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Some 80-year-olds still have razor-sharp brains — and now scientists know why

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Some 80-year-olds still have razor-sharp brains — and now scientists know why

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Older adults classified as “SuperAgers” generate at least twice as many neurons in the hippocampus than their typical aging peers, a new study has revealed.

These findings, released on Wednesday by the University of Illinois Chicago and Northwestern University, could help explain why SuperAgers have exceptional memory and cognitive resilience even well past 80 years old.

Northwestern has been studying SuperAgers for decades, defining them as “extraordinary individuals aged 80 and above whose memory performance rivals that of people three decades younger.” The researchers use special memory recall tests to make this determination.

In this study, they analyzed post-mortem brain tissue — nearly 356,000 individual cell nuclei — with a focus on the hippocampus, which is essential for forming new memories and supporting learning and spatial navigation.

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They compared tissue from SuperAgers, typical older adults, older adults with early dementia/Alzheimer’s and younger healthy adults.

SuperAger Ralph Rehbock sits with his wife in his home. New findings from the University of Illinois Chicago and Northwestern University could help explain why SuperAgers have exceptional memory and cognitive resilience well past 80 years old. (Shane Collins, Northwestern University)

The researchers found that SuperAgers produced at least twice as many new neurons compared to “cognitively normal” older adults and those with Alzheimer’s pathology.

They also found that changes in certain brain support cells (astrocytes) and key memory cells (CA1 neurons) are linked to preserved cognitive ability, helping to keep the brain sharp with age.

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The SuperAgers also had different genetic activity patterns in their brains compared to those in Alzheimer’s disease. 

“SuperAgers have more immature neurons and neuroblasts in the hippocampus, which is an indication of stronger neurogenesis when compared with other groups,” study co-author Changiz Geula, research professor of cell and developmental biology and neuroscience at Northwestern University Feinberg School of Medicine, told Fox News Digital.

Northwestern University study co-author Ivan Ayala examines a SuperAger brain sample on a slide. (Shane Collins, Northwestern University)

“The study also showed that specific cells in the hippocampus show unique gene expression profiles that relate to neuronal function and transmission and are associated with superior cognitive function.”

The findings were published in the journal Nature.

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“We’ve always said that SuperAgers show that the aging brain can be biologically active, adaptable and flexible, but we didn’t know why,” said co-author Tamar Gefen, associate professor of psychiatry and behavioral sciences at Northwestern University Feinberg School of Medicine and a neuropsychologist at Northwestern’s Mesulam Institute for Cognitive Neurology and Alzheimer’s Disease, in the release. 

“This is biological proof that their brains are more plastic, and a real discovery that shows that neurogenesis of young neurons in the hippocampus may be a contributing factor.”

Dr. Tamar Gefen examines a slide of a SuperAger brain. (Shane Collins, Northwestern University)

Dr. Marc Siegel, Fox News senior medical analyst, commented that the study discovered signs of plasticity and regeneration in SuperAgers.

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“It confirmed not only preservation of brain tissue in the hippocampus, which is crucial for memory and cognition, but also regeneration and increased development of brain cells in that area,” Siegel, who was not involved in the study, told Fox News Digital.

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“This is an important study because it may lead to certain cell gene treatments that could lead to more SuperAgers,” the doctor said. “It may also lead to more advanced testing to determine who will be a SuperAger and guide clinical treatment and management.”

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The study did have some limitations, primarily that the research relied on tissue samples taken at one specific point, instead of tracking changes over time.

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Brain samples are fixed in blocks of wax so they can be stored and examined. (Shane Collins, Northwestern University)

Geula noted that studies using human brain tissue typically involve fewer cases than animal research, which can be a limitation. However, he emphasized that each case in this study was analyzed thoroughly.

“While these findings are not directly translatable to changes in everyday life and activities, they suggest that cognitive resilience is associated with greater integrity of many brain systems,” he told Fox News Digital. “This implies that attending to brain health is crucial for maintaining cognitive function in old age.”

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“Thus, maintaining good overall health by keeping systemic diseases in check, maintaining a healthy diet and exercise, and ensuring the elderly remain mentally active assume more importance.”

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The study was funded by the National Institute on Aging, which is part of the National Institutes of Health.

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Loneliness may be silently eroding your memory, new research reveals

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Loneliness may be silently eroding your memory, new research reveals

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Feeling lonely may take a toll on older adults’ memory — but it may not speed up cognitive decline, according to a new study.

Researchers from Colombia, Spain and Sweden analyzed data from more than 10,000 adults ages 65 to 94 across 12 European countries and found those who reported higher levels of loneliness did worse on memory tests at the start of the study, according to research published this month in the journal Aging & Mental Health.

Over a seven-year period, however, memory decline occurred at a similar rate regardless of how lonely participants felt.

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“The finding that loneliness significantly impacted memory, but not the speed of decline in memory over time was a surprising outcome,” lead author Dr. Luis Carlos Venegas-Sanabria of the School of Medicine and Health Sciences at the Universidad del Rosario said in a statement.

Loneliness may be linked to memory performance in older adults, a new study suggests. (iStock)

“It suggests that loneliness may play a more prominent role in the initial state of memory than in its progressive decline,” Venegas-Sanabria said, adding that the findings highlight the importance of addressing loneliness as a factor in cognitive performance.

The findings add to debate about whether loneliness contributes to dementia risk. While loneliness and social isolation are often considered risk factors for cognitive decline, research results have been mixed.

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The study looked at data from the long-running Survey of Health, Ageing and Retirement in Europe (SHARE), which tracked 10,217 older adults between 2012 and 2019. Participants were asked to recall words immediately and after a delay to measure memory performance.

Social isolation and loneliness could play a surprising role in cognitive health among seniors. (iStock)

Loneliness was assessed using three questions about how often participants felt isolated, left out or lacking companionship.

About 8% of participants reported high levels of loneliness at the outset. That group tended to be older, more likely to be female and more likely to have conditions such as depression.

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Researchers found that those with higher loneliness had lower scores on both immediate and delayed memory tests at baseline. Still, all groups — regardless of loneliness level — experienced similar declines in memory over time.

The results suggest loneliness may not directly accelerate the progression of memory loss, though it remains linked to poorer cognitive performance overall.

Researchers look at a brain scan at the National Institutes of Health in Bethesda, Maryland. (Saul Loeb/AFP/Getty Images)

Experts warn, however, that the findings should not be interpreted to mean loneliness is harmless.

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“The finding that lonely older adults start with worse memory but don’t decline faster is actually the most interesting part of the paper, and I think it’s easy to misread,” said Jordan Weiss, Ph.D., a scientific advisor and aging expert at Assisted Living Magazine and a professor at NYU Grossman School of Medicine.

“It likely means loneliness does its damage earlier in life, well before people show up in a study like this at 65-plus,” Weiss told Fox News Digital.

By older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold, an aging expert says. (iStock)

He suggested that by older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold.

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“By the time you’re measuring someone in their late 60s, decades of social connection patterns are already baked in,” he said.

Weiss, who was not involved in the research, added that loneliness may coincide with other health conditions, and noted that participants who felt more isolated also had higher rates of depression, high-blood pressure and diabetes. The link, he said, may reflect a cluster of health risks rather than a direct cause.

“While they can go hand-in-hand, it’s not clear that loneliness contributes to dementia,” a psychotherapist says. (iStock)

Amy Morin, a Florida-based psychotherapist and author, said the findings reflect a broader pattern in research on loneliness and brain health, and that the relationship may be more complex than it appears.

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“The evidence shows there’s a link between loneliness and cognitive decline but there’s no direct evidence of a cause and effect relationship,” she said. “So while they can go hand-in-hand, it’s not clear that loneliness contributes to dementia.”

Morin added that loneliness, which can fluctuate, may not be the root of the problem, but rather a symptom of other underlying mental or physical health issues.

Researchers suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging. (iStock)

She said staying socially and mentally engaged is crucial for overall brain health.

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“It’s important to be proactive about social activities,” Morin said. “Joining a book club, having coffee with a friend, or attending faith-based services can be a powerful way to maintain connections in older age.”

The researchers also suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging.

Fox News Digital reached out to the researchers for comment.

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day


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Intermittent fasting’s real benefit may come after you start eating again

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Intermittent fasting’s real benefit may come after you start eating again

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Research continues to uncover new details on how fasting may help extend life.

A new study published in the journal Nature Communications investigated how intermittent fasting can boost longevity in small worms often used in aging research.

Researchers from the University of Texas Southwestern Medical Center in Dallas compared worms that were fed normally to those that underwent a 24-hour fast in early adulthood and were then fed again, according to a press release.

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The scientists measured a variety of factors, including stored fat, gene activity related to fat metabolism and lifespan.

The results showed that the life-boosting benefit did not depend on the fasting itself but on the body’s behavior after eating again.

Experts say sustainability is key when choosing a long-term weight-loss strategy. (iStock)

Study lead Peter Douglas, associate professor of molecular biology and a member of the Hamon Center for Regenerative Science and Medicine at UT Southwestern, suggested that these discoveries “shift the focus toward a neglected side of the metabolic coin – the re-feeding phase.”

“Our data suggest that the health-promoting effects of intermittent fasting are not merely a product of the fast itself, but are dependent on how the metabolic machinery recalibrates during the subsequent transition back to a fed state,” he said.

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“Our findings bridge a gap between lipid metabolism and aging research,” he added. “By targeting aging, the single greatest risk factor for human disease, we move beyond treating isolated conditions toward a preventive model of medicine that enhances quality of life for all individuals.”

Lauri Wright, director of nutrition programs at the University of South Florida’s College of Public Health, called this a “high-quality” study that adds an “important nuance to how we think about fasting and longevity.”

Intermittent fasting typically involves limiting meals to an eight-hour daily window or fasting every other day. (iStock)

The benefits of the refeeding phase after fasting were “especially interesting,” Wright, who was not involved in the study, told Fox News Digital.

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“The researchers showed that longevity was linked to the body’s ability to turn off fat breakdown after fasting, allowing cells to restore energy balance,” she reiterated.

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“From a scientific standpoint, that’s a meaningful shift because it suggests fasting is not just about burning fat, but about metabolic flexibility.”

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Fasting may support longevity through triggering metabolic switching, enhancing cellular repair and stress resistance and improving markers like insulin sensitivity, research shows.

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Limitations and cautions

Although this study provides “important insight” on the power of refeeding, Wright noted that the findings should be approached with caution, as the study was done on worms and cannot always be translated to humans.

“Additionally, it explains how a process might work in a controlled lab condition rather than real-world eating behaviors,” she added as a limitation. “Finally, the study is short-term and doesn’t give us the long-term translation on lifespan outcomes.”

The review found intermittent fasting was barely more effective than doing nothing, according to the study authors. (iStock)

Wright cautioned that fasting is “not a magic solution for longevity, and how you eat overall matters more than when you eat.”

“I advise, first and foremost, to focus on diet quality, including a variety of fruits and vegetables, healthy fats and minimally processed foods,” she said.

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For those who are considering fasting, it’s better to stick with a moderate plan — like a 12- to 14-hour overnight fast — rather than going to extremes, Wright said. After fasting, she recommends focusing on well-balanced meals.

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Several groups of people should be cautioned against fasting, according to Wright, including those with diabetes who are on insulin or hypoglycemic medications, those who are pregnant or breastfeeding, anyone with a history of eating disorders and older adults at risk of malnutrition.

Anyone considering intermittent fasting should consult with a doctor before starting.

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