions of diarrheal illnesses each year.
The technology has now been licensed to French vaccine manufacturer Valneva for further development.
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The findings come after decades of research led by scientists at the University of Bergen and the Norwegian Research Center (NORCE).
One of the most common bacterial causes of severe diarrhea worldwide, ETEC is known to disproportionately affect children in low- and middle-income countries. Despite years of research, there is currently no broadly effective vaccine to prevent the infection, according to the study.
Researchers have made a major breakthrough in the decades-long effort to develop a vaccine against ETEC, a leading cause of diarrheal disease worldwide. (iStock)
The researchers focused on a toxin produced by ETEC that has long been considered one of the biggest obstacles to vaccine development.
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James Fleckenstein, MD, a professor of medicine and molecular microbiology at the Washington University School of Medicine in St. Louis, said the findings represent a promising step.
“We still have a lot of work to do to translate these findings to an actual vaccine,” Fleckenstein, who was not involved in the research, told Fox News Digital. “But the approach does look promising in the sense that the proteins elicit strong antibody responses that appear to offer protection against diarrheal illness after the first infection in children in developing countries.”
ETEC is a leading bacterial cause of severe diarrhea worldwide, especially among children in low- and middle-income countries. (iStock)
If the vaccine eventually reaches patients, researchers hope it could help protect children against some of the most severe forms of diarrheal disease caused by ETEC.
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In the meantime, Fleckenstein said travelers can take steps to reduce their risk of diarrheal illnesses. He recommends avoiding high-risk foods — including meals from street vendors in areas where sanitation may be poor — drinking bottled water in higher-risk regions, and practicing good hand hygiene.
While a vaccine is still years away, experts recommend avoiding high-risk foods, drinking bottled water and washing your hands to reduce the risk of ETEC. (iStock)
Fleckenstein also noted that vaccines are available to protect against typhoid fever, and said travelers should consult their physician before traveling internationally.
The research did have some limitations, the researchers noted.
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The technology is still in development and has not yet been tested as an approved vaccine among the public.
While the licensing agreement allows Valneva to continue advancing the research, additional laboratory studies, clinical trials and regulatory review will be required before the vaccine becomes available.
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Bryan Johnson, a biohacker and longevity guru who has claimed “we may be the first generation who won’t die,” revealed he has an autoimmune condition causing his stomach to “eat itself.”
The Los Angeles-based tech entrepreneur, 48, has previously shared publicly that he is hoping to live until the year 2140, when he would in theory be 160 years old.
Now, Johnson says he has been diagnosed with autoimmune gastritis (AIG), a chronic autoimmune disease in which the immune system attacks the stomach’s acid-producing parietal cells, reducing stomach acid and impairing vitamin B12 absorption, according to Nature Reviews Disease Primers.
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“My stomach is eating itself,” he wrote in an Instagram post. Johnson also shared that anywhere from 2% to 5% of people likely have this disease.
“I’m going to try to solve it,” Johnson went on. “Will share all.”
Bryan Johnson, a biohacker and longevity guru who has claimed “we may be the first generation who won’t die,” revealed he has an autoimmune condition causing his stomach to “eat itself.” (Getty Images)
The biohacker shared that as a child, he ate sugary cereal, drank sugary soda and “gobbled down fast food.”
“I became a young father of three and began building a business,” Johnson went on. “Juggling that stress and grind, I let my health slip and gained 40 lbs. Within a few years I’d fallen into a deep, chronic depression.”
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“Somewhere in that timeline, my body began developing an autoimmune process affecting my thyroid and then my stomach lining,” he added.
Fox News Digital reached out to Johnson for comment.
AIG can remain hidden and can be challenging to diagnose, Johnson noted, often surfacing years after damage has already occurred to the stomach. It can cause iron deficiency, B12 deficiency and anemia, and can also increase the risk of stomach cancer, the expert warned.
“Low iron stores get normalized and rarely investigated at all when anemia hasn’t shown up yet,” Johnson wrote. “That blind spot is what hid mine for a decade.”
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He also shared that for 11 years, he has had low levels of ferritin, a protein that stores iron inside the body’s cells. Ferritin releases iron when the body needs it, supports muscle function and carries out other essential processes.
“We continually tried to raise my iron levels with food and supplementation, but nothing would work,” he said.
The Los Angeles-based tech entrepreneur, 48, has previously shared publicly that he is hoping to live until the year 2140. (Getty Images)
Johnson acknowledged that some common biohacking techniques — including hard training, sauna and hyperbaric oxygen — all raise the body’s demand for iron.
“But none of them explained the core failure: Despite me taking iron orally, trailing every formulation and using every timing trick, none of the iron would stick.”
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Johnson underwent a colonoscopy and upper endoscopy, which examined his entire intestinal tract. Five biopsies were also taken from his stomach, which found “clear signs of early autoimmune gastritis: early atrophy confined to the acid-producing lining.”
In January 2026, the biohacker stated in a post on his website that “by 2039, my goal is immortality.”
“In the age of AI, multiomics, and custom-built DNA, proteins and cells, no condition should be presumed incurable simply because no one has yet tried to cure it with today’s stack,” Johnson said in his post. (Getty Images)
He detailed his strategy for defying aging, which includes embracing a strict regimen to slow or stop biological aging, using AI to accelerate longevity research, testing new treatments in lab-grown cells and organs, and reaching “longevity escape velocity” — in which medical advances would eventually extend lifespan faster than he ages.
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“I may fail at this task, but my team and I will try our best,” he wrote at the time.
There is currently no cure for AIG, which Johnson said he wants to change.
Johnson acknowledged that some common biohacking techniques — including hard training, sauna and hyperbaric oxygen — all raise the body’s demand for iron. (iStock)
“In the age of AI, multiomics, and custom-built DNA, proteins and cells, no condition should be presumed incurable simply because no one has yet tried to cure it with today’s stack.”
Johnson ended his post by urging others to prioritize their health.
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“Care for yourself, care for others, care for the planet and care for our animal friends. Care for life, as it’s the most precious gift there is.”
The longevity guru also shared an image showing the detailed findings of his five stomach biopsies.
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At 93, sprightly referee Frank Foster is still brandishing red and yellow cards and running the field three times a week for his local soccer association.
Having taken charge of around 5,500 matches over a 46-year officiating career, the great-grandfather credits his longevity and match-day stamina to a lifetime of healthy habits and a foundational diet, news agency SWNS reported.
Foster puts his remarkable fitness down to the strict wartime rations he was fed as a teenager, noting that it ensured he grew up eating “healthy food” rather than “sweets and cakes.”
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Decades later, his game-day preparation is still fueled by wholesome nutrition, always starting with a morning bowl of oatmeal, cereal or marmalade on toast to give him the energy to last the full 90 minutes.
The meal keeps him active enough to referee men’s, women’s and children’s games, a hobby he jokes he will never blow the final whistle on.
Frank Foster started refereeing in 1980. Today, he still officiates men’s, women’s and children’s games around three times a week. (SWNS)
His sharp mind and authoritative presence on the field are just as strong as his physical endurance.
A military veteran who aced his referee exam in 1980 with a 98% score, Foster relies on old-school discipline to keep matches under control, SWNS reported.
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He believes modern elite officials are too “soft” and allow player antics to ruin the sport. To maintain order and keep players from acting out, he lays down strict ground rules before kickoff. He has no patience for intimidation or theatrical diving. “Those who go down like they have been shot, well, I would just book them,” he said.
He is equally uncompromising when squads try to crowd him on the field.
Frank Foster is pictured before he became a referee. (Frank Foster/SWNS)
“I wouldn’t let them surround me at all,” Foster told SWNS.
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“I would say to the players, ‘Stay where you are,’ and ‘If you move one more inch, I will give you a yellow card.’ You need to stamp your authority and let them know who is in control.”
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He also avoids the modern stress of video-reviewing plays, which he believes creates unnecessary “aggression and disappointment” over microscopic offside calls, adding, “I think it spoils the game.”
Foster credits his longevity to wartime rations, adding that he avoided sweets. (SWNS)
“Sometimes it is only the player’s toe that is offside — it is ridiculous.”
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Foster says he “never thought” he’d still be doing this at age 93, but he makes the most of that gift.
He keeps his kit freshly washed, making sure it is “neat and tidy” for when he gets on that field.
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Foster, of South Yorkshire, England, also scrubs his black Adidas boots after every game, making sure they are “nice and clean” for his next match.
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