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GLP-1 drugs may reach fewer than one in 10 people who need them, experts predict

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GLP-1 drugs may reach fewer than one in 10 people who need them, experts predict

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The World Health Organization (WHO) has announced its official guidance on the use of GLP-1 drugs for treating obesity.

GLP-1 drugs are medications that mimic the natural hormone glucagon-like peptide-1 (GLP-1), which are most commonly used for type 2 diabetes and medical weight loss.

The first guideline, released on Dec. 1, aims to address the “growing global health challenge of obesity,” WHO wrote in a press release.

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Obesity affects more than one billion people globally and was associated with 3.7 million deaths. The number of people with obesity is expected to double by 2030.

While GLP-1 medications were added to the WHO’s Essential Medicines List for managing type 2 diabetes in high-risk groups in September 2025, the new guideline adds two key “conditional recommendations” for people with obesity.

The World Health Organization has announced its official guidance on the use of GLP-1 drugs for treating obesity. (Reuters/Denis Balibouse/File Photo)

“GLP-1 therapies may be used by adults, but excluding pregnant women, for the long-term treatment of obesity,” the first condition states.

“While the efficacy of these therapies in treating obesity and improving metabolic and other outcomes was evident, the recommendation is conditional due to limited data on their long-term efficacy and safety, maintenance and discontinuation, their current costs, inadequate health-system preparedness and potential equity implications.”

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“Our new guidance recognizes that obesity is a chronic disease that can be treated with comprehensive and lifelong care.”

The second condition allows “intensive behavioral interventions,” including healthy diets, regular physical activity and support from health professionals, to be offered to adults with obesity who are prescribed a GLP-1, as part of a “comprehensive approach.”

The price of health

In addition to the health impacts, the cost of obesity is projected to hit $3 trillion annually by 2030. The WHO’s guideline attempts to reduce “skyrocketing” health costs associated with management of the condition and other complications.

The WHO guideline emphasized the importance of fair access to GLP-1 therapies.

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“Without deliberate policies, access to these therapies could exacerbate existing health disparities,” they wrote. “WHO calls for urgent action on manufacturing, affordability and system readiness to meet global needs.”

“GLP-1 therapies may be used by adults, but excluding pregnant women, for the long-term treatment of obesity,” the first condition states. (iStock)

Despite the “rapid expansion” of GLP-1 production, the health agency revealed that by 2030, these therapies are predicted to reach less than 10% of people who could benefit from them.

“The guideline calls on the global community to consider strategies to expand access, such as pooled procurement, tiered pricing and voluntary licensing among others,” WHO stated.

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Dr. Tedros Adhanom Ghebreyesus, director-general of WHO, wrote in a statement addressing the guideline that obesity is a “major global health challenge that WHO is committed to addressing by supporting countries and people worldwide to control it, effectively and equitably.”

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“Our new guidance recognizes that obesity is a chronic disease that can be treated with comprehensive and lifelong care,” he said. “While medication alone won’t solve this global health crisis, GLP-1 therapies can help millions overcome obesity and reduce its associated harms.”

The new WHO guideline offers support for those with obesity by offering behavioral interventions like diet, exercise and access to doctors. (iStock)

The agency added that obesity is a “complex, chronic disease” that is a driver of other illnesses like cardiovascular disease, type 2 diabetes and some cancers.

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While GLP-1 therapies alone won’t solve the obesity problem, these therapies represent the “first efficacious treatment option for adults,” WHO stated.

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The organization stressed that obesity requires creating healthier environments to promote wellness and prevent obesity, protecting high-risk individuals through screening and early interventions and ensuring lifelong access to healthcare.

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Common household chemicals linked to increased risk of serious neurological condition

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Common household chemicals linked to increased risk of serious neurological condition

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A study from Sweden’s Uppsala University discovered a link between microplastics and multiple sclerosis (MS).

The research, published in the journal Environmental International, discovered that exposure to two common environmental contaminants, PFAS and PCBs, could increase the risk of the autoimmune disease.

PFAS, or per- and polyfluoroalkyl substances, known as “forever chemicals,” are used in some common household products, such as non-stick cookware, textiles and cleaning products. They have also been found in drinking water throughout the U.S., according to the U.S. Environmental Protection Agency.

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PCBs, or polychlorinated biphenyls, are toxic industrial chemicals once widely used in electrical equipment before being banned decades ago, as stated by the National Institute of Environmental Health Sciences.

The new study findings were based on blood samples of 1,800 Swedish individuals, including about 900 who had recently been diagnosed with MS, according to a university press release.

PFAS, or per- and polyfluoroalkyl substances, known as “forever chemicals,” are used in some common household products, including non-stick cookware. (iStock)

The first phase of the trial studied 14 different PFAS contaminants and three substances that appear when PCBs are broken down in the body. These were then investigated for a link to the odds of diagnosis.

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“We saw that several individual substances, such as PFOS and two hydroxylated PCBs, were linked to increased odds for MS,” lead study author Kim Kultima said in a statement. “People with the highest concentrations of PFOS and PCBs had approximately twice the odds of being diagnosed with MS, compared to those with the lowest concentrations.”

The researchers then examined the combined effects of these substances and found that the mixture was also linked to increased risk.

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Fellow researcher Aina Vaivade noted that risk assessments should consider chemical mixtures, not just individual exposures, because people are typically exposed to multiple substances at the same time.

“We saw that several individual substances, such as PFOS and two hydroxylated PCBs, were linked to increased odds for MS,” the lead study author said. (iStock)

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The final phase of the study investigated the relationship between inheritance, chemical exposure and the odds of MS diagnosis, revealing that those who carry a certain gene variant actually have a reduced MS risk.

However, individuals who carried the gene and had higher exposure to PFOS a singular type of chemical in the PFAS family had an “unexpected” increased risk of MS.

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“This indicates that there is a complex interaction between inheritance and environmental exposure linked to the odds of MS,” Kultima said. 

“We therefore think it is important to understand how environmental contaminants interact with hereditary factors, as this can provide new knowledge about the genesis of MS and could also be relevant for other diseases.”

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Multiple sclerosis is a disease that leads to the breakdown of the protective covering of the nerves, according to Mayo Clinic. (iStock)

Fox News senior medical analyst Dr. Marc Siegel commented on these findings in an interview with Fox News Digital.

“MS is a complex disease that is somewhat autoimmune and somewhat post-inflammatory,” said Siegel, who was not involved in the study. “Epstein-Barr virus infection greatly increases the risk of MS.”

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“There is every reason to believe that environmental triggers play a role, including microplastics, and this important study shows a correlation, but not causation — in other words, it doesn’t prove that the microplastics caused MS.”

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The study had some limitations, the researchers acknowledged, including that the chemical exposure was measured only once, at the time of blood sampling. This means it may not accurately represent participants’ long-term or past exposure levels relevant to MS development.

“There is every reason to believe that environmental triggers play a role.”

Fox News Digital reached out to several industry groups and manufacturers requesting comment on the potential link between PFAS chemicals and multiple sclerosis. 

Several have issued public statements, including the American Chemistry Council, which states on its website that “manufacturers and many users of today’s PFAS are implementing a variety of practices and technologies to help minimize environmental emissions.”

In April 2024, the EPA enacted a new federal rule that sets mandatory limits on certain PFAS chemicals in drinking water, aiming to reduce exposure. The agency also aims to fund testing and treatment efforts.

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A woman working out outdoors takes a sip of water from a plastic bottle. (iStock)

Multiple sclerosis is a disease that leads to the breakdown of the protective coverings that surround nerve fibers, according to Mayo Clinic.

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The immune system’s attack on these nerve sheaths can cause numbness, weakness, trouble walking and moving, vision changes and other symptoms, and can lead to permanent damage.

There is currently no cure for MS, Mayo Clinic reports, but treatment is available to manage symptoms and modify the course of the disease.

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Natural Ozempic? 6 GLP-1 Foods That Work Just Like the Shot

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Natural Ozempic? 6 GLP-1 Foods That Work Just Like the Shot


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6 GLP-1 Foods That Boost Weight Loss Naturally—No Injections Needed | Woman’s World




















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Simple daily habit could help people with type 2 diabetes manage blood sugar

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Simple daily habit could help people with type 2 diabetes manage blood sugar

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Sitting next to a window may help people with type 2 diabetes control their insulin levels, according to new research.

The study, published in Cell Metabolism, found that exposure to natural light — even indoors next to a window — changes how the body processes glucose and uses energy.

People in Western societies spend 80% to 90% of their time under artificial lights, which are much dimmer and less dynamic than sunlight, the researchers noted. Natural daylight is a powerful cue for the body’s internal clock, also known as the circadian rhythm.

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The body’s internal clock influences many processes, including digestion, hormone release and metabolism, according to research. When it gets out of sync, it can worsen insulin resistance and blood sugar control, which are two of the main issues caused by type 2 diabetes.

Typical lighting in homes and offices is much dimmer and lacks the biological signals provided by natural daylight. (iStock)

To test the effects of daylight on blood sugar, scientists recruited 13 adults with type 2 diabetes. Each person spent two separate 4.5-day periods in a controlled office setting, according to a press release.

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In one period, they worked in front of large windows with natural daylight streaming in. In the other period, participants worked in the same room with the windows covered and were exposed only to typical indoor lighting.

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Daylight isn’t a replacement for medication or traditional management strategies like diet and exercise, the researchers noted.

Everyone ate similar meals, followed the same schedule and continued their usual diabetes medications in both conditions.

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While average blood sugar levels didn’t differ drastically between the two conditions, people spent more time in the healthy glucose range when they were exposed to natural daylight — their blood sugar fluctuated less and stayed within a desirable range for a greater portion of the day.

Participants who were exposed to daylight burned more fat and fewer carbohydrates, a metabolic pattern linked to better blood sugar regulation. (iStock)

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Exposure to natural light also affected metabolism. In daylight, participants burned more fat and fewer carbohydrates for energy.

Muscle biopsies and laboratory tests further showed that the genes responsible for the body’s cellular clocks were more synchronized under natural light conditions, the study revealed.

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Better alignment of these genes can improve nutrient processing and how cells respond to insulin, the researchers concluded.

Sitting near windows or spending more time outdoors could support diabetes management alongside standard treatments, researchers say. (iStock)

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However, daylight isn’t a replacement for medication or traditional management strategies like diet and exercise, according to the team.

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The study did have some limitations, including that the group of patients was small. The researchers cautioned that larger studies are needed to confirm these results and determine how much natural light exposure is optimal.

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“This study also highlights the often unnoticed impact of the built environment on our health, and raises further concerns about the prevalence of office environments with poor (natural) daylight access,” the researchers noted.

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