Health
Surgeons keep man alive without lungs, paving new path to transplant
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Surgeons at Northwestern Medicine in Chicago were able to keep a critically ill patient alive for 48 hours after removing both of his lungs, the hospital reported last week.
The patient, a 33-year-old Missouri resident whose name was not shared, was originally flown to Northwestern Memorial Hospital with lung failure linked to a flu infection in spring 2023.
When his condition escalated to severe pneumonia and sepsis, his heart stopped and the team performed CPR, according to a press release on the case.
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“He had developed an infection of his lungs that just could not be treated with any antibiotics because it was resistant to everything,” said Ankit Bharat, M.D., chief of thoracic surgery and executive director of the Northwestern Medicine Canning Thoracic Institute. “That infection caused his lungs to liquify and then continued to progress to the rest of his body.”
The lungs needed to be removed to stop the spread of infection, but there was a dangerous risk of immediate heart failure.
“He had developed an infection of his lungs that just could not be treated with any antibiotics because it was resistant to everything,” said Ankit Bharat, M.D., chief of thoracic surgery and executive director of the Northwestern Medicine Canning Thoracic Institute (pictured). (Northwestern Medicine)
“The lungs act as a ‘shock absorber’ for the right side of the heart; when you remove them, the heart pumps against high resistance and can fail instantly,” Bharat told Fox News Digital.
“Another critical danger is that without blood flowing from the lungs to the left heart, the left heart chambers can collapse or form deadly clots.”
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While the man remained on life support, the medical team designed a “total artificial lung system” (TAL) that took over gas exchange (oxygenation and CO₂ removal) and maintained blood flow to the heart in hopes that it could keep the patient alive after both of his diseased lungs were removed.
“A key innovation here is that we maintained the heart’s natural physiology. By using a ‘flow-adaptive’ design, we allowed the patient’s own heart to regulate blood flow, rather than forcing it with a machine,” Bharat said.
“Just one day after we took out the lungs, his body started to get better because the infection was gone.”
“Just one day after we took out the lungs, his body started to get better because the infection was gone.”
After 48 hours, the patient was stable enough to proceed with a double-lung transplant. Two years later, he is back to his regular routine.
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“The patient is doing remarkably well,” Dr. Bharat said. “He has excellent lung function, his heart function is preserved and he is completely functionally independent.”
This was the first successful application of this specific type of system, according to the medical team.
The medical team designed a “total artificial lung system” that maintained blood flow to the heart until the transplant could be placed. (Northwestern Medicine)
“While the concept of removing lungs and bridging to transplant has been attempted in rare cases historically, those prior attempts faced significant limitations regarding blood flow management and the risk of clots,” Bharat told Fox News Digital.
“Our system is novel because it includes a self-regulating ‘shunt’ that mimics the natural physics of the lung to protect the heart, and it uses dual return tubes to maintain normal blood flow through the left heart chambers.”
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In a case study, which was published last week in the Cell Press journal Med, experts revealed a “molecular analysis” of the removed lungs, showing extensive scarring and damage. This supports the idea that in some severe cases of acute respiratory distress syndrome, transplantation may be the only viable option.
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Researchers hope that the TAL system could eventually be a viable strategy for patients who are waiting for donor lungs — specifically, those with severe acute respiratory distress syndrome (ARDS) along with necrotizing pneumonia or septic shock.
The patient’s new transplant is shown at left, and his old lungs are shown at right. “This technology allows us to ‘clean the slate’ by removing the infection, stabilizing the patient and bridging them to a successful transplant,” the lead surgeon said. (Northwestern Medicine)
“These patients have a mortality rate exceeding 80% and are often turned down for transplant because they are too infected,” Dr. Bharat said. “This technology allows us to ‘clean the slate’ by removing the infection, stabilizing the patient and bridging them to a successful transplant.”
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In the future, he added, they hope to develop durable, implantable artificial lungs that patients can live with long-term, not just as a bridge to transplant.
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The American Cancer Society (ACS) has updated its guidelines for colorectal cancer screening.
The organization released the update in its flagship journal on Wednesday, noting that the new recommendations “re-affirm” that adults at average risk should be screened for colorectal cancer at age 45 and continue through 75, for those with a life expectancy greater than 10 years.
In addition to the standard colonoscopy, the ACS also recommends that patients receive a blood-based screening test in a doctor’s office, which is designed to detect tumor DNA in the blood.
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The ACS also suggested an at-home screening option that looks for hidden blood and molecular markers in stool samples.
These new guidelines reflect recent advancements in disease detection, as well as a “critical shift in public health strategy to expand screening options and lower barriers to access,” the ACS stated in a press release.
The ACS recommends blood-based testing and at-home stool sampling as options for colorectal cancer screening. (iStock)
Dr. Robert Smith, senior vice president of early cancer detection science at the American Cancer Society and senior author of the report, wrote in a statement that colorectal cancer should be emphasized as a “highly preventable disease as much as a treatable one.”
“By offering more screening tools in our guideline update, more eligible adults will be able to participate in lifesaving colorectal cancer testing, helping to close the screening gap and catch more cancers at an earlier, treatable stage,” he added.
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According to the ACS, colorectal screening “dramatically improves survival,” as studies show early-stage detection yields a five-year survival rate of more than 90% in the U.S.
About one in three American adults are eligible for colorectal cancer screening but have not been tested, although ACS research marks colorectal cancer as the top cancer killer of adults under 50.
Colorectal cancer is the top cancer killer of adults under the age of 50, according to the ACS. (iStock)
People at a high risk of colorectal cancer may need to begin screening before age 45 or be screened more often, the ACS added. Those over 85 years old should no longer be screened for colorectal cancer, per the guidelines.
Dr. William Dahut, chief scientific officer at the ACS, commented that “no matter which test you choose, what’s most important is to get screened, and that includes underserved, rural and minority populations.”
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These guideline changes follow a surge in colorectal cancer diagnoses in younger individuals. Recent ACS research revealed a 50% relative increase in diagnoses in adults aged 45 to 49 from 2021 to 2022.
Dr. Aparna Parikh, medical director of the Center for Young Adult Colorectal Cancer at the Mass General Cancer Center, who is not affiliated with the ACS, shared that experts don’t “entirely understand why” cases are on the rise.
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“But it seems to be an interplay of a person’s risk factors, overall makeup and early exposures,” she previously told Fox News Digital. “[Those] include dietary exposures, environmental exposures and possible antibiotic exposures, as well as lifestyle factors in the right host.”
Changes in bowel habits are the primary red flag that should raise the suspicion of colorectal cancer. (iStock)
Another recent ACS study found that drinking heavily and consistently over an adult’s lifetime could lead to a higher risk of colorectal cancer.
Other known risk factors include family history, obesity, smoking, a diet high in red and processed meats, inflammatory bowel disease, and a personal history or family history of polyps.
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While there may be no symptoms of colorectal cancer before diagnosis, especially in the early stages, certain symptoms should not be overlooked, experts say.
Dr. Eitan Friedman, PhD, an oncologist and founder of The Suzanne Levy-Gertner Oncogenetics Unit at the Sheba Medical Center in Israel, confirmed to Fox News Digital that changes in bowel habits are the primary red flag that should raise the suspicion of colorectal cancer.
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Other symptoms include fatigue as a result of anemia, stomach pain or abdominal discomfort, rectal bleeding or blood in the stool, weakness and unexplained weight loss.
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The sudden death of Kyle Busch has drawn attention to a rare but devastating medical progression: when pneumonia escalates into fatal sepsis.
An ER doctor spoke with Fox News Digital about how sepsis can trigger a rapid health decline.
“Sepsis is actually not a specific disease or diagnosis, but rather the syndrome that occurs when the body has certain abnormal findings and a presumed infection,” said Dr. Kenneth J. Perry, a South Carolina-based emergency medicine physician.
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The markers of sepsis include elevated white blood cell counts, a high or low temperature, and elevated heart and respiratory rates, according to Perry. Because of this, a patient with pneumonia is often already technically septic by definition.
In the wake of Kyle Busch’s sudden passing, there is a focus on the rapid decline from pneumonia to fatal sepsis. (Getty; iStock)
While many people assume a worsening infection means bacteria are multiplying uncontrollably, it often has more to do with the body’s internal environment.
“It is often not the bacteria itself that is causing the specific decline,” Perry said. “In most cases, it is a cascade of inflammatory processes that are set in motion by the infection.”
When this inflammation spirals out of control, the body moves from having a manageable infection into severe sepsis. This is when otherwise healthy people can rapidly deteriorate.
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“The concerning thing that can happen with any individual … is that sepsis can then lead to low blood pressure, worsening vital signs and organ damage,” Perry said.
“As multiple organs fail, it becomes very difficult for the medical team to treat and can sometimes lead ultimately to death.”
“The medical evaluation provided to the Busch Family concluded that severe pneumonia progressed into sepsis, resulting in rapid and overwhelming associated complications,” the family shared in a statement. (James Gilbert/Getty Images)
It is very unlikely to have pneumonia and not have any symptoms, according to Perry. Early signs can mimic a severe flu, including fevers, chills, a productive cough, and chest or back pain in cases where the lung is infected.
When sepsis begins to take hold, time becomes the most critical factor. “We have known for a number of years that early antibiotic therapy is beneficial in the treatment of sepsis,” Perry said.
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If you or a loved one are managing an infection at home, the doctor says the following red flags mean you should bypass the clinic and head straight to the emergency room.
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- Shortness of breath or difficulty breathing
- A racing heart rate or fever that continues to worsen even after starting treatment
- Severe chest pain associated with a productive cough
The slide into sepsis is, in most cases, a cascade of inflammatory processes that are set in motion by the infection, the doctor said. (iStock)
While cases like Busch’s are tragic, Perry stressed that this shouldn’t cause widespread panic. Most patients with pneumonia do very well with standard oral antibiotics.
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The NASCAR star’s rapid decline underscores the importance of medical vigilance and “having a primary care physician with whom you have a good relationship,” according to the ER doctor.
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“Monitoring symptoms while having easy access to primary care is a very beneficial and appropriate plan for most patients,” he added.
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