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As White House Presses for Booster Shots, Americans Are Slow to Get Them

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As White House Presses for Booster Shots, Americans Are Slow to Get Them

BALTIMORE — The brand new coronavirus booster pictures have discovered a modest variety of takers at one in all this metropolis’s few remaining public vaccination websites, with 9 doses given on one latest day and 15 on one other.

Greater than a month after the retooled pictures have been rolled out, solely about 5 % of Baltimore residents have acquired one, a determine that displays the gradual uptake nationally. In a metropolis with stark well being disparities, native officers see a purpose to be nervous.

“The truth that we’ve been getting it so typically is making it uninteresting to individuals,” Rebecca Dineen, town’s Covid-19 vaccine coordinator, stated of the rounds of coronavirus pictures.

The anemic turnout underscores one more take a look at of the Biden administration’s pandemic technique, as federal and native officers cope with dwindling public endurance and diminishing funds for the virus response.

Solely about 15 million doses of the brand new pictures have been administered nationally since their introduction at first of September, representing lower than one in 10 people who find themselves eligible, and there are indicators that many People are unaware of or just tired of them. In a Kaiser Household Basis survey final month, half of adults stated that they had heard little or nothing in regards to the pictures.

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As soon as outlined by provide shortages and mass vaccination websites, the nation’s ever-expanding inoculation marketing campaign has these days been characterised by apathy, with doubtlessly severe well being penalties for probably the most weak People ought to one other Covid wave sweep the nation this winter.

The tepid response to the pictures, public well being specialists say, is greater than only a advertising and marketing dilemma. Many People have just lately had a coronavirus an infection, drawing out the timeline for after they may search one other booster or inflicting them to skip one altogether. Others are cautious of continuous boosting or unintended effects that may maintain them from going to highschool or work.

The turnout for the brand new pictures, for which kids as younger as 5 grew to become eligible this week, may fall far in need of the response to the preliminary booster marketing campaign that the federal authorities undertook round a yr in the past, when administration officers say there was much less fatigue round vaccination and the pandemic extra broadly. Round 110 million individuals acquired a minimum of one dose of the unique booster formulation earlier than the brand new pictures have been approved on the finish of August.

Dr. Ashish Ok. Jha, the White Home Covid-19 coordinator, stated in an interview that the early turnout for the up to date boosters amounted to a “good begin” and that uptake was prone to steadily enhance this fall. Many People, he stated, have been treating the brand new vaccines like flu pictures, contemplating receiving one because the climate turned colder.

“We didn’t have an inside quantity in our heads, or a minimum of I didn’t have one in thoughts, of what we have been going to attain,” Dr. Jha stated. “My form of psychological mannequin was that it will actually begin ramping up as soon as we bought into October.”

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Administration officers made an costly guess on the brand new marketing campaign at a fraught second in congressional funding negotiations, shopping for over 170 million doses with billions in repurposed funds — sufficient to vaccinate a lot of the roughly 225 million People who’ve had an preliminary spherical of vaccination.

One senior official stated the acquisition was modeled on how the federal authorities usually buys flu vaccines, with sufficient doses to achieve any American at tens of 1000’s of web sites whereas limiting what number of go to waste. Round 80 % of doses in latest weeks got at retail pharmacies, Dr. Jha stated, a rise from earlier Covid-19 vaccination campaigns.

Whereas many People nonetheless have substantial safety from previous vaccinations and infections, federal officers have pointed to analyses that present the brand new boosters may nonetheless save 1000’s of lives. Vaccine specialists say they anticipate the pictures to ship an preliminary burst of antibodies and a broadened immune response. The Covid vaccines have been redesigned to focus on Omicron subvariants on the belief that extra present formulations would offer higher and extra sturdy safety.

But researchers are nonetheless working to find out how properly the pictures shield individuals and the way lengthy these defenses final. The information that federal regulators gathered from the producers of the boosters, Pfizer-BioNTech and Moderna, continues to be preliminary, leaving specialists to invest in regards to the further advantages the brand new vaccines might provide, together with its affect on transmission or longer-lasting signs of Covid-19.

Federal officers will not be anticipated to have early knowledge from Pfizer and Moderna on what sort of short-term antibody responses the brand new vaccines induced in trial members till later this fall.

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Well being officers and suppliers already know whom they should attain with the brand new pictures, as People over 75 have represented a majority of deaths from Covid-19 in latest months. Round half of these vaccinated with the brand new boosters to date are seniors, Dr. Jha stated.

White Home officers say they’ve tried to publicize the brand new pictures with federal advert campaigns, clinics at state and county gala’s and partnerships with native leaders. The administration is focusing on older People with outreach from the Facilities for Medicare and Medicaid Providers, whereas the White Home is working with CVS and Walgreens to extend booster consciousness, Dr. Jha stated.

“Once you stroll into CVS, you see indicators for the flu shot,” he stated, including, “We need to ensure that that’s getting tied into their outreach on Covid-19 vaccines as properly.”

Dr. Swati Gaur, the medical director for 2 long-term care services in Georgia, stated the problem had shifted from getting a provide of vaccine doses to waging a piecemeal persuasion marketing campaign to coax seniors into taking them.

In a single latest encounter, she stated, she spoke with a resident at one in all her services who had grown bored with getting vaccinated in opposition to the virus after 4 pictures and refused a fifth. She walked him by the potential advantages, and he agreed to get the shot.

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Dr. Gaur stated it was essential that workers at long-term care services calling households and asking for consent to vaccinate knew find out how to have comparable conversations.

Biden administration officers have provided typically competing concepts of the urgency of the booster marketing campaign for youthful, more healthy individuals. Federal regulators scrambled to make the up to date pictures accessible forward of schedule late in the summertime, choosing that strategy as a substitute of providing second booster doses of the unique vaccine formulation to all adults. With case counts decrease, some prime officers have just lately provided a extra relaxed timeline, turning to an October theme.

Dr. Jha inspired People to get the brand new pictures by Halloween so their immunity can be bolstered by Thanksgiving. “What we’ve been making an attempt to do is give recommendation that simplifies it,” he stated, including, “The concept is that you simply don’t need to type of suppose too exhausting about are you eligible or are you not eligible.”

Some specialists have warned that makes an attempt to simplify messaging may backfire.

Dr. Walid F. Gellad, a drug security professional on the College of Pittsburgh, stated that efforts to achieve all age teams had diluted consideration to those that most want enhanced safety. When specialists over the previous yr have questioned whether or not youthful, more healthy People want boosting, he stated, “to these listening solely halfheartedly, it is going to simply sound like criticism of the booster, though it was criticism of the booster in these age teams.”

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With the brand new pictures, extra People are making guesswork out of the timing. Performing on professional recommendation, a few of those that have just lately had the virus are ready three or extra months to get boosted, whereas others are timing the shot for the vacations or journey, or one other uptick in circumstances.

Amanda First, 32, a lawyer in New York, stated that after having a light case of Covid in July, she was not in a rush to get the following vaccine dose. However she bought one of many new boosters this month in order that she would have extra safety when spending time with household throughout the holidays.

“I’m cautiously optimistic it is going to present me safety,” she stated of the brand new shot. “However I wouldn’t be stunned if I’m reinfected.”

Munro Wooden, a 33-year-old net developer close to St. Louis, stated he acquired his first booster in June however had grown bored with the thought of standard Covid-19 pictures. He was nonetheless undecided on whether or not to get the brand new dose.

“Annual and even biannual boosters are uncomfortable sufficient that they don’t overcome the risk-reward threshold for me,” he stated, including, “If one other, a lot worse variant comes out and begins spreading as quickly because the preliminary Omicron wave, I’ll in all probability perk up and pay extra consideration.”

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Baltimore’s preliminary vaccine rollout included intensive promoting and grass-roots work, and three-quarters of residents have now acquired a minimum of one vaccine dose.

Ms. Dineen, town’s Covid-19 vaccine coordinator, stated that metropolis officers have been nonetheless prioritizing getting first and second doses to weak individuals in poorly vaccinated neighborhoods, the place canvassers proceed to go door-to-door with the pictures.

These on the metropolis clinic in the future this month have been the vaccine-dedicated. “It’s one thing that wanted to be carried out,” Melvin Battle, a metropolis worker, stated, noting that “winter’s coming alongside.”

Paula Ladson-Gillis, one other metropolis worker, stated she knew a dose of one of many new vaccines may not forestall her from getting Covid-19, however it will a minimum of assist to maintain her from getting very ailing.

“I do know loads of individuals are relaxed — I’m not one in all them,” Ms. Ladson-Gillis stated. “And that even says extra to me why I need to get it, as a result of too many individuals will not be getting it.”

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We Tried Three Doctor-Approved, Ozempic-Friendly Recipes | Woman's World

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We Tried Three Doctor-Approved, Ozempic-Friendly Recipes | Woman's World


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Weight-loss medications may also benefit common medical problem, study finds

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Weight-loss medications may also benefit common medical problem, study finds

Weight-loss medications known as glucagon-like peptide-1 (GLP-1) agonists, which have gained popularity for treating type 2 diabetes and obesity, have been shown to have the surprising secondary benefit of reducing alcohol intake.

A team of international researchers from Ireland and Saudi Arabia followed 262 adult patients with obesity who started taking two GLP-1 medications: liraglutide or semaglutide.

Among the regular drinkers, weekly alcohol intake decreased by 68%, from approximately 23 units of alcohol to around 8 units.

WEIGHT LOSS, DIABETES DRUGS CAN CAUSE MOOD CHANGES: WHAT TO KNOW ABOUT BEHAVIORAL SIDE EFFECTS

The findings were recently published in the journal Diabetes, Obesity and Metabolism and were also presented last week at the European Congress on Obesity in Spain.

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GLP-1 agonists mimic a hormone called GLP-1, which is released from the gastrointestinal system after eating, according to study co-author Carel Le Roux, a professor at University College Dublin.

Weight-loss medications known as glucagon-like peptide-1 (GLP-1) agonists have been shown to have the surprising secondary benefit of reducing alcohol intake. (iStock)

These medications activate GLP-1 receptors in the brain, decreasing the sense of “reward” people feel after eating or drinking, eventually leading to reduced cravings for both food and alcohol, he told Fox News Digital.

“It is this commonality of function that suggests the GLP-1 receptors in the brain may be a therapeutic target for not just the disease of obesity, but also for alcohol use disorder,” the professor said.

Study findings

Before the participants started the weight-loss drugs, they self-reported their weekly alcohol intake, then were categorized as non-drinkers, rare drinkers or regular drinkers.

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Approximately 72% had at least two follow-up visits and 68% reported regular alcohol consumption.

WEIGHT-LOSS DRUGS’ IMPACT ON CANCER RISK REVEALED IN NEW STUDY

After starting the weight-loss medications, the participants’ weekly average alcohol intake decreased by almost two-thirds overall — from approximately 11 units of alcohol to four units after four months of treatment with the GLP-1 agonists.

The reduction in alcohol use was comparable to the decrease that can be achieved by nalmefene, a drug that decreases the “buzz” feeling in people with alcohol use disorder in Europe, according to the researchers.

Man drinking alcohol

Among the regular drinkers, weekly alcohol intake decreased by 68%, from approximately 23 units of alcohol to around 8 units. (iStock)

For the 188 patients who were followed over an average of four months, none had increased their alcohol intake after starting the weight-loss medications.

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Patients reported that after an evening meal, they were too full to have their usual drink — and when they did drink, they reported becoming full extremely quickly and drinking at a slower pace, Le Roux noted.

“The findings in this study suggest that we may have just found a therapeutic target for alcohol use disorder.”

This suggests that the experience was less enjoyable, partly due to the reduced rate of alcohol absorption.

Some patients also reported that they didn’t enjoy the flavor of the alcoholic beverages as much, and also that hangovers were much worse.

All of these experiences showed that the weight-loss medications create “guard rails” that prevent most patients from drinking excessively, giving them a degree of control over their alcohol intake, according to Le Roux.

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Woman drinking wine

After starting the weight-loss medications, the participants’ weekly average alcohol intake decreased by almost two-thirds overall. (iStock)

“The findings in this study suggest that we may have just found a therapeutic target for alcohol use disorder — the GLP-1 receptor,” the professor told Fox News Digital.

“This finding potentially opens the possibility of an entirely new pharmacological treatment paradigm, which could be used in conjunction with conventional methods, such as behavior therapy and group support.”

Potential limitations

The study was limited by its relatively small number of patients, the researchers acknowledged.

Also, the researchers were not able to verify the participants’ self-reported alcohol intake, and roughly one-third of them were not available for follow-up.

SEMAGLUTIDE FOUND TO HAVE SHOCKING BENEFIT FOR LIVER DISEASE PATIENTS IN NEW STUDY

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There was also no control group, which means the researchers couldn’t prove that taking weight-loss medication reduces alcohol intake.

A woman prepares to administer an insulin injection

The main advantage of GLP-1 agonists is that they only need to be taken once a week and continue to work for the entire week. (iStock)

“Randomized, controlled trials with diverse patient populations — including patients diagnosed with alcohol use disorder — are needed to provide the quality and quantity of data that could be used to support an application for licensing the medication for the treatment of alcohol use disorder,” Le Roux said.

(One such trial is currently underway in Denmark.)

Study implications

With the current medications available to treat alcohol use disorder, the “major problem” is compliance, Le Roux said — “because the cravings for alcohol tend to come in waves.”

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“This means a patient might be fully committed to treatment at one point in the week, but then stop taking the medication later in the week when a craving comes,” the professor added.

two wine glasses

“This research suggests a promising ancillary benefit of GLP-1 analogs, potentially influencing cravings for alcohol and offering a new avenue for managing alcohol use disorder,” a physician said. (iStock)

There are currently three FDA-approved medications to treat alcohol use disorder: naltrexone (which helps decrease cravings by reducing the “buzz” feeling that comes with drinking alcohol); disulfiram (which helps some people avoid alcohol by making them feel sick when they drink), and acamprosate (which restores the balance of hormones in the brain to reduce cravings), according to the National Institute on Alcohol Abuse and Alcoholism.

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But less than 10% of people with alcohol use disorder get the proper treatment, with many resuming use within the first year of treatment, past research shows.

The main advantage of the GLP-1 agonists is that they only need to be taken once a week and continue to work for the entire week.

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For the 188 patients who were followed over an average of four months, none had increased their alcohol intake after starting the weight-loss medications. (iStock)

Outside experts say the study’s findings highlight the potential of weight-loss medications to help treat alcohol use disorder.

“This research suggests a promising ancillary benefit of GLP-1 analogs, potentially influencing cravings for alcohol and offering a new avenue for managing alcohol use disorder,” Dr. Fatima Cody Stanford, obesity medicine physician at Massachusetts General Hospital and Harvard Medical School, who was not part of the study, told Fox News Digital.

For more Health articles, visit www.foxnews.com/health

“While the exact mechanisms are still being explored, the findings contribute to our understanding of the broader benefits of GLP-1 analogs beyond obesity treatment,” Stanford added.

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Surgeons Perform First Human Bladder Transplant

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Surgeons Perform First Human Bladder Transplant

Surgeons in Southern California have performed the first human bladder transplant, introducing a new, potentially life-changing procedure for people with debilitating bladder conditions.

The operation was performed earlier this month by a pair of surgeons from the University of California, Los Angeles, and the University of Southern California on a 41-year-old man who had lost much of his bladder capacity from treatments for a rare form of bladder cancer.

“I was a ticking time bomb,” the patient, Oscar Larrainzar, said on Thursday during a follow-up appointment with his doctors. “But now I have hope.”

The doctors plan to perform bladder transplants in four more patients as part of a clinical trial to get a sense of outcomes like bladder capacity and graft complications before pursuing a larger trial to expand its use.

Dr. Inderbir Gill, who performed the surgery along with Dr. Nima Nassiri, called it “the realization of a dream” for treating thousands of patients with crippling pelvic pain, inflammation and recurrent infections.

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“There is no question: A potential door has been opened for these people that did not exist earlier,” said Dr. Gill, the chairman of the urology department at U.S.C.

Until now, most patients who undergo a bladder removal have a portion of their intestine repurposed to help them pass urine. Some receive an ileal conduit, which empties urine into a bag outside the abdomen, while others are given a so-called neobladder, or a pouch tucked inside the body that attaches to the urethra and allows patients to urinate more traditionally.

But bowel tissue, riddled with bacteria, is “inherently contaminated,” Dr. Gill said, and introducing it to the “inherently sterile” urinary tract leads to complications in up to 80 percent of patients, ranging from electrolyte imbalances to a slow reduction in kidney function. The loss of the intestinal segment can also cause new digestive issues.

Dr. Despoina Daskalaki, a transplant surgeon at Tufts Medical Center who was not involved in the new procedure, said advances in transplant medicine (from critical life-sustaining organs, like hearts and livers, to other body parts, like faces, hands, uteri and penises) had led doctors to start “pushing the envelope.”

“They’re asking: ‘Why do we have to put up with all the complications? Why don’t we try and give this person a new bladder?’” Dr. Daskalaki said.

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In late 2020, Dr. Nassiri was in his fourth year of residency at the University of Southern California when he and Dr. Gill sat down in the hospital cafeteria to begin brainstorming approaches. After Dr. Nassiri began a fellowship on kidney transplantation at U.C.L.A., the two surgeons continued working together across institutions to test both robotic and manual techniques, practicing first on pigs, then human cadavers, and finally, human research donors who no longer had brain activity but maintained a heartbeat.

One of the challenges of transplanting a bladder was the complex vascular infrastructure. The surgeons needed to operate deep inside the pelvis of the donor to capture and preserve a rich supply of blood vessels so the organ could thrive inside the recipient.

“When we’re removing a bladder because of cancer, we basically just cut them. We do it in less than an hour on a near-daily basis,” Dr. Gill said. “For a bladder donation, that is a significantly higher order of technical intensity.”

The surgeons also chose to conjoin the right and left arteries — as well as the right and left veins — while the organ was on ice, so that only two connections were needed in the recipient, rather than four.

When their strategy was perfected in 2023, the two drew up plans for a clinical trial, which eventually would bring the world’s first recipient: Oscar.

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When Mr. Larrainzar walked into Dr. Nassiri’s clinic in April 2024, Dr. Nassiri recognized him. Almost four years earlier, Mr. Larrainzar, a husband and father of four, had been navigating end-stage kidney disease and renal cancer, and Dr. Nassiri helped remove both of his kidneys.

But Mr. Larrainzar had also survived urachal adenocarcinoma, a rare type of bladder cancer, and a surgery to resect the bladder tumor had left him “without much of a bladder at all,” Dr. Nassiri said. A normal bladder can hold more than 300 cubic centimeters of fluid; Mr. Larrainzar’s could hold 30.

Now, years of dialysis had begun to fail; fluid was building up inside his body. And with so much scarring in the abdominal region, it would have been difficult to find enough usable length of bowel to pursue another option.

“He showed up serendipitously,” Dr. Nassiri said, “but he was kind of an ideal first candidate for this.”

On a Saturday night earlier this month, Dr. Nassiri received a call about a potential bladder match for Mr. Larrainzar. He and Dr. Gill drove straight to the headquarters of OneLegacy, an organ procurement organization, in Azusa, Calif., and joined a team of seven surgeons working overnight to recover an array of organs from a donor.

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The two brought the kidney and bladder to U.C.L.A., then stopped home for a shower, breakfast and a short nap. They completed the eight-hour surgery to give Mr. Larrainzar a new bladder and kidney later that day.

Dr. Nassiri said that kidney transplants can sometimes take up to a week to process urine, but when the kidney and bladder were connected inside Mr. Larrainzar, there was a great connection — “immediate output” — and his creatinine level, which measures kidney function, started to improve immediately. Mr. Larrainzar has already lost 20 pounds of fluid weight since the surgery.

The biggest risks of organ transplantation are the body’s potential rejection of the organ and the side effects caused by the mandatory immune-suppressing drugs given to prevent organ rejection. That is why, for Dr. Rachel Forbes, a transplant surgeon at Vanderbilt University Medical Center who was not involved in the procedure, the excitement is more tempered.

“It’s obviously a technical advance,” she said, but “we already have existing options for people without bladders, and without the downside of requiring immunosuppression.” Unless a patient is — like Mr. Larrainzar — going to be on those medications anyway, “I would be a little bit nervous that you would be exchanging some complications for others,” she said.

A new bladder transplant also does not have nerve connections in the recipient, so while it works well as a storage organ, doctors did not know whether Mr. Larrainzar would ever be able to sense a full bladder, let alone hold and empty it naturally. They spoke about catheters, abdomen maneuvers and eventually developing an on-demand bladder stimulator to help with the release.

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But at a follow-up appointment on Thursday morning — just two days after Mr. Larrainzar was discharged from the hospital — Dr. Nassiri removed the catheter and gave him fluids, and Mr. Larrainzar immediately felt that he could urinate.

Dr. Nassiri called it a miracle, then phoned Dr. Gill, who was in a U.S.C. operating room, and exclaimed two words: “He peed!”

“No way! What the hell?” Dr. Gill said. “My jaw is on the floor.”

After finishing the surgery, Dr. Gill drove straight to U.C.L.A. and watched Mr. Larrainzar do it again.

“Of course, this is very, very early. Let’s see how everything goes,” Dr. Gill cautioned. “But it’s the first time he has been able to pee in seven years. For all of us, this is huge.”

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Mr. Larrainzar, exhausted, smiled, and Dr. Nassiri brought him a bottle of mineral water to celebrate.

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