Health
Combination nasal spray vaccine could protect against COVID, flu and pneumonia at once
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A single spritz could eventually offer simultaneous protection against several infectious diseases.
Researchers at Stanford Medicine have developed a new vaccine that could prevent multiple viruses at once, including COVID-19, influenza and pneumonia.
The vaccine is administered “intranasally” through a nasal spray, which provides “broad protection in the lungs for several months,” according to a Stanford Medicine press release.
Researchers claim this is the closest science has gotten to creating a universal vaccine that protects against respiratory viruses, bacteria and allergens.
The study, published in the journal Science, examined the impact of the vaccine on mice. The animals were given a drop in the nose, some receiving multiple doses a week apart.
The new universal nasal spray vaccine could protect against multiple viruses and allergens at once, researchers say. (iStock)
Every mouse was then exposed to a respiratory virus. While vaccinated mice saw protection for at least three months, unvaccinated mice experienced dramatic weight loss due to illness, lung inflammation and death. Every vaccinated mouse survived and had clear lungs, the release stated.
The vaccinated mice were also found to be protected against SARS-CoV02 and other coronaviruses, as well as Staphylococcus aureus and Acinetobacter baumannii — which are common hospital-acquired infections — and house dust mites, a common allergen.
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The universal vaccine does not target a single virus, but instead trains the immune system in the lungs to “provide broad protection against many different respiratory viruses,” senior study author Bali Pulendran, PhD, a professor of microbiology and immunology at Stanford, told Fox News Digital.
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“By reprogramming the innate immune cells that act within hours of infection, the vaccine prepares the lungs to fight off many different respiratory viruses, even new ones,” he said.
“Our findings point toward what may be possible in the future, but they are not a substitute for existing vaccines today.”
If translated to humans, a vaccine like this could replace “multiple jabs every year for seasonal respiratory infections and be on hand should a new pandemic virus emerge,” according to Pulendran.
“Imagine getting a nasal spray in the fall months that protects you from all respiratory viruses, including COVID-19, influenza, respiratory syncytial virus and the common cold, as well as bacterial pneumonia and early spring allergens,” the researcher said. “That would transform medical practice.”
The preclinical trial in mice shows promise, as none of the vaccinated mice died from illness, the researchers shared. (iStock)
The results of the study suggest that the immune system can “be trained to mount a more generalized antiviral defense in the lungs,” Pulendran added.
The researcher acknowledged that the study has some limitations.
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It is a preclinical study conducted in animal models, making it an “important proof of concept rather than a finished human vaccine,” Pulendran said.
“While the results are encouraging, additional studies are needed to determine safety, optimal dosing and effectiveness in people,” he added.
The lead researcher predicted that with the necessary funding, the nasal spray vaccine could be available in five to seven years. (iStock)
This research should not change current medical advice, according to Pulendran, and the public should continue relying on approved vaccines and public health guidance.
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“Our goal is not to replace current vaccines, but to complement them by developing strategies that could provide an added layer of protection against a wide range of respiratory threats, including future pandemics,” Pulendran added. “Translation to humans will require careful clinical testing.”
The scientists’ next step will be to test the vaccine in humans. With sufficient funding, Pulendran predicts that the vaccine could be available in five to seven years.
The public should continue relying on available vaccinations, the researchers advise. (iStock)
Dr. Robert H. Hopkins, Jr., the Arkansas-based medical director of the National Foundation for Infectious Diseases, confirmed that there has “long been interest” in developing universal vaccines.
Hopkins, who was not involved in the study, cautioned that the immune responses in mice are not identical to those in humans.
“This process is a fascinating concept, and the study is very interesting, but many additional steps need to be completed successfully and safely before this could be considered in humans,” he told Fox News Digital.
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“It will likely take many years, require significant financial investment and involve multiple additional studies before we know whether this particular universal vaccine candidate can be safely given to humans and whether it will provide similar protection against respiratory bacteria and viruses.”
The study received funding from the National Institutes of Health, the Violetta L. Horton Professor endowment, the Soffer Fund endowment and Open Philanthropy.
Health
Want to age better? Researchers say 4-minute routine may help prevent dangerous falls
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Just four minutes of daily strength exercises can dramatically improve mobility, balance and leg strength in older adults, per new research from the Penn State College of Medicine.
Standard public health guidelines recommend at least 150 minutes of moderate exercise per week. However, the study suggests that fewer than one in five older adults meet the recommended muscle-strengthening guidelines.
The research team designed a home-based program called Functional Activity Strength Training, or FAST-2. They evaluated 97 sedentary participants 65 and older, with an average age of 74.
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Before entering the study, these individuals were averaging just 18 minutes of total physical activity each week.
The older adults were randomly split into two groups, with one group performing the daily exercise routine and the other serving as a control group that received no intervention, according to the study’s press release.
Just four minutes of daily home strength training can significantly improve mobility, balance and leg strength in older adults, according to a Penn State College of Medicine study. (iStock)
Participants performed four basic movements for 30 seconds each, separated by 30-second rest intervals. The entire routine lasted exactly four minutes. The circuit consisted of push-ups, chair stands, two-arm resistance-band rows and stair stepping.
To keep the routine accessible, researchers provided written explanations and simple modifications. For example, participants could perform push-ups against a kitchen counter or wall, or use their hands on their knees for support during chair stands.
Participants were also given four elastic resistance bands and an adjustable step platform.
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“Exercise is actually really complicated, because you have to decide how many repetitions, how far, how many sets, how much rest and how many times per week,” co-author Smita Dandekar, associate professor of pediatrics at Penn State College of Medicine, said in the press release.
“It’s hard work … so if we can make it short, we’re part [of the] way there.”
The program consisted of four basic movements: push-ups, chair stands, resistance-band rows and stair stepping. (iStock)
As the participants grew stronger, they were encouraged to progress to higher levels of difficulty, such as transitioning away from modifications or increasing the height of the stepper.
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After 12 weeks, the results suggested that a tiny dose of regular exercise could yield noticeable physical benefits. In a 30-second chair-stand test, the exercise group performed an average of 4.2 more repetitions than the control group.
“These indicators … give you a sense of whether or not you’re going to be able to be active in the future.”
The adults doing the exercises also shaved 2.3 seconds off their time during a test measuring how they could stand up and sit down five times consecutively. Furthermore, they extended their one-legged balance time by an average of 3.6 seconds.
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The researchers emphasized that these specific measurements are critical medical indicators of an older adult’s future health.
By keeping the routine ultra-short, researchers eliminated common barriers like time constraints and exhaustion, resulting in an exceptionally high 81% workout completion rate. (iStock)
“These indicators predict your future ability to go into a nursing home, your future likelihood of falling and of developing difficulty walking,” noted lead author Christopher Sciamanna, professor of medicine and of public health at Penn State College of Medicine, in the press release.
“They give you a sense of whether or not you’re going to be able to be active in the future.”
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While traditional home exercise programs generally see low engagement, the participants in this study successfully completed their workouts on 81% of the tracked days, according to the researchers.
After 12 weeks, exercising seniors gained the ability to complete an average of four more chair-stand repetitions than those who did not exercise. (iStock)
The study had several noted limitations. As it tracked a relatively small sample size of fewer than 100 individuals over a brief 12-week time frame, it is unknown whether these mobility gains can be sustained long-term.
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Additionally, the researchers did not specify the exact dropout rates or detail how the routine might affect seniors who already relied on assistive devices like walkers or canes.
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Because the final trial results reflected a specific group of participants who met the entry criteria, further investigation is required to determine whether the short routine can safely benefit older adults facing more severe physical limitations or cognitive decline.
The study was published in the journal PLOS One.
Health
Popular mommy blogger dies at 48 two years after devastating cancer diagnosis
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Jill Smokler, founder of Scary Mommy, has died at age 48 after a battle with glioblastoma, an aggressive form of brain cancer.
The popular “mommy blogger” had been fighting the disease for the past two years, according to an announcement posted on ScaryMommy.com on Monday.
The stay-at-home mother of three launched the blog in 2008 as a place to share the “joys and pitfalls” of parenting, according to the article.
As Scary Mommy expanded from a personal blog into a major parenting brand, Smokler built a following with her honest, often self-deprecating take on motherhood. She went on to speak at blogging conferences, author bestselling books, appear on national television programs and earn three Webby Awards, her biography states.
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“Jill spent her life telling the truth about motherhood — that it could be wonderful and impossible in the very same breath — and in doing so, she gave millions of women permission to stop pretending and feel a little less alone,” her family shared in a statement following her passing.
Jill Smokler, founder of Scary Mommy (pictured in 2018), has died at age 48 after a battle with glioblastoma, an aggressive form of brain cancer. (Lloyd Fox/Baltimore Sun/ZUMA Press Wire / Shutterstock)
“She was funny, fearless, generous and entirely herself. More than anything she built, Jill was proudest of her three children, Lily, Ben and Evan. We are heartbroken to lose her, and endlessly proud of the mark she left on the world.”
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Smokler’s first sign of the disease was in April 2024, when she experienced a sudden seizure. She then underwent surgery to remove a brain tumor, after which she didn’t recognize her own children, she previously shared with Today.
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“I am definitely grateful that I don’t remember the looks on their faces when I didn’t recognize them,” she said. “That must have been gutting.”
Smokler was diagnosed with glioblastoma, the most common malignant primary brain tumor in adults and one of the deadliest forms of brain cancer. There is currently no cure.
About 13.9% of all brain tumors are glioblastomas, according to the American Brain Tumor Association. (iStock)
Following surgery, the blogger underwent radiation and chemotherapy, during which she was open about her treatment side effects, including fatigue and hair loss. Additional surgeries and clinical trials followed, according to previous interviews.
“Thank you, Jill, for everything. May you rest in peace,” the Scary Mommy post concluded.
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About 13.9% of all brain tumors are glioblastomas, according to the American Brain Tumor Association. More than 12,000 new cases are diagnosed in the U.S. each year.
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Median survival is approximately 12 to 18 months after diagnosis, even with treatment. Only about 5% to 7% of patients survive five years after diagnosis, data shows.
Health
8 common food preservatives linked to higher risk of high blood pressure and heart disease
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Common food preservatives may contribute to higher risks of high blood pressure and cardiovascular disease, according to a large French study.
Researchers analyzed data from 112,395 adults averaging 42 years of age, assessing their detailed dietary intake with an average follow-up of nearly eight years.
Among the participants, 5,544 developed hypertension during the follow-up period, and 2,450 experienced cardiovascular disease events.
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Higher consumption of total non-antioxidant preservatives was associated with a 29% greater risk of hypertension and a 16% higher risk of cardiovascular disease.
Higher consumption of total antioxidant preservatives was linked to a 22% spike in hypertension risk.
Common food preservatives may contribute to higher risks of high blood pressure and cardiovascular disease, according to a large French study. (iStock)
Out of the 17 preservative additives consumed by at least 10% of participants, eight in particular were associated with higher rates of hypertension, including the following.
- Potassium sorbate
- Sorbic acid
- Sodium nitrite
- Potassium nitrite
- Sodium metabisulphite
- Potassium metabisulphite
- Citric acid
- Tripotassium citrate
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Only one of the preservatives – ascorbic acid, which is the food additive form of vitamin C – was significantly associated with higher cardiovascular disease risk.
The finding does not mean that dietary vitamin C itself causes cardiovascular disease, the researchers noted. The study examined ascorbic acid in the form used as a food additive in processed foods, not vitamin C from fruits, vegetables or supplements.
Out of the 17 preservative additives consumed by at least 10% of participants, eight in particular were associated with higher rates of hypertension. (iStock)
The findings were published in the European Heart Journal.
“This is a very important study that puts together what we already know – that preservatives of all kinds raise blood pressure and contribute directly to heart disease and stroke over eight years,” Dr. Marc Siegel, Fox News senior medical analyst, told Fox News Digital.
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“Whereas potassium itself can lower blood pressure, the additive potassium sorbate has previously been found to be associated with hypertension in a large study in the European Heart Journal,” the doctor, who was not involved in the study, told Fox News Digital. “Potassium metabisulphite was also found to raise pressure in the same study.”
The same was found for sodium nitrite in the new study, Siegel noted, with 73% of participants consuming it regularly – “mostly in processed foods like hot dogs, ham, bacon and deli meats.”
“Preservatives of all kinds raise blood pressure and contribute directly to heart disease and stroke over eight years,” a doctor told Fox News Digital. (iStock)
“This has been found in previous research for many years,” he added.
Siegel also discussed the 22% increased risk linked to ascorbic acid. “I am dubious about this association, as it has not generally been found before, but perhaps the risk is when it is used as a chemical preservative.”
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“For all the sodium additives, this is expected, but surprising with extracts of rosemary and citric acid – the key to both of these ingredients is when they are used as preservatives (chemicals),” he added.
Potential limitations
As this was an observational study, it could not prove that the additives caused the health conditions.
Also, the participants who volunteered for the study were generally healthier, more educated and more often female than the general French population, the researchers noted.
As this was an observational study, it could not prove that the additives caused the health conditions. (FG Trade / Getty Images)
There was also the chance that hypertension was underdiagnosed in some participants.
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While the researchers estimated people’s dietary intake as accurately as possible, there was a chance that some consumption was inaccurately reported.
The authors emphasized that these findings need to be confirmed in further research of other populations.
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If the results are replicated in future research, some food preservatives may face additional safety reviews focused on their effects on the cardiovascular system, the researchers suggested.
“The take-home is to use natural ingredients as much as possible, and especially beware of sodium chemical preservatives when it comes to risk of heart disease and stroke from associated hypertension,” Siegel concluded.
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