Health
FDA approves opioid-free pain medication with 'no sign of addiction'

A new opioid-free pain medication was approved by the U.S. Food and Drug Administration (FDA) on Thursday, marking a non-addictive alternative for patients.
Journavx (suzetrigine), made by Vertex, is the “first and only approved non-opioid oral pain signal inhibitor,” according to a press release from the Massachusetts-based company.
The new drug is intended for treatment of moderate to severe acute pain in adults.
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Importance of a non-opioid alternative
Patients with acute pain after surgery or due to a broken bone or an injury are often prescribed opioid medications, according to Julie Pilitsis, MD, PhD, a neurosurgeon at Banner – University Medicine and chair of the Department of Neurosurgery at the University of Arizona College of Medicine in Tucson.
A new opioid-free pain medication was approved by the FDA on Thursday, marking a non-addictive alternative for patients. (iStock)
“This is the first time many patients receive opioids, and a subset of patients are known to go on to become dependent or addicted to the medications,” she told Fox News Digital.
“Patients with pain have had very few options to treat their pain with medications that don’t have addictive properties or side effects they can’t tolerate.”
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The main reason traditional pain relievers have addictive properties or intolerable side effects is that they work by modifying receptors in the brain, Pilitsis noted.
“This medication — which is a drug that inhibits sodium channels — works outside the brain on pain receptors,” she noted.
“To have a non-opioid option to prescribe in these cases is exciting — and this is the first time in nearly two decades that we have something new to offer patients for acute pain.”
‘Major unmet need’
Acute pain — sudden or urgent pain that results from injury, trauma or surgery — affects more than 80 million Americans annually and is the most common reason for emergency department visits, according to statistics.
Around half of these will be prescribed an opioid, and 10% of those will have “prolonged opioid use.”

Acute pain — sudden or urgent pain that results from injury, trauma or surgery — affects more than 80 million Americans annually and is the most common reason for emergency department visits. (iStock)
In 2023, more than five million Americans 12 and older reported a “prescription use disorder” within the past year, according to the Centers for Disease Control and Prevention (CDC).
Approximately 294,000 people died from prescription opioid overdoses between 1999 and 2022, the above source stated.
By managing acute pain effectively, suzetrigine may help prevent it from developing into chronic pain without the danger of dependency, meeting a “major unmet need,” noted Jianguo Cheng, MD, PhD, a pain management specialist at Cleveland Clinic.
“This is the first time in nearly two decades that we have something new to offer patients for acute pain.”
“Many current therapies rely on opioids, contributing to dependency and misuse,” he told Fox News Digital. “Suzetrigine’s non-opioid mechanism eliminates risks of misuse, addiction and respiratory depression, making it a safer alternative for acute pain management.”
In addition to acute pain, suzetrigine may also be a solution for neuropathic (nerve) pain, depending on the results of further studies, the doctor added.

In addition to acute pain, suzetrigine may also be a solution for neuropathic (nerve) pain, depending on the results of further studies, a doctor noted. (iStock)
Dr. Marc Siegel, clinical professor of medicine at NYU Langone Health and Fox News senior medical analyst, also applauded the approval of suzetrigine.
“It has no sign of addiction, which makes it a hugely important new tool as we fight the opioid epidemic,” he told Fox News Digital.
In clinical trials, the non-opioid medication received high patient satisfaction ratings, with 83% reporting “good” to “excellent” pain relief in real-world applications, Cheng noted.
“This drug is a big step forward and has been well-studied.”
Siegel noted that the drug has shown to decrease pain by about half, which he described as “excellent.”
“This drug is a big step forward and has been well-studied,” he added.
Access and side effects
Suzetrigine has become available for patients with acute pain, noted Pilitsis.
“It will be important to find physicians who are comfortable prescribing pain medications and to check with your insurance company to ensure that it is covered,” she advised.
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The medication is expected to fall under the Non-Opioids Prevent Addiction in the Nation (NOPAIN) Act, effective January 2025, which provides Medicare coverage for FDA-approved non-opioid pain therapies, according to Cheng.
“This policy aims to improve access and affordability, ensuring suzetrigine’s inclusion in outpatient and surgical settings while reducing reliance on opioids,” he said.

In 2023, more than five million Americans 12 and older reported a “prescription use disorder” within the past year, per the CDC. (iStock)
The most common side effects of Journavx, according to the company’s website, include itching, muscle spasms, rash, and increased levels of an enzyme called creatine phosphokinase in the blood, among others.
The drug may also cause temporary fertility challenges.
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Certain medications can increase the risk of side effects and affect the drug’s effectiveness, the company cautioned, as can food or drink containing grapefruit.
Patients should see their doctor if any side effects become bothersome or do not go away.
Fox News Digital reached out to Vertex for additional comment.

Health
Teen with ‘werewolf syndrome’ breaks world record for hairiest face

Clean beauty brand owner calls for higher safety standards
In an on-camera interview with Fox News Digital, TV personality and clean beauty brand owner Emily Austin expressed her excitement about the push for change with the MAHA movement, calling for U.S.-made products to meet EU standards.
A teenager has landed a spot in Guinness World Records for having the world’s hairiest face.
Lalit Patidar, an 18-year-old from India, was found to have 201.72 hairs per square centimeter, covering 95% of his face, according to Guinness.
The excessive hair growth is the result of a rare medical condition called hypertrichosis, informally known as “werewolf syndrome.”
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The condition can be genetic and can occur at birth, according to Healthline. There are also acquired cases that can occur as a result of other skin conditions, malnutrition, eating disorders, cancer or medication side effects.
Lalit Patidar, an 18-year-old from India, was found to have 201.72 hairs per square centimeter, covering 95% of his face. (Guinness World Records)
There have only been around 50 documented cases of the condition worldwide, according to JAMA Dermatology.
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To confirm the record, Patidar saw a trichologist (a specialist who treats hair and scalp disorders) to get an official measurement of his facial hairs.
The teen was excited to learn that he had broken the record.
“I am speechless, I don’t know what to say, because I’m very happy to get this recognition,” he said to Guinness.

The teen was excited to learn that he had broken the record. “I am speechless, I don’t know what to say, because I’m very happy to get this recognition,” he said. (Guinness World Records)
Patidar also told Guinness that children were afraid of him when he first started school.
“They were scared of me, but when they started knowing me and talking to me, they understood I was not so different from them, and it was just on the outside that I looked different, but I’m not different inside,” he said.
The teen is now embracing his uniqueness, and has started a YouTube channel that chronicles his daily life.

When people tell Patidar he should remove his facial hair, he says, “I like how I am and I don’t want to change my look.” (Guinness World Records)
When people tell Patidar he should remove his facial hair, he shares the following response.
“I tell them that I like how I am and I don’t want to change my look.”

To confirm the record, Patidar saw a trichologist to get an official measurement of his facial hairs. (Guinness World Records)
There is no cure for hypertrichosis, Healthline noted.
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Hair can be removed through short-term methods (shaving, waxing, chemical peels, etc.) or through longer-term methods (electrolysis and laser surgery).
Health
Video: What We Know About mRNA Vaccines

On the five-year anniversary of the Covid pandemic, a Times reporter, Apoorva Mandavilli, looks back at the success of, and the backlash to, the mRNA vaccine. There’s no question that this vaccine technology saved millions of lives. But the vaccine couldn’t provide total protection against transmission or infection, and there were rare cases of side effects, leading to confusion among the American public.
Health
Measles more likely to be severe among malnourished, RFK says

As measles cases continue to spread in several U.S. states, the spotlight is on prevention of the highly contagious disease.
While vaccines are widely regarded as the first line of defense, some experts have suggested that nutrition plays a role in reducing the severity of the disease.
HHS Secretary Robert F. Kennedy Jr. discussed the topic during a recent exclusive interview with Dr. Marc Siegel, clinical professor of medicine at NYU Langone Health and Fox News’ senior medical analyst.
WATCH FULL INTERVIEW WITH DR. MARC SIEGEL AND RFK JR. ON FOX NATION
“We need to understand the relationship between good health and chronic disease,” RFK Jr. told Siegel.
“If you are healthy, it’s almost impossible for you to be killed by an infectious disease, in modern times — because we have nutrition … and access to medicines. What we need is good science on all of these things so that people can make rational choices.”
As measles cases continue to spread in several U.S. states, the spotlight is on prevention of the highly contagious disease. (iStock)
During the interview, RFK noted that in Texas — where more than 200 cases of measles have been reported in the current outbreak — malnourishment may be a factor.
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“The doctors that I’m talking to on the ground, the leaders of the community, are reporting that the people who are getting sick are people who are [malnourished],” he said.
“There’s a lot of poverty in that area, [which] is kind of a food desert,” RFK added.
In 1963, prior to the vaccine’s introduction, between 400 and 500 people died from measles each year in the U.S., according to the Centers for Disease Control and Prevention (CDC).

“The doctors that I’m talking to on the ground, the leaders of the community, are reporting that the people who are getting sick are people who are [malnourished],” RFK Jr. said. (iStock)
“Almost all of them were malnourished children,” RFK said. “Measles still is a very, very lethal disease in foreign countries and developed countries where there is low malnutrition.”
He added, “The best thing Americans can do is to keep themselves healthy. It is very, very difficult for measles to kill a healthy, well-nourished person.”
“We see a correlation between people who get hurt by measles and people who don’t have good nutrition.”
Nutrition is “critical” for overall disease prevention, the HHS secretary told Siegel.
“We need to eat good foods. We need whole foods. We need to get plenty of exercise,” he said.
“We see a correlation between people who get hurt by measles and people who don’t have good nutrition or don’t have a good exercise regimen.”
Infectious disease experts weigh in
Dr. Jacob Glanville, CEO of Centivax, a San Francisco biotechnology company, agreed that measles is more likely to severely affect children in developing countries who are extremely malnourished.
“Historically, less than 1% of American children die from measles, while the Pan American Health Organization reports that as [many] as 10% of children die from measles in some developing countries, and it has been reported as high as 25% to 50% in a study of malnourished African infants,” he told Fox News Digital.

“Historically, less than 1% of American children die from measles, while the Pan American Health Organization reports that as high as 10% of children die from measles in some developing countries.” (Getty Images)
The lack of quality medical care in many areas of the developing world also contributes to disease severity, Glanville noted.
“While better nutrition is important for American children, it’s unlikely to make a difference when it comes to measles infection or severity — 90% of well-fed but unvaccinated American children exposed to measles will become infected, around 20% of those children will be hospitalized, and 0.1-1% of those children will die.”
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Dr. Trish Perl, an infectious disease expert at UT Southwestern Medical Center in Dallas, Texas, noted that malnutrition can impair some of the immune system responses to many infections — but in the case of measles, the answer is “complicated.”
“For example, malnutrition may decrease the robustness of the response to the MMR vaccine,” she told Fox News Digital.
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“The vaccine is still effective, but in some cases, an additional dose may be required.”
Studies have shown that children who are malnourished with vitamin A deficiency and living in low- and middle-income countries have more severe illness with measles infection, face an increased risk of death and blindness, and take longer to get better, Perl said.

The CDC recommends that adults and teens are up-to-date on MMR (measles, mumps and rubella) vaccinations with either one or two doses, depending on individual risk factors. (iStock)
“There is no treatment for measles beyond supportive care,” she said. “However, in low- and middle-income countries — whose mortality is greater than 1% — the World Health Organization recommends vitamin A (two doses) to reduce the severity of measles and prevent complications.”
The issue isn’t as prevalent in the U.S., where vitamin A deficiency is “extremely rare,” the doctor added.
There haven’t been formal studies into whether giving vitamin A to children with measles in the U.S. or other high-income countries prevents complications, according to Perl.
The American Academy of Pediatrics, however, recommends that hospitalized children with severe measles receive two doses of vitamin A as supervised by a healthcare provider.
Dr. Jonathan Jennings, a board-certified internist with the Medical Offices of Manhattan, also noted that multiple studies have found nutrition can “heavily impact” the clinical course of children who contract the measles virus.
“The risk of fatal outcomes is increased in children who are already malnourished prior to being infected,” he told Fox News Digital.
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“The infection has been known to worsen the nutritional status, which impacts the child’s immune system and ability to recover.”
Jennings recommends a balanced diet with a variety of colorful fruits, vegetables, protein and healthy fats as a means of preventing complications once infected with the virus.

An expert recommended a balanced diet with a variety of colorful fruits, vegetables, protein and healthy fats as a means of preventing complications once infected with the virus. (iStock)
“Vitamin A-containing foods are particularly helpful, such as carrots, spinach and dairy products,” he said.
“Many studies have identified vitamin A supplementation as a means to prevent eye damage, which is a complication of the measles infection.”
Nutrition not substitute for vaccine, experts say
While proper nutrition is important for preventing many chronic health conditions, Perl emphasized that vaccination is the “only documented method” of preventing measles infection and “is the most important action anyone can take.”
“Vaccination should be given whether an individual is malnourished or not.”
“The vaccine has been in use since 1963 and is considered extremely safe,” she said.
“Vaccination should be given whether an individual is malnourished or not, as it is the only way to prevent measles.”
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RFK also recognized the importance of vaccines, noting that the HHS is “making sure that anybody who wants the vaccine can get that vaccine.”
“The measles vaccine protects the community,” he told Dr. Siegel. “We are recommending that people in this country get vaccines … [and] we are also respectful of their personal choices.”
For more Health articles, visit www.foxnews.com/health
Jennings also reiterated the importance of vaccines.
“The most effective way to protect and prevent you and your family from getting measles is to get everyone vaccinated against the virus,” he said.
The CDC recommends that adults and teens are up-to-date on MMR (measles, mumps and rubella) vaccinations with either one or two doses, depending on individual risk factors.
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