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Is mpox the next COVID? Infectious disease experts address pandemic potential

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Is mpox the next COVID? Infectious disease experts address pandemic potential

As mpox (formerly monkeypox) has been declared a global public health emergency, some are wondering whether the virus poses the risk of a COVID-like pandemic.

The World Health Organization (WHO) officially declared the mpox outbreak a “public health emergency of international concern” on Aug. 14, based on a surge of cases in the Democratic Republic of the Congo (DRC) and multiple African countries.

As of Aug. 17, there were 545 reports of mpox cases since the outbreak was declared, 474 of which were confirmed, according to data from WHO.

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Symptoms include a sometimes painful rash on various parts of the body, fever, chills, exhaustion, muscle aches, headache, swollen lymph nodes and respiratory symptoms, according to the U.S. Centers for Disease Control and Prevention (CDC).

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There are two types of mpox: Clade 1 and Clade 2.

The World Health Organization officially declared the mpox outbreak a “public health emergency of international concern” on Aug. 14. (iStock)

Clade 2 was the strain that caused the 2022 global outbreak, the CDC noted. Survival rates for this type are more than 99.9%.

Clade 1, which is responsible for the current outbreak in the DRC and Africa, causes more severe illness and deaths. 

MONKEYPOX: WHAT YOU MUST KNOW ABOUT THE VIRUS – AND HOW TO PROTECT YOURSELF

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“Some outbreaks have killed up to 10% of the people who get sick, although more recent outbreaks have had lower death rates,” the CDC noted. 

“The emergence of a new clade of mpox, its rapid spread in eastern DRC, and the reporting of cases in several neighboring countries are very worrying,” said WHO Director-General Dr Tedros Adhanom Ghebreyesus when announcing the public health emergency. 

“People are not going to catch mpox by being on the same bus or running into someone at the grocery store.”

“On top of outbreaks of other mpox clades in DRC and other countries in Africa, it’s clear that a coordinated international response is needed to stop these outbreaks and save lives.”

Is mpox the next COVID?

While health officials have expressed concern about the spread of a new strain of the potentially deadly virus, the consensus is that mpox is not likely to become a pandemic like COVID — primarily because it doesn’t spread in the same way.

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“Certainly not,” said Dr. Daniel Kuritzkes, chief of infectious diseases at Brigham and Women’s Hospital in Boston, during a conversation with Fox News Digital.

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“What made COVID so contagious is that it is a respiratory virus spread by aerosols, so that even casual contact — being in the same room with someone for a reasonable period of time — meant you could catch [the virus]” from that person.

Another difference is that COVID is contagious starting from a day or so before someone develops symptoms, Kuritzkes pointed out. 

Symptoms of mpox include a sometimes painful rash on various parts of the body, fever, chills, exhaustion, muscle aches, headache, swollen lymph nodes and respiratory symptoms. (iStock)

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“By contrast, mpox requires close contact (skin-to-skin) for transmission in the vast majority of cases,” he said.

“Rarely, heavily contaminated material such as bedding can be infectious, but people are not going to catch mpox by being on the same bus or running into someone at the grocery store.”

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While mpox is far less contagious than COVID, it could potentially cause a “widely distributed epidemic” through sexual contact, according to Kuritzkes.

“HIV is now pandemic (found in all countries across the globe), but as high as the numbers are, it is not transmitted by casual contact,” he said. “The same is true of mpox.”

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To prevent transmission of mpox, the U.S. Centers for Disease Control and Prevention recommends vaccination for men who are gay, bisexual or have sex with men, are age 18 or older, and have other specific risks. (PASCAL GUYOT/AFP via Getty Images)

Dr. Marc Siegel, senior medical analyst for Fox News and clinical professor of medicine at NYU Langone Medical Center, echoed that mpox is “not the new COVID.”

“It spreads via direct contact or sex, and kissing, and very close respiratory droplets, but not over longer distances by respiratory spread,” he told Fox News Digital.  

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“Clade 1 is currently in DRC and neighboring African countries,” Siegel said. 

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“The U.S. has increased surveillance, including wastewater analysis, but there have been no cases [of Clade 1] found here yet.” 

This undated image provided by the National Institute of Allergy and Infectious Diseases shows a colorized transmission electron micrograph of mpox particles (red) found within an infected cell (blue), cultured in a laboratory at the NIAID Integrated Research Facility in Fort Detrick, Maryland. (NIAID via AP, File)

Dr. Brad Perkins, chief medical officer at Karius, a California life sciences company focused on saving lives from infectious diseases, reiterated that mpox is “considerably less infectious” for person-to-person spread than COVID-19. 

“Mpox is primarily spread from person-to-person, usually through direct contact, including intimate contact — but on average, there are fewer people who become infected as a result of contact with a mpox case compared to COVID-19,” he told Fox News Digital.

Who is most at risk?

“While mpox can affect anyone, data has shown that men who have sex with men are disproportionately impacted, with a notable disease burden among Black and Hispanic men,” Perkins noted.

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“This highlights the importance of early recognition and diagnosis, in addition to awareness and targeted vaccination of those who are at highest risk.”

“While mpox can affect anyone, data has shown that men who have sex with men are disproportionately impacted.”

As with other viral infections, those who are immunocompromised or very young are at the greatest risk of severe infection, according to Kuritzkes.   

“For mpox, the main concern is for people with HIV who are not currently receiving effective antiretroviral therapy,” he added.

Patients wait outside the consultation room of an mpox treatment center in the Democratic Republic of Congo, on Aug. 16, 2024. Health Minister Samuel-Roger Kamba said in a video message that the country “has recorded 15,664 potential cases and 548 deaths since the beginning of the year,” with all 26 provinces affected. (Getty Images)

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Even after the infection has cleared, survivors can face long-term effects and complications, Perkins warned.

“Conditions like vision impairment, encephalitis and scarring have been reported,” he told Fox News Digital. 

“We need deeper research into characterizing and addressing these long-term sequelae.”

      

To prevent transmission of mpox, the U.S. Centers for Disease Control and Prevention (CDC) recommends vaccination for men who are gay, bisexual or have sex with men, are age 18 or older, and have other specific risks.

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Those risks include new diagnoses of sexually transmitted diseases and a recent history of multiple sex partners, among others.

“Second, and most obviously, would be to avoid close contact with people who have mpox lesions,” said Kuritzkes.

Doctors take samples from a patient at an mpox treatment center in the Democratic Republic of Congo, on Aug. 16, 2024. (Getty Images)

“The big issue is getting the vaccine to the people who need it in Central and West Africa to end the current outbreak.”

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The United States Agency for International Development (USAID) has sent 50,000 doses of the JYNNEOS mpox vaccine to DRC, Siegel noted — “but there is still a worldwide shortage of this vaccine, which will prove crucial to stop the spread, especially if the outbreak widens.”

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In addition to the current vaccines and antiviral treatments that are available, Perkins stressed the need for new innovations in mpox diagnostics, therapeutics and preventive measures.

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Do collagen supplements really improve skin? Major review reveals the truth

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Do collagen supplements really improve skin? Major review reveals the truth

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Collagen supplements have exploded in popularity, touted as everything from an anti-aging miracle to a muscle recovery booster.

But a sweeping new review conducted by U.K. researchers suggests that while collagen may help improve skin elasticity and ease arthritis pain, it does little for athletic performance or wrinkle reduction.

Researchers from Anglia Ruskin University analyzed 16 systematic reviews and 113 randomized controlled trials involving nearly 8,000 participants worldwide, which they say is the most extensive evaluation of collagen’s health effects to date. 

The review found consistent evidence that collagen supplementation improves skin elasticity and hydration over time and provides significant relief from osteoarthritis-related joint pain and stiffness, according to findings published in Aesthetic Surgery Journal Open Forum. 

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A large U.K. review found that collagen supplements may improve skin elasticity and hydration over time. (iStock)

The researchers, however, did not find meaningful improvements in post-exercise muscle recovery, soreness or tendon mechanical properties (strength, springiness and stretch resistance).

“Collagen is not a cure-all, but it does have credible benefits when used consistently over time, particularly for skin and osteoarthritis,” co-author Lee Smith, professor of public health at Anglia Ruskin University, said in a statement.

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“Our findings show clear benefits in key areas of healthy aging, while also dispelling some of the myths surrounding its use,” Smith added.

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Collagen, the most abundant protein in the body, supports skin, bones, tendons, cartilage and connective tissue, according to experts. Natural collagen production begins to drop in early adulthood and declines more sharply with age.

The study found that collagen supplements may help reduce joint pain and stiffness in people with osteoarthritis. (iStock)

The review found that long-term collagen supplementation was linked to improved skin firmness and hydration, but did not help skin roughness — a proxy for visible wrinkles. 

Benefits appear to accumulate gradually, suggesting that collagen should not be viewed as an “anti-wrinkle ‘quick fix,’ but as a foundational dermal support for individuals seeking holistic skin maintenance,” the researchers said.

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“If we define anti-aging as a product or technique designed to prevent the appearance of getting older, then I believe our findings do support this claim for some parameters,” Smith told the BBC. “For example, an improvement in skin tone and moisture is associated with a more youthful-looking appearance.”

Collagen supplementation was linked to reduced pain and stiffness in people with osteoarthritis, with stronger benefits seen over longer periods of use, and showed modest improvements in muscle mass and tendon structure that may support healthy aging. 

Collagen did not significantly improve skin roughness, a marker of visible wrinkles. (iStock)

However, it did not show meaningful results when used as a fast-acting sports performance supplement, and evidence for benefits related to cholesterol, blood sugar, blood pressure and oral health was mixed or inconclusive.

Dr. Daniel Ghiyam, a California-based physician and longevity specialist, said the findings align with what he sees in clinical practice.

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“Collagen is a targeted support tool, not a foundation of health or performance,” Ghiyam, who was not involved in the study, told Fox News Digital. “When marketed that way, it makes sense. When marketed as a cure-all, it doesn’t hold up to the data.”

The authors noted that while many previous collagen studies have received financial support from the supplement industry, the current review did not receive industry funding.

Experts say collagen supplements may offer modest benefits for skin hydration and joint comfort, but they are not a cure-all. (iStock)

The team called for more high-quality clinical trials examining long-term outcomes, optimal dosages and differences between collagen sources, such as marine, bovine and plant-based alternatives. 

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Among its limitations, the review could not determine whether certain forms of collagen work better than others or what the optimal regimen should be. 

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While the review included randomized controlled trials, the quality of the studies varied, with newer research generally showing stronger results.

Experts say more data and studies are needed to build on the findings. They also noted that diet plays a crucial role in skin health.

Collagen supplements, often sold as powders or pills, may improve skin elasticity and ease joint pain, experts say. (iStock)

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Dr. Erum Ilyas, a Pennsylvania-based dermatologist and chair of dermatology at Drexel University College of Medicine, noted that the review analyzed previously published meta-analyses rather than generating new primary data.

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“At this time, I have not seen sufficiently strong independent evidence to routinely recommend collagen supplements to my patients,” Ilyas, who was not involved in the review, told Fox News Digital.

“Although some studies show modest improvements in markers such as hydration and elasticity, there remains limited independent, biopsy-confirmed evidence demonstrating sustained increases in dermal collagen content,” she added.

Fox News Digital has reached out to the researchers for comment.

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Origin of deadly cancer affecting young adults revealed in alarming report

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Origin of deadly cancer affecting young adults revealed in alarming report

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As colorectal cancer (CRC) is now the leading cause of cancer death in adults under 50, a new report reveals some surprising shifts in the incidence of the disease.

Although rates of CRC have been declining among seniors, those 65 and under are facing a rise in diagnoses, according to a report titled Colorectal Cancer Statistics, 2026, from the American Cancer Society.

Adults 65 and younger comprise nearly half (45%) of all new colorectal cancer cases — a significant increase from 27% in 1995, states the report, which was published in CA: A Cancer Journal for Clinicians.

The disease is rising fastest among adults 20 to 49 years old, at a rate of 3% per year.

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Colorectal cancer is now the leading cause of cancer death in adults under 50. (iStock)

Among adults 50 and under, 75% of colorectal cancers are diagnosed at an advanced stage. Half of the diagnoses in that age range are made between the ages of 45 and 49. Although that age group is eligible to receive routine screenings, just 37% do so.

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The report also revealed that rectal cancer is on the rise, now accounting for about one-third (32%) of all CRC cases — an increase from 27% in the mid-2000s.

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“After decades of progress, the risk of dying from colorectal cancer is climbing in younger generations of men and women, confirming a real uptick in disease because of something we’re doing or some other exposure,” said Rebecca Siegel, senior scientific director, surveillance research at the American Cancer Society and lead author of the report, in a press release.

Among adults 50 and under, 75% of colorectal cancers are diagnosed at an advanced stage. Half of the diagnoses in that age range are made between the ages of 45 and 49.  (iStock)

“We need to redouble research efforts to understand the cause, but also circumvent deaths through earlier detection by educating clinicians and the general public about symptoms and increasing screening in people 45-54 years.”

It is projected that 158,850 new cases of colorectal cancer will be diagnosed this year, and that the disease will cause 55,230 deaths, per the report.

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More than half of CRC cases can be linked to high-risk behaviors, the researchers said. Those include lack of nutrition, high alcohol consumption, smoking, lack of exercise and obesity.

“These findings further underscore that colorectal cancer is worsening among younger generations and highlight the immediate need for eligible adults to begin screening at the recommended age of 45,” said Dr. William Dahut, chief scientific officer at the American Cancer Society.

When the disease is caught at a local (early) stage, the five-year survival rate is 95%. (iStock)

“The report also shines a light on the crucial importance of continued funding for research to help discover new therapies to treat the disease and advance patient care.”

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When the disease is caught at a local (early) stage, the five-year survival rate is 95%, the report stated.

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Aging process could accelerate due to ‘forever chemicals’ exposure, study finds

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Aging process could accelerate due to ‘forever chemicals’ exposure, study finds

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A new study suggests that middle-aged men may be more vulnerable to faster biological aging, potentially linked to exposure to “forever chemicals.”

The research, published in the journal Frontiers in Aging, examined how perfluoroalkyl and polyfluoroalkyl substances, more commonly known as PFAS, could impact aging at the cellular level.

PFAS are synthetic chemicals commonly used in nonstick cookware, food packaging, water-resistant fabrics and other consumer products, the study noted. 

Their chemical structure makes them highly resistant to breaking down, allowing them to accumulate in water, soil and the human body.

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Chinese researchers analyzed blood samples from 326 adults enrolled in the U.S. National Health and Nutrition Examination Survey between 1999 and 2000.

A new study suggests that middle-aged men could face accelerated biological aging at the cellular level due to exposure to PFAS. (iStock)

The researchers measured levels of 11 PFAS compounds in participants’ blood and used DNA-based “epigenetic clocks” — tools that analyze chemical changes to DNA to estimate biological age — to determine how quickly their bodies were aging at the cellular level, the study stated.

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Two compounds, perfluorononanoic acid (PFNA) and perfluorooctanesulfonamide (PFOSA), were detected in 95% of participants.

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Higher concentrations of those chemicals were associated with faster biological aging in men of certain age groups, but not in women.

“People should not panic.”

The compounds most strongly linked to accelerated aging were not the PFAS chemicals that typically receive the most public attention, the researchers noted.

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“The associations were strongest in adults aged 50 to 64, particularly in men,” Dr. Xiangwei Li, professor at Shanghai Jiao Tong University School of Medicine and the study’s corresponding author, told Fox News Digital. 

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“While this does not establish that PFAS cause aging, it suggests that these widely present ‘forever chemicals’ may be linked to molecular changes related to long-term health and aging.”

The study found that two of the compounds were detected in 95% of participants, and higher levels were linked to faster biological aging in men ages 50–64. (iStock)

Midlife may represent a more sensitive biological period, when the body becomes more vulnerable to age-related stressors, according to the researchers.

Lifestyle factors, such as smoking, may influence biological aging markers, potentially increasing vulnerability to environmental pollutants.

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While Li said “people should not panic,” she does recommend looking for reasonable ways to reduce exposure. 

That might mean checking local drinking water reports, using certified water filters designed to reduce PFAS, and limiting the use of stain- or grease-resistant products when alternatives are available.

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Meaningful reductions in PFAS exposure will likely depend on broader regulatory action and environmental cleanup efforts, Li added.

The researchers noted that midlife could be a particularly sensitive stage, when the body is more susceptible to stressors associated with aging. (iStock)

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Study limitations

The researchers outlined several important limitations of the research, including that the findings show an association, but do not prove that PFAS directly causes accelerated aging.

“The study is cross-sectional, meaning exposure and aging markers were measured at the same time, so we cannot determine causality,” Li told Fox News Digital.

The study was also relatively small, limited to 326 adults age 50 or older, which means the findings may not apply to younger people or broader populations.

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Researchers measured PFAS levels using data collected between 1999 and 2000, and today’s exposure patterns may differ.

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Li added that while PFAS is known to persist in the environment and the body, these results should be validated through larger, more recent studies that follow participants over time.

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