Health
Blood test could predict when Alzheimer’s symptoms will start years in advance
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A simple blood test could predict not only a person’s risk of developing Alzheimer’s disease, but also the year symptoms will begin.
Researchers at the Washington University School of Medicine in St. Louis set out to determine if levels of a specific protein in the blood could be used as a “biological clock” to predict when signs of the disease will emerge.
The specific protein, known as p-tau217, forms “tangles” in the brain that disrupt communication between nerve cells. In a healthy brain, tau helps to stabilize the structure of nerve cells.
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In some cases, brain scans can be used to detect these tangles when diagnosing Alzheimer’s. Preliminary studies have suggested that the same method could be used to determine a progression timeline.
As these imaging tests are often complex and expensive, the research team wanted to explore whether a blood test could monitor the same proteins and produce similar results.
By comparing blood samples with participants’ cognitive performance over several years, the team found that p-tau217 levels rise in a “remarkably consistent” pattern long before memory loss begins. (iStock)
The study, published in the journal Nature Medicine, analyzed data from more than 600 older adults enrolled in two long-term Alzheimer’s research projects.
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By comparing blood samples with participants’ cognitive performance over several years, the team found that p-tau217 levels rise in a “remarkably consistent” pattern long before memory loss begins, according to a press release.
The team then created a model that uses a patient’s age and protein levels to estimate when symptoms will appear, with a margin of error of three to four years.
The team created a model that uses a patient’s age and protein levels to estimate when symptoms will appear, with a margin of error of three to four years. (iStock)
“We show that a single blood test measuring p-tau217 can provide a rough estimate of when an individual is likely to develop symptoms of Alzheimer’s disease,” lead author Kellen K. Petersen, PhD, instructor of neurology at Washington University in St. Louis, told Fox News Digital.
The researchers found that older adults developed symptoms much more rapidly after p-tau217 became abnormal, he noted.
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“For example, people who first had abnormal p-tau217 levels around age 60 didn’t develop Alzheimer’s symptoms for about 20 years, whereas those who first had abnormal p-tau217 levels around age 80 developed symptoms after only about 10 years,” Petersen said.
This suggests that age and disease-related changes in the brain can influence how quickly Alzheimer’s symptoms become apparent, the researcher concluded.
“At this point, we do not recommend that any cognitively unimpaired individuals have any Alzheimer’s disease biomarker test.”
“This could transform how researchers design clinical trials and, eventually, how clinicians identify people at highest risk for cognitive decline associated with Alzheimer’s years before decline begins,” Chicago-based Rebecca M. Edelmayer, PhD, vice president of scientific engagement at the Alzheimer’s Association, told Fox News Digital.
“A blood test is generally much less expensive and easier to administer than a brain scan or spinal‑fluid test. In the future, it could help doctors and researchers identify people who may benefit from early treatments,” added Edelmayer, who was not involved in the study.
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The study did have some limitations and caveats.
“We were only able to make predictions for individuals whose p-tau217 levels fell within a certain range, although it was a fairly wide range,” Petersen shared. “The models were developed in relatively healthy and well-educated research cohorts that were not diverse, so the results may not apply well to the broader population.”
The research suggests that age and disease-related changes in the brain can influence how quickly Alzheimer’s symptoms become apparent. (iStock)
While the researchers referenced in-home blood tests in this study, they cautioned against people seeking out and taking these tests themselves.
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“At this point, we do not recommend that any cognitively unimpaired individuals have any Alzheimer’s disease biomarker test,” Dr. Suzanne Schindler, a neurologist at Washington University who was a co-author of the study, said in the press release.
Peterson acknowledged that these results are still experimental and ripe for improvement.
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“The current estimate is not yet accurate enough for clinical use or personal medical decision-making, but we expect that it will be possible to create more accurate models,” he told Fox News Digital.
Looking ahead, the team hopes to refine the test by researching other Alzheimer’s-linked proteins to narrow the margin of error, Schindler said. More diverse participants are also needed to confirm the results.
Two large clinical trials are in progress to determine whether people with high levels of the protein can benefit from treatment. (iStock)
Two large clinical trials are now in progress, aiming to determine whether people with high levels of this protein can benefit from treatment with one of two Alzheimer’s drugs before symptoms appear.
Lecanemab and donanemab are the only approved drugs designed to reduce levels of plaques in the brain associated with Alzheimer’s disease. Researchers hope that treating people earlier may boost the drugs’ effectiveness.
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“There are many other blood and imaging biomarkers, as well as cognitive tests, that we can combine with plasma p-tau217 to improve the accuracy of predicting symptom onset,” Petersen said. “We hope this work will lead to even better models that will be useful to individuals.”
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Along a bustling sidewalk in Boston, a bright yellow payphone invites folks to “call a Boomer.”
Almost 3,000 miles away in Reno, Nevada, a nearly identical phone prompts residents of Sierra Manor – an apartment complex for seniors – to “Call a Zoomer.” The goal is simple: to get strangers to talk to each other.
The project, often referred to as simply “Call a Boomer,” is the latest initiative from Matter Neuroscience, a New York-based company dedicated to mapping the “biomarkers of happiness.”
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By connecting “two of the loneliest demographics” (older adults and younger adults), the project aims to prove that on a molecular level, “humans need one another in order to be happy,” according to Calla Kessler, a social strategist at Matter Neuroscience.
Along a bustling sidewalk in Boston, a bright yellow payphone invites folks to “Call a Boomer.” (Matter Neuroscience)
“Younger adults and older adults tend to experience the highest levels of loneliness of any age group,” the company wrote on its website. “So the goal of this project is to inspire generational connection through meaningful conversations, despite differences in age, lifestyle or politics.”
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The hope, according to Kessler, is that the calls will shift the brain’s focus from stress to bonding.
“Our neuroscience angle is cannabinoids over cortisol,” Kessler told Fox News Digital. “Cannabinoids are the feel-good neurotransmitter in our brain that creates that warm feeling with a friendship — and when you activate cannabinoids, you’re counteracting the negative effects of cortisol, which is our primary stress hormone.”
“Younger adults and older adults tend to experience the highest levels of loneliness of any age group,” the company noted. (Matter Neuroscience)
This isn’t Matter’s first round of payphones. Its initial experiment connected one of the most liberal cities in the U.S. (San Francisco) with one of the most conservative (Abilene, Texas).
“We basically just wanted people to find common ground and encourage people to think beyond labels,” Kessler said.
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She noted that the negative results were “almost negligible,” with most participants enjoying their time speaking to different people.
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Now, the focus has shifted from political labels to generational divides.
The negative results have beem “almost negligible,” with most participants enjoying their time speaking to different people. (Matter Neuroscience)
As the “Call a Boomer” experiment continues, the team is busy collecting audio files of these intergenerational chats to prove that simple connections with other humans can help improve mental health.
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“Our research is essentially trying to find a non-pharmaceutical cure to depression,” Kessler added.
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Looking ahead, she said, “we’ll definitely be doing fun things that we hope get people’s attention and inspire them to learn a little more about themselves.”
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A New York City father is desperately seeking a donor to save his teenage son’s life.
Max Uribe, now 15 and a high-school freshman, has just weeks until he will need to be hospitalized with a rare blood disorder that could lead to a deadly cancer.
“Max was just 6 when we first noticed there was something wrong with his blood counts,” his father, Juan Uribe, told Fox News Digital. “At the time, we thought it was due to a viral infection, but they never fully recovered back to their normal level.”
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In December 2024, Max’s condition grew worse, and he was diagnosed with clonal cytopenia, a condition involving the blood and bone marrow.
“All three of his blood counts are low — red, white and platelets,” Uribe said.
Max Uribe, pictured with his parents and sister, is in urgent need of a stem cell transplant to save his life. (Uribe Family)
In August 2025, another bone marrow biopsy revealed that Max is on a path to bone marrow failure, creating an urgent need for a stem cell transplant.
“The disease has continued to progress, as his blood counts continue to drop, and therefore, we have to take him to transplant in May of this year,” Uribe said.
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If left untreated, Max’s condition could lead to MDS (myelodysplastic syndrome), a type of blood cancer, and from there possibly into acute myeloid leukemia (AML).
A bone marrow match must have a specific type of HLA (human leukocyte antigen), which are proteins found on the surface of most cells in the body, according to the National Marrow Donor Program (NMDP).
Max Uribe, pictured with his parents, will be hospitalized for a transplant in May, as his blood count has been steadily decreasing. (Uribe Family)
The closer the donor’s HLA markers are to the patient’s, the more likely the body will accept the new cells without a high risk of complications.
People from the same ethnic background are more likely to share similar HLA types, meaning a patient is most likely to find a compatible donor among individuals with similar ancestry, per the NMDP.
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Non-Hispanic White patients have a 79% chance of a perfect match. That drops to 49% for Hispanic/Latino patients, 29% for Black patients and even lower for mixed ancestries, the NMDP reports.
Because Max is a “very rare combination” of half-Colombian from his father and a mix of Italian, British and German from his mother, his path to a perfect match is proving much more difficult, Uribe noted.
“For a kid like Max, with complex, mixed heritage, the math is devastating.”
“For a kid like Max, with complex, mixed heritage, the math is devastating,” he said. “The thinking is, we need large numbers if we’re going to have that perfect match for my son.”
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Max, who participates in competitive tennis and varsity wrestling, just had additional blood work done on Friday, which revealed that his counts continue to plummet.
“We’re at the point where this is beginning to manifest a bit more, which is why the urgency is so critical,” Uribe said.
Because Max is a “very rare combination” of half-Colombian from his father and a mix of Italian, British and German from his mother, his path to a perfect match is proving much more difficult. (Uribe Family)
If a donor is not secured by Max’s hospitalization in May, the medical team will have to proceed with a partial match, which is not ideal for a number of reasons.
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“The survival rate is meaningfully lower with a partial match, and there’s more risk of graft versus host disease (GVHD), which could lead to complications in the process,” Uribe said. With GVHD, the donor cells begin to attack the body.
Max Uribe, an active athlete, is on a path to bone marrow failure, requiring a stem cell transplant. (Uribe Family)
To help prevent this with a partial match, Max would likely need chemotherapy and immunosuppressants for a longer period of time, which could weaken his immune system.
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Anyone interested in donating can order a free test kit on the Team Max website. The kit includes a quick cheek swab that is sent back to the lab to determine whether someone is a match.
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