Health
Surgeons keep man alive without lungs, paving new path to transplant
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Surgeons at Northwestern Medicine in Chicago were able to keep a critically ill patient alive for 48 hours after removing both of his lungs, the hospital reported last week.
The patient, a 33-year-old Missouri resident whose name was not shared, was originally flown to Northwestern Memorial Hospital with lung failure linked to a flu infection in spring 2023.
When his condition escalated to severe pneumonia and sepsis, his heart stopped and the team performed CPR, according to a press release on the case.
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“He had developed an infection of his lungs that just could not be treated with any antibiotics because it was resistant to everything,” said Ankit Bharat, M.D., chief of thoracic surgery and executive director of the Northwestern Medicine Canning Thoracic Institute. “That infection caused his lungs to liquify and then continued to progress to the rest of his body.”
The lungs needed to be removed to stop the spread of infection, but there was a dangerous risk of immediate heart failure.
“He had developed an infection of his lungs that just could not be treated with any antibiotics because it was resistant to everything,” said Ankit Bharat, M.D., chief of thoracic surgery and executive director of the Northwestern Medicine Canning Thoracic Institute (pictured). (Northwestern Medicine)
“The lungs act as a ‘shock absorber’ for the right side of the heart; when you remove them, the heart pumps against high resistance and can fail instantly,” Bharat told Fox News Digital.
“Another critical danger is that without blood flowing from the lungs to the left heart, the left heart chambers can collapse or form deadly clots.”
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While the man remained on life support, the medical team designed a “total artificial lung system” (TAL) that took over gas exchange (oxygenation and CO₂ removal) and maintained blood flow to the heart in hopes that it could keep the patient alive after both of his diseased lungs were removed.
“A key innovation here is that we maintained the heart’s natural physiology. By using a ‘flow-adaptive’ design, we allowed the patient’s own heart to regulate blood flow, rather than forcing it with a machine,” Bharat said.
“Just one day after we took out the lungs, his body started to get better because the infection was gone.”
“Just one day after we took out the lungs, his body started to get better because the infection was gone.”
After 48 hours, the patient was stable enough to proceed with a double-lung transplant. Two years later, he is back to his regular routine.
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“The patient is doing remarkably well,” Dr. Bharat said. “He has excellent lung function, his heart function is preserved and he is completely functionally independent.”
This was the first successful application of this specific type of system, according to the medical team.
The medical team designed a “total artificial lung system” that maintained blood flow to the heart until the transplant could be placed. (Northwestern Medicine)
“While the concept of removing lungs and bridging to transplant has been attempted in rare cases historically, those prior attempts faced significant limitations regarding blood flow management and the risk of clots,” Bharat told Fox News Digital.
“Our system is novel because it includes a self-regulating ‘shunt’ that mimics the natural physics of the lung to protect the heart, and it uses dual return tubes to maintain normal blood flow through the left heart chambers.”
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In a case study, which was published last week in the Cell Press journal Med, experts revealed a “molecular analysis” of the removed lungs, showing extensive scarring and damage. This supports the idea that in some severe cases of acute respiratory distress syndrome, transplantation may be the only viable option.
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Researchers hope that the TAL system could eventually be a viable strategy for patients who are waiting for donor lungs — specifically, those with severe acute respiratory distress syndrome (ARDS) along with necrotizing pneumonia or septic shock.
The patient’s new transplant is shown at left, and his old lungs are shown at right. “This technology allows us to ‘clean the slate’ by removing the infection, stabilizing the patient and bridging them to a successful transplant,” the lead surgeon said. (Northwestern Medicine)
“These patients have a mortality rate exceeding 80% and are often turned down for transplant because they are too infected,” Dr. Bharat said. “This technology allows us to ‘clean the slate’ by removing the infection, stabilizing the patient and bridging them to a successful transplant.”
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In the future, he added, they hope to develop durable, implantable artificial lungs that patients can live with long-term, not just as a bridge to transplant.
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A new report by the American Heart Association (AHA) included some troubling predictions for the future of women’s health.
The forecast, published in the journal Circulation on Wednesday, projected increases in various comorbidities in American females by 2050.
More than 59% of women were predicted to have high blood pressure, up from less than 49% currently.
The review also projected that more than 25% of women will have diabetes, compared to about 15% today, and more than 61% will have obesity, compared to 44% currently.
As a result of these risk factors, the prevalence of cardiovascular disease and stroke is expected to rise to 14.4% from 10.7%.
The prevalence of cardiovascular disease and stroke in women is expected to rise to 14.4% from 10.7% by 2050. (iStock)
Not all trends were negative, as unhealthy cholesterol prevalence is expected to drop to about 22% from more than 42% today, the report stated.
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Dr. Elizabeth Klodas, a cardiologist and founder of Step One Foods in Minnesota, commented on these “jarring findings.”
“The fact that on our current trajectory, cardiometabolic disease is projected to explode in women within one generation should be a huge wake-up call,” she told Fox News Digital.
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“Hypertension, diabetes, obesity — these are all major risk factors for heart disease, and we are already seeing what those risks are driving. Heart disease is the No. 1 killer of women, eclipsing all other causes of death, including breast cancer.”
Cardiovascular disease is the leading cause of death for women in the U.S. and around the world. (iStock)
Klodas warned that heart disease starts early, progresses “stealthily,” and can present “out of the blue in devastating ways.”
The AHA published another study on Thursday revealing one million hospitalizations, showing that heart attack deaths are climbing among adults below the age of 55.
The more alarming finding, according to Klodas, is that young women were found more likely to die after their first heart attack than men of the same age.
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“This is all especially tragic since heart disease is almost entirely preventable,” she said. “The earlier you start, the better.”
Children can show early evidence of plaque deposition in their arteries, which can be reversed through lifestyle changes if “undertaken early enough and aggressively enough,” according to the expert.
Moving more is one part of protecting a healthy heart, according to experts. (iStock)
Klodas suggested that rising heart conditions are associated with traditional risk factors, like smoking, high blood pressure, high cholesterol, diabetes, obesity and a sedentary lifestyle.
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Doctors are also seeing higher rates of preeclampsia, or high blood pressure during pregnancy, as well as gestational diabetes. Klodas noted that these are sex-specific risk factors that don’t typically contribute to complications until after menopause.
The best way to protect a healthy heart is to “do the basics,” Klodas recommended, including the following lifestyle habits.
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Klodas especially emphasized making improvements to diet, as the food people eat affects “every single risk factor that the AHA’s report highlights.”
“High blood pressure, high blood sugar, high cholesterol, excess weight – these are all conditions that are driven in part or in whole by food,” she said. “We eat multiple times every single day, which means what we eat has profound cumulative effects over time.”
“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health,” a doctor said. (iStock)
“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health.”
The doctor also recommends changing out a few snacks per day for healthier choices, which has been proven to “yield medication-level cholesterol reductions” in a month.
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“Keep up that small change and, over the course of a year, you could also lose 20 pounds and reduce your sodium intake enough to avoid blood pressure-lowering medications,” Klodas added.
“Women should not view the AHA report as inevitable. We have power over our health destinies. We just need to use it.”
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Nearsightedness (myopia) is skyrocketing globally, with nearly half of the world’s population expected to be myopic by 2050, according to the World Health Organization.
Heavy use of smartphones and other devices is associated with an 80% higher risk of myopia when combined with excessive computer use, but a new study suggests that dim indoor lighting could also be a factor.
For years, scientists have been puzzled by the different ways myopia is triggered. In lab settings, it can be induced by blurring vision or using different lenses. Conversely, it can be slowed by something as simple as spending time outdoors, research suggests.
Nearsightedness occurs when the eyeball grows too long from front to back, according to the American Optometric Association (AOA). This physical elongation causes light to focus in front of the retina rather than directly on it, making distant objects appear blurry.
The study suggests that myopia isn’t caused by the digital devices themselves, but by the low-light environments where they are typically used. (iStock)
Researchers at the State University of New York (SUNY) College of Optometry identified a potential specific trigger for this growth. When someone looks at a phone or a book up close, the pupil naturally constricts.
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“In bright outdoor light, the pupil constricts to protect the eye while still allowing ample light to reach the retina,” Urusha Maharjan, a SUNY Optometry doctoral student who conducted the study, said in a press release.
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“When people focus on close objects indoors, such as phones, tablets or books, the pupil can also constrict — not because of brightness, but to sharpen the image,” she went on. “In dim lighting, this combination may significantly reduce retinal illumination.”
High-intensity natural light prevents myopia because it provides enough retinal stimulation to override the “stop growing” signal, even when pupils are constricted. (iStock)
The hypothesis suggests that when the retina is deprived of light during extended close-up work, it sends a signal for the eye to grow.
In a dim environment, the narrowed pupil allows so little light through that the retinal activity isn’t strong enough to signal the eye to stop growing, the researchers found.
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In contrast, being outdoors provides light levels much brighter than indoors. This ensures that even when the pupil narrows to focus on a nearby object, the retina still receives a strong signal, maintaining healthy eye development.
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The team noted some limitations of the study, including the small subject group and the inability to directly measure internal lens changes, as the bright backgrounds used to mimic the outdoors made pupils too small for standard equipment.
Researchers believe that increasing indoor brightness during close-up work could be a simple, testable way to slow the global nearsightedness epidemic. (iStock)
“This is not a final answer,” Jose-Manuel Alonso, MD, PhD, SUNY distinguished professor and senior author of the study, said in the release.
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“But the study offers a testable hypothesis that reframes how visual habits, lighting and eye focusing interact.”
The study was published in the journal Cell Reports.
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