Health
Some 80-year-olds still have razor-sharp brains — and now scientists know why
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Older adults classified as “SuperAgers” generate at least twice as many neurons in the hippocampus than their typical aging peers, a new study has revealed.
These findings, released on Wednesday by the University of Illinois Chicago and Northwestern University, could help explain why SuperAgers have exceptional memory and cognitive resilience even well past 80 years old.
Northwestern has been studying SuperAgers for decades, defining them as “extraordinary individuals aged 80 and above whose memory performance rivals that of people three decades younger.” The researchers use special memory recall tests to make this determination.
In this study, they analyzed post-mortem brain tissue — nearly 356,000 individual cell nuclei — with a focus on the hippocampus, which is essential for forming new memories and supporting learning and spatial navigation.
They compared tissue from SuperAgers, typical older adults, older adults with early dementia/Alzheimer’s and younger healthy adults.
SuperAger Ralph Rehbock sits with his wife in his home. New findings from the University of Illinois Chicago and Northwestern University could help explain why SuperAgers have exceptional memory and cognitive resilience well past 80 years old. (Shane Collins, Northwestern University)
The researchers found that SuperAgers produced at least twice as many new neurons compared to “cognitively normal” older adults and those with Alzheimer’s pathology.
They also found that changes in certain brain support cells (astrocytes) and key memory cells (CA1 neurons) are linked to preserved cognitive ability, helping to keep the brain sharp with age.
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The SuperAgers also had different genetic activity patterns in their brains compared to those in Alzheimer’s disease.
“SuperAgers have more immature neurons and neuroblasts in the hippocampus, which is an indication of stronger neurogenesis when compared with other groups,” study co-author Changiz Geula, research professor of cell and developmental biology and neuroscience at Northwestern University Feinberg School of Medicine, told Fox News Digital.
Northwestern University study co-author Ivan Ayala examines a SuperAger brain sample on a slide. (Shane Collins, Northwestern University)
“The study also showed that specific cells in the hippocampus show unique gene expression profiles that relate to neuronal function and transmission and are associated with superior cognitive function.”
The findings were published in the journal Nature.
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“We’ve always said that SuperAgers show that the aging brain can be biologically active, adaptable and flexible, but we didn’t know why,” said co-author Tamar Gefen, associate professor of psychiatry and behavioral sciences at Northwestern University Feinberg School of Medicine and a neuropsychologist at Northwestern’s Mesulam Institute for Cognitive Neurology and Alzheimer’s Disease, in the release.
“This is biological proof that their brains are more plastic, and a real discovery that shows that neurogenesis of young neurons in the hippocampus may be a contributing factor.”
Dr. Tamar Gefen examines a slide of a SuperAger brain. (Shane Collins, Northwestern University)
Dr. Marc Siegel, Fox News senior medical analyst, commented that the study discovered signs of plasticity and regeneration in SuperAgers.
“It confirmed not only preservation of brain tissue in the hippocampus, which is crucial for memory and cognition, but also regeneration and increased development of brain cells in that area,” Siegel, who was not involved in the study, told Fox News Digital.
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“This is an important study because it may lead to certain cell gene treatments that could lead to more SuperAgers,” the doctor said. “It may also lead to more advanced testing to determine who will be a SuperAger and guide clinical treatment and management.”
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The study did have some limitations, primarily that the research relied on tissue samples taken at one specific point, instead of tracking changes over time.
Brain samples are fixed in blocks of wax so they can be stored and examined. (Shane Collins, Northwestern University)
Geula noted that studies using human brain tissue typically involve fewer cases than animal research, which can be a limitation. However, he emphasized that each case in this study was analyzed thoroughly.
“While these findings are not directly translatable to changes in everyday life and activities, they suggest that cognitive resilience is associated with greater integrity of many brain systems,” he told Fox News Digital. “This implies that attending to brain health is crucial for maintaining cognitive function in old age.”
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“Thus, maintaining good overall health by keeping systemic diseases in check, maintaining a healthy diet and exercise, and ensuring the elderly remain mentally active assume more importance.”
The study was funded by the National Institute on Aging, which is part of the National Institutes of Health.
Health
Common nighttime noise exposure may trigger heart problems, study suggests
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Living near heavy traffic could negatively impact your heart health.
A European study, published in the journal Environmental Research, found that exposure to nighttime road traffic noise is linked to changes in the blood, leading to worsened cholesterol and cardiovascular risks.
The researchers considered data from the U.K. Biobank, Rotterdam Study, and Northern Finland Birth Cohort 1966, including more than 272,000 adults over the age of 30, according to a press release.
Nighttime road noise exposure was estimated at all participants’ homes based on national noise maps. Researchers also took blood samples to measure the participants’ metabolic biomarkers for disease, then mapped the link between nightly noise levels and existence of biomarkers.
Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers. (iStock)
The study found that people exposed to louder noise at night — especially sounds above 55 decibels — showed changes in 48 different substances in their blood. Twenty of these associations “remained robust” throughout all cohorts.
Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers, especially LDL “bad” cholesterol, IDL (intermediate-density lipoprotein) and unsaturated fatty acids.
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As noise levels increased, starting at around 50 decibels, cholesterol markers rose steadily, the release stated.
The authors concluded that this study “provides evidence that nighttime road traffic noise exposure from 50 dB upward is associated with alterations in blood cholesterol and lipid profiles in adults.”
Researchers noted a link between traffic noise and cardiometabolic disease. (iStock)
Study co-author Yiyan He, doctoral researcher at the University of Oulu in Finland, noted that in this type of research, small effect sizes are expected, and environmental exposures such as traffic noise are “typically modest.”
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“Despite this, we observed statistically robust and consistent associations across many biomarkers, especially those related to LDL and IDL lipoproteins,” she told Fox News Digital.
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“We also identified a clear exposure-response pattern starting at around 50 dB, suggesting that metabolic changes become more evident as noise levels increase.”
This aligns with public health guidance, as the World Health Organization recommends lower nighttime noise limits at around 40 to 45 dB, Yiyan He added.
“This finding may clarify the association between traffic noise and cardiometabolic diseases,” the researchers wrote. (iStock)
“The 55 dB level is often used as an interim benchmark associated with substantial noise annoyance and sleep disturbance,” she said. “In our study, we observed associations not only at 55 dB, but also indications of effects emerging at around 50 dB.”
The strength and consistency of the cholesterol-related associations were surprising, as these changes are usually “subtle.”
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“Instead, we found consistent associations across multiple large European cohorts, which strengthens confidence that the findings may reflect real biological patterns,” Yiyan He went on. “We were also interested to see that effects were minimal below ~50 dB, suggesting a possible threshold-like pattern.”
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The researcher noted that these findings were consistent across genders, education levels and obesity status.
The study was restricted to White Europeans, which posed a limitation. There was also a lack of information on the fasting status in the UK Biobank.
Changes in cholesterol levels were more severe than researchers expected. (iStock)
“Fasting can influence levels of certain metabolites, particularly fatty acids,” Yiyan He said. “However, based on UK Biobank documentation, fewer than 10% of participants were fasting for at least eight hours, and our main findings focused on cholesterol-related biomarkers, which are generally less sensitive to short-term fasting.”
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The researchers also lacked information on bedroom location, indoor noise exposure and time spent at home.
“These factors may introduce non-differential exposure misclassification,” Yiyan He said. “Additionally, noise exposure estimates were based on participants’ temporary residential addresses at the time of blood sampling, without considering the duration of residence.”
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“Many of these limitations would tend to bias results toward the null, so the consistent associations we observed remain noteworthy.”
Experts recommend taking measures to limit traffic noise at night. (iStock)
Based on this latest research, Yiyan He noted that nighttime noise is a “health-relevant exposure,” not just “an annoyance.”
“Our findings suggest that nighttime traffic noise may subtly but consistently affect metabolic health,” she said. “While the changes in cholesterol and lipid levels for any one individual are small, traffic noise affects a very large number of people, which means the potential public health impact could be substantial.”
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The researcher recommends taking measures like improving sound insulation, using noise-reducing strategies and placing bedrooms on the quieter side of the home when possible.
“Because sleep is a key pathway linking noise to health, protecting the nighttime sleep environment is especially important,” she added.
Health
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Health
‘SuperAgers’ stay mentally sharp well past 80, as scientists reveal the reason
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Top stories
→ Some 80-year-olds still have razor-sharp brains — and now scientists know why
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SuperAger Ralph Rehbock sits with his wife in his home. (Shane Collins, Northwestern University)
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