Health
'Body clock' could determine biological age and longevity, researchers say
Researchers have developed a new “body clock” tool that calculates people’s biological age — and could even predict the risk of disability or death.
The tool, which comes from the University of Washington (UW) School of Medicine, uses eight different metrics from a patient’s physical exam and bloodwork to determine the results, according to a press release from UW.
The tool’s method — officially named the Health Octo Tool — is detailed in the journal Nature Communication in a May 5 publication.
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The researchers see this method as more comprehensive than current health assessments, which typically focus on individual diseases rather than overall wellness, according to the report’s first author, Dr. Shabnam Salimi, a physician-scientist and acting instructor in the Department of Anesthesiology & Pain Medicine at UW.
Researchers have developed a new “body clock” tool that calculates people’s biological age — and could even predict the risk of disability or death. (iStock)
Using data from large longevity studies, the Health Octo Tool was found to predict disability, geriatric syndrome (a group of common health conditions in older adults), Short Physical Performance Battery (a clinical tool that assesses lower extremity function in older adults) and mortality with 90% accuracy or greater, the study reported.
“An aging-based framework offers a new path to discover biomarkers and therapeutics that target organ-specific or whole-body aging, rather than individual diseases,” Salimi said in the release.
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The tool focuses on “health entropy,” which encompasses the amount of molecular and cellular damage the body has sustained over time.
That has a direct impact on the function of a person’s organs and overall body systems, which can be used to determine how fast they are aging, the researchers noted.
“Aging is a truly analog and non-digital process.”
The tool starts by assigning a “body organ disease number,” ranging from 1 to 14, based on whether the patient has experienced any diseases affecting the heart, lungs, brain or other specific organ systems.
“Our findings demonstrated that organ systems age at different rates, prompting us to develop a Bodily System-Specific Age metric to reflect the aging rate of each organ system and the Bodily-Specific Clock to represent each organ system’s intrinsic biological age,” Salimi said.
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“Extending this concept to the whole body, we define the Body Clock as a composite measure of overall intrinsic age and body age as the corresponding rate of aging.”
Two of the components of the tool, Speed-Body Clock and Speed-Body Age, measure how biological age affects walking speed.
“An aging-based framework offers a new path to discover biomarkers and therapeutics that target organ-specific or whole-body aging, rather than individual diseases,” said the lead researcher. (iStock)
The Disability-Body Clock and Disability-Body Age components measure aging’s impact on cognitive function and physical disability, the release stated.
One takeaway from the research was that some seemingly minor conditions, such as untreated hypertension early in life, could have a significant impact on aging in later years, according to Salimi. This indicates that treating these conditions sooner could slow down biological aging.
Looking ahead, the researchers plan to develop a digital app that people can use to track their own biological age, track how fast they are aging, and measure the impact of lifestyle changes.
“Whether someone is adopting a new diet, exercise routine or taking longevity-targeting drugs, they will be able to visualize how their body — and each organ system — is responding,” said Salimi.
“Aging is not a linear or wholly quantifiable process — it is influenced by myriad known and unknown genetic, molecular, environmental and psychosocial factors,” one doctor said. (iStock)
Dr. Brett Osborn, a Florida neurosurgeon who also runs a longevity practice, was not involved in the tool’s development, but commented on its potential benefits and limitations.
“This tool distinguishes itself by basing its model on readily accessible physical exam findings and standard lab tests, offering a potentially practical framework for clinical application,” he told Fox News Digital.
“An app is also being developed to empower patients and potentially encourage the development of health habits that will positively impact their healthspan — or how long they will remain functional and disease-free.”
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The doctor also praised the Octo Tool’s focus on system-based aging metrics rather than disease-specific assessments.
Osborn noted, however, that there are limitations to these types of proposed biological aging clocks — primarily that they can’t counter the “inherent complexity of aging.”
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“Aging is not a linear or wholly quantifiable process — it is influenced by myriad known and unknown genetic, molecular, environmental and psychosocial factors,” the doctor said.
“It is a truly ‘analog’ and ‘non–digital’ process. Therefore, it should be no surprise that no model has captured its entire landscape.”
The most important thing, according to one expert, is to use comprehensive testing and tracking as a springboard to the formation of lifelong health habits. (iStock)
UW’s tool doesn’t take into account certain genetic and DNA processes that influence biological aging, Osborn noted.
“Aging clocks have also often fallen short when applied across diverse populations or when predicting individual outcomes (lifespan),” he added.
“If it saves one person’s life by bringing their ailing health to their attention, that’s a win.”
Rather than determining absolute biological age, Osborn suggests using these tools to track trends over time.
“For example, tools like the Health Octo can help evaluate an individual’s response to interventions — be it a new exercise regimen, medication or lifestyle change.”
The most important thing, according to Osborn, is to use comprehensive testing and tracking as a springboard to the formation of lifelong health habits.
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“If it saves one person’s life by bringing their ailing health (manifested as a downward trend) to their attention, that’s a win,” he said.
The research was supported by a National Institutes of Health grant from the U.S. National Institute on Aging.
Health
Detransitioner Chloe Cole shares complications after gender procedures: ‘I am grieving’
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Washington, DC – Medical victim Chloe Cole was at the center of the U.S. Department of Health and Human Services’ Thursday announcement of proposed regulatory actions to end “sex-rejecting procedures” on minors.
The proposed regulatory actions by the HHS are part of President Donald Trump‘s January executive order calling on the department to protect children from “chemical and surgical mutilation.”
The department is rolling out a series of policy updates and regulatory actions that would effectively defund hospitals that provide gender transition procedures, according to an HHS official.
NUMBER OF YOUNG ADULTS IDENTIFYING AS TRANSGENDER PLUNGES BY NEARLY HALF IN TWO YEARS
Cole, now 21 years old, went through the process of medical transition from female to male between the ages of 12 and 16.
The California native took to the stage alongside HHS Secretary Robert F. Kennedy Jr. and other officials Thursday to advocate for the protection of children. Afterward, she told Fox News Digital the puberty blockers, testosterone injections and double mastectomy she endured have irreversibly and permanently affected her health.
Detransitioner Chloe Cole joined HHS Secretary Robert F. Kennedy Jr. on Thursday as he announced proposed regulations ending gender treatments for children. (Fox News Digital)
“As soon as gender was in the picture, none of my doctors or psychologists asked the real questions that they should have,” said Cole. “The entire focus was on my feelings and what I wanted rather than what I really needed in that moment.”
What she needed, Cole said, was to be loved and affirmed for the way God created her — “as a young and yet tomboyish little girl.”
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She maintained that her doctors neglected to share risks, only touting the “benefits” of stopping female puberty and using testosterone to promote body hair growth, musculature and different fat distribution.
“There was nothing they could say to me that would make me understand the gravity of what I was about to go through, because I was still growing up,” said Cole. “I had very little experience in the world, and I simply would not be mature enough to be equipped to undergo such a life-changing procedure in every way.”
“I had very little experience in the world, and I simply would not be mature enough to be equipped to undergo such a life-changing procedure in every way,” Cole, pictured above in both pictures, told Fox News Digital. (Chloe Cole; Fox News Digital)
Cole noted that her parents never thought she was transgender, but felt like the odds were stacked against them.
“At the time when we started going through this as a family, there really were no resources that would speak to the reality of transgenderism, especially for children,” she said. “Most people were not aware then that this was something that was even happening in our hospital systems.”
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Cole said her parents were warned that if they did not allow her to transition, she would likely commit suicide.
“My legal guardians were forced to make this decision under duress,” she shared in a previous statement. “But even if my parents had supported transitioning medically from the start, no parent or any adult, ultimately, has a right to determine whether a child gets to be chemically sterilized or mutilated.”
“While there are only two sexes, there’s a million different ways that you can be yourself,” said Cole, pictured above during her surgeries. (Chloe Cole)
Cole said she’s suffered numerous complications from her medications and surgery. “My quality of life is still being impacted to this day,” she wrote in her statement.
Her fertility status now remains unknown, she said. She will not be able to breastfeed because her breasts were surgically removed.
“As an adult, I am now grieving, and on top of that, the areolar skin grafts they used in my surgery began to fail two years afterward. I must wear bandages on my chest every day,” Cole wrote.
“As an adult, I am now grieving.”
In 2023, Cole filed a lawsuit with the Center for American Liberty (CAL) against hospitals for pushing her into what she believes is medical mutilation.
Mark Trammell of CAL told Fox News Digital that Thursday’s HHS announcement “represents a critical acknowledgment that experimental medical interventions on children with gender distress have failed to meet basic standards of safety and effectiveness.”
Cole, who detransitioned after medical procedures, is warning others to wait and seek family support before transitioning. (Fox News Digital)
“It signals that medicine must return to its core ethical obligation: First, do no harm,” Trammell added.
“We will continue fighting to ensure accountability for the institutions that promoted these practices and to secure justice for the children and detransitioners whose lives were forever altered.”
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In a previous statement provided to Fox News Digital, Dr. Marc Siegel, Fox News senior medical analyst, said he is in favor of a “more conservative approach” for minors.
“Long-term effects of puberty blockers may include bone loss, trouble concentrating, interference with learning and interference with fertility,” he said. “I think it makes sense in most cases to treat underlying mental health concerns before jumping into treatments, including surgery, that may be difficult to reverse.”
“It makes sense in most cases to treat underlying mental health concerns before jumping into treatments.”
The doctor also emphasized that gender issues should not be overly politicized. “This means not superimposing an ideology or pushing physicians to act in a certain way or under pressure,” Siegel said.
Cole began the gender transition process at age 12 and received a double mastectomy surgery at 15 years old. (Fox News Digital)
“The welfare of the child must come first. In this case, it means going very slowly and providing support to a child or teen with gender dysphoria.”
Cole shared that she hopes any children who are questioning whether they should transition wait.
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“While there are only two sexes, there are a million different ways that you can be yourself,” she added.
“God is there for you. He is the one who has created you this way, and you can seek his counsel,” Cole went on.
“You can continue praying, and I think ultimately it’s connecting with your family, building your purpose in this world, and looking to the gospel and up to God.”
Fox News Digital’s Emma Colton contributed reporting.
Health
Simple lifestyle changes could slash heart attack risk for millions, scientists report
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Those at risk of type 2 diabetes may be able to prevent heart problems later.
A new study published in The Lancet Diabetes & Endocrinology discovered that lowering the blood sugar of those with prediabetes could reduce the risk of heart attack by half.
Diabetes researchers and endocrine experts across Europe, China and the U.S. investigated how bringing blood sugar back to normal levels affected the chances of heart problems later in life, based on a 20-year American study and a 30-year Chinese study, according to a press release.
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In both studies, the prediabetic participants were coached to make appropriate lifestyle changes to lower blood sugar (the amount of glucose in the bloodstream) through diet and exercise, also targeting weight loss.
Participants worked to lower blood sugar through diet and exercise targeted at weight loss. (iStock)
The researchers split the participants into a remission group (where blood sugar returned to normal) and a non-remission group, which included those still in the prediabetes range. They then determined who in these groups had died from heart disease or were hospitalized for heart failure.
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Participants who went into remission had a 58% lower risk of dying from heart disease and being hospitalized for heart failure. This group also had a lower risk of other major heart events and lower overall death rates.
These heart-protective benefits lasted for decades after the program ended, the researchers found.
Those in prediabetes remission had their risk of a heart event reduced by more than half. (iStock)
“Reaching prediabetes remission is linked to a decades-long benefit, halving the risk of cardiovascular death or hospitalization for heart failure in diverse populations,” the researchers commented in the publication of the study. “Targeting remission might represent a new approach to cardiovascular prevention.”
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In an interview with Fox News Digital, Dr. Andreas Birkenfeld, study co-author and professor of medicine at the University Hospital Tübingen in Germany, reiterated that reaching prediabetes remission is not only relevant for reducing the progression of type 2 diabetes, but may also be associated with a “meaningful reduction in… heart attack risk, cardiac death and heart failure.”
“Importantly, this underscores that prediabetes is a modifiable stage where timely, evidence-based interventions (especially lifestyle measures, and in selected cases, medication) can make a real difference,” he added.
“Reaching prediabetes remission is linked to a decades-long benefit, halving the risk of cardiovascular death or hospitalization for heart failure in diverse populations,” the researchers commented. (iStock)
The study did have some limitations, including that it is based on analysis of trials not originally designed to measure cardiovascular outcomes, which means the results show association but cannot prove causation.
In addition, unmeasured lifestyle and health factors, population differences and lack of randomization for heart outcomes may have influenced the reduced cardiovascular risk, the researchers acknowledged.
“This underscores that prediabetes is a modifiable stage where timely, evidence-based interventions … can make a real difference.”
Birkenfeld suggested that those with prediabetes should ask their doctors the following questions: “What is my current status? What is my personal cardiovascular risk? What is my target blood glucose level?”
Patients should also inquire about the frequency of testing for blood sugar and key risk factors like blood pressure, cholesterol and other related conditions, such as kidney function or sleep apnea, he advised.
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“If lifestyle changes aren’t enough or my risk is high, would medication be appropriate for me — and what are the benefits and downsides?” the researcher asked as an example.
About 98 million American adults, more than one in three, have prediabetes, according to CDC data. Eight in 10 of these adults are unaware that they have the disease.
Health
New Weight Loss Drug Beats Ozempic and Eases Joint Pain With ‘Insane’ Results, Doctors Say
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