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Major cannabis study finds little proof for popular medical claims, flags big dangers

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Major cannabis study finds little proof for popular medical claims, flags big dangers

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Cannabis has been linked to some significant medical benefits, but recent research calls those into question.

A major new analysis published in JAMA examined more than 2,500 scientific papers from the last 15 years, including other reviews, clinical trials and guidelines focused on medical marijuana.

“While many people turn to cannabis seeking relief, our review highlights significant gaps between public perception and scientific evidence regarding its effectiveness for most medical conditions,” Dr. Michael Hsu of University of California – Los Angeles (UCLA) Health Sciences, author of the study, said in a press release.

Many medical claims about cannabis are not supported by strong scientific evidence, according to a comprehensive review published in JAMA. (iStock)

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The researchers led by UCLA with contributions from Harvard, UC San Francisco, Washington University School of Medicine and New York University set out to determine how strong the research is on the effectiveness of medical cannabis and to offer evidence-based clinical guidance.

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The review found that evidence supporting most medical uses of cannabis or cannabinoids is limited or insufficient, the release stated.

“Whenever a substance is widely used, there is likely to be a very wide set of outcomes,” Alex Dimitriu, MD, double board-certified in Psychiatry and Sleep Medicine and founder of Menlo Park Psychiatry & Sleep Medicine, told Fox News Digital. 

“Cannabis is now used by about 15 to 25% of U.S. adults in the past year, for various reasons ranging from recreational to medicinal. This study points to the reality that this widely used substance is not a panacea,” said Dimitriu, who was not involved in the study.

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There are very few conditions for which cannabinoid therapies have clear, well-established benefits backed by high-quality clinical data, according to the researchers.

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The strongest evidence supports FDA-approved cannabinoid medications for treating specific conditions, including HIV/AIDS-related appetite loss, chemotherapy-induced nausea and vomiting, and certain severe pediatric seizure disorders.

The review identified significant safety concerns, with high-potency cannabis use among young people linked to higher rates of mental health issues. (iStock)

For many other conditions that are commonly treated with cannabis — such as chronic pain, insomnia, anxiety or post-traumatic stress disorder — evidence from randomized trials did not support meaningful benefit.

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The analysis also examined safety concerns — in particular, how young people using high-potency cannabis may be more likely to suffer higher rates of psychotic symptoms and anxiety disorder.

Daily inhaled cannabis use was also linked to increased risks of coronary heart disease, myocardial infarction (heart attack) and stroke when compared with non-daily use.

Daily inhaled cannabis use is associated with increased cardiovascular risks, including coronary heart disease, heart attack and stroke. (iStock)

Based on these findings, the review emphasizes that clinicians should weigh potential benefits against known risks when discussing cannabis with patients.

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The authors suggest that clinicians screen patients for cardiovascular risk, evaluate mental health history, check for possible drug interactions and consider conditions where risks may outweigh benefits.

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They recommend open, realistic conversations and caution against assuming that cannabis is broadly effective for medical conditions.

The review highlights the need for caution, urging clinicians to weigh risks, screen patients appropriately and avoid assuming cannabis is broadly effective. (iStock)

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“Patients deserve honest conversations about what the science does and doesn’t tell us about medical cannabis,” Hsu said.

This article is a narrative review rather than a systematic review, so it did not use the strict, standardized methods that help reduce bias in how studies are selected and evaluated, the researchers noted.

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The review notes further limitations, including that some evidence comes from observational research rather than randomized trials, which means it cannot establish cause and effect.

The trial results also may not apply to all populations, products or doses.

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A 17¢ Supplement Is Changing Lives for Women Over 50—Here’s How

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Celebrity chef reveals No. 1 mistake sabotaging your weight loss: ‘Fuzzy math’

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Celebrity chef reveals No. 1 mistake sabotaging your weight loss: ‘Fuzzy math’

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FIRST ON FOX: Eating healthy doesn’t have to be complicated, according to celebrity chef Rocco DiSpirito.

In an exclusive interview with Fox News Digital, the restaurateur and owner of New York City’s new Bar Rocco – whose philosophy and cookbooks are rooted in health-conscious dieting – shared a few misconceptions about healthy eating, especially when the end goal is weight loss.

“There is no one fix, there’s no one cure for everyone,” he said. “Everyone has different needs and their weight-loss journey is going to be different. So, you really have to figure out what your problem is.”

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This could be a body composition imbalance, a lack of exercise or a generally poor diet, DiSpirito mentioned. “Figure out what will help you address those issues most quickly,” he advised.

Rocco DiSpirito recently opened Bar Rocco in New York City. The Rockefeller Center location offers breakfast, lunch and dinner. (Eric Medsker)

“Even if you’re working out, unless you’re LeBron James and burning 8,000 calories a game, there’s no way to out-train a bad diet, so at some point in our lives, we have to come to a reckoning with what we consume.”

DiSpirito says it’s “always a good idea” to start with the basics, including consuming less sugar, less alcohol, fewer processed foods and fewer processed carbs, as well as eating more protein.

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The chef revealed that the No. 1 issue he’s witnessed is that people have “no idea how many calories they’re consuming.”

“We’re all consuming two to three times more than we realize,” he noted. “And even when we count and use the apps, there’s a lot of fuzzy math going on.”

“So, getting a handle on how much you’re consuming, even the little picking that you do while you’re cooking and cleaning, all that counts and adds up quickly.”

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As the healthy eating movement gains traction, DiSpirito called it “very important” for most of the U.S., as the country faces an “obesity issue.”

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“Restaurants are definitely thinking about it as well,” he said. “[But] I wouldn’t say restaurants are making it their [top] priority.”

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“We still have a lot of work to do just getting people in and seated and fed and their checks to them when they want. But there are some restaurants that are focused on it.”

As the healthy eating movement gains traction, DiSpirito called it “very important” for most of the U.S., as the country faces an “obesity issue.” (iStock)

Privately, DiSpirito said he has focused on providing healthy meal plans for clients.

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“But for restaurants to approach healthy eating is a little difficult, because it’s a whole different kind of cooking and a [different] kind of energy,” he said.

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“Healthy eating isn’t fun – so to bring that into a fun atmosphere is kind of difficult. It’s difficult to mix the two.”

This crossroads between indulgence and health may be a tricky mix, especially among the food supply in America, DiSpirito acknowledged – but the two align more easily in other countries where the food is not tampered with, he added.

Celebrity chef Rocco DiSpirito says other countries, like Italy, “don’t allow a lot of messing around with food that we allow in the United States.” (Jonathan Pushnik)

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“If you go to Italy, for example, and just eat everything they eat, it feels indulgent … and it’s also very healthy,” he said. “And the key is the food supply is still natural. It’s still organic.”

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“There aren’t lots of sprayed food [or] sprayed vegetables in Italy,” DiSpirito went on. “They don’t allow a lot of messing around with food that we allow in the United States, the GMO-ing, the modifying.”

“So healthy and indulgent are not mutually exclusive, but in [our] food supply system … it’s very difficult.”

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Guava for Weight Loss Is a Real Thing—Here’s the Juicy Truth

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