Health
Parvovirus or ‘slapped cheek disease’ is on the rise, CDC warns: Here’s what to know
A respiratory disease known as parvovirus B19 is on the rise in the U.S. among all age groups, according to a recent advisory from the U.S. Centers for Disease Control and Prevention (CDC).
The CDC issued the health alert on Aug. 13 after European public health authorities reported “unusually” high numbers of cases in 14 countries during the first quarter of 2024, the advisory said.
The virus typically causes a blotchy rash on the cheeks that appears as if someone has slapped them — hence its nickname, “slapped cheek disease.”
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“Parvovirus can be a very mild infection in many people, but if you are pregnant or are immunocompromised in any way, you are at a much greater risk of serious illness,” Dr. Aaron Glatt, chief of infectious diseases at Mount Sinai South Nassau Hospital on Long Island, New York, told Fox News Digital.
What is parvovirus B19?
Parvovirus B19 is a virus that can be easily spread by respiratory droplets in the air after an infected person coughs or sneezes, according to the CDC.
A respiratory disease known as parvovirus B19 is on the rise in the U.S. among all age groups, according to a recent advisory from the U.S. Centers for Disease Control and Prevention (CDC). (iStock)
Children are often infected at school and spread it to other kids through close personal contact, then later to adults when they come home, experts say.
Approximately 50% of people who were not previously infected contract the virus from an infected family member — while 20% to 50% of susceptible students and staff become infected during school outbreaks, the advisory notes.
“The virus is highly contagious and can spread asymptomatically,” Dr. Marc Siegel, senior medical analyst for Fox News and clinical professor of medicine at NYU Langone Medical Center, told Fox News Digital.
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Parvovirus B12 is also known as “fifth disease” because it was previously listed fifth on a list of common childhood viral illnesses that cause rashes, according to Mayo Clinic.
(The top three on this list are measles, rubella and scarlet fever.)
Symptoms of the virus
Many people who get infected don’t have symptoms, but some will experience sickness, according to the advisory.
About a week after an exposure, susceptible children may complain of flu-like symptoms, including fever, muscle pain and fatigue, which generally last less than a week.
People are most contagious in this early phase of the illness.
The virus typically causes a blotchy rash on the cheeks that appears as if someone has slapped them — hence the nickname “slapped cheek disease.” (iStock)
Several days after the fever starts, children often develop the hallmark blotchy “slapped cheek” rash — a helpful clue that health care providers use to diagnose the illness.
People are generally not infectious by the time they develop the rash, experts say.
A fine, “lacy” rash may follow on the chest, back, buttocks, or arms and legs that is sometimes itchy, according to the CDC. It usually goes away in about a week to 10 days.
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Adults are less likely to develop the “slapped cheek” rash. Their most common symptoms are a generalized rash on the body and joint pain that affects the hands, feet and knees.
In some cases, adults only experience joint pain, which usually lasts one to three weeks – although it can last for months. It usually resolves without long-term complications.
Antibodies provide immunity
Antibodies from prior infection help prevent recurrence of parvovirus B12, the CDC said.
“Once infected, you have a lifetime immunity,” Siegel noted.
The largest increase in infections was among children ages 5 to 9.
Most adults in the United States are immune — with 50% having detectable antibody levels by age 20, and more than 70% acquiring them by age 40, per the advisory.
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The share of people who have had a recent infection dropped below 3% between 2022 and 2024, but increased to 10% in June of this year.
The largest increase in infections was among children ages 5 to 9, going from 15% to 40% in that time frame, the health alert noted.
People who work in settings with close contact with children, such as schools and day cares, are at a greater risk of infection.
High-risk populations
Most healthy adults and children only have a mild illness, but people with weakened immune systems, pregnant women and those with chronic blood disorders can develop serious health complications from this virus, according to the CDC.
“Anyone with those conditions should be very quick to seek out medical attention to help address potential complications,” Glatt noted.
Pregnant women who are susceptible to the virus may spread the illness to their babies, the CDC warned. (iStock)
Pregnant women who are susceptible to the virus may spread the illness to their babies, the CDC warned.
“Unfortunately, there is an increased risk of miscarriage if you get parvovirus during pregnancy,” Glatt said.
Parvovirus infection may lead to adverse outcomes — such as severe anemia in the fetus and miscarriage — in 5% to 10% of cases during pregnancy, with the highest risk at between 9 and 20 weeks of fetal gestation, per the advisory.
While parvovirus B19 can affect humans of all ages, only two out of 10 individuals will have physical symptoms. (iStock)
“There is an increased risk of complications in patients with significant immunocompromising conditions, such as those who have leukemia, have received an organ transplant or have an HIV infection,” Glatt added.
Since most adults are immune to the virus, however, many pregnant women are protected from the virus, the CDC noted.
Treatment is mainly ‘supportive care’
Infected pregnant women primarily receive supportive care, which means treating the underlying symptoms and monitoring for severe fetal anemia, according to the advisory.
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People with weakened immune systems or those with chronic blood disorders can sometimes develop bone marrow failure as a result of the virus, the advisory added.
In that case, treatment often includes blood cell transfusions and intravenous immunoglobulin (IVIG).
People are generally not infectious by the time they develop the rash, experts say. (iStock)
(IVIG is a collection of antibodies that strengthens the immune system, according to Mayo Clinic’s website.)
There is currently no vaccine to prevent parvovirus B19, and most people infected with the virus will recover without any long-term complications.
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“While there is no specific treatment for parvovirus infection, recognizing the complications and addressing them early may be of benefit,” Glatt added.
Hand-washing can also help to prevent transmission, according to Siegel.
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A new injectable therapy is showing positive results in reducing melanoma throughout a five-year period.
The personalized mRNA cancer therapy, called intismeran autogene, combined with the cancer immunotherapy drug KEYTRUDA (pembrolizumab), is a collaboration between Merck and Moderna.
The results from the phase 2b KEYNOTE-942 study were presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago on May 27.
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After about a five-year follow-up, the combo drug was found to reduce the risk of melanoma recurrence or death by 49% compared to pembrolizumab alone.
The researchers analyzed data from 157 patients with high-risk stage 3 and 4 melanoma whose cancer had been removed via surgery. The participants were split into two groups — one received the combo therapy and the other only received pembrolizumab, according to a press release.
The therapy was found to reduce the risk of melanoma recurrence or death by 49% compared to pembrolizumab alone after a five-year follow-up. (iStock)
The findings revealed that the combination group saw benefits that were “sustained and durable over time.”
Intismeran autogene is designed using mutations identified in a patient’s own tumor, with the intention of teaching the immune system what the cancer looks like so that it can recognize and attack it.
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According to the researchers, intismeran is “well-tolerated” with a “manageable” safety profile.
The most commonly cited side effects of the personalized mRNA vaccine plus KEYTRUDA were fatigue, injection-site pain, chills, fever and headache. The researchers reported no new long-term safety concerns and no severe vaccine-related adverse events.
The combination therapy is currently being evaluated in a phase 3 study — the final confirmation stage.
Patients with late-stage melanoma have a “significant risk” of cancer recurrence, according to an expert. (iStock)
In a Merck press release from January, Kyle Holen, MD, Moderna’s senior vice president and head of development, oncology and therapeutics, noted that this data highlights the “potential of a prolonged benefit … in patients with resected high-risk melanoma.”
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“We continue to invest in our platform in oncology because of encouraging outcomes like these, which illustrate mRNA’s potential in cancer care,” he said.
Dr. Marjorie Green, senior vice president and head of oncology, global clinical development at Merck Research Laboratories, also commented that for many patients with stage 3 or 4 melanoma, there is a “significant risk of recurrence following surgery.”
Researchers confirmed that the combination therapy is currently being evaluated in a phase 3 study. (iStock)
“As such, demonstrating the longer-term potential of intismeran autogene and KEYTRUDA to reduce the risk of recurrence for certain patients with melanoma is a meaningful milestone,” she said.
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The company cited encouraging five-year follow-up data and pointed to upcoming late-stage INTerpath trial results with Moderna in several hard-to-treat cancers.
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An accidental lab discovery has opened the door to entirely new ways of preventing the flu.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells, SWNS reported.
By targeting the specific molecules the viruses rely on, scientists found that they could block them from entering new cells and halt their replication altogether.
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Researchers say these “fundamental insights” into seasonal influenza highlight a clear path toward developing better preventive medications.
“The hope is that fundamental, curiosity-based research like this helps to pave the way for novel strategies to treat and prevent influenza infections,” principal investigator Dr. Emily Bruce, from the University of Vermont’s Larner College of Medicine, said in the SWNS report.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells. (iStock)
While several flu strains cause illness, H1N1 and H3N2 influenza A viruses are the most common. However, current flu tests cannot differentiate between them, and clinical treatments are identical for both.
Although vaccines and antivirals are available, Bruce noted a “dire” need for better medications to stop the virus from spreading cell to xxcell.
“You don’t get sick when a virus is in one cell,” he noted. “You get sick because a virus replicates itself and goes into many more cells.”
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The study, which was published in The Journal of Virology, originally aimed to map how viral RNA segments are transported within cells to create new viral particles.
The team used H1N1 and H3N2 viruses isolated from the nasal passages of positive patients in 2022.
Clinical treatments remain identical for both primary strains of the flu virus. (iStock)
During the investigation, the team unexpectedly stumbled upon a cellular pathway that blocked the virus from entering lung cells, SWNS reported.
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The data revealed that when a specific human protein called Rab11B was depleted, H3N2 viruses failed to enter human lung cells. H1N1 viruses were completely unaffected.
Using reverse genetics, the team mapped this defect and uncovered a brand-new, H3N2-specific role for Rab11B during viral entry.
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This discovery challenged the scientific assumption that all flu viruses enter cells the same way.
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“Viruses are like pirates from different countries hijacking someone’s ship,” Bruce said. “Different viruses, like different types of pirates, use different methods to get onboard.”
This discovery challenged the scientific assumption that all flu viruses enter cells the same way. (iStock)
“We had previously thought that all flu viruses used the same way to get into a cell, but we discovered that this is not true,” she went on. “H1N1 and H3N2 need different proteins to get in, and if you get rid of the right protein, a specific virus can’t get in.”
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While these findings identify a critical cellular pathway for viral entry, the study was conducted using isolated cells, the researchers acknowledged.
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Further research is needed to determine whether blocking the protein is safe and effective within a live, complex human respiratory system.
Bruce and the team hope to conduct further research to determine whether this Rab11B-dependency is a fundamental property of H3N2, or if it’s a trait unique to currently circulating flu strains.
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Eating processed meat like ham, sausage and bacon may be linked to a higher risk of certain types of cancer, according to new research.
While health organizations have already confirmed that processed meat can contribute to colon cancer, this study looked closer at cancers in the upper digestive tract, where the link has historically been less clear.
To understand these connections, researchers from the European Prospective Investigation into Cancer and Nutrition (EPIC), one of the world’s largest long-term nutrition and cancer cohorts, tracked the health and diets of 450,112 people across Europe for an average of 14 years.
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The study group included 131,426 men and 318,686 women, according to the study’s press release.
During the follow-up period, 876 people developed stomach cancer and 215 people developed esophageal adenocarcinoma, which is cancer of the tube connecting the mouth to the stomach.
For female participants, eating both processed meat and white meat was linked to an increased risk of developing the disease. (iStock)
Researchers tracked where the stomach cancers grew, separating them into the upper part of the stomach near the throat and the lower part of the stomach.
The researchers also sorted the tumors into two categories based on how the cancer cells appeared under a microscope: intestinal, which forms more organized structures, and diffuse, in which the cells are more scattered throughout the tissue.
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After adjusting for other lifestyle factors, the researchers found that for every extra 30 grams of processed meat a person ate per day, their overall risk of stomach cancer went up by 9%. Eating that same extra 30 grams a day was also linked to a 13% higher risk of esophageal adenocarcinoma.
A standard single slice of regular deli-sliced ham or lunch meat averages around 28 grams, according to USDA data and nutritional tracking databases.
An extra 20 grams of white meat, such as chicken and turkey, was linked to a 12% higher risk of cancer in the main body of the stomach. (iStock)
An extra 20 grams of white meat, such as chicken or turkey, was linked to a 12% higher risk of cancer in the main body of the stomach, the researchers noted.
The study also revealed differences between men and women. For male participants, only processed meat showed a clear, statistically significant link to a higher risk of stomach cancer. For female participants, however, eating both processed meat and white meat was linked to an increased risk.
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These findings align with global health benchmarks, particularly those established by the World Health Organization’s International Agency for Research on Cancer.
The agency has long classified processed meat as a known human carcinogen, primarily due to its strong, well-documented links to colorectal cancer.
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However, health organizations have also consistently pointed to a potential, yet less definitive, relationship between these meats and cancers of the stomach.
Eating 30 grams of processed meat a day, or the equivalent to one slice of ham, was linked to a 13% higher risk of esophageal adenocarcinoma. (iStock)
Further scientific investigation is needed to confirm the findings and to account for other underlying risk factors, such as certain stomach infections, which could interact with dietary habits.
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A key limitation of the study is its reliance on self-reported diets, which can sometimes lead to inaccuracies in how participants recall their meat consumption over time, the researchers noted.
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The findings were published in the International Journal of Cancer.
Fox News Digital reached out to the researchers requesting comment.
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