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Brain aging may accelerate after cancer treatment, study suggests

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Brain aging may accelerate after cancer treatment, study suggests

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Surviving cancer as a child or young adult may have a lasting impact on aging, new research suggests.

Researchers at the University of Rochester Medical Center looked at whether life-saving treatments, like chemotherapy and radiation, could speed up biological aging.

They also aimed to determine whether this age acceleration was linked to cognitive issues related to memory, focus and learning.

The team analyzed blood samples from a group of 1,400 long-term survivors treated at St. Jude Children’s Research Hospital, using epigenetic clocks — tools that estimate biological age by examining chemical tags on DNA.

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Biological age is determined based on damage the cells accumulate over time, versus chronological age, which is measured by how long someone has been alive, according to scientists.

Biological age is determined based on the damage cells accumulate over time, according to scientists. (iStock)

“These well-established aging-related biomarkers have previously been associated with neurocognitive impairment and decline in older non-cancer populations, particularly in cognitive domains related to aging and dementia, such as memory, attention and executive function,” the study stated.

Most of the group consisted of acute lymphoblastic leukemia survivors, or Hodgkin lymphoma survivors. Participants were at least five years past their treatment, though some had survived for several decades.

They underwent neurocognitive testing to measure their attention span, memory and information processing speed.

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Chemotherapy was found to have the greatest impact on aging acceleration. The study suggests the treatment can alter DNA structure and cause cellular damage.

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“It’s no surprise to find out that young people with cancer who have chemo early in life are affected in terms of long-term aging,” Dr. Marc Siegel, senior medical analyst for Fox News, told Fox News Digital.

Participants underwent neurocognitive testing to measure their attention span, memory and speed of information processing. (iStock)

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Researchers also found that cellular aging was closely linked to cognitive performance, as survivors of a higher biological age had more difficulty with memory and attention.

“Chemo poisons and damages cellular function — hopefully the cancer cells more than normal cells, but there is a significant impact on normal cells as well,” said Siegel, who was not involved in the study.

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“There is also something called ‘chemo brain,’ which causes at least temporary difficulty with memory, concentration, word finding and brain fog,” the doctor added.

The research team hopes to use these findings to focus on intervention efforts, specifically by determining when accelerated aging begins.

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“Young cancer survivors have many more decades of life to live,” lead study author AnnaLynn Williams, PhD, said in a press release. “If these accelerated aging changes are occurring early on and setting them on a different trajectory, the goal is to intervene to not only increase their lifespan, but improve their quality of life.”

The team hopes this research will help in the development of early intervention tools that aim to prevent cognitive decline. (iStock)

There were some limitations to the study. The researchers could not adjust for chronic health conditions or education because they are directly impacted by treatment.

Additionally, the study only looked at the survivors at a single point of time, so it could not directly prove causation.

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The study was published in the journal Nature Communications.

Fox News Digital reached out to the researchers for comment.

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Contrave Helped Her Lose 61 Pounds—‘I Stopped Thinking About Food’


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‘No contact’ on the rise: Nearly 2 in 5 Americans cut ties with loved ones

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‘No contact’ on the rise: Nearly 2 in 5 Americans cut ties with loved ones

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More Americans are choosing to walk away from difficult relationships instead of working through them, a new survey has revealed.

Nearly two in five Americans — 38% — say they have gone “no contact” with a friend or family member in the past year, according to a survey of 2,000 adults conducted in March by Talker Research for the therapy platform Talkspace.

“These results suggest that avoiding relationship challenges is becoming more common,” Dr. Nikole Benders-Hadi, chief medical officer at Talkspace, said in a statement. 

“But that approach can come with its own risks, making it harder to sustain meaningful connections over time and leading to more loneliness.”

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Younger Americans were far more likely than older generations to report cutting someone off. The survey found that 60% of Gen Z respondents had gone “no contact,” compared to 50% of millennials, 38% of Gen X and 20% of baby boomers.

A new survey found that about 38% of Americans have gone “no contact” with a friend or family member in the past year. (iStock)

John Puls, a Florida-based psychotherapist and adjunct professor at Florida Atlantic University, said he has seen a growing trend of young adults, including Gen Zers, going no contact with their parents in his practice.

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“This generation appears to have a low tolerance for otherwise poor behavior from their parents,” Puls, who was not involved in the study, told Fox News Digital. “They are often conflict-avoidant, which prevents them from trying to meaningfully work through their issues with their parents.”

Their parents, meanwhile, are often unwilling to examine their role in any of the conflict within the relationship, Puls added. 

“This creates a situation where neither party is willing to compromise or take ownership.”

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Thirty-six percent of overall respondents said the top reason for severing ties with someone was feeling disrespected. Nearly 30% said the relationship negatively affected their mental health or that the other person was too negative.

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Younger Americans are more likely than older generations to cut off contact with loved ones, according to the survey. (iStock)

The cutoffs often appear to last. Among those who said they went “no contact” in the past year, 59% said they are still not speaking to the person, according to the survey.

The findings also suggest that “no contact” may be part of a wider retreat from uncomfortable interactions. Nearly three-quarters of respondents, 73%, said their instinct during relationship problems is to distance themselves rather than communicate and work through the issue.

Other behaviors in the poll point in the same direction. More than a third of respondents said they had blocked a friend or family member on social media in the past year, while 30% said they had removed a loved one from a group chat.

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The trend may reflect a broader shift toward avoiding uncomfortable conversations instead of resolving relationship issues. (iStock)

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While the study was sponsored by a therapy platform and has not undergone peer review, experts have previously told Fox News Digital that “cutoff culture” is becoming normalized, with some arguing that media messaging, including from figures like Oprah Winfrey and the Beckhams, has helped drive the trend.

Many experts agree the tactic should be used only as a last resort.

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Puls stressed that no case of going zero contact with a family member or friend is the same, and while it is necessary in rare situations, it often comes with long-term regret and resentment. 

“I always recommend my patients try ongoing family therapy, compromise and implementing boundaries,” he said.

Experts recommend trying family therapy, setting boundaries and working toward compromise before resorting to cutting off contact. (iStock)

Nari Jeter, a Florida-based licensed marriage and family therapist, agreed. 

“Some people think that once you go no-contact, you’ll immediately feel peace. That’s usually not the case,” she said.

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“This is often a heart-wrenching and even agonizing process,” Jeter, who was not involved in the research, added.

But the move doesn’t have to be forever, she noted: “No contact can become fertile ground for future reconciliation.”

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This common habit could be quietly hurting men’s fertility, experts warn

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This common habit could be quietly hurting men’s fertility, experts warn

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As the Trump administration moves to loosen federal restrictions on drugs — including a new step to ease regulations on state-licensed medical marijuana — questions are growing about cannabis use and its broader health effects.

Among them is a lesser discussed concern: men’s fertility.

During National Infertility Awareness Week, experts are drawing attention to the potential negative impact of both recreational and medical cannabis on male reproductive health.

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Cannabis use has been associated with changes in reproductive health for both males and females, though human evidence remains mixed.

“This is especially disheartening when men and women are actively trying to conceive and start a family,” Dr. Alta DeRoo, chief medical officer of the Hazelden Betty Ford Foundation in Minnesota, told Fox News Digital.

As the Trump administration moves to loosen federal restrictions on drugs, questions are growing about cannabis use and its broader health effects. (AP Photo/Martin Meissner, File)

A 2025 Harvard-linked study involving women undergoing fertility treatment revealed twice as many miscarriages among those using cannabis compared to non-users.

It’s a common misconception, however, that fertility issues are always due to an issue with the woman. Male infertility is more common than many think, according to Stephanie Seminar, MD, chief of the Reproductive Endocrine Unit at Massachusetts General Hospital, a founding member of Mass General Brigham in Boston, Massachusetts.

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“Many individuals think infertility is a woman’s problem, [but] male infertility is common and under-evaluated,” Seminar told Fox News Digital.

Out of the 10% to 15% of couples worldwide who experience infertility, male factors cause or contribute to approximately 45% of those cases, data shows.

Cannabis use, particularly when heavy and chronic, can have negative effects on male fertility, a doctor cautioned.  (iStock)

Having normal sexual drive and performance does not mean that a man has normal fertility, Seminar noted.

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An evaluation of male infertility goes beyond semen analysis, examining factors like sexual dysfunction, toxin exposure, tobacco/cannabis use, childhood illnesses and past testosterone use, according to medical experts.

How cannabis may affect male fertility

Cannabis use, particularly when heavy and chronic, can have negative effects on male fertility, Seminar cautioned. Those can include changes in reproductive hormones and semen parameters, including decreased sperm counts or mobility.

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Cannabis can also impact sperm quality, the doctor said. “The sperm count or volume can be lower, and those sperm produced may be malformed and unable to swim effectively,” the doctor said.

Research supports this decline – a 2019 review published in The Journal of Urology found associations between cannabis use, especially the smoked form, and reduced semen quality.

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“Many individuals think infertility is a woman’s problem, [but] male infertility is common and under-evaluated.”

Another study of 1,215 healthy young Danish men, published in the American Journal of Epidemiology, found that smoking cannabis more than once per week was associated with a 28% lower sperm concentration and 29% lower total sperm count.

Combining marijuana with other recreational drugs more than once a week reduced sperm concentration and count even higher – by 52% and 55%, respectively.

Disruption of reproductive hormones

The human body produces its own natural endocannabinoids to regulate vital functions like fertility, as described in a Nature Reviews Urology analysis.

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Cannabis mimics these molecules with its two main compounds: cannabidiol (CBD) and THC (tetrahydrocannabinol), which interact directly with the body’s endocannabinoid system. 

Cannabis may interfere with the brain’s regulation of reproductive hormones, experts say. (iStock)

While THC can relieve pain or stimulate appetite, it also triggers the “high” that often leads to adverse side effects, like anxiety or paranoia, which have been widely documented in cannabinoid research.

When cannabis is consumed, external cannabinoids enter the body and bind to the same receptors as natural endocannabinoids, which may impair sperm quality and reproductive function, according to previous studies.

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Cannabis may interfere with the brain’s regulation of reproductive hormones, with some research suggesting it can alter levels of FSH (follicle-stimulating hormone) and LH (luteinizing hormone), which signal the testes to support sperm production.

This hormonal suppression could contribute to fertility challenges in some cases, though researchers noted that human evidence remains mixed and continues to be studied.

Potentially reversible

Men planning to conceive should stop using cannabis, experts recommend, as it can significantly impair sperm quality, with higher usage correlating to worse outcomes.

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Any negative effects may be reversible, as fertility can be improved when couples stop cannabis use, DeRoo noted.

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Experts recommend discontinuing cannabis use at least three months prior to conceiving to allow the body to generate a full cycle of healthy sperm.

Men planning to conceive should stop using cannabis, experts recommend, as it can significantly impair sperm quality. (iStock)

The American Society for Reproductive Medicine also encourages couples trying to conceive to avoid recreational drugs to maximize their chances of a healthy birth.

“Stopping the use of cannabis improves other areas of health in a person’s life, and conception or pregnancy can be a strong motivator for abstinence,” DeRoo added.

Cannabis use in the US

In 2021, nearly one in five Americans (52.5 million people) used cannabis, making it the most common federally illegal drug in the country, per CDC data.

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Statistics show that about 30% of users may develop cannabis use disorder at some point, which adversely impacts their daily activities.

Recreational cannabis is legal in roughly half of U.S. states, while medical marijuana is legal in a large majority (well over 30 states), according to the CDC. A small number of states still prohibit most forms of cannabis use.

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