Health
Sleep deprivation dangers: How pulling an all-nighter affects your physical and mental health
Most people have sacrificed sleep at some point, but those extra waking hours could come at a price.
While it can be tempting to burn the midnight oil — whether it’s to get some work done, knock out a home project or care for a loved one — forgoing rest can wreak havoc on your health.
Fox News Digital spoke to experts about the short- and long-term effects of pulling an all-nighter — and how to rebound after a period of missed sleep.
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Here’s a deep dive.
What does staying up all night do to the body?
Pulling an all-nighter can have several impacts on the body, both physically and mentally, according to Dr. Leah Joseph, a primary care physician with New York-based Teladoc Health.
Pulling an all-nighter can have several impacts on the body, both physically and mentally, doctors warned. (iStock)
“The physical effects include weakening your immune system, which makes you more susceptible to illnesses,” she told Fox News Digital.
“Your body may also release a higher level of cortisol, which leads to elevated stress levels.”
In addition, sleep deprivation can result in impaired memory, concentration and overall cognitive function, Joseph noted.
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“The mental effects include mood changes, which can contribute to irritability, anxiety or depression,” she said.
“It also affects your decision-making, as your judgment may be negatively affected.”
Alex Dimitriu, M.D., who is double board-certified in psychiatry and sleep medicine and is founder of Menlo Park Psychiatry & Sleep Medicine in California, also warned of adverse effects.
“Even a single night of insufficient sleep leads to a buildup of toxins in the brain similar to those seen in people with Alzheimer’s disease.”
“There is evidence that even a single night of insufficient — or worse yet, absent — sleep leads to a buildup of toxins in the brain similar to those seen in people with Alzheimer’s disease,” he told Fox News Digital.
“Similar to Alzheimer’s, even one night of lost sleep can cause fatigue, impaired impulse control, mood instability, diminished attention and memory — all symptoms similar to ADHD.”
Staying up all night can significantly disrupt your sleep schedule and circadian rhythm, a doctor warned. (iStock)
“Underslept” people are more likely to suffer from a variety of psychiatric conditions, Dimitriu said.
Those include depression, anxiety, substance use, memory impairment and possibly an eventual increased risk of dementia.
“The brain needs sleep to clean up and reset,” he said.
Physically, lost sleep causes increased carb craving, diminished immunity and increased stress hormones, such as cortisol and adrenaline, he added.
“The brain needs sleep to clean up and reset.”
“The increased stress hormones, in turn, can elevate heart rate, blood pressure and blood sugar.”
Is an occasional all-nighter safe?
While pulling an occasional all-nighter may include include fatigue, irritability, impaired cognitive function and a temporary disruption of the sleep-wake cycle, Joseph said it may not cause significant long-term damage on its own.
Consistently skipping sleep over an extended period can lead to chronic sleep deprivation, which can have severe consequences over time. (iStock)
“Occasional all-nighters may not cause significant long-term damage if followed by sufficient recovery sleep,” she said. “The human body is resilient and can generally recover from short-term sleep deprivation.”
Consistently skipping sleep over an extended period can lead to chronic sleep deprivation, however, which can have more severe consequences over time.
Those impacts can include an increased risk of cardiovascular disease, diabetes, obesity, impaired immune function and mental health issues, Joseph said.
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Sleep deprivation will affect different people in different ways, she noted, as individual factors and resilience play a role.
“An all-nighter never killed anyone,” Dimitriu agreed. “However, they add up, and you will still feel miserable after a night of no sleep, and will not perform at your best.”
The physical effects of all-nighters include weakening of the immune system, which makes people more susceptible to illness. (iStock)
What to do after an all-nighter
Staying up all night can significantly disrupt your sleep schedule and circadian rhythm, Joseph said.
“The circadian rhythm is a natural, internal process that regulates the sleep-wake cycle and repeats roughly every 24 hours,” the doctor said.
“When you stay up all night, you throw off this cycle, leading to several potential effects on your sleep schedule.”
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After pulling an all-nighter, it may take some time for the body to readjust, and this can lead to temporary insomnia or difficulties falling asleep at the usual time, according to Joseph.
“Some potential effects that someone can suffer from include delayed sleep onset, irregular sleep patterns, increased sleep debt and difficulty regaining normalcy,” she said.
Exposure to morning sunlight can help regulate the circadian rhythm and get back to a regular sleep schedule, experts say. (iStock)
To mitigate the impact on your sleep schedule, prioritize getting back on track as soon as possible, said Joseph.
Some strategies include shifting to an earlier bedtime, spending time outdoors during daylight hours to help regulate your circadian rhythm, and establishing a consistent sleep routine by going to bed and waking up at the same time each day, according to Joseph.
“Personally, I also like to limit caffeine close to bedtime and stay hydrated,” she said. “If I do need a nap, I limit it to 20 to 30 minutes.”
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Dimitriu also recommended getting some sunlight exposure in the morning to reset your rhythm.
“Morning light is really important to getting you to bed at night,” he said.
Getting outdoor physical activity during the day, eating a light dinner and going to bed a little earlier than usual can also help regulate sleep cycles, the doctor advised.
“Prioritizing regular, sufficient sleep is essential for your overall well-being,” a doctor advised. (iStock)
Both experts agreed that the best strategy is to plan for healthy sleep and avoid all-nighters.
“Your performance after a night of not sleeping can be markedly diminished,” Dimitiu said. “All-nighters are often the result of poor planning, so try to plan ahead and avoid nights of lost sleep.”
Joseph added, “While occasional all-nighters may not have severe long-term consequences, making them a habit can contribute to health issues over time.”
“Prioritizing regular, sufficient sleep is essential for your overall well-being.”
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Health
‘Fire-breathing’ trend linked to severe burns in teens, officials warn
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Parents are being warned of a new trend among kids, involving alcohol and an open flame.
The “fire-breathing” challenge has led to reports of severe burns, according to local news outlets.
Kids and teens are reportedly holding alcohol in their mouths and blowing it onto a match or another open flame to mimic “breathing fire.”
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According to Philadelphia’s 6ABC News (WPVI), a teen in Pitcairn, Pennsylvania, was intubated and treated for burns to the face, neck and chest after attempting the trend.
A “fire-breathing” challenge is leaving kids with severe burns, according to local reports. (iStock)
“Luckily, in this particular case, it did not burn the building down,” Al Hussey, Wilmerding Borough fire marshal, told WPVI.
“But somebody really got hurt, and, you know, is going to have life-altering injuries.”
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Pitcairn Fire Chief Tommy Dick told CBS News Pittsburgh (KDKA) the 14-year-old girl was playing with isopropyl alcohol at an apartment complex.
“It’s not a very smart thing for anybody to do, let alone children,” Dick said. “It’s supposed to be for cleaning off wounds and cuts and stuff, not ingesting and trying to blow fire.
A local fire chief told CBS News Pittsburgh that the incident could have been fatal for the teen. (iStock)
“This could have easily gone inside their digestive tract, and she could have died.”
Anyone who has ingested isopropyl alcohol requires immediate medical attention, according to Healthline, because it can cause stomach pain, dizziness, confusion and slowed breathing. In severe cases, it can lead to a coma.
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Fire experts are urging parents to closely monitor which household products are within their children’s reach.
Ingesting isopropyl alcohol requires immediate medical attention, according to experts. (iStock)
“If they’re doing their hair with chemicals, if they’re taking isopropyl alcohol in the room or any type of fingernail polish remover,” Hussey said. “Obviously, monitor your lighters and your matches and educate your children.”
Multiple cases of children’s injuries have occurred in recent weeks after being allegedly “inspired” by online stunts, WPVI reported. One trend involved microwaving a toy that burst and left severe burns on a 9-year-old’s face.
Health
Ancient herb known as ‘nature’s Valium’ touted for improving sleep and anxiety
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Valerian, an herbal supplement long used for sleep and relaxation, has been referred to as “nature’s Valium” — but experts are divided on whether it truly compares to the prescription sedative.
The herb, which is sold as a dietary supplement in the U.S., is a common ingredient in products marketed as “mild sedatives” and sleep aids, according to the National Institutes of Health.
Valium, the brand name for diazepam, is used to treat anxiety, seizures and muscle spasms by calming the nervous system, Cleveland Clinic notes.
Valerian supplements are derived from the roots of Valeriana officinalis, a flowering plant native to Europe and Asia that has also naturalized in northeastern America, according to the American Botanical Council (ABC).
The plant has a “long history of medicinal use,” per the ABC, with the primary goal of reducing anxiety and stress as well as improving sleep quality. It has historically also been used for migraines, fatigue and stomach cramps.
Valerian has historically been used for migraines, fatigue and stomach cramps. (iStock)
Dried valerian roots can be prepared as teas or tinctures, while other plant materials and extracts have been distributed as capsules or tablets, per the NIH.
The agency noted, however, that there is a “relatively small amount of research” investigating the herb’s impact on various conditions.
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However, Stefan Gafner, Ph.D., chief science officer of the American Botanical Council in Texas, confirmed that some clinical trials have explored valerian root’s effects.
A 2020 medical review published in the Journal of Evidence-Based Integrative Medicine found that both powdered root and root extracts show a “clear” benefit in treating anxiety, Gafner told Fox News Digital.
Valerian root and other parts of the plant can be prepared as teas, extracts, capsules and tablets. (iStock)
The researchers concluded that valerian could be a “safe and effective herb to promote sleep and prevent associated disorders.”
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While valerian may have some benefits, Gafner said he doesn’t think it “makes sense” to compare it to diazepam (Valium).
“I can understand that both are used to relieve anxiety, but valerian is a much milder ingredient, and is really used for mild cases of anxiety and sleep issues,” he told Fox News Digital.
Some valerian users have reported improved sleep and reduced anxiety, according to recent research. (iStock)
Unlike valerian, diazepam carries a risk of dependence and is generally prescribed short-term, the expert said, and the spectrum of potential adverse effects is “very different.”
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Gafner said he “absolutely” recommends the use of valerian root to relieve anxiety and stress and to improve sleep.
“I have used it myself and I believe it’s an ingredient with well-documented benefits, especially for people with problems falling asleep,” he said. “It is well-tolerated and very safe… although some sources caution [against] driving a car or using heavy machinery when using valerian.”
Valeriana officinalis, a herbal plant used as a mild sedative, in bloom. (iStock)
Dr. Joseph Mercola, a board-certified family medicine osteopathic physician and author of the new book “Weight Loss Cure,” said valerian’s comparisons to Valium may “exaggerate what the science actually shows.”
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“Valerian root contains compounds that appear to enhance calming brain chemicals, particularly the neurotransmitter GABA, which helps quiet nerve activity and supports relaxation,” the Florida-based expert told Fox News Digital.
“Some studies do report modest improvements in sleep quality or shorter time to fall asleep, while others find no meaningful difference compared with placebo.”
Valerian supplementation may not be right for everyone seeking better sleep, one doctor said. (iStock)
Side effects may include headaches, dizziness, digestive upset or next-day grogginess, Mercola noted, adding that he would not recommend it as a primary strategy for anxiety, stress or sleep.
“Because long-term safety studies remain limited, and supplement quality varies widely, you should approach valerian with caution rather than view it as a universal sleep solution,” he advised.
“You should approach valerian with caution rather than view it as a universal sleep solution.”
“I encourage people to focus first on strategies that correct the underlying drivers of poor sleep,” Mercola advised. “When you fix those foundations, you often find that you no longer need an herbal sedative at all.”
“I encourage people to focus first on strategies that correct the underlying drivers of poor sleep,” one doctor advised. (iStock)
“Bright sunlight during the day helps regulate your circadian rhythm and signals your brain to produce melatonin later at night,” he said. “At the same time, complete darkness [at night] supports the hormonal signals that allow deep, restorative sleep.”
Certain nutrients can also promote relaxation and sleep quality, including magnesium, which helps to regulate the nervous system, according to the doctor.
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GABA may help to calm nerve activity, reduce stress markers and improve perceived sleep quality, Mercola said, while glycine — taken at about 3 grams an hour before bed — may support relaxation, promote the body’s nighttime temperature drop, and improve sleep onset and overall quality.
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“When you combine sunlight exposure, magnesium, GABA and glycine, you support the biological systems that control sleep instead of relying on a sedating herb with mixed evidence,” the doctor concluded.
Fox News Digital reached out to valerian root manufacturers requesting comment.
Health
GLP-1 drugs linked to higher fracture risk, osteoporosis and gout, new studies suggest
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GLP-1 medications such as Ozempic and Wegovy have transformed treatment for Type 2 diabetes and obesity, but new research suggests doctors may need to pay closer attention to bone health, especially in older patients taking the drugs.
Older adults with Type 2 diabetes who started GLP-1s had an 11% higher risk of fragility fractures compared to those taking other diabetes medications, a study published in February in the Journal of Clinical Endocrinology & Metabolism found.
Dr. Michal Kasher Meron, an endocrinologist at Meir Medical Center in Israel and lead author of the study, said the relative increase may sound small, but it carries weight for an at-risk population.
“Both older age and Type 2 diabetes are independent risk factors for fragility fractures,” Kasher Meron told Fox News Digital. “This is a population that deserves special attention.”
A new study suggests older adults with Type 2 diabetes taking GLP-1 medications may face increased fracture risk. (iStock)
Fragility fractures are breaks from minor falls or routine activity, often linked to osteoporosis, and can lead to hospitalization, loss of independence and even increased mortality in older adults, Kasher Meron noted.
The study followed more than 46,000 adults 65 and older for nearly three years. After adjustments, GLP-1 users had a modest but statistically significant increase in fracture risk.
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Previous research in younger patients using older GLP-1s did not show increased fracture risk, but newer, more potent versions are now widely prescribed to older adults, Kasher Meron noted.
“In older adults treated with contemporary medications, the fracture risk picture looks different and warrants close attention,” she said.
Separate research found slightly higher rates of osteoporosis and gout among adults using GLP-1s. (iStock)
The study, however, was observational, meaning it shows an association but not causation. Researchers were unable to determine whether the risk was driven by weight loss, changes in diet, muscle loss or a direct effect on bone.
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Nonetheless, Kasher Meron says, “Bone health should be assessed before starting these medications in older patients — not as an afterthought.”
The findings come as separate research presented at the American Academy of Orthopaedic Surgeons’ annual meeting this month raised additional bone health concerns.
In an analysis of more than 146,000 adults with obesity and Type 2 diabetes, GLP-1 users were found to have a 29% higher relative risk of osteoporosis over five years compared to nonusers, according to reports.
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Rates of gout were also slightly higher, affecting 7.4% of GLP-1 users compared to 6.6% of nonusers — about a 12% relative increase.
Experts recommend bone density screening for older adults taking GLP-1 medications. (iStock)
Osteomalacia, a softening of the bones, was rare but occurred about twice as often in GLP-1 users, according to the study, which has not yet been peer reviewed. It was also observational, showing only an association. Fox News Digital has reached out to the researcher for comment.
Several mechanisms could be at play, experts say. GLP-1 medications suppress appetite and can lead to rapid weight loss. Significant weight loss is known to reduce bone density, partly because less mechanical load is placed on the skeleton.
“It’s the same idea as when we always hear about astronauts going up into space, and they’re in a gravity-zero environment for too long,” lead author Dr. John Horneff, an associate professor of orthopedic surgery at the University of Pennsylvania, told NBC News.
“There’s nothing forcing their bones to kind of hold their weight anymore. And a lot of those astronauts come back with low bone density.”
Additionally, eating fewer calories may also mean lower intake of calcium, vitamin D and protein, nutrients critical for bone strength.
GLP-1 medications like Ozempic and Wegovy are widely used to treat Type 2 diabetes and obesity. (iStock)
Rapid weight loss can also temporarily increase uric acid levels, a byproduct of tissue breakdown, which may explain the uptick in gout cases.
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Despite the findings, experts say the results should not discourage appropriate use of GLP-1 medications, which have proven benefits for blood sugar control, weight loss and cardiovascular risk reduction.
In addition to bone density screening, experts say patients should ensure adequate nutrition and resistance training to help preserve muscle and bone during weight loss.
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A spokesperson for Novo Nordisk, which manufactures GLP-1 medications, said the company prioritizes patient safety, works closely with the U.S. Food and Drug Administration (FDA) and welcomes independent research into its products.
Experts also recommend proper nutrition and resistance training to help preserve muscle and bone health during weight loss. (iStock)
The known risks and benefits of the drugs are reflected in the current FDA-approved labeling, Liz Skrbkova, head of U.S. media relations for Novo Nordisk, told Fox News Digital. She emphasized that semaglutide has demonstrated cardiovascular, kidney and liver benefits when used under medical supervision.
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“Osteoporosis is a complex condition that develops over many years as a result of interdependent risk factors,” Skrbkova added.
Fox News Digital’s Melissa Rudy contributed reporting.
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