Health
Alzheimer’s on mother’s side of the family could increase disease risk, study finds
Having a mother with Alzheimer’s could lead to a higher risk of inherited disease than a paternal history.
That’s according to a recent study from Mass General Brigham. Researchers analyzed 4,400 adults between ages 65 and 85 who did not have any signs of cognitive decline, but did have amyloid show up in brain-imaging scans.
The people with the higher amounts of amyloid were more likely to have mothers with symptoms of Alzheimer’s — primarily memory loss, the researchers found.
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Amyloid, a protein that builds up in the brain and forms plaques that affect cognitive function, is one of the hallmarks of Alzheimer’s disease (AD).
The findings were published in JAMA Neurology in June.
Having a mother with Alzheimer’s could lead to a higher risk of inherited disease than a paternal history, a new study has found. (iStock)
“Our study showed a striking asymmetry in the impact of maternal versus paternal history of dementia on the risk of offsprings’ brain amyloid-beta protein accumulation, with maternal history having a greater impact,” senior corresponding author Hyun-Sik Yang, M.D., a neurologist at Mass General Brigham, told Fox News Digital via email.
“In our study, maternal history of dementia increased their children’s risk of having preclinical AD, while paternal history had less impact.”
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The researchers — a collaborative team from Mass General Brigham, Vanderbilt and Stanford — expected to see similar genetic risks to be passed down by mothers and fathers, Yang noted.
“Our results suggest otherwise, raising intriguing questions about AD genetics and how AD risk is inherited,” he said.
“In our study, maternal history of dementia increased their children’s risk of having preclinical AD, while paternal history had less impact,” a researcher said. (iStock)
The participants in the study had what is referred to as “preclinical Alzheimer’s disease,” Yang noted, which occurs when there is amyloid buildup but no symptoms.
“This stage might represent a unique opportunity to treat AD before it irreversibly destroys the brain,” he said.
The researchers also found a correlation between amyloid buildup and a history of Alzheimer’s on both sides of the family, as well as fathers with early-onset dementia.
“It’s interesting from a genetic perspective to see one sex contributing something the other sex isn’t.”
“If your father had early onset symptoms, that is associated with elevated levels in the offspring,” said Mabel Seto, PhD, first author and a postdoctoral research fellow in the Department of Neurology at the Brigham, in a press release.
“However, it doesn’t matter when your mother started developing symptoms — if she did at all, it’s associated with elevated amyloid.”
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Women are nearly twice as likely to develop Alzheimer’s than men, according to data from the Alzheimer’s Society.
“It’s really interesting from a genetic perspective to see one sex contributing something the other sex isn’t,” Seto said.
Limitations of the study
Courtney Kloske, PhD, director of scientific engagement at the Alzheimer’s Association in Chicago, Illinois, was not involved in the study but shared her insights on the findings.
“This study sheds light on the interplay between genetics and cognition in individuals with a family history of cognitive decline,” Kloske told Fox News Digital in an email.
A protein called amyloid that builds up in the brain and forms plaques — affecting cognitive function — is one of the hallmarks of Alzheimer’s disease. (iStock)
The expert did point out some limitations in the study, which the researchers also acknowledged.
“The authors mention that their findings should be interpreted cautiously,” she said.
One key limitation was that the study participants self-reported their family history, which could introduce some degree of bias or inaccuracy.
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“Additionally, the generally longer lifespan of women compared to men may contribute to the higher observed prevalence of cognitive impairment among women,” Kloske added.
Yang also spoke to this limitation, adding that the study participants were older adults and that the average life expectancy was shorter in their parents’ generation, especially for males.
While having elevated amyloid levels significantly increases the risk of someone eventually having dementia, more research is needed to determine the full impact of family history on the course of Alzheimer’s disease. (AP Newsroom)
“That might have made it even more challenging to assess the actual risk of dementia in their fathers, as they might have passed away before getting to the age when dementia becomes more prevalent,” he said.
Another consideration, according to Kloske, is that the parents in the current study lived in a “different, earlier era” when women were less likely to be in the workforce and had lower levels of education.
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“These trends limit the generalizability of these results,” she said.
Yang also reiterated that none of the study participants had dementia — “we asked about their family history and matched them with the amyloid PET scan results.”
While having elevated amyloid levels significantly increases the risk of someone eventually having dementia, Yang noted, more research is needed to determine the full impact of family history on the course of Alzheimer’s disease.
Women are nearly twice as likely to develop Alzheimer’s than men, according to data from the Alzheimer’s Society. (iStock)
“We think it is important for doctors evaluating dementia patients to gather detailed family history information, including the history of both parents and their age at onset if there was a memory loss or dementia history,” he said.
It is also important to seek out ways to decrease the risk, especially if someone has a family history, according to the researcher.
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“Lifestyle and environmental factors are thought to play a significant role in dementia risk,” Yang said.
“I always tell my patients to focus on a healthy lifestyle, such as a heart-healthy diet, regular physical activity, and a socially and intellectually active lifestyle.”
Health
Common household chemicals linked to increased risk of serious neurological condition
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A study from Sweden’s Uppsala University discovered a link between microplastics and multiple sclerosis (MS).
The research, published in the journal Environmental International, discovered that exposure to two common environmental contaminants, PFAS and PCBs, could increase the risk of the autoimmune disease.
PFAS, or per- and polyfluoroalkyl substances, known as “forever chemicals,” are used in some common household products, such as non-stick cookware, textiles and cleaning products. They have also been found in drinking water throughout the U.S., according to the U.S. Environmental Protection Agency.
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PCBs, or polychlorinated biphenyls, are toxic industrial chemicals once widely used in electrical equipment before being banned decades ago, as stated by the National Institute of Environmental Health Sciences.
The new study findings were based on blood samples of 1,800 Swedish individuals, including about 900 who had recently been diagnosed with MS, according to a university press release.
PFAS, or per- and polyfluoroalkyl substances, known as “forever chemicals,” are used in some common household products, including non-stick cookware. (iStock)
The first phase of the trial studied 14 different PFAS contaminants and three substances that appear when PCBs are broken down in the body. These were then investigated for a link to the odds of diagnosis.
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“We saw that several individual substances, such as PFOS and two hydroxylated PCBs, were linked to increased odds for MS,” lead study author Kim Kultima said in a statement. “People with the highest concentrations of PFOS and PCBs had approximately twice the odds of being diagnosed with MS, compared to those with the lowest concentrations.”
The researchers then examined the combined effects of these substances and found that the mixture was also linked to increased risk.
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Fellow researcher Aina Vaivade noted that risk assessments should consider chemical mixtures, not just individual exposures, because people are typically exposed to multiple substances at the same time.
“We saw that several individual substances, such as PFOS and two hydroxylated PCBs, were linked to increased odds for MS,” the lead study author said. (iStock)
The final phase of the study investigated the relationship between inheritance, chemical exposure and the odds of MS diagnosis, revealing that those who carry a certain gene variant actually have a reduced MS risk.
However, individuals who carried the gene and had higher exposure to PFOS — a singular type of chemical in the PFAS family — had an “unexpected” increased risk of MS.
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“This indicates that there is a complex interaction between inheritance and environmental exposure linked to the odds of MS,” Kultima said.
“We therefore think it is important to understand how environmental contaminants interact with hereditary factors, as this can provide new knowledge about the genesis of MS and could also be relevant for other diseases.”
Multiple sclerosis is a disease that leads to the breakdown of the protective covering of the nerves, according to Mayo Clinic. (iStock)
Fox News senior medical analyst Dr. Marc Siegel commented on these findings in an interview with Fox News Digital.
“MS is a complex disease that is somewhat autoimmune and somewhat post-inflammatory,” said Siegel, who was not involved in the study. “Epstein-Barr virus infection greatly increases the risk of MS.”
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“There is every reason to believe that environmental triggers play a role, including microplastics, and this important study shows a correlation, but not causation — in other words, it doesn’t prove that the microplastics caused MS.”
The study had some limitations, the researchers acknowledged, including that the chemical exposure was measured only once, at the time of blood sampling. This means it may not accurately represent participants’ long-term or past exposure levels relevant to MS development.
“There is every reason to believe that environmental triggers play a role.”
Fox News Digital reached out to several industry groups and manufacturers requesting comment on the potential link between PFAS chemicals and multiple sclerosis.
Several have issued public statements, including the American Chemistry Council, which states on its website that “manufacturers and many users of today’s PFAS are implementing a variety of practices and technologies to help minimize environmental emissions.”
In April 2024, the EPA enacted a new federal rule that sets mandatory limits on certain PFAS chemicals in drinking water, aiming to reduce exposure. The agency also aims to fund testing and treatment efforts.
A woman working out outdoors takes a sip of water from a plastic bottle. (iStock)
Multiple sclerosis is a disease that leads to the breakdown of the protective coverings that surround nerve fibers, according to Mayo Clinic.
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The immune system’s attack on these nerve sheaths can cause numbness, weakness, trouble walking and moving, vision changes and other symptoms, and can lead to permanent damage.
There is currently no cure for MS, Mayo Clinic reports, but treatment is available to manage symptoms and modify the course of the disease.
Health
Natural Ozempic? 6 GLP-1 Foods That Work Just Like the Shot
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Health
Simple daily habit could help people with type 2 diabetes manage blood sugar
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Sitting next to a window may help people with type 2 diabetes control their insulin levels, according to new research.
The study, published in Cell Metabolism, found that exposure to natural light — even indoors next to a window — changes how the body processes glucose and uses energy.
People in Western societies spend 80% to 90% of their time under artificial lights, which are much dimmer and less dynamic than sunlight, the researchers noted. Natural daylight is a powerful cue for the body’s internal clock, also known as the circadian rhythm.
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The body’s internal clock influences many processes, including digestion, hormone release and metabolism, according to research. When it gets out of sync, it can worsen insulin resistance and blood sugar control, which are two of the main issues caused by type 2 diabetes.
Typical lighting in homes and offices is much dimmer and lacks the biological signals provided by natural daylight. (iStock)
To test the effects of daylight on blood sugar, scientists recruited 13 adults with type 2 diabetes. Each person spent two separate 4.5-day periods in a controlled office setting, according to a press release.
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In one period, they worked in front of large windows with natural daylight streaming in. In the other period, participants worked in the same room with the windows covered and were exposed only to typical indoor lighting.
Daylight isn’t a replacement for medication or traditional management strategies like diet and exercise, the researchers noted.
Everyone ate similar meals, followed the same schedule and continued their usual diabetes medications in both conditions.
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While average blood sugar levels didn’t differ drastically between the two conditions, people spent more time in the healthy glucose range when they were exposed to natural daylight — their blood sugar fluctuated less and stayed within a desirable range for a greater portion of the day.
Participants who were exposed to daylight burned more fat and fewer carbohydrates, a metabolic pattern linked to better blood sugar regulation. (iStock)
Exposure to natural light also affected metabolism. In daylight, participants burned more fat and fewer carbohydrates for energy.
Muscle biopsies and laboratory tests further showed that the genes responsible for the body’s cellular clocks were more synchronized under natural light conditions, the study revealed.
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Better alignment of these genes can improve nutrient processing and how cells respond to insulin, the researchers concluded.
Sitting near windows or spending more time outdoors could support diabetes management alongside standard treatments, researchers say. (iStock)
However, daylight isn’t a replacement for medication or traditional management strategies like diet and exercise, according to the team.
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The study did have some limitations, including that the group of patients was small. The researchers cautioned that larger studies are needed to confirm these results and determine how much natural light exposure is optimal.
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“This study also highlights the often unnoticed impact of the built environment on our health, and raises further concerns about the prevalence of office environments with poor (natural) daylight access,” the researchers noted.
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