Health
Breast cancer diagnoses spiking among women under 50, new report reveals
Although breast cancer deaths have been declining for decades in the U.S., diagnoses have been on the uptick among women 50 and younger.
That’s according to a new report from the American Cancer Society (ACS) — Breast Cancer Statistics, 2024.
The good news is that since 1989, breast cancer mortality has declined overall by 44% — but diagnoses of the disease have been rising by 1% each year between 2012 and 2021.
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The biggest spike was seen among women younger than 50 (1.4% per year) and Asian-American/Pacific-Islander women (up to 2.7% per year), the report revealed.
The findings were published in CA: A Cancer Journal for Clinicians.
“Although the breast cancer death rate has declined by 44% thanks to advances in early detection and treatment, the continued increase in breast cancer incidence may slow progress in the future,” lead author Angela Giaquinto, associate scientist in cancer surveillance research at the ACS, told Fox News Digital.
That is especially the case among women younger than 50, she said, whose rates are increasing by 1.4% per year compared to 0.7% per year in older women.
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Dr. William Dahut, chief scientific officer at the ACS, noted that women are “a lot less likely” to die from breast cancer, but that “alarming disparities” still remain — particularly for Asian-American, Pacific Islander, Native American and Black women.
“These gaps need to be rectified through systematic efforts to ensure access to high-quality screening and treatment for every woman,” he said in the release.
The report compiled cancer data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) program, the Centers for Disease Control and Prevention’s National Program of Cancer Registries (NPCR), and the National Center for Health Statistics.
Second only to skin cancer, breast cancer is the most prevalent cancer among women.
“The reasons for the increased prevalence of breast cancer in younger patients are complicated, multifaceted and still being studied.”
This year, approximately 310,720 women will be diagnosed with invasive breast cancer and around 42,250 will die from the disease, according to the ACS.
“The increased prevalence of breast cancer is not only an issue in the U.S. — we are seeing similar trends in other countries as well,” Dr. Christopher McGreevy, associate chief of breast surgery at Hackensack University Medical Center in New Jersey, told Fox News Digital.
Potential reasons for the younger trend
“The reasons for the increased prevalence of breast cancer in younger patients are complicated, multifaceted and still being studied,” said McGreevy, who was not involved in the report.
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One reason for early-onset breast cancer is that more patients are obese, the doctor noted.
“Excess weight, particularly after menopause, fuels estrogen production, a key driver of certain breast cancers,” he said.
Delayed childbearing can also increase the onset of the disease, McGreevy noted, as pregnancy reduces women’s breast cancer risk.
“Environmental toxins, lurking in everything from plastics to pesticides, are also suspected contributors,” he said.
“These endocrine disruptors mimic estrogen in the body, potentially triggering abnormal cell growth.”
Genetics could also factor into the uptick, according to the doctor.
“Certain gene mutations, like BRCA1 and BRCA2, significantly elevate the risk of breast cancer, even at a young age,” he said.
The rise among younger women could also be a consequence of the COVID-19 pandemic, fueled by delayed diagnoses due to interruptions in screening, according to the researchers.
Potential limitations
There were some limitations associated with the study, the researchers acknowledged.
“The risk and trends in the study are for all women and are not able to account for individual patient characteristics, such as comorbidities or treatment received, or control for social determinants of health, such as insurance status,” Giaquinto told Fox News Digital.
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“We also present statistics for the broadly defined racial and ethnic groups, which mask substantial differences within these populations.”
Prevention tips
The best means of prevention is to talk to your doctor about getting screened, according to Giaquinto.
“Early detection of breast cancer is one of the best tools we have for improving survival,” she told Fox News Digital.
“All women should keep up to date with their recommended breast cancer screenings. This is especially relevant for younger women, as the recommended age of the United States Preventive Services Task Force was recently dropped to age 40.”
Women should also be aware of their family history and personal risk factors, Giaquinto added.
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“Women can also reduce their risk of breast cancer by moderating alcohol consumption if they drink, maintaining a healthy body weight and being physically active,” the researcher advised.
“About 30% of all breast cancers are attributed to these lifestyle factors.”
Health
How Kathy Bates Lost 100 Lbs—Plus Her Tips for Sustainable Weight Loss
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Health
California fires and mental health toll: Celebrities and therapists offer tips
As Los Angeles battles the worst wildfires in the city’s history, thousands of people have been displaced or have seen their homes burn to the ground.
Around 130,000 people were ordered to evacuate and some 10,000 structures were destroyed, according to the Associated Press. At least 10 people have died as a result of the blazes.
The devastation of the fires has undoubtedly taken a grave toll on the psyches of those affected, experts agree.
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Fox News Digital spoke with celebrities and mental health experts, who offered the following guidance for the people impacted.
Recognize your feelings
For those who have experienced a loss from the fires, common reactions include shock, disbelief and confusion, according to David Kessler, a grief counselor in Los Angeles and founder of Grief.com.
“I call it grief brain,” he told Fox News Digital.
“Your mind is trying to comprehend what happened, and it’s a hard thing for it to do, because this is unimaginable that your house, your safety, is suddenly gone.”
Not all grief is related to death, Kessler noted, as there are many different types of losses.
“I always say grief is a change you didn’t want — and certainly a fire is a change we didn’t want,” he added.
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It’s important to “self-validate” the reality of the loss, he said.
“People might give you toxic positivity of, ‘well, at least no one died,’” he said. “And while that’s true, the reality is you still have lost your home. Don’t let anyone minimize that.”
“The loss of a home is devastating and it can take years to recover.”
“I think we’re going to deal with a lot of depression after this, a lot of sadness.”
Actor Steve Guttenberg, who lives in Pacific Palisades, California, where fires erupted on Tuesday, shared how the disaster has impacted his own mental health.
“I’ve seen so much tragedy the last three or four days that I’ve got to be careful to … keep a hold of my mind,” he said in an interview with Fox News Digital.
“And I think that we’re going to deal with a lot of depression after this, a lot of sadness. And it’s going to be really tough because this is like nothing you’ve ever seen.”
Gutenberg noted that while it’s “very normal” to be down, he is trying not to let himself “go down that hole.”
“But I’m pretty sad about this,” he added.
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Jonathan Alpert, a psychotherapist in Manhattan and Washington, D.C., noted that the grief following the Los Angeles fires is “profound.”
“It’s not just about the physical loss of homes or belongings — it’s also about the sense of safety and normalcy that has been lost,” he told Fox News Digital.
“It’s important for people to feel emotions and not ignore them. This is a normal reaction to such overwhelming loss and tragedy.”
Reach out for support
Guttenberg emphasized the importance of maintaining connections with others and drawing support from the community during a disaster of this magnitude.
“We’re social animals — we need people,” he said. “So I’m reaching out to my friends. There’s no way to meet right now because it’s so dangerous — so the best thing you cn do … is call and reach out and maybe you can drive somewhere.”
Most of the people in town have evacuated, he pointed out. “There’s probably 10% of the population left here. Or less.”
Kessler reiterated that connection is critical after this type of trauma. “We need to be taken care of. We need other people around us. People equal safety,” he said.
“We need other people around us. People equal safety.”
Pastor Jesse Bradley of Grace Community Church outside Seattle, Washington, agreed that it’s essential to avoid isolating yourself after a loss.
“We need God and we need each other. Community is vital,” he told Fox News Digital.
“Family, friends and neighbors care about you. God sends His love through these people. Reject isolation. Don’t shut down and don’t shut people out.”
Take action
“In times of crisis such as this, regaining even small amounts of control can be grounding,” Alpert said.
He recommends creating a plan for what’s next, whether it’s finding temporary housing, accessing local resources or starting the process of rebuilding.
“Taking action — no matter how small — can help you move forward.”
Kessler agreed, noting that people who are in the area but did not experience loss may feel a sense of relief mixed with guilt.
“If you do have survivor’s guilt, I always say the best thing is to take action,” he advised.
In the longer term, advocacy efforts can be a powerful tool in dealing with trauma, Alpert noted.
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“Working to improve fire prevention policies, supporting relief efforts or helping neighbors rebuild can provide a sense of purpose and empowerment during this difficult time,” he said.
Some people may be angry about the systems that failed to prevent the fires in the first place, Alpert acknowledged, and this anger can be a “powerful motivator.”
“Taking action — no matter how small — can help you move forward.”
“Use that energy to demand better, but don’t get stuck on the anger,” he advised.
“By holding leaders accountable for the policies — or lack thereof — that contributed to this devastation, and by asking the right questions and demanding answers, you might start to feel better.”
Seek professional help as needed
“The L.A. fires no doubt will not just leave physical scars, but deep emotional ones, too,” Alpert said.
“For many people, the fear, panic and helplessness experienced during the fires don’t just disappear — they linger, creating flashbacks, anxiety and difficulty functioning.”
In many cases, this can lead to post-traumatic stress disorder (PTSD). Symptoms of this condition can include vivid memories of the fires, nightmares, hypervigilance or avoidance of anything that reminds someone of the event, Alpert said.
“It’s important to see this not as weakness, but rather, the mind’s and body’s way of trying to cope with extreme stress.”
“While the fires were devastating, they don’t diminish your strength or character.”
As you seek help, it’s also important to understand that PTSD doesn’t define you, he added.
“It’s a part of your experience, not your identity. While the fires were devastating, they didn’t diminish your strength or character.”
Lean on your faith
For those who have experienced traumatic grief, Kessler emphasized the importance of faith and spirituality.
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“They help ground us in a world full of fear,” he said. “And when we’ve lost everything, it can feel like our faith is the one thing we have to hold onto.”
During a time of crisis, Guttenberg said it’s important to “rely on anything that you believe in.”
“If you believe in your mom and dad, you rely on them, your brothers and sisters, your friends, your family. God, the universe.”
Above all, he added, “Just remember, you’re not alone. God is always with you. Jesus is always with you. You’ve got to hang on to that.”
Find ways to exercise gratitude
During times of hardship, it’s important to recognize the good things that are still in your life, Pastor Bradley said.
“It’s easy to be consumed with what you no longer have,” he told Fox News Digital.
For more Health articles, visit www.foxnews.com/health
“You need to be intentional to take inventory of the blessings in your life. For example, you might lose a home or business, but you still have family.”
This mindset will help you keep a healthy perspective and protect gratitude, Bradley added.
Health
Scientists May Be Able to Make Grapefruits Compatible With Medications They Currently Interfere With
You may be among the millions of people who have seen a surprisingly specific warning like this on the labels of drugs you take:
Avoid eating grapefruit or drinking grapefruit juice while using this medication.
Such warnings are issued for dozens of substances, including docetaxel, a cancer drug; erythromycin, an antibiotic; and some statins, the cholesterol-lowering drugs prescribed to more than a third of American adults over 40.
The problem is a set of molecules, furanocoumarins. High levels of furanocoumarins interfere with human liver enzymes, among other processes. In their presence, medications can build up to unhealthy levels in the body. And grapefruits and some related citrus fruits are full of them.
But there is no such warning for other kinds of citrus, such as mandarins and other oranges. Citrus researchers at the Volcani Center in Israel reported Wednesday in the journal The New Phytologist that, by crossing mandarins and grapefruit, they’ve uncovered genes that produce furanocoumarins in some citrus fruits. It’s a finding that opens the possibility of creating grapefruit that doesn’t require a warning label.
Scientists had worked out the compounds’ structures and pieced together a basic flowchart of how they are made years ago, said Yoram Eyal, a professor at the Volcani Center. But the precise identities of enzymes catalyzing the process — the proteins that snip off a branch here, or add a piece there — remained mysterious. He and his colleagues knew that one way to identify them was to breed citrus high in furanocoumarins with those without. If the offspring of such a cross had varying levels of the substances, it should be possible, by digging into their genetics, to pinpoint the genes for the proteins.
“We were afraid to approach it, because it’s very time-consuming and it takes many years,” he said, noting how involved it can be to grow new trees from seeds and assess their genetics. “But finally, we decided we have to dive in.”
When they examined the offspring of a mandarin and a grapefruit, the researchers saw something remarkable. Fifty percent of the young plants had high levels of furanocourmains, and 50 percent had none. That particular signature meant something very specific, in terms of how the ability to make these substances is inherited.
“We saw there was only one gene that could have controlled it,” said Livnat Goldenberg, a Volcani Center researcher who is the lead author of the new study.
The researchers soon identified the gene controlling the production of furanocoumarins in leaves and fruit, which produces an enzyme called 2-oxoglutarate-dependent dioxygenase, or 2OGD for short. Mandarins, it turns out, have a mutated form of this gene that keeps the enzyme from functioning properly. This version cropped up in all the mandarin and orange varieties the researchers checked, explaining why they do not cause the same problems as grapefruit in people taking prescription medications. In these plants, furanocoumarin production is paused.
With gene editing technology, it should be possible to alter the gene in grapefruit as well, Dr. Eyal suggests. The team at the Volcani Center is now exploring that project.
Looking at how widespread this mutated version is in mandarins and some other citrus, the scientists speculate that some gene nearby on the genome must play an important role in a highly prized trait. A long-ago citrus breeder, selecting for some unknown quality, must have unwittingly spread this furanocoumarin-busting version of the gene to an ancestor of modern varieties of mandarins and oranges.
All these years later, that person’s work is coming to light, under the gaze of geneticists, who may, someday, put grapefruit back on the menu.
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