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Fasting could reduce signs of Alzheimer’s disease, studies suggest: ‘Profound effects’

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Fasting could reduce signs of Alzheimer’s disease, studies suggest: ‘Profound effects’

It’s been proven that what people eat can help prevent or slow Alzheimer’s disease — but what about when they eat?

Participating in intermittent (time-restricted) fasting could lead to a reduced risk of cognitive deterioration, a recent study published in the journal Cell Metabolism suggests.

Researchers at University of California San Diego School of Medicine adjusted the feeding schedule of certain groups of mice so that they only ate within six-hour windows each day.

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(This would be equivalent to 14 hours of fasting for humans, the researchers noted.)

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Compared to a control group of mice that ate on demand, the fasting mice showed improvements in memory, were less hyperactive in the evenings and had fewer sleep disruptions.

Participating in intermittent (time-restricted) fasting could lead to a reduced risk of cognitive deterioration, according to a recent study published in the journal Cell Metabolism. (iStock)

They also were shown to have less buildup of amyloid proteins in the brain, which is a hallmark of Alzheimer’s disease. 

The goal of the restricted eating is to restore the circadian rhythm, the researchers said, which could help counteract the numerous disruptions that Alzheimer’s patients face when it comes to sleep and schedule-related confusion.

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“Our study emphasizes the power of feeding timing in aligning the circadian clock and its impact on the brain,” said senior study author Paula Desplats, PhD, professor in the Department of Neurosciences at UC San Diego School of Medicine, in a statement to Fox News Digital. 

“We were hopeful to see some improvements in pathology, but did not expect such profound effects in reducing plaques and inflammation and improving memory,” she went on. 

Mouse eating

Compared to a control group of mice that ate on demand, the fasting mice showed improvements in memory, were less hyperactive in the evenings and had fewer sleep disruptions. (iStock)

“The effects of time-restricted feeding on lower amyloid pathology were also measurable in blood using markers found in the clinic, which was another important finding.”

The researchers hope that these findings will lead to human trials. 

The goal is to obtain funding to start a pilot study of patients next year.

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“Accessible interventions like this have great translational potential, as they are available and are usually very well-tolerated,” Desplats said.

The goal is to obtain funding to start a pilot study of patients next year.

“This may have special importance for the elderly, as time-restricted eating does not require limitation in calories or change in the diet, but may offer important benefits ranging from metabolic and sleep regulation to potential cognitive improvement.”

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Adopting a new dietary pattern should not be a replacement for medical care, however, as Desplats emphasized the importance of patients’ discussions about options with their clinicians.

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Man with dementia

More than six million Americans of all ages have Alzheimer’s, and every 67 seconds, someone in America develops the disease, according to the Alzheimer’s Association. (iStock)

One major limitation of the study is that it uses animal models that only represent certain aspects of disease and “do not present comorbidities or other clinical diseases associated with aging, which are very common in Alzheimer’s patients,” noted Desplats. 

“Furthermore, the study was done under strictly controlled conditions that did not resemble the variety of people’s habits and environments,” she added.

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The researchers hope that the public recognizes the importance of the circadian clock in regulating many aspects of health.

“Sustaining healthy sleep and eating habits that are more synchronized with the natural environment are vital in a society that is constantly exposed to food, light and shift work,” said Desplats.

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Older couple eating

“Fasting-mimicking diets have the potential to drastically reduce many aging and disease risk factors by reducing neuroinflammation or superoxide production in the brain,” a researcher told Fox News Digital. (iStock)

Previous studies have supported this association between fasting and reduced Alzheimer’s risk.

Last year, a study led by the USC Leonard Davis School of Gerontology in Los Angeles also found that mice that followed a fasting diet showed lower levels of “plaques and tangles” in the brain, reduced brain inflammation and better performance on cognitive tests.

“Cycles of a fasting-mimicking diet (FMD) had strong effects against Alzheimer’s symptoms in two different types of Alzheimer’s mouse models,” the lead author of that study, USC biogerontologist Dr. Valter Longo, told Fox News Digital. 

“Fasting decreases pro-aging factors that are secreted after we eat, which can slow down the aging of the brain.”

“In mice, the effects of FMD cycles were very strong and wide, meaning they affected both learning and memory and also Alzheimer’s pathology peptides/proteins (amyloid and tau).”

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Based on these findings, Longo recommends that people talk to their neurologist about considering fasting-mimicking diets and other nutrition-based approaches in support of standard-of-care drugs and therapies.

“Especially for Alzheimer’s disease, for which pharmacological interventions have had very limited efficacy, it will be very important to continue to study fasting-mimicking diets and other dietary interventions that can make drugs more effective,” he added.

Food timing - fasting

“The main difference is that we tested an approach that does not require calorie reduction, which may be more sustainable and safer for older people whose metabolisms are already impacted by aging changes.” (iStock)

Desplats, lead author of the UC San Diego study, told Fox News Digital that Longo’s studies are on a similar track, demonstrating the connection between metabolism, fasting and brain health. 

“The main difference is that we tested an approach that does not require calorie reduction, which may be more sustainable and safer for older people whose metabolisms are already impacted by aging changes,” she said.

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Dr. Joseph Antoun, CEO and chairman of the nutritech company L-Nutra in California, was also involved in the USC study.

“In these studies, mice fed the fasting-mimicking diet showed improved cognitive performance, motor learning and both short- and long-term memory, and promoted the growth of new neurons in the brain,” he told Fox News Digital via email. 

“Fasting-mimicking diets have the potential to drastically reduce many aging and disease risk factors by reducing neuroinflammation or superoxide production in the brain.”

Alzheimer's brain

Mice that followed a fasting diet showed lower levels of “plaques and tangles” in the brain, which are known to be the hallmarks of Alzheimer’s disease in the human brain. (iStock)

Fasting can help the brain function in a myriad of ways, said Antoun.

“Fasting decreases pro-aging factors that are secreted after we eat, which can slow down the aging of the brain,” he told Fox News Digital in an emailed statement.

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Time-restricted eating can also improve the quality of sleep, he noted, which can help the brain recover better.

Because fasting-mimicking diets can be done in longer periods, they can help the body go into higher levels of ketosis, Antoun noted, “which is wonderful for the brain.”

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(Ketosis, which is when the body burns fat for energy instead of glucose, has been shown to have cognitive benefits.)

“Prolonged fasting can also help with leaky gut, which then can aid the brain,” added Antoun.

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In addition, intermittent fasting can help to control blood sugar, which can slow down the progression of Alzheimer’s, the doctor said.

Doctor with patient

Adopting a new dietary pattern should not be a replacement for medical care, the researchers said. (iStock)

Over the past several decades, there has been a steady increase in diagnoses of Alzheimer’s disease, Antoun noted.

“However, when we are able to detect neurodegenerative conditions early, we can take positive steps that may slow the process and mitigate any major side effects of the disorder.”

During prolonged periods of fasting, cells undergo a process called autophagy, which involves removing and recycling damaged cellular components, Antoun said. 

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“This process is essential for maintaining proper cellular function and can help protect the brain from neurodegenerative diseases such as Alzheimer’s.”

More than six million Americans of all ages have Alzheimer’s, and every 67 seconds, someone in America develops the disease, according to the Alzheimer’s Association.

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Mom’s Gripes About Sister-in-Law Put Daughter in a Bind

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Mom’s Gripes About Sister-in-Law Put Daughter in a Bind

My mother is hypercritical of my brother’s wife, to the point that she blames my sister-in-law for my brother’s “failings” (not getting a better job, not taking better care of his health, etc.). It has gotten worse now that there are grandchildren. My mother constantly criticizes how my sister-in-law is raising the kids, who are lovely and adore their grandparents.

Although my mother will occasionally raise criticisms with my sister-in-law and brother, I am mostly her audience.

I have a great relationship with my sister-in-law, and when my mother goes off on one of her rants, I defend her. I tell my mother how lucky she is to have such wonderful grandchildren, and point out that my brother is an adult who makes his own decisions. This just leads to an argument between my mother and me.

When I finally told my mother how much it hurts me to hear her say these things about my sister-in-law, she said that she needed to air her frustrations with someone. I want to be there for my mother, but I don’t like being put in this position. How do I navigate this?

From the Therapist: The short answer to your question is that you can navigate this by no longer engaging in these conversations. But I imagine you already know this. What you might be less aware of is that you aren’t being “put in this position” of supportive daughter, protective sister-in-law and unwilling confidante. You’ve chosen it, and it’s worth examining why you’ve signed up for a job you don’t want — and what makes it hard to resign.

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Usually when we find ourselves repeatedly engaging in uncomfortable family patterns, it’s because they echo familiar roles from our childhood. It sounds as if you’re struggling with enmeshment, a relationship pattern in which boundaries between family members become blurred or are nonexistent.

Think of enmeshment as being like two trees that have grown so close together that their branches have become intertwined. While this might look like closeness, it actually prevents either tree from growing in a healthy way. In your case, your mother’s emotions and grievances have become so entangled with your own emotional life that it’s hard to distinguish where her feelings end and yours begin.

You mention wanting to “be there” for your mom even though these conversations hurt you. Many adult children who struggle to say no to their parents grew up serving as their parents’ emotional support system, or absorbing their parents’ feelings, even at the expense of their own. When you told your mother how much her venting hurt you, she responded not by acknowledging your feelings, but by asserting her need to “air her frustrations.” Her response reveals something important: She sees you as a vessel for her emotional overflow rather than as someone with valid feelings of your own. And yet, despite your hurt, you’re still more concerned about her feelings than yours.

You’re asking how to navigate this situation, but I think the deeper question is: How can you begin to value your own emotional needs?

You can start by reframing what it means to make a reasonable request, which is essentially what setting a boundary is. A boundary isn’t about pushing someone away. Instead, it’s about making a bid for connection. It’s saying:I want to feel good being close to you, but when you do X, it makes me want to avoid you. Help me come closer.”

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Establishing a boundary consists of three steps:

  • State the issue and the desire to come closer (what will make this possible): “Mom, I love you and want to support you, but these conversations about my sister-in-law put me in an impossible position and make me want to avoid talking with you, which I know isn’t what either of us wants. I’m happy to talk about other things together, but in order to keep our relationship strong, I need this topic to be off limits.”

  • Set the boundary (what you will do): “If you’re struggling with their choices, I’m happy to support you in finding a therapist who can help you work through these feelings. But if you bring up these frustrations with me, I’m going to end the conversation and we can talk another time about other things.”

  • Hold the boundary (do what you say): A boundary isn’t about what the other person will or won’t do. A boundary is a contract with yourself. If you say you’ll end the conversation when your mom brings up your sister-in-law, you need to hold that boundary every single time. If you end the conversation only 90 percent of the time, then why would the other person honor your request when 10 percent of the time, you can’t honor it yourself? Honoring your request might sound like: “Mom, I’m going to end the conversation now because I’m not comfortable talking about my sister-in-law. I love you, and we’ll talk later.”

If you start to feel guilty, remember that just because someone sends you guilt doesn’t mean you have to accept delivery. Remind yourself that when you become your mother’s outlet for criticism of your sister-in-law, you’re participating in a cycle that strains loyalties and causes you personal distress. And keep in mind that being a good daughter means setting boundaries that encourage our parents to grow, rather than enabling patterns that harm our family relationships.

Want to Ask the Therapist? If you have a question, email askthetherapist@nytimes.com. By submitting a query, you agree to our reader submission terms. This column is not a substitute for professional medical advice.

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Cancer death rates decline yet new diagnoses spike for some groups, says report

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Cancer death rates decline yet new diagnoses spike for some groups, says report

A major annual cancer report has revealed a mix of good news and points of concern.

Cancer diagnoses are expected to exceed two million in 2025, with approximately 618,120 deaths predicted, according to the American Cancer Society’s annual cancer trends report, which was published today in CA: A Cancer Journal for Clinicians.

ACS researchers compiled data from central cancer registries and from the National Center for Health Statistics.

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While mortality rates have declined, certain groups are seeing a spike in diagnoses, the report noted.

Cancer diagnoses are expected to exceed two million in 2025, with approximately 618,120 deaths predicted. (iStock)

“Continued reductions in cancer mortality because of drops in smoking, better treatment and earlier detection is certainly great news,” said lead author Rebecca Siegel, senior scientific director of surveillance research at the ACS in Georgia, in a press release.

“However, this progress is tempered by rising incidences in young and middle-aged women, who are often the family caregivers, and a shifting cancer burden from men to women, harkening back to the early 1900s, when cancer was more common in women.”

Overall decline in death rates

Cancer death rates dropped 34% between 1991 and 2022, according to the ACS report.

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That equates to approximately 4.5 million deaths avoided due to early detection, reductions in smoking, and improvements in treatment, the report stated.

Cancer death rates dropped 34% between 1991 and 2022.

Several factors likely contributed to this decline, noted John D. Carpten, Ph.D., chief scientific officer at City of Hope, a national cancer research and treatment organization in California.

“I think a big one is smoking cessation and the battle against lung cancer, which has always been the most common form of cancer and is tied to tobacco use,” Carpten told Fox News Digital in an on-camera interview.

Cancer screenings

“Screening programs are a critical component of early detection, and expanding access to these services will save countless lives.” (iStock)

“But without a doubt, I think new and better methods for early detection, and screening for colorectal cancer and other forms of the disease, have also allowed us to see a decrease.” 

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Lifestyle improvements have also helped to decrease mortality, he said, along with the development of new and better therapies for cancer.

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Despite overall declines in mortality, the report revealed that death rates are rising for cancers of the oral cavity, pancreas, uterine corpus and liver (for females).

Some common cancers have also seen an increase in diagnoses, including breast (female), prostate, pancreatic, uterine corpus, melanoma (female), liver (female) and oral cancers associated with the human papillomavirus, the report stated.

Increased diagnoses among certain groups

Diagnoses for many cancer types are increasing among certain groups.

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Cancer rates for women 50 to 64 years of age have surpassed those for men, the report revealed. For women under 50, rates are 82% higher than males in that age group.

Doctor with cancer patient

The report revealed that diagnoses of colorectal cancer in men and women under 65 and cervical cancer in women between 30 and 44 years of age has increased. (iStock)

As far as what is influencing the “disconcerting trend” in women’s cancers, Carpten said it is likely “highly nuanced” and will require additional research.

“The decrease in fertility and increases in obesity that we’ve seen are risk factors for breast cancer, especially in postmenopausal middle-aged women,” he said. 

“But there could be other modifiable risk factors at play, like alcohol and physical activity.”

Cancer rates for women 50 to 64 years of age have surpassed those for men.

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Another trend in the increase in early cancers is occurring in individuals under the age of 50, Carpten noted.

In particular, the report revealed that diagnoses of colorectal cancer in men and women under 65 and cervical cancer in women between 30 and 44 years of age has increased.

Woman cancer mother

Some common cancers have also seen an increase in diagnoses, including breast (female), prostate, pancreatic, uterine corpus, melanoma (female), liver (female) and oral cancers associated with the human papillomavirus. (iStock)

The report also discusses inequities in cancer rates among certain ethnic groups, with Native American and Black people experiencing higher diagnoses of some cancer types.

“Progress against cancer continues to be hampered by striking, wide static disparities for many racial and ethnic groups,” said senior author Dr. Ahmedin Jemal, senior vice president of surveillance and health equity science at the ACS, in the release.

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The report shows mixed trends for children, with diagnoses declining in recent years for patients 14 years of age and younger, but rising for adolescents between 15 and 19.

“Mortality rates have dropped by 70% in children and by 63% in adolescents since 1970, largely because of improved treatment for leukemia,” the ACS stated in the release.

Pancreatic cancer a growing concern

The ACS report also warns about “lagging progress” against pancreatic cancer, the third-leading cause of cancer death in the U.S. 

pancreatic cancer 3D rendering

The ACS report also warns about “lagging progress” against pancreatic cancer, the third-leading cause of cancer death in the U.S.  (iStock)

Rates of diagnoses and deaths from the disease type are on the rise.

“Pancreatic is an incredibly deadly form of cancer,” Carpten said. 

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One of the main issues with pancreatic cancer, he said, is that it sometimes can grow in an individual for up to 10 years before it’s detected.

“If we can identify those cancers when they’re at at a curable stage, we can improve outcomes.”

One of the best opportunities for beating pancreatic cancer is early detection, Carpten said. 

“By the time those cancers have advanced, they’ve spread to the liver or other organs, and they’re almost impossible to cure at that stage,” he said.

      

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“If we can identify those cancers when they’re at a curable stage, we can improve outcomes.”

‘It takes a village’

Making progress in fighting cancer “takes a village,” Carpten told Fox News Digital.

“It will require partnerships between the community, the health care system, cancer researchers, government, industry — we all have to work together if we want to continue to see a decrease and an ultimate increase in cures,” he said.

young doctor researches in lab

“We all have to work together if we want to continue to see a decrease and an ultimate increase in cures,” a cancer researcher said. (iStock)

Dr. Wayne A. I. Frederick, interim chief executive officer of the American Cancer Society and the American Cancer Society Cancer Action Network (ACS CAN), stated that the report highlights the need to “increase investment in both cancer treatment and care, including equitable screening programs.”

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“Screening programs are a critical component of early detection, and expanding access to these services will save countless lives,” he said in the release.

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“We also must address these shifts in cancer incidence, mainly among women. A concerted effort between health care providers, policymakers and communities needs to be prioritized to assess where and why mortality rates are rising.”

Fox News Digital reached out to the ACS for further comment.

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FDA Moves Forward With Last-Minute Push to Cut Nicotine Levels in Cigarettes

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FDA Moves Forward With Last-Minute Push to Cut Nicotine Levels in Cigarettes

The Biden administration unveiled a proposal on Wednesday to cut the level of nicotine in cigarettes, a last-minute push on a plan that could meaningfully cut cancer rates nationwide and extend the lives of millions of cigarette smokers.

If finalized, the proposal would require cigarette makers to significantly reduce the levels of nicotine in their products in an effort to make smoking less addictive and less satisfying. Research has suggested that the move would result in fewer people taking up the habit and would help the nation’s roughly 30 million smokers quit or switch to less harmful alternatives like e-cigarettes.

The policy is a centerpiece of antismoking initiatives by Dr. Robert Califf, commissioner of the Food and Drug Administration, who has recounted treating cardiology patients ravaged by smoking during his medical career.

“It’s the biggest thing I’ve ever seen in terms of societal benefit, cost saving and lives saved, and strokes prevented and cancers prevented,” Dr. Califf said.

The policy’s companion effort to ban menthol cigarettes has been set aside indefinitely after vehement opposition from cigarette makers and other opponents, including convenience store retailers.

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Whether the nicotine reduction plan would survive the incoming administration of President-elect Donald J. Trump is unclear. Mr. Trump has traditionally been industry friendly and opposed to heavily regulating businesses. In addition, he has had the support of tobacco companies, including Reynolds American, which contributed at least $8 million to Mr. Trump’s main super PAC during the presidential campaign. Reynolds has already expressed its opposition to the proposed requirement.

Mr. Trump’s campaign co-chair and incoming chief of staff, Susie Wiles, is a former lobbyist for Swisher, a company that makes cigars. The rule applies to cigarettes, roll-your-own tobacco, pipe tobacco and cigars (though not premium cigars).

Some public health advocates are holding out hope that the Trump administration will allow the proposal to move forward, given that a previous version was considered by the F.D.A. during his first term. At minimum, officials could continue to allow the public to comment on the initiative without killing it or putting it into effect.

The F.D.A.’s proposal includes projections that by 2100, the nicotine reduction measure would prevent an estimated 48 million young people from starting to smoke. By 2060, the agency also estimates that 1.8 million tobacco-related deaths would be prevented, and that $30 trillion in benefits would accrue over 40 years, mostly from the generation that would not begin smoking.

“We do have an extremely toxic and addictive product with cigarettes that remain on the marketplace, that still kills almost a half a million people a year,” said Dorothy Hatsukami, a tobacco researcher from the University of Minnesota who has studied low-nicotine cigarettes for about 15 years. “So it’s really kind of an unfortunate situation that we haven’t really done anything dramatically about it.”

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In 2022, Dr. Califf released an updated proposal to lower nicotine levels, and opposition began to grow almost immediately.

Tobacco companies have viewed the initiative as a major threat to their business. Luis Pinto, a spokesman for Reynolds American, said the proposal would “effectively eliminate legal cigarettes and fuel an already massive illicit nicotine market.”

“These actions would also have a significant negative economic impact on farmers, retailers and others,” he added.

Convenience store retailers have also opposed earlier versions of the proposal, saying they would sustain substantial losses in revenue from a projected decline in cigarette sales.

Congressional Republicans have also tried to thwart restrictions on nicotine levels. In 2023, members of an influential House subcommittee passed a measure that would have prevented the F.D.A. from spending any money to advance limits on nicotine, with nearly all of the supporting votes by Republicans. The Senate did not include the provision in a final budget package.

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Still, supporters of the plan point to signs that incoming public health officials may be receptive to it, including to the popularity of Robert F. Kennedy Jr.’s pledge to tackle chronic diseases and improve the health of Americans if he is confirmed to lead the nation’s top health agency. Mr. Trump himself has said that he is personally opposed to cigarette smoking.

“Given these enormous benefits, we urge the incoming Trump administration to move forward in finalizing and implementing this rule,” Yolonda C. Richardson, the president of Campaign for Tobacco-Free Kids, said in a statement. “Few actions would do more to fight chronic diseases such as cancer and cardiovascular disease that greatly undermine health in the United States, and that the incoming administration has indicated should be a priority to address.”

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