Health
Spinal cord treatment restores function for paralyzed patients in study: ‘New hope’
Ninety percent of paralyzed patients regained strength or function in their upper limbs after receiving an experimental therapy, a new study found.
After receiving spinal cord simulation from ONWARD Medical’s ARC-EX system, the participants saw “significant improvement” in their hand and arm function, according to a press release.
The study, published on Monday in Nature Medicine, included 65 participants at 14 leading spinal cord injury centers in the U.S., Europe and Canada.
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The participants received non-invasive electrical stimulation of the spinal cord using ARC-EX, and then researchers gauged the safety and effectiveness of the system.
Improvement was seen even in people whose injuries occurred up to 34 years ago, the release stated.
After receiving spinal cord simulation from ONWARD Medical’s ARC-EX system, the participants saw “significant improvement” in hand and arm function, according to a new study. (Nature Medicine)
“When a person suffers a spinal cord injury, after two to three months of rehabilitation, they are sent home and told there is nothing further that can be done,” Dave Marver, CEO of ONWARD Medical, told Fox News Digital.
The company is global; its main headquarters is in The Netherlands.
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“This week’s publication in Nature Medicine heralds a new era in spinal cord injury care. The Up-LIFT trial demonstrated that ONWARD ARC therapy can restore strength and function of the hands and arms up to 34 years after a spinal cord injury.”
“This is a game-changer for the spinal cord injury community and their loved ones.”
Improvement was seen even in people whose injuries occurred up to 34 years ago, the release stated. (iStock)
The trial results far exceeded the researchers’ expected 50% response rate — giving “new hope” to people with SCI, noted lead study author Chet Moritz, Ph.D., professor of electrical and computer engineering and rehabilitation medicine at the University of Washington, in the release.
After two months, more than half the paralyzed participants regained enough “grasp force” to lift up a filled cup, pick up an item with a fork or insert a key, according to Moritz.
“This is a game-changer for the spinal cord injury community and their loved ones.”
“This indicates not only improved strength and function, but also the potential for greater independence with ARC-EX Therapy,” he said.
Additional benefits included reduced muscle spasms, improved sleep and a greater sense of touch in the upper body, the release said.
Eighty-seven percent of the participants reported having an improved quality of life after receiving the therapy.
After two months, more than half of the paralyzed participants regained enough “grasp force” to lift up a filled cup, the study noted. (iStock)
“Improvement in arm and hand function is among the highest priorities for people with tetraplegia (paralysis in the upper and lower body) who have endured far too long without effective therapies for functional recovery,” Marver, the company CEO, said in the release.
“The findings published in Nature Medicine provide critical and compelling evidence that ARC-EX has the potential to restore independence in daily activities and improve [the patients’] quality of life.”
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Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, was not involved in the trial but commented on the results.
“This has been tried for many years with reports that it helps, but it has not yet gone mainstream in patients with upper and lower spinal cord paralysis,” he told Fox News Digital.
“Improvement in arm and hand function is among the highest priorities for people with tetraplegia.”
“This small study in a very prominent journal is very encouraging in terms of some return of upper extremity function,” Siegel continued.
“It warrants further study and more universal use in these patients.”
It’s possible that this type of spinal cord stimulation could be combined with the increasing use of other brain and spine interfaces to restore function, the doctor added.
ONWARD Medical’s ARC-EX system, pictured here, performs non-invasive electrical stimulation of the spinal cord. (ONWARD Medical)
John Hinson, M.D., an orthopedic surgeon in Florida, was also not involved in the study but shared his insights on the findings.
“Patients with incomplete quadriplegia can be left with weakness and muscle spasm, as well as sensory changes that can cause significant loss of function,” he told Fox News Digital.
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Traditional treatments for these injuries have included physical therapy, he noted, but results can be limited.
“Review of the trial results shows that by two months of use, over half of the patients showed significant functional improvement in activities such as grasping and pinching required for basic daily tasks,” Hinson said.
“If these results can be predictably achieved, it would greatly improve the lives of patients with spinal cord injuries that resulted in incomplete quadriplegia.”
Traditional treatments for these injuries have included physical therapy, but results can be limited, one doctor noted. (iStock)
This could potentially be a “big factor” in the treatment of these patients, according to Hinson.
ONWARD has submitted an application to the U.S. Food and Drug Administration (FDA) to gain approval for the ARC-EX system, with clearance expected later this year.
“We are laser-focused on our commitment to bringing this first-of-its-kind technology to the SCI community as soon as possible,” Marver said.
The ARC-EX System will require a prescription from a qualified health care professional once it is cleared for use, according to the company.
For more Health articles, visit www.foxnews.com/health.
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Stat of the week
More than 59% of women may have high blood pressure by 2050, according to a new report from the American Heart Association.
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Health
Heart disease threat projected to climb sharply for key demographic
NEWYou can now listen to Fox News articles!
A new report by the American Heart Association (AHA) included some troubling predictions for the future of women’s health.
The forecast, published in the journal Circulation on Wednesday, projected increases in various comorbidities in American females by 2050.
More than 59% of women were predicted to have high blood pressure, up from less than 49% currently.
The review also projected that more than 25% of women will have diabetes, compared to about 15% today, and more than 61% will have obesity, compared to 44% currently.
As a result of these risk factors, the prevalence of cardiovascular disease and stroke is expected to rise to 14.4% from 10.7%.
The prevalence of cardiovascular disease and stroke in women is expected to rise to 14.4% from 10.7% by 2050. (iStock)
Not all trends were negative, as unhealthy cholesterol prevalence is expected to drop to about 22% from more than 42% today, the report stated.
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Dr. Elizabeth Klodas, a cardiologist and founder of Step One Foods in Minnesota, commented on these “jarring findings.”
“The fact that on our current trajectory, cardiometabolic disease is projected to explode in women within one generation should be a huge wake-up call,” she told Fox News Digital.
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“Hypertension, diabetes, obesity — these are all major risk factors for heart disease, and we are already seeing what those risks are driving. Heart disease is the No. 1 killer of women, eclipsing all other causes of death, including breast cancer.”
Cardiovascular disease is the leading cause of death for women in the U.S. and around the world. (iStock)
Klodas warned that heart disease starts early, progresses “stealthily,” and can present “out of the blue in devastating ways.”
The AHA published another study on Thursday revealing one million hospitalizations, showing that heart attack deaths are climbing among adults below the age of 55.
The more alarming finding, according to Klodas, is that young women were found more likely to die after their first heart attack than men of the same age.
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“This is all especially tragic since heart disease is almost entirely preventable,” she said. “The earlier you start, the better.”
Children can show early evidence of plaque deposition in their arteries, which can be reversed through lifestyle changes if “undertaken early enough and aggressively enough,” according to the expert.
Moving more is one part of protecting a healthy heart, according to experts. (iStock)
Klodas suggested that rising heart conditions are associated with traditional risk factors, like smoking, high blood pressure, high cholesterol, diabetes, obesity and a sedentary lifestyle.
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Doctors are also seeing higher rates of preeclampsia, or high blood pressure during pregnancy, as well as gestational diabetes. Klodas noted that these are sex-specific risk factors that don’t typically contribute to complications until after menopause.
The best way to protect a healthy heart is to “do the basics,” Klodas recommended, including the following lifestyle habits.
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Klodas especially emphasized making improvements to diet, as the food people eat affects “every single risk factor that the AHA’s report highlights.”
“High blood pressure, high blood sugar, high cholesterol, excess weight – these are all conditions that are driven in part or in whole by food,” she said. “We eat multiple times every single day, which means what we eat has profound cumulative effects over time.”
“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health,” a doctor said. (iStock)
“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health.”
The doctor also recommends changing out a few snacks per day for healthier choices, which has been proven to “yield medication-level cholesterol reductions” in a month.
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“Keep up that small change and, over the course of a year, you could also lose 20 pounds and reduce your sodium intake enough to avoid blood pressure-lowering medications,” Klodas added.
“Women should not view the AHA report as inevitable. We have power over our health destinies. We just need to use it.”
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