Health
'Body clock' could determine biological age and longevity, researchers say
Researchers have developed a new “body clock” tool that calculates people’s biological age — and could even predict the risk of disability or death.
The tool, which comes from the University of Washington (UW) School of Medicine, uses eight different metrics from a patient’s physical exam and bloodwork to determine the results, according to a press release from UW.
The tool’s method — officially named the Health Octo Tool — is detailed in the journal Nature Communication in a May 5 publication.
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The researchers see this method as more comprehensive than current health assessments, which typically focus on individual diseases rather than overall wellness, according to the report’s first author, Dr. Shabnam Salimi, a physician-scientist and acting instructor in the Department of Anesthesiology & Pain Medicine at UW.
Researchers have developed a new “body clock” tool that calculates people’s biological age — and could even predict the risk of disability or death. (iStock)
Using data from large longevity studies, the Health Octo Tool was found to predict disability, geriatric syndrome (a group of common health conditions in older adults), Short Physical Performance Battery (a clinical tool that assesses lower extremity function in older adults) and mortality with 90% accuracy or greater, the study reported.
“An aging-based framework offers a new path to discover biomarkers and therapeutics that target organ-specific or whole-body aging, rather than individual diseases,” Salimi said in the release.
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The tool focuses on “health entropy,” which encompasses the amount of molecular and cellular damage the body has sustained over time.
That has a direct impact on the function of a person’s organs and overall body systems, which can be used to determine how fast they are aging, the researchers noted.
“Aging is a truly analog and non-digital process.”
The tool starts by assigning a “body organ disease number,” ranging from 1 to 14, based on whether the patient has experienced any diseases affecting the heart, lungs, brain or other specific organ systems.
“Our findings demonstrated that organ systems age at different rates, prompting us to develop a Bodily System-Specific Age metric to reflect the aging rate of each organ system and the Bodily-Specific Clock to represent each organ system’s intrinsic biological age,” Salimi said.
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“Extending this concept to the whole body, we define the Body Clock as a composite measure of overall intrinsic age and body age as the corresponding rate of aging.”
Two of the components of the tool, Speed-Body Clock and Speed-Body Age, measure how biological age affects walking speed.
“An aging-based framework offers a new path to discover biomarkers and therapeutics that target organ-specific or whole-body aging, rather than individual diseases,” said the lead researcher. (iStock)
The Disability-Body Clock and Disability-Body Age components measure aging’s impact on cognitive function and physical disability, the release stated.
One takeaway from the research was that some seemingly minor conditions, such as untreated hypertension early in life, could have a significant impact on aging in later years, according to Salimi. This indicates that treating these conditions sooner could slow down biological aging.
Looking ahead, the researchers plan to develop a digital app that people can use to track their own biological age, track how fast they are aging, and measure the impact of lifestyle changes.
“Whether someone is adopting a new diet, exercise routine or taking longevity-targeting drugs, they will be able to visualize how their body — and each organ system — is responding,” said Salimi.
“Aging is not a linear or wholly quantifiable process — it is influenced by myriad known and unknown genetic, molecular, environmental and psychosocial factors,” one doctor said. (iStock)
Dr. Brett Osborn, a Florida neurosurgeon who also runs a longevity practice, was not involved in the tool’s development, but commented on its potential benefits and limitations.
“This tool distinguishes itself by basing its model on readily accessible physical exam findings and standard lab tests, offering a potentially practical framework for clinical application,” he told Fox News Digital.
“An app is also being developed to empower patients and potentially encourage the development of health habits that will positively impact their healthspan — or how long they will remain functional and disease-free.”
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The doctor also praised the Octo Tool’s focus on system-based aging metrics rather than disease-specific assessments.
Osborn noted, however, that there are limitations to these types of proposed biological aging clocks — primarily that they can’t counter the “inherent complexity of aging.”
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“Aging is not a linear or wholly quantifiable process — it is influenced by myriad known and unknown genetic, molecular, environmental and psychosocial factors,” the doctor said.
“It is a truly ‘analog’ and ‘non–digital’ process. Therefore, it should be no surprise that no model has captured its entire landscape.”
The most important thing, according to one expert, is to use comprehensive testing and tracking as a springboard to the formation of lifelong health habits. (iStock)
UW’s tool doesn’t take into account certain genetic and DNA processes that influence biological aging, Osborn noted.
“Aging clocks have also often fallen short when applied across diverse populations or when predicting individual outcomes (lifespan),” he added.
“If it saves one person’s life by bringing their ailing health to their attention, that’s a win.”
Rather than determining absolute biological age, Osborn suggests using these tools to track trends over time.
“For example, tools like the Health Octo can help evaluate an individual’s response to interventions — be it a new exercise regimen, medication or lifestyle change.”
The most important thing, according to Osborn, is to use comprehensive testing and tracking as a springboard to the formation of lifelong health habits.
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“If it saves one person’s life by bringing their ailing health (manifested as a downward trend) to their attention, that’s a win,” he said.
The research was supported by a National Institutes of Health grant from the U.S. National Institute on Aging.
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More than 59% of women may have high blood pressure by 2050, according to a new report from the American Heart Association.
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Health
Heart disease threat projected to climb sharply for key demographic
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A new report by the American Heart Association (AHA) included some troubling predictions for the future of women’s health.
The forecast, published in the journal Circulation on Wednesday, projected increases in various comorbidities in American females by 2050.
More than 59% of women were predicted to have high blood pressure, up from less than 49% currently.
The review also projected that more than 25% of women will have diabetes, compared to about 15% today, and more than 61% will have obesity, compared to 44% currently.
As a result of these risk factors, the prevalence of cardiovascular disease and stroke is expected to rise to 14.4% from 10.7%.
The prevalence of cardiovascular disease and stroke in women is expected to rise to 14.4% from 10.7% by 2050. (iStock)
Not all trends were negative, as unhealthy cholesterol prevalence is expected to drop to about 22% from more than 42% today, the report stated.
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Dr. Elizabeth Klodas, a cardiologist and founder of Step One Foods in Minnesota, commented on these “jarring findings.”
“The fact that on our current trajectory, cardiometabolic disease is projected to explode in women within one generation should be a huge wake-up call,” she told Fox News Digital.
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“Hypertension, diabetes, obesity — these are all major risk factors for heart disease, and we are already seeing what those risks are driving. Heart disease is the No. 1 killer of women, eclipsing all other causes of death, including breast cancer.”
Cardiovascular disease is the leading cause of death for women in the U.S. and around the world. (iStock)
Klodas warned that heart disease starts early, progresses “stealthily,” and can present “out of the blue in devastating ways.”
The AHA published another study on Thursday revealing one million hospitalizations, showing that heart attack deaths are climbing among adults below the age of 55.
The more alarming finding, according to Klodas, is that young women were found more likely to die after their first heart attack than men of the same age.
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“This is all especially tragic since heart disease is almost entirely preventable,” she said. “The earlier you start, the better.”
Children can show early evidence of plaque deposition in their arteries, which can be reversed through lifestyle changes if “undertaken early enough and aggressively enough,” according to the expert.
Moving more is one part of protecting a healthy heart, according to experts. (iStock)
Klodas suggested that rising heart conditions are associated with traditional risk factors, like smoking, high blood pressure, high cholesterol, diabetes, obesity and a sedentary lifestyle.
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Doctors are also seeing higher rates of preeclampsia, or high blood pressure during pregnancy, as well as gestational diabetes. Klodas noted that these are sex-specific risk factors that don’t typically contribute to complications until after menopause.
The best way to protect a healthy heart is to “do the basics,” Klodas recommended, including the following lifestyle habits.
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Klodas especially emphasized making improvements to diet, as the food people eat affects “every single risk factor that the AHA’s report highlights.”
“High blood pressure, high blood sugar, high cholesterol, excess weight – these are all conditions that are driven in part or in whole by food,” she said. “We eat multiple times every single day, which means what we eat has profound cumulative effects over time.”
“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health,” a doctor said. (iStock)
“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health.”
The doctor also recommends changing out a few snacks per day for healthier choices, which has been proven to “yield medication-level cholesterol reductions” in a month.
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“Keep up that small change and, over the course of a year, you could also lose 20 pounds and reduce your sodium intake enough to avoid blood pressure-lowering medications,” Klodas added.
“Women should not view the AHA report as inevitable. We have power over our health destinies. We just need to use it.”
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