Health
People taking common sleep drug may not realize they’re too impaired to drive, study finds
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A popular antipsychotic medication was found to reduce obstructive sleep apnea (OSA) – but it also led to impaired driving the next morning.
That’s according to a small randomized controlled trial published in the Annals of the American Thoracic Society.
Researchers from Flinders University in Adelaide, Australia, conducted the study in 15 adults with OSA who also had difficulty maintaining sleep. Each participant underwent two overnight sleep studies approximately one week apart, according to a press release.
Researchers from Flinders University in Adelaide, Australia, conducted the study in 15 adults with OSA who also had difficulty maintaining sleep. Each participant underwent two overnight sleep studies approximately one week apart. (iStock)
The participants took 50mg of quetiapine (Seroquel) before bed one night, and took a placebo the following night.
Quetiapine is a widely prescribed antipsychotic that is prescribed for schizophrenia, bipolar disorder and depression. It is also often used off-label at lower doses to treat insomnia, anxiety and other sleep issues.
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The researchers monitored the participants throughout the night, looking at their breathing, brain activity, oxygen levels and leg movements.
A female driver yawns while sitting behind the wheel, illustrating the concept of falling asleep at the wheel. (iStock)
The participants who took the quetiapine had more than 40 minutes more total sleep time and 45% less wakefulness during the night, the study found. Their apnea-related events also reduced from 27 to 20 events per hour.
Despite these improvements, the drug appeared to slow reaction time behind the wheel compared to those taking a placebo. This was based on a driving simulator test and a 10-minute reaction time test, administered within 30 minutes of waking up.
SLEEP APNEA MAY BE QUIETLY CHANGING YOUR BODY IN AN UNEXPECTED WAY, STUDY FINDS
Those taking quetiapine experienced more than triple the number of attention lapses and swerved out of their lane more often in the driving simulator.
Eleven out of 15 of the participants reported feeling sleepier the morning after taking the medication, but roughly one in four people did not recognize their level of impairment. This was concerning because they may be more likely to operate a vehicle or machinery without realizing their reaction time had slowed.
Other mild to moderate side effects included nausea, restless legs and a sudden blood pressure drop upon standing. (iStock)
Other mild to moderate side effects included nausea, restless legs and a sudden blood pressure drop upon standing, which affected one in three people taking quetiapine.
The study did have some limitations, including the small sample size, the authors noted. The participants were only evaluated for one night, and the study’s laboratory setting may not reflect the participants’ real-world use.
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Larger, longer-term studies are needed to confirm the findings before making decisions about prescribing quetiapine for sleep apnea and insomnia, the researchers said.
Pending follow-up studies, the researchers recommend that people avoid driving or other safety-critical tasks for at least 9.5 hours after taking quetiapine.
Women generally metabolize these drugs more slowly than men, which can influence both efficacy and the risk of next-day side effects, an expert said. (iStock)
Ashley Curtis, PhD, director of the Cognition, Aging, Sleep and Health (CASH) Lab at the University of South Florida, noted that certain hypnotic medications exhibit sex differences in metabolism.
Women generally metabolize these drugs more slowly than men, which can influence both efficacy and the risk of next-day side effects, warned the expert, who was not involved in the study.
“Future studies should carefully examine whether these newer agents demonstrate similar sex-specific patterns to ensure optimal dosing and safety recommendations,” she told Fox News Digital.
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The impact of quetiapine on next-day cognitive function warrants further investigation, particularly among older adults, according to Curtis.
“This population is already vulnerable to cognitive and related side effects related to polypharmacy, making it essential to understand the potential trade-offs between sleep benefits and daytime functioning,” she added.
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Insomnia is often the result of “learned behavioral and cognitive factors” that persist over time, according to Curtis.
“Even when medications are effective in the short term, behavioral interventions such as cognitive behavioral therapy for insomnia remain an important component of long-term management,” she said.
“This population is already vulnerable to cognitive and related side effects related to polypharmacy.”
Chelsie Rohrscheib, head sleep expert at Wesper, a sleep analysis company in New York, agreed that patients shouldn’t be alarmed by these findings.
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“But if they’re taking quetiapine for sleep, especially if they have sleep apnea or wake up feeling groggy, they should talk with their doctor about whether the benefits outweigh the risks and whether other treatment options might be appropriate,” noted Rohrscheib, who was not affiliated with the research.
Fox News Digital reached out to the drug manufacturer and to the study researchers for comment.
Health
Former reality star opens up about new diagnosis after years-long health ordeal
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A former “Real Housewives of Beverly Hills” star is speaking out about a fresh wave of health issues.
Brandi Glanville, 53, has been speaking publicly about ongoing swelling, lumps and paralysis of her face since 2023.
At the time, the reality star shared that she believed she had been infected with a parasite during a trip to Morocco, Fox News Digital previously reported.
BRANDI GLANVILLE SPENDING ‘ALL OF MY MONEY’ LOOKING FOR ANSWERS TO MYSTERY ILLNESS THAT LEFT HER DISFIGURED
After the initial diagnosis, she suspected she contracted a parasite in Morocco and said she could feel it moving within her face.
Brandi Glanville attends the grand opening of Beverly Hills Rejuvenation Clinic West Hollywood in West Hollywood, Calif., on April 25, 2024. (Paul Archuleta/Getty Images)
Glanville was first diagnosed with stress-induced angioedema, a sudden swelling of the deeper layers of the skin and mucous membranes, according to Cleveland Clinic.
Angioedema “is a reaction similar to hives that affects deeper layers of the skin. It can appear with hives or alone,” Mayo Clinic states.
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Most recently, in a June 18 episode of her podcast “Brandi Glanville Unfiltered,” Glanville revealed that doctors discovered a “benign tumor” in one of her facial lymph nodes.
The reality star, who has previously speculated that a parasite may be contributing to her facial symptoms, said the finding could help explain the swelling and fluid buildup she has experienced and noted that she has had a lump in her face for “years.”
Brandi Glanville, 53, has been speaking publicly about ongoing swelling, lumps and paralysis of her face since 2023. (Mega/GC Images)
“I don’t know what’s wrong with me, guys. I thought I was fixed, and then it happened again and now it’s sinking in again,” Glanville said in another June podcast.
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“It could be why the fluid is going around my face and why I’m having a hard time,” she added.
While benign tumors of the face have been known to arise from fat tissue, blood vessels, skin structures, salivary glands or lymphatic tissue, Glanville has not publicly disclosed the specific type of diagnosis she received.
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Prior to learning of the tumor, Glanville said she saw dozens of doctors and spent over $100,000 trying to pinpoint the source of the issue.
Brandi Glanville shares images of painful facial burns caused by Nair hair removal cream in a viral TikTok video. (Brandi Glanville/TikTok)
The reality star emphasized that the tumor is “not cancerous.”
“I haven’t had a face lift yet!” she added.
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Glanville also said she suspected her ruptured breast implants could have played a role in her health issues, claiming the leaking silicone had clogged her lymph nodes.
Fox News Digital reached out to Glanville for comment.
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Health
One common type of fat may increase diabetes risk, while another helps fight it
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A new review suggests that the type of fat you eat may affect your risk of developing type 2 diabetes.
Saturated fats rich in palmitic acid – the most common saturated fatty acid in U.S. foods – appear to make it harder for the body to respond to insulin.
Meanwhile, monounsaturated fats rich in oleic acid — such as those found in olive oil — may help protect against insulin resistance, the review concluded.
ONE TYPE OF OLIVE OIL HAS A SURPRISING EFFECT ON BRAINPOWER DURING AGING
“Palmitic acid is found in meats, dairy products, cocoa butter and in the form of palm oil in foods, including margarine, cereal, sweets, baked goods and fast foods,” Tanya Freirich, a registered dietitian nutritionist in Charlotte, North Carolina, told Fox News Digital. She was not involved in the review.
“Oleic acid, on the other hand, is in higher concentration in foods like olive oil, canola oil, nuts, sunflower seeds, eggs, olive, avocados and also in meats (beef, chicken, pork), milk, cheese and pasta.”
Saturated fats rich in palmitic acid – the most common saturated fatty acid in U.S. foods – appear to make it harder for the body to respond to insulin. (iStock)
The review, which was published in the journal Trends in Endocrinology & Metabolism, was led by researchers from the University of Barcelona and the CIBER Area for Diabetes and Associated Metabolic Diseases (CIBERDEM) in Spain.
The findings suggest that fat quality may be more important than total fat quantity when it comes to metabolic health and diabetes risk.
DIABETES RISK LINKED TO THESE ULTRAPROCESSED FOOD COMBINATIONS
This appears to support the idea that diets rich in monounsaturated fats, such as the Mediterranean diet, may contribute to lower rates of type 2 diabetes.
“Palmitic acid promotes several molecular processes that impair insulin action,” study investigator Dr. Manuel Vázquez-Carrera, from the Department of Pharmacology, Toxicology and Therapeutic Chemistry at the University of Barcelona, told Fox News Digital.
“Palmitic acid is found in meats, dairy products, cocoa butter and in the form of palm oil in foods, including margarine, cereal, sweets, baked goods and fast foods,” a nutritionist said. (iStock)
Too much palmitic acid can cause harmful fat byproducts to build up in the body, which can impair the body’s ability to respond to insulin, he warned. This makes it harder to control blood sugar and increases the risk of insulin resistance and type 2 diabetes.
“It also promotes inflammation, oxidative stress, mitochondrial dysfunction and cellular stress responses, which contribute to insulin resistance and β-cell dysfunction,” Vázquez-Carrera added.
VITAMIN SUPPLEMENT MAY DELAY DIABETES IN SELECT GROUPS, RESEARCHERS SAY
By contrast, oleic acid – a hallmark of the Mediterranean diet – does not have these harmful effects, according to the researcher.
“In fact, oleic acid can counteract many of the detrimental effects triggered by palmitic acid, by promoting the storage of fatty acids in relatively inert triglycerides, preserving mitochondrial function and reducing inflammation,” he said.
“All sources of fat in our diet contain a mix of saturated and unsaturated fatty acids.”
Freirich confirmed that the review is consistent with previous research supporting the use of olive oil in the diet for metabolic benefits.
“Also confirming previous research, the consumption of saturated fats is associated with some negative metabolic changes,” she told Fox News Digital.
THE WORST FOODS TO BUY IN THE SUPERMARKET AND THE BETTER CHOICES INSTEAD
Given the complexity of foods and diets, there is an overlap between foods that contain both types of fatty acids, the nutritionist noted.
“Palmitic acid and oleic acid can both be found in olive oil, baked goods and fast foods, in differing amounts,” she said. “All sources of fat in our diet contain a mix of saturated and unsaturated fatty acids.”
Study limitations
Vázquez-Carrera noted that these findings come from a review of numerous experimental, clinical and epidemiological studies rather than a single clinical trial.
“One important limitation is that much of the mechanistic evidence comes from cell culture and animal studies,” he said.
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“Although these studies provide valuable insights into how specific fatty acids affect insulin signaling, further human intervention studies are needed to confirm the extent to which these mechanisms operate in everyday dietary settings.”
In addition, many of the human studies in the review relied on self-reported dietary intake, which can introduce inaccuracies.
Type 2 diabetes develops over many years, with genetics, lifestyle and environmental factors all playing a role, the researcher noted. (iStock)
“Another challenge is that people consume foods containing complex mixtures of fatty acids and bioactive compounds rather than isolated fatty acids,” Vázquez-Carrera added. “Therefore, it remains difficult to fully disentangle the specific contribution of individual fatty acids in free-living populations.”
Nutritional recommendations
The review’s findings appear to support current dietary recommendations that emphasize replacing part of the saturated fat intake with unsaturated fats, according to Vázquez-Carrera.
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“This means favoring dietary patterns rich in foods such as extra-virgin olive oil, nuts, seeds, legumes, vegetables, fruits and fish, while limiting excessive consumption of foods rich in saturated fats, especially highly processed foods,” he advised.
The review does not suggest that a single nutrient alone determines diabetes risk, the researcher pointed out.
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“Rather, maintaining a healthy body weight, engaging in regular physical activity and following an overall healthy dietary pattern, such as the Mediterranean diet, remain fundamental strategies for preventing insulin resistance and type 2 diabetes.”
Type 2 diabetes develops over many years, with genetics, lifestyle and environmental factors all playing a role, Vázquez-Carrera noted.
Improving the quality of dietary fat intake could prove to be an effective strategy for reducing type 2 diabetes risk, the review suggests. (iStock)
“Future research should move beyond simply classifying fats as ‘good’ or ‘bad’ and instead focus on understanding how specific fatty acids, their dietary sources and their interactions within whole dietary patterns affect metabolic health,” he said.
Improving the quality of dietary fat intake could prove to be an effective strategy for reducing type 2 diabetes risk, according to the researcher.
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“A simple takeaway for consumers is to swap out foods high in saturated fat more often with foods rich in heart-healthy fats, like olive oil, nuts and avocados, to better support blood sugar and metabolic health,” advised New Jersey-based registered dietitian Erin Palinski-Wade, who was also not involved in the review.
Anyone at a higher risk for type 2 diabetes should consult a healthcare provider for personalized guidance on nutrition, exercise and other preventive measures, experts say.
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