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GLP-1 drugs may reach fewer than one in 10 people who need them, experts predict

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GLP-1 drugs may reach fewer than one in 10 people who need them, experts predict

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The World Health Organization (WHO) has announced its official guidance on the use of GLP-1 drugs for treating obesity.

GLP-1 drugs are medications that mimic the natural hormone glucagon-like peptide-1 (GLP-1), which are most commonly used for type 2 diabetes and medical weight loss.

The first guideline, released on Dec. 1, aims to address the “growing global health challenge of obesity,” WHO wrote in a press release.

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Obesity affects more than one billion people globally and was associated with 3.7 million deaths. The number of people with obesity is expected to double by 2030.

While GLP-1 medications were added to the WHO’s Essential Medicines List for managing type 2 diabetes in high-risk groups in September 2025, the new guideline adds two key “conditional recommendations” for people with obesity.

The World Health Organization has announced its official guidance on the use of GLP-1 drugs for treating obesity. (Reuters/Denis Balibouse/File Photo)

“GLP-1 therapies may be used by adults, but excluding pregnant women, for the long-term treatment of obesity,” the first condition states.

“While the efficacy of these therapies in treating obesity and improving metabolic and other outcomes was evident, the recommendation is conditional due to limited data on their long-term efficacy and safety, maintenance and discontinuation, their current costs, inadequate health-system preparedness and potential equity implications.”

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“Our new guidance recognizes that obesity is a chronic disease that can be treated with comprehensive and lifelong care.”

The second condition allows “intensive behavioral interventions,” including healthy diets, regular physical activity and support from health professionals, to be offered to adults with obesity who are prescribed a GLP-1, as part of a “comprehensive approach.”

The price of health

In addition to the health impacts, the cost of obesity is projected to hit $3 trillion annually by 2030. The WHO’s guideline attempts to reduce “skyrocketing” health costs associated with management of the condition and other complications.

The WHO guideline emphasized the importance of fair access to GLP-1 therapies.

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“Without deliberate policies, access to these therapies could exacerbate existing health disparities,” they wrote. “WHO calls for urgent action on manufacturing, affordability and system readiness to meet global needs.”

“GLP-1 therapies may be used by adults, but excluding pregnant women, for the long-term treatment of obesity,” the first condition states. (iStock)

Despite the “rapid expansion” of GLP-1 production, the health agency revealed that by 2030, these therapies are predicted to reach less than 10% of people who could benefit from them.

“The guideline calls on the global community to consider strategies to expand access, such as pooled procurement, tiered pricing and voluntary licensing among others,” WHO stated.

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Dr. Tedros Adhanom Ghebreyesus, director-general of WHO, wrote in a statement addressing the guideline that obesity is a “major global health challenge that WHO is committed to addressing by supporting countries and people worldwide to control it, effectively and equitably.”

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“Our new guidance recognizes that obesity is a chronic disease that can be treated with comprehensive and lifelong care,” he said. “While medication alone won’t solve this global health crisis, GLP-1 therapies can help millions overcome obesity and reduce its associated harms.”

The new WHO guideline offers support for those with obesity by offering behavioral interventions like diet, exercise and access to doctors. (iStock)

The agency added that obesity is a “complex, chronic disease” that is a driver of other illnesses like cardiovascular disease, type 2 diabetes and some cancers.

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While GLP-1 therapies alone won’t solve the obesity problem, these therapies represent the “first efficacious treatment option for adults,” WHO stated.

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The organization stressed that obesity requires creating healthier environments to promote wellness and prevent obesity, protecting high-risk individuals through screening and early interventions and ensuring lifelong access to healthcare.

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Heavy drinkers cut alcohol use by nearly 30% after adopting one new habit, study finds

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Heavy drinkers cut alcohol use by nearly 30% after adopting one new habit, study finds

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Certain people who use cannabis tend to drink less alcohol, a new study found.

Researchers from Brown University’s Center for Alcohol and Addiction Studies set out to determine whether cannabis use has an effect on alcohol craving and consumption — specifically, whether smoking marijuana can reduce alcohol use in heavy drinkers.

The randomized, controlled study included 157 adults between the ages of 21 and 44 who reported heavy drinking and regular cannabis use (at least bi-weekly). 

ALCOHOL DEATHS HAVE MORE THAN DOUBLED IN RECENT YEARS, ESPECIALLY AMONG WOMEN

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Each participant completed three two-hour “lab sessions” with different types of cannabis use. They received one of two levels of THC or a placebo, and then were given the choice to drink alcohol or accept a cash payment.

Those who smoked cannabis with the higher level of THC (7.2%) consumed about 27% less alcohol than those who smoked a placebo. They also reported an immediate reduction in the urge to drink.

Those who smoked cannabis with the higher level of THC (7.2%) consumed about 27% less alcohol than those who smoked a placebo. (iStock)

Participants who smoked cannabis with 3.1% THC smoked about 19% less alcohol.

“In our controlled bar lab study, after people smoked cannabis, they drank about a quarter less alcohol over the next two hours,” lead study author Jane Metrik, Ph.D., professor of behavioral and social sciences at Brown’s Center for Alcohol and Addiction Studies, told Fox News Digital.

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Cannabis had mixed effects on alcohol cravings, the researchers reported.

“We found a significant decrease in alcohol urge immediately after smoking cannabis, but not a consistent effect on a different measure of alcohol craving,” Metrik said. “This suggests that cannabis may not exert a uniform effect on alcohol motivation, and that other mechanisms may also explain how cannabis impacts subsequent alcohol use.”

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The study, which was funded by the National Institute on Alcohol Abuse and Alcoholism, was published last month in the American Journal of Psychiatry.

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Risks and limitations

The study did have limitations, the researchers acknowledged.

“The study tested only one cannabinoid (THC) in smoked cannabis, which means the results may not generalize to the wide range of cannabis products, formulations and other cannabinoids,” Metrik told Fox News Digital. “The study sample also consisted of individuals who used cannabis nearly every day, so those who use cannabis less often may show different alcohol-related behaviors.”

THESE ARE THE TOP HEALTH RISKS OF MARIJUANA USE, ESPECIALLY SMOKING CANNABIS

The researchers also did not look at the effects of using cannabis and alcohol at the same time.

As the research was short-term and conducted in a “lab” setting, it’s unclear whether the reduced alcohol use would continue in the longer term or in real-world settings, they noted.

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“In our controlled bar lab study, after people smoked cannabis, they drank about a quarter less alcohol over the next two hours,” the lead researcher said. (iStock)

The study results do not justify recommending cannabis as a substitute for alcohol among people with alcohol-use disorder, the researchers stated, as the long-term health effects and addiction risks for cannabis remain uncertain.

“It is important to understand that cannabis’ impact varies substantially across individuals,” Mitek said, noting that while the substance may reduce drinking in the short term, it also presents its own risks.

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“Our study is a first step, and we need more long-term research before drawing conclusions for public health,” she said. “We do not have clear evidence of long-term safety and efficacy of using cannabis as alcohol treatment. For now, I would not recommend using cannabis to cut down on alcohol use.”

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For people who are already substituting cannabis for alcohol, Mitek recommends that they closely monitor their use and be aware of the risk of cannabis use disorder. She also “strongly encourages” them to consider evidence-based alcohol treatments.

Experts weigh in

Marcel Bonn-Miller, Ph.D., a cannabis researcher with Ajna BioSciences in Colorado, noted that the study highlights the current market trends, which show that alcohol sales have decreased significantly as THC has become more accessible. 

“In our controlled bar lab study, after people smoked cannabis, they drank about a quarter less alcohol over the next two hours.”

“As many consumers report using THC beverages and other non-inhaled methods of administration as alternatives to alcohol, it would be important for future clinical trials to determine the effect of these formats on alcohol use behavior over time,” the researcher, who was not involved in the study, told Fox News Digital.

Riana Durrett, director of the Cannabis Policy Institute at the University of Nevada, Las Vegas, praised the study’s “rigorous” design.

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“Overall, the experimental design is a rare feature in this area of research because it can be logistically difficult to give people cannabis in the lab (given its federal Schedule I status), so this is a really unique study,” Durrett, who was also not involved in the study, told Fox News Digital.

The results align with the “California sober” trend, where smoking cannabis may be a way to reduce other substance use, she noted.

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While some individuals have reported that cannabis has helped them recover from other substance use disorders, the effect hasn’t been tested extensively, according to Durrett.

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While the study infers cannabis use does decrease alcohol use in a single session, the long-term effects of cannabis use on alcohol consumption are unknown. (iStock)

The expert agreed that while the study infers cannabis use does decrease alcohol use in a single session, there are some unknowns, including the long-term effects of cannabis use on alcohol consumption.

“So, it is still possible that in the longer term, cannabis use may be harmful for drinking outcomes,” she said. “We also don’t know the net effect of swapping out one substance (such as alcohol) for another (such as cannabis).” 

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“It might be easy to believe that using cannabis instead of alcohol is a win, but we really don’t know if that is true or not from the current research.”

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Durrett added, “Hopefully, this study and similar ones can add tools to our toolkit on how to reduce problem drinking.”

Mitek noted that additional research is needed to evaluate “clinically relevant alcohol outcomes,” particularly among people who are seeking treatment for alcohol-use disorder.

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Men with ‘beer bellies’ may face serious heart damage regardless of weight

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Men with ‘beer bellies’ may face serious heart damage regardless of weight

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People with “beer bellies” may have an increased risk of heart damage, raising fresh concerns about the health risks tied to extra weight around the midsection.

German researchers found that men with fat deposits around the abdomen showed clear signs of early heart damage, even when their overall weight wasn’t especially high.

Scientists wanted to better understand whether abdominal fat — the kind stored deep around internal organs — is more harmful to the heart than general body fat.

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Doctors have long suspected that fat distribution, not just total pounds, plays a major role in heart disease. This study tested that idea using cardiac MRI scans.

“Abdominal obesity, a high waist-to-hip ratio, is associated with more concerning cardiac remodeling patterns than high body mass index (BMI) alone,” said study lead author Jennifer Erley, M.D., radiology resident at University Medical Center Hamburg-Eppendorf, Germany, in a press release.

Men with higher waist-to-hip ratios showed early signs of heart damage even when their overall weight wasn’t very high. (iStock)

The research team examined 2,244 adults between the ages of 46 and 78, none of whom had been diagnosed with heart disease. Each participant underwent high-resolution MRI scans that measured the size, thickness and volume of the heart’s chambers.

Researchers also collected detailed health information, including weight, blood pressure, cholesterol, smoking status and diabetes history.

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RESEARCHERS SAY BEING ‘FAT BUT FIT’ COULD BE LESS DEADLY THAN BEING UNDERWEIGHT

Instead of relying solely on BMI, which can miss where fat is stored, the team used a measurement of waist-to-hip ratio, which compares the circumference of the waist to the hips and determines how much fat sits around the abdomen. 

High ratios point to visceral fat, which is the deeper, metabolically active fat linked to inflammation and organ stress.

MEN MAY NEED TO WORK TWICE AS HARD AS WOMEN TO PREVENT POTENTIALLY DEADLY DISEASE

Men with higher waist-to-hip ratios showed a pattern of thicker heart muscles and smaller internal chamber volume. That means the heart muscle becomes bulkier but holds less blood, forcing it to work harder, according to the researchers.

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Cardiac MRI scans revealed thicker heart walls and smaller chamber volume in people with excess belly fat. (iStock)

“[Abdominal obesity] appears to lead to a potentially pathological form of cardiac remodeling,” said Erley.

Based on BMI alone, 69% of males and 56% of females in the study were overweight or obese. Using waist-to-hip ratio, however, 91% of the males and 64% of females met the criteria for obesity.

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General obesity based on BMI was more often linked to enlarged heart chambers for all participants. Abdominal obesity was associated with thickening of the heart muscle and smaller heart chamber volumes.

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Over time, those structural changes can lead to heart failure or other cardiovascular problems, the researchers warned.

“[Abdominal obesity] appears to lead to a potentially pathological form of cardiac remodeling.”

These associations remained strong even after researchers accounted for age, smoking, blood pressure and other risk factors.

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The same trend appeared in women, but the effect was significantly stronger in men. Researchers noted that men tend to store fat in the abdomen more readily than women, especially as they age, which may explain the sharper impact.

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The heart effect was strongest in men, likely due to differences in how men and women store fat. (iStock)

The findings help to clarify why some people with normal or moderately elevated BMI still develop heart disease, while others weighing more do not. It also suggests that simply stepping on a scale may not capture the full picture of heart risk.

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The study did have some limitations, primarily that it was observational in design, meaning that it identified patterns but could not prove direct causation.

Additionally, researchers did not follow participants long enough to see who eventually developed heart disease, they acknowledged. 

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And waist-to-hip ratio, while useful, is a simplified measure that doesn’t capture all variations in body composition.

The findings are being presented this week at the annual meeting of the Radiological Society of North America in Chicago.

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