Health
Feeding peanuts to babies could prevent allergies through the teen years, study finds
Feeding peanut butter to babies — starting during infancy and continuing until age 5 — has been shown effective in reducing allergies into adolescence, according to a new study by King’s College London.
The LEAP-Trio study, published on Tuesday in NEJM Evidence, showed that children who consumed peanuts early in life were 71% less likely to develop peanut allergies all the way up to 13 years of age.
This was a follow-up to the Learning Early About Peanut Allergy (LEAP) clinical trial. The National Institute of Allergy and Infectious Diseases (NIAID) sponsored and co-funded both studies.
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In the original trial, half the participants were asked to consume peanuts regularly from infancy until age 5, while the other half were asked to avoid the food during that period.
Researchers found that early introduction of peanuts reduced the risk of peanut allergy at age 5 by 81%.
Feeding peanut butter to babies has shown to be effective in reducing allergies into adolescence, according to a new study. (iStock)
This latest trial included 508 participants from the original study, averaging 13 years of age.
The children were given peanuts in a “carefully controlled setting” to gauge any allergic reactions.
Peanut allergies were “significantly more prevalent” among the children who avoided peanuts in the first five years of life.
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“Regular, early peanut consumption reduced the risk of peanut allergy in adolescence by 71% compared to early peanut avoidance,” the study authors wrote.
This effect persisted regardless of whether the children had eaten peanuts regularly or avoided them over a period of many years.
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“The key finding of this study is that early consumption of peanut, starting early in the first year of life, confers long-term protection against peanut allergy all the way into adolescence, even without continued consumption of peanut beyond the age of five years,” lead study investigator Gideon Lack, a professor at King’s College London, told Fox News Digital.
Children who consumed peanuts early in life were 71% less likely to develop peanut allergies all the way up to 13 years of age, researchers found. (iStock)
“This is the first study to establish long-term oral tolerance as a protective strategy against peanut allergy.”
To prevent peanut allergy, young babies as early as 4 months of age should be given peanuts in the form of peanut puffs or peanut butter “regularly and frequently” — at least three times a week — over the first four to five years of life, the researchers recommended.
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“I was not entirely surprised, but nevertheless impressed by the strong protective effect of early peanut consumption preventing peanut allergy all the way into adolescence,” Lack noted.
“This indicates that lifelong tolerance may have been achieved.”
“Early introduction of infant-safe peanut foods has been proven to help prevent peanut allergies, especially but not exclusively in infants at risk for peanut allergies,” a registered dietitian told Fox News Digital. (iStock)
Sherry Coleman Collins, a food allergy dietitian in Marietta, Georgia, was not involved in the study but shared her insights on the topic.
“Early introduction of infant-safe peanut foods has been proven to help prevent peanut allergies, especially but not exclusively in infants at risk for peanut allergies,” she told Fox News Digital.
“In this study, they found that even if children who ate peanut foods in infancy stopped eating peanuts for a period of time, they were still protected against developing a peanut allergy,” Collins continued.
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This supports the idea that tolerance to foods developed in infancy can extend into adolescence, according to Collins.
“Infants who have moderate to severe eczema and/or egg allergy should discuss early introduction of peanut foods to help prevent peanut allergies because they are at highest risk,” she advised.
“Infants who have moderate to severe eczema and/or egg allergy should discuss early introduction of peanut foods to help prevent allergies.”
The study did have some limitations, Lack acknowledged.
“One weakness of the study is that it was carried out in a high-risk population of babies with severe eczema or hens egg allergy,” he told Fox News Digital.
“However, the findings of the original LEAP study have now been replicated in other lower-risk normal populations and therefore are applicable to the general population.”
These findings could likely be effective for other types of food allergies, the researchers said.
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Cases of gout are rising in younger individuals, according to a global study.
The condition, which is a type of inflammatory arthritis, steadily increased in people aged 15 to 39 between 1990 and 2021, researchers in China announced.
Although rates vary widely between countries, the total number of young people with the condition is expected to continue rising through 2035.
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The study, published in the journal Joint Bone Spine, investigated 2021 data from the Global Burden of Disease (GBD), spanning 204 countries within the 30-year timeframe.
The data measured gout prevalence, incidence and years lived with disability, tracking global trends over time. The results showed a global increase across all three outcomes.
Gout is expected to continue rising in young people through 2035. (iStock)
Prevalence and disability years increased by 66%, and incidence rose by 62%. In 2021, 15- to 39-year-olds accounted for nearly 14% of new gout cases globally, the study found.
Men from 35 to 39 years old and people in high-income regions had the highest burden, but high-income North America topped the list for highest rates.
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Men were also found to have lived more years with gout due to high BMI, while women tended to have the condition as a link to kidney dysfunction, the study noted.
The total number of cases is expected to increase globally due to population growth, but the study projected that rates per population would decrease.
The researchers noted that data quality, especially in low-income settings, could have posed a limitation to the broad GBD data.
What is gout?
Gout is a common form of arthritis involving sudden and severe attacks of pain, swelling, redness and tenderness in the joints, according to Mayo Clinic. It most often occurs in the big toe.
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The condition occurs when urate crystals accumulate in the joint. These form when there are high levels of uric acid in the blood, which the body produces when it breaks down a natural substance called purines.
A gout flare-up can happen at any time, often at night, causing the affected joint to feel hot, swollen, tender and sensitive to the touch.
Urate crystals, described as sharp and needle-like, build up in the joint, causing intense pain and swelling. (iStock)
Purines can also be found in certain foods, like red meat or organ meats like liver and some seafood, including anchovies, sardines, mussels, scallops, trout and tuna, according to the Mayo Clinic. Alcoholic drinks, especially beer, and drinks sweetened with fruit sugar can also lead to higher uric acid levels.
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Uric acid will typically dissolve in the blood and pass through the kidneys into urine, but when the body produces too much or too little uric acid, it can cause a build-up of urate crystals. These are described by the Mayo Clinic as sharp and needle-like, causing pain, inflammation and swelling in the joint or surrounding tissue.
Risk factors for gout include a diet rich in high-purine foods and being overweight, which causes the body to produce more uric acid and the kidneys to have trouble eliminating it.
Experts urge patients to seek medical attention for gout flare-ups. (iStock)
Certain conditions like untreated high blood pressure, diabetes, obesity, metabolic syndrome and heart and kidney diseases can increase the risk of gout, as well as certain medications.
A family history of gout can also increase risk. Men are more likely to develop the condition, as women tend to have lower uric acid levels, although symptoms generally develop after menopause.
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Untreated gout can cause worsening pain and joint damage, experts caution. It may also lead to more severe conditions, such as recurrent gout, advanced gout and kidney stones.
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The Mayo Clinic advises patients to seek immediate medical care if a fever occurs or if a joint becomes hot and inflamed, which is a sign of infection. Certain anti-inflammatory medications can help treat gout flares and complications.
Fox News Digital reached out to the researchers for comment.
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A new study suggests that annual mammograms may not be the only effective approach for preventing breast cancer.
The research, published in the Journal of the American Medical Association (JAMA), tested a risk-based breast cancer screening approach against standard annual mammography.
The WISDOM randomized clinical trial, led by study authors from universities and healthcare systems across the U.S., considered more than 28,000 women aged 40 to 74 years old, splitting them into a risk-based screening group and an annual mammography group.
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Researchers calculated each woman’s individual risk based on genetics (sequencing of nine breast cancer genes) and other health factors.
A new study suggests that annual mammograms may not be the only effective approach for preventing breast cancer. (iStock)
Those who were at the highest risk were advised to alternate between a mammogram and an MRI scan every six months. Patients with elevated risk were told to get an annual mammography and counseling.
Average-risk women were guided to get mammograms every two years, while low-risk individuals were advised to have no screening until they became higher risk or reached age 50.
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The researchers found that risk-based screening did not lead to more advanced cancer diagnoses (stage 2B or higher) compared with annual screening, indicating that it is just as safe as traditional methods. The risk-based approach, however, did not reduce the number of biopsies overall, as researchers had hoped.
Among the risk-based group of women, those with higher risk had more screening, biopsies and detected cancers. Women at lower risk had fewer procedures.
The research, published in the Journal of the American Medical Association (JAMA), tested a risk-based breast cancer screening approach against standard annual mammography. (iStock)
“[The] findings suggest that risk-based breast cancer screening is a safe alternative to annual screening for women aged 40 to 74 years,” the researchers noted in the research summary. “Screening intensity matched individual risk, potentially reducing unnecessary imaging.”
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Fox News medical contributor Dr. Nicole Saphier, associate professor of radiology at Memorial Sloan Kettering Cancer Center in New Jersey, commented that while these findings are important, the study “completely sidelines” what screenings are designed to do — detect cancer early.
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“If you don’t measure stage 0, stage 1 or stage 2A cancers, you can’t tell whether personalized screening delays diagnosis in a way that matters for survival and treatment intensity,” Saphier, who was not involved in the study, told Fox News Digital in an interview.
Those who were at the highest risk were advised to alternate between a mammogram and an MRI scan every six months. (iStock)
More than 60% of breast cancers in the U.S. are diagnosed at stage 1 or 2A, where cure rates exceed 90%, the doctor noted.
The trial doesn’t “fully evaluate” whether risk-based screening changes detection at the earliest and most treatable stages, where screening “delivers its greatest benefit,” according to Saphier.
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“Mammography is not without risk — radiation exposure, false positives, anxiety and potential over-diagnosis are real and should be acknowledged,” she said. “But it remains the most effective, evidence-based tool for detecting breast cancer early, when treatment is most successful.”
The expert added that labeling women under 50 as “low risk” is “outdated,” as breast cancer diagnoses are on the rise in younger females.
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“Until long-term mortality data support alternative approaches, annual screening beginning at 40 for average risk women should continue,” Saphier added. “Women should be assessed for breast cancer risk by 25 years old to determine if screening should begin earlier.”
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