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Sepsis a top killer in US behind heart disease, cancer: What to know, how to avoid the condition

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Sepsis a top killer in US behind heart disease, cancer: What to know, how to avoid the condition

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Real Housewives of Orange County” star Vicki Gunvalson, 62, is sharing her recent health scare after she was hospitalized with sepsis, a potentially deadly disease that results from the body’s response to an infection.

“This entire health scare came unannounced — with no warning,” Gunvalson told Fox News Digital.

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As Sepsis Awareness Month kicks off this September, Gunvalson’s timely story is helping to raise awareness of the illness.

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“Sepsis awareness can and does save lives, yet only 65% of American adults have ever heard of it,” Selena A. Gilles, clinical professor and associate dean at New York University Rory Meyers College of Nursing, told Fox News Digital.  

Gilles is on the advisory board of the Sepsis Alliance, a California-based organization that works across the country to decrease suffering from sepsis. 

Sepsis kills 350,000 American adults each year and is a leading cause of death in U.S. hospitals, statistics show. (iStock)

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“Prompt recognition and treatment can be of great importance in preventing significant illness and even mortality,” Dr. Aaron Glatt, chief of infectious diseases at Mount Sinai South Nassau Hospital on Long Island, New York, told Fox News Digital. 

Gunvalson’s diagnosis

Gunvalson shared the details of her sepsis diagnosis with Fox News Digital.

“Two weeks ago, when I was heading to my office, I was very delirious and unclear on where I was going,” Gunvalson said via email.

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“Once I got into the office, my staff realized I was not acting normal,” she went on. “My assistant thought that I was possibly having a stroke.”

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The emergency room diagnosed Gunvalson with a “sinus disease” and sent her home, but by the next morning, she was “extremely incoherent” — so her boyfriend took her back to the hospital.

“Real Housewives of Orange County” star Vicki Gunvalson, 62, is sharing her recent health scare after she was hospitalized with sepsis, a potentially deadly disease that results from the body’s response to an infection. (Amanda Edwards/Getty Images)

“I was admitted for six days with sepsis and pneumonia,” she said. 

Gunvalson was treated with a course of antibiotics and is now recovering at home, while staying in regular contact with the sepsis team at the hospital. 

OHIO WOMAN WHO LOST ALL FOUR LIMBS TO FLU COMPLICATIONS SPEAKS OUT TO RAISE AWARENESS

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The reality TV star has experienced some memory loss and difficulty concentrating, but said she hopes the “brain fog” will improve over time.

In retrospect, the sepsis may have stemmed from a sinus infection two months ago that was treated by multiple rounds of antibiotics, Gunvalson said.

Symptoms and dangers

Common symptoms of sepsis include fever, chills, rapid heart rate, confusion, shortness of breath, extreme pain, and clammy or sweaty skin, according to Gilles.

A high fever – especially in those who are at increased risk of infection and are feeling extremely unwell – should warrant seeking medical attention as soon as possible, Glatt added.

“Sepsis awareness can and does save lives, yet only 65% of American adults have ever heard of it.” 

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“Fatigue and lethargy in the setting of infection can be a sign of pneumonia and potential sepsis, even without overt pulmonary symptoms,” Dr. Marc Siegel, Fox News’ senior medical analyst and clinical professor of medicine at NYU Langone Medical Center, told Fox News Digital. 

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As sepsis can start within hours, Gilles suggested following the acronym “TIME” to remember that time is of the essence when it comes to seeking treatment.

T – Temperature (higher or lower than normal)

I – Infection (know the signs and symptoms)

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M – Mental decline (confusion, sleepiness and difficulty awakening)

E – Extremely ill (severe pain, discomfort and shortness of breath)

Approximately 1.7 million adults are diagnosed with sepsis every year in the U.S., according to the Centers for Disease Control and Prevention (CDC).

Approximately 1.7 million adults are diagnosed with sepsis every year in the U.S., according to the Centers for Disease Control and Prevention. (iStock)

The illness kills 350,000 American adults each year and is a leading cause of death in U.S. hospitals, Gilles noted. 

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It is the third-leading killer behind heart disease, which takes just over 700,000 lives each year, and cancer, which causes more than 600,000 annual deaths, per CDC data.

“Sepsis takes a life every 90 seconds — that’s more lives than opioids, breast cancer, prostate cancer and stroke combined,” she said.

Common myths about sepsis

Many people mistakenly assume that sepsis is an infection.

“Sepsis is the body’s overwhelming and life-threatening response to infection, which can lead to tissue damage, organ failure and death,” Gilles said. 

The condition can come after any infection — whether just a scrape or cut, a dental procedure or surgery, or even a [bacteria], fungus or parasite — triggers a “chain reaction” in the body, the doctor added.

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Treatment of sepsis will vary based on the underlying infection, but it often involves administering antibiotics as soon as possible. (iStock)

Another common myth is that sepsis only occurs in those who are (or were recently) hospitalized.

Most cases of sepsis, around 87%, start before a patient enters the hospital, Gilles said.

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“Community-acquired infections, such as urinary tract infections, pneumonia and even simple cuts or scrapes can lead to sepsis if not treated properly,” Gilles noted.

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Many people also think sepsis only affects immunocompromised people.

Older adults, infants and those with chronic illnesses or weakened immune systems are at a higher risk of sepsis. (iStock)

“Sepsis can strike almost anyone at almost any time,” Glatt said.

“While certain individuals are at higher risk of getting a severe infection that can even be deadly, serious infections can strike even a perfectly healthy young person with rare but potentially fatal consequences,” he went on.

      

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Older adults, infants and those with chronic illnesses or weakened immune systems are at a higher risk, however.

Treatment and prevention

The first step is discovering the underlying cause of the infection, according to the CDC.

Sepsis often starts in the gastrointestinal tract, lungs, skin or urinary tract.

“Sepsis is the body’s overwhelming and life-threatening response to infection, which can lead to tissue damage, organ failure and death,” a doctor said.  (iStock)

Treatment will vary based on the underlying infection, but often involves administering antibiotics as soon as possible.

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“While antibiotics are crucial for treating an underlying bacterial infection, managing sepsis often requires a comprehensive approach — including fluids, medications to support blood pressure, and sometimes surgery or [a ventilator], depending on the severity,” said Gilles.

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Surgery is sometimes necessary to remove tissue damaged by the infection, the CDC states.

It’s also important to maintain blood flow to the organs, often with fluids.

“Sepsis can strike almost anyone at almost any time.” 

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“If you suspect sepsis, seek medical attention right away,” Gilles advised.

The risk can be reduced by quickly identifying and managing infections, according to the doctor.

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Added Gilles, “It can also be prevented by practicing good hygiene, staying current with vaccinations, staying in good health, keeping cuts clean and dry, and promptly seeking treatment when infections are suspected.”

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New ways to prevent flu revealed in ‘accidental’ lab breakthrough, study finds

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New ways to prevent flu revealed in ‘accidental’ lab breakthrough, study finds

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An accidental lab discovery has opened the door to entirely new ways of preventing the flu.

While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells, SWNS reported.

By targeting the specific molecules the viruses rely on, scientists found that they could block them from entering new cells and halt their replication altogether.

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Researchers say these “fundamental insights” into seasonal influenza highlight a clear path toward developing better preventive medications.

“The hope is that fundamental, curiosity-based research like this helps to pave the way for novel strategies to treat and prevent influenza infections,” principal investigator Dr. Emily Bruce, from the University of Vermont’s Larner College of Medicine, said in the SWNS report.

While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells. (iStock)

While several flu strains cause illness, H1N1 and H3N2 influenza A viruses are the most common. However, current flu tests cannot differentiate between them, and clinical treatments are identical for both.

Although vaccines and antivirals are available, Bruce noted a “dire” need for better medications to stop the virus from spreading cell to xxcell.

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“You don’t get sick when a virus is in one cell,” he noted. “You get sick because a virus replicates itself and goes into many more cells.”

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The study, which was published in The Journal of Virology, originally aimed to map how viral RNA segments are transported within cells to create new viral particles.

The team used H1N1 and H3N2 viruses isolated from the nasal passages of positive patients in 2022.

Clinical treatments remain identical for both primary strains of the flu virus. (iStock)

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During the investigation, the team unexpectedly stumbled upon a cellular pathway that blocked the virus from entering lung cells, SWNS reported.

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The data revealed that when a specific human protein called Rab11B was depleted, H3N2 viruses failed to enter human lung cells. H1N1 viruses were completely unaffected.

Using reverse genetics, the team mapped this defect and uncovered a brand-new, H3N2-specific role for Rab11B during viral entry.

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This discovery challenged the scientific assumption that all flu viruses enter cells the same way.

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“Viruses are like pirates from different countries hijacking someone’s ship,” Bruce said. “Different viruses, like different types of pirates, use different methods to get onboard.”

This discovery challenged the scientific assumption that all flu viruses enter cells the same way. (iStock)

“We had previously thought that all flu viruses used the same way to get into a cell, but we discovered that this is not true,” she went on. “H1N1 and H3N2 need different proteins to get in, and if you get rid of the right protein, a specific virus can’t get in.”

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While these findings identify a critical cellular pathway for viral entry, the study was conducted using isolated cells, the researchers acknowledged.

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Further research is needed to determine whether blocking the protein is safe and effective within a live, complex human respiratory system.

Bruce and the team hope to conduct further research to determine whether this Rab11B-dependency is a fundamental property of H3N2, or if it’s a trait unique to currently circulating flu strains.

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One extra serving of processed meat a day linked to higher cancer risk

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One extra serving of processed meat a day linked to higher cancer risk

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Eating processed meat like ham, sausage and bacon may be linked to a higher risk of certain types of cancer, according to new research.

While health organizations have already confirmed that processed meat can contribute to colon cancer, this study looked closer at cancers in the upper digestive tract, where the link has historically been less clear.

To understand these connections, researchers from the European Prospective Investigation into Cancer and Nutrition (EPIC), one of the world’s largest long-term nutrition and cancer cohorts, tracked the health and diets of 450,112 people across Europe for an average of 14 years. 

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The study group included 131,426 men and 318,686 women, according to the study’s press release.

During the follow-up period, 876 people developed stomach cancer and 215 people developed esophageal adenocarcinoma, which is cancer of the tube connecting the mouth to the stomach.

For female participants, eating both processed meat and white meat was linked to an increased risk of developing the disease. (iStock)

Researchers tracked where the stomach cancers grew, separating them into the upper part of the stomach near the throat and the lower part of the stomach.

The researchers also sorted the tumors into two categories based on how the cancer cells appeared under a microscope: intestinal, which forms more organized structures, and diffuse, in which the cells are more scattered throughout the tissue.

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After adjusting for other lifestyle factors, the researchers found that for every extra 30 grams of processed meat a person ate per day, their overall risk of stomach cancer went up by 9%. Eating that same extra 30 grams a day was also linked to a 13% higher risk of esophageal adenocarcinoma.

A standard single slice of regular deli-sliced ham or lunch meat averages around 28 grams, according to USDA data and nutritional tracking databases.

An extra 20 grams of white meat, such as chicken and turkey, was linked to a 12% higher risk of cancer in the main body of the stomach. (iStock)

An extra 20 grams of white meat, such as chicken or turkey, was linked to a 12% higher risk of cancer in the main body of the stomach, the researchers noted.

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The study also revealed differences between men and women. For male participants, only processed meat showed a clear, statistically significant link to a higher risk of stomach cancer. For female participants, however, eating both processed meat and white meat was linked to an increased risk.

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These findings align with global health benchmarks, particularly those established by the World Health Organization’s International Agency for Research on Cancer.

The agency has long classified processed meat as a known human carcinogen, primarily due to its strong, well-documented links to colorectal cancer.

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However, health organizations have also consistently pointed to a potential, yet less definitive, relationship between these meats and cancers of the stomach.

Eating 30 grams of processed meat a day, or the equivalent to one slice of ham, was linked to a 13% higher risk of esophageal adenocarcinoma. (iStock)

Further scientific investigation is needed to confirm the findings and to account for other underlying risk factors, such as certain stomach infections, which could interact with dietary habits.

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A key limitation of the study is its reliance on self-reported diets, which can sometimes lead to inaccuracies in how participants recall their meat consumption over time, the researchers noted.

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The findings were published in the International Journal of Cancer.

Fox News Digital reached out to the researchers requesting comment.

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The Surprising Hormone That Could Make Menopause Weight Loss Easier

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The Surprising Hormone That Could Make Menopause Weight Loss Easier


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The Hormone That Could Make Menopause Weight Loss Easier




















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