Health
Aggressive cancer warning signs revealed after JFK’s granddaughter’s diagnosis
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Days after Tatiana Schlossberg announced that she has terminal cancer, the spotlight is on the warning signs of acute myeloid leukemia (AML).
John F. Kennedy’s granddaughter, 35, shared the details of her diagnosis in an essay published in The New Yorker on Nov. 22.
Schlossberg, who is the daughter of Kennedy’s daughter, Caroline Kennedy, and Edwin Schlossberg, learned of her disease in May 2024.
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She wrote that one doctor predicted she would live for about a year.
The first indicator of Schlossberg’s disease was an abnormally high white blood cell count, which doctors detected just hours after she gave birth to her second child.
John F. Kennedy’s granddaughter, 35, shared the details of her diagnosis in an essay published in The New Yorker on Nov. 22. She’s pictured here in 2023. (AP Newsroom)
What is acute myeloid leukemia?
AML is a type of leukemia that begins in the bone marrow, the soft, inner tissue of certain bones where new blood cells are produced, according to the American Cancer Society.
This type of cancer typically spreads rapidly from the bone marrow into the bloodstream and can also reach other parts of the body, such as the lymph nodes, liver, spleen, brain and spinal cord, and testicles, per ACS.
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In some cases, clusters of leukemia cells may form a solid mass known as a myeloid sarcoma.
Schlossberg’s AML stems from a rare gene mutation known as inversion 3, which is an abnormality of chromosome 3 in the leukemia cells.
Schlossberg, the daughter of Caroline Kennedy (left) and Edwin Schlossberg, learned of her disease in May 2024. (Getty Images)
“Inversion 3 correlates with a very high rate of resistance to standard chemotherapy treatments and, therefore, very poor clinical outcomes,” Dr. Stephen Chung, a leukemia expert and oncologist at UT Southwestern Medical Center in Dallas, Texas, told Fox News Digital. (Chung was not involved in Schlossberg’s care.)
Red flags and risk factors
The most common symptoms of Schlossberg’s type of cancer include sudden onset of severe fatigue, shortness of breath with exertion, unusual bleeding or bruising, fever and infections, according to Dr. Pamela Becker, professor in the Division of Leukemia at City of Hope, a U.S. cancer research and treatment organization in California, who also did not treat Schlossberg.
AML can sometimes resemble a severe flu with a generally unwell feeling.
Chung noted that AML usually causes abnormally low blood cell counts, or in some cases an abnormally high white blood cell count.
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“This may be picked up in routine testing for other purposes, or because the patient develops symptoms from these low blood counts,” he said.
AML can sometimes resemble a severe flu with a generally unwell feeling, noted Robert Sikorski, M.D., Ph.D., a hematology/oncology expert and chief medical officer of Cero Therapeutics in California.
“Some patients also experience bone pain or night sweats,” he told Fox News Digital.
Standing outside the John F. Kennedy Library in Boston, from left, Edwin Schlossberg, Rose Schlossberg, Victoria Reggie Kennedy, Ted Kennedy, Tatiana Schlossberg and Caroline Kennedy Schlossberg. Tatiana Schlossberg said a doctor gave her an estimated one year to live. (Getty Images)
Known risk factors for AML include prior chemotherapy or radiation, smoking, long-term benzene exposure and certain inherited syndromes, although most cases occur without any identifiable cause, according to Sikorski, who has not treated Schlossberg.
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In some rare cases, people can inherit mutations that cause AML to run in families, with recent research suggesting that these cases may be more common than previously thought, Chung noted.
“We used to only check for this in younger AML patients, but we now believe all patients should be screened for these mutations,” he said.
Treatment for AML
The standard treatment for AML is intensive chemotherapy with a combination of two drugs, with additional agents added based on each patient’s specific characteristics, according to Becker.
“We now believe all patients should be screened for these mutations.”
For patients with higher-risk types of AML, the chemotherapy is usually followed by a stem cell (bone marrow) transplant to prevent relapse. The transplants come from matched donors, often family members.
“This is a much more involved process that usually involves another month in the hospital, followed by close follow-up for many months, as well as a much higher risk for treatment-related side effects,” Chung said.
There is not a specific treatment that is effective for Schlossberg’s specific chromosome abnormality, the doctors noted, although some new cellular therapies and immunotherapies are being investigated.
Caroline Kennedy’s children, Jack and Tatiana Schlossberg, and her husband Edwin Schlossberg are pictured on Capitol Hill in 2013. The first indicator of Schlossberg’s disease was an abnormally high white blood cell count, which doctors detected just hours after she gave birth to her second child in 2024. (Getty Images)
For older patients who are not strong enough to receive intensive chemotherapy, the standard treatment is venetoclax/azacytidine (a combination therapy used to treat certain types of AML), Chung said.
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“This can often be given mostly outside the hospital on a monthly basis,” he said. “While it technically is not considered to be curative, it can work very well — in some cases, patients remain in remission for many months, if not years.”
Hope ahead
There is hope on the horizon, as AML treatment has advanced more in the past decade than in the previous 30 years, according to Sikorski.
Caroline Kennedy is pictured with her children Rose Schlossberg (left), Tatiana Schlossberg (center) and Jack Schlossberg at the 2008 Democratic Convention in Denver, Colorado. There is hope on the horizon for AML treatment, doctors say. (Getty Images)
“New targeted drugs have been approved in several AML subtypes, and early work in immune-based therapies, including CAR-T and other engineered cell therapies, is beginning to reach clinical trials for AML,” Sikorski, told Fox News Digital.
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“Supportive care has also improved significantly, which helps patients tolerate treatment more effectively.”
While there is not yet a drug tailored specifically to inversion 3, he reiterated, “many studies focused on high-risk AML are actively enrolling these patients, and the overall treatment landscape continues to expand.”
Health
Flu hospitalizations hit all-time weekly high in densely populated state, officials warn
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The New York State Department of Health has announced the highest number of flu hospitalizations recorded in a single week.
The state confirmed the uptick in hospital visits in a press release on Jan. 2, as flu cases continue to rise in the region and nationwide.
New York State, including New York City, has consistently tracked the highest numbers of recorded respiratory illness cases in the country for the last few weeks, according to CDC data. Several other states have climbed to the “very high” category for respiratory activity as well, as of the week ending Dec. 27.
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The most recent data from the New York health department showed a total of 4,546 hospitalizations from Dec. 26, 2025, to Jan. 2, 2026 – a week-over-week increase of nearly 1,000. The prior week, the department announced the highest number of flu cases ever recorded in a single seven-day period.
The New York State Department of Health reported a total of 4,546 hospitalizations from Dec. 26, 2025, to Jan. 2, 2026. (iStock)
In a statement, New York’s Acting Commissioner of Health Dr. James McDonald noted the severity of this flu season compared to previous years.
“Almost 1,000 more people were admitted to a hospital during this most recent seven-day period compared to the prior week,” he confirmed. “There is still time to get a flu shot, and remember, flu can be treated with antiviral medication if started within 48 hours of symptom onset [as] your doctor deems appropriate.”
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Health officials are pushing for Americans to consider getting the flu vaccine, as experts consider it to be a top line of defense for preventing viral exposure and spread.
Flu symptoms can include fever, chills, headache, fatigue, cough, sore throat and runny nose. (iStock)
In a previous interview with Fox News Digital, Dr. Neil Maniar, professor of public health practice at Boston’s Northeastern University, emphasized that it’s not too late to get the flu vaccine, as peak season typically occurs in January.
“The vaccine still provides protection against serious illness resulting from the subclade K variant that seems to be going around,” he said.
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Even healthy individuals can become seriously ill from the flu, Maniar noted, “so a vaccine is beneficial for almost everyone.”
“Individuals typically start to develop some degree of protection within a few days and gain the full benefit within about two weeks, so now is the time for anyone who hasn’t gotten the vaccine yet.”
“The vaccine still provides protection against serious illness resulting from the subclade K variant that seems to be going around,” one doctor said. (iStock)
Flu symptoms can include fever, chills, headache, fatigue, cough, sore throat and runny nose.
A mutation of influenza A H3N2, called subclade K, has been detected as the culprit in rising global cases, causing more intense symptoms and higher risk of spread.
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“It’s becoming evident that this is a pretty severe variant of the flu,” Maniar said. “Certainly, in other parts of the world where this variant has been prevalent, it’s caused some severe illness, and we’re seeing an aggressive flu season already.”
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New York State recommends taking preventive actions to avoid flu infection. These include washing hands often; avoiding touching the eyes, nose and mouth; avoiding close contact with sick people; cleaning and disinfecting objects and surfaces; and staying home when feeling sick.
Health
Not all cancers should be treated right away, medical experts say — here’s why
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When someone gets a cancer diagnosis, the initial reaction is usually to undergo treatment as quickly as possible — but for some types of disease, doctors may recommend a more conservative approach.
For certain cancers, immediate or aggressive treatment can cause more harm than good, according to multiple medical experts.
For example, treating slow-growing tumors with surgery, radiation or chemotherapy could create significant side effects without a survival benefit.
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“The fact that so many cancers will never kill you is not a justification for not knowing, because there is still plenty of room for ‘watchful waiting,’ as well as interventions that may improve quality of life even if they don’t extend life,” Dr. Marc Siegel, Fox News senior medical analyst, told Fox News Digital.
This is especially true as targeted cancer treatments emerge, which are more personalized and less likely to cause severe side effects, according to the doctor.
For precancerous, very early-stage breast conditions, careful monitoring may be more prudent than immediate surgery, research shows. (iStock)
“The fact that cancers are occurring earlier is a justification for heightened screenings, not the opposite,” Siegel added. “Information is power — what you do with that information is based on clinical judgment and the art of medicine.”
Below are some types of cancer that may not warrant treatment, according to research and doctors’ guidance.
No. 1: Prostate cancer (low-risk)
While some types of prostate cancer should be treated right away, others are better addressed by “watchful waiting,” according to Sanoj Punnen, M.D., a urologic oncologist with Sylvester Comprehensive Cancer Center, part of the University of Miami Health System.
“With respect to prostate cancer, for most low-risk cancers (Gleason 6 or grade group 1), we recommend initial observation and surveillance rather than immediate treatment,” he told Fox News Digital.
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The Gleason score is a grading system that ranks prostate cancer cells in terms of how abnormal they are, with 6 being the lowest grade and 10 being the highest grade (barely resembling normal cells).
“For high-grade tumors like Gleason 8, 9 or 10, we believe they progress quickly, so we recommend treatment to prevent the risk of metastasis,” said Punnen, who is also vice chair of research and a professor with the Desai Sethi Urology Institute at UHealth. “For low-risk tumors, we think they pose little risk, so we recommend just observation.”
“The fact that cancers are occurring earlier is a justification for heightened screenings, not the opposite.”
“But in the end, we can’t be sure, so our approach to observation includes serial monitoring of cancer status with PSA, MRI and occasional biopsy to ensure the tumor isn’t progressing.”
No. 2: Ductal carcinoma in situ (DCIS)
Also known as stage 0 breast cancer, DCIS is a non-invasive disease marked by abnormal cells in the lining of the breast milk ducts. The “in situ” is Latin for “in the original place,” which indicates that the cancer has not spread outside the milk ducts.
For this precancerous, very early-stage breast condition, careful monitoring may be more prudent than immediate surgery, research shows.
While some types of prostate cancer should be treated right away, others are better addressed by “watchful waiting,” according to a urologic oncologist. (iStock)
A 2024 study by the Dana-Farber Cancer Institute found that active monitoring for DCIS resulted in similar quality of life, mental health and symptom progression over a two-year period compared to a standard surgical approach.
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“These results suggest that in the short term, active monitoring is a reasonable approach to management of low-risk DCIS,” the lead researcher said in a press release. “If longer-term follow-up supports the safety of active management from a cancer outcome standpoint, this approach could be considered as an option for women with this condition.”
“But it is also critical that we understand how women feel when they are living with this ‘watch and wait’ approach and how it impacts their overall quality of life.”
Other research has suggested that women with low-risk DCIS did not have a higher rate of invasive cancer after two years of active monitoring, although each patient should discuss their individual risk level with an oncologist.
No. 3: Indolent (slow-growing) lymphomas
Non-Hodgkin lymphoma (NHL) is a type of cancer that starts in the lymphatic system, which includes the lymph nodes, spleen, thymus, bone marrow and other tissues.
Indolent lymphomas are those that “grow and spread slowly,” according to the American Cancer Society.
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The National Comprehensive Cancer Network (NCCN) recommends watchful waiting for asymptomatic, slow-growing follicular lymphoma, as a means of avoiding the toxicity of chemotherapy and immunotherapy until it’s absolutely necessary.
The Lymphoma Research Foundation confirms that doctors recommend “active surveillance” for some patients with slow-growing lymphoma.
Indolent lymphomas are those that “grow and spread slowly,” according to the American Cancer Society. (iStock)
“This approach may be started after the initial diagnosis or after relapse, depending on the situation,” the foundation states on its website. “Active treatment is started if the patient begins to develop lymphoma-related symptoms or if there are signs that the disease is progressing.”
Treatment should be started right away for aggressive (fast-growing) lymphomas.
No. 4: Chronic lymphocytic leukemia
One of the most common adult leukemias, chronic lymphocytic leukemia (CLL) originates in white blood cells (lymphocytes) in the bone marrow and then spreads to the bloodstream, according to the American Cancer Society.
CLL tends to grow slowly, with many patients experiencing no symptoms for years. Eventually, the cancer calls can spread to the lymph nodes, liver and spleen.
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Some studies have shown that early treatment for CLL does not improve survival rates compared to observation, and that the benefits may not outweigh the risks.
In a 2023 study presented at the European Hematology Association 2023 Congress in Frankfurt, Germany, researchers found that early treatment did not prolong overall survival compared to a placebo in patients with early, asymptomatic CLL.
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“I believe it’s fair to conclude that ‘watch-and-wait’ should remain the standard of care in the era of targeted drugs,” said researcher Petra Langerbeins, M.D., when presenting the findings.
No. 5: Low-grade endometrial cancer
For most patients with endometrial cancer, surgery is the first treatment, which entails removing the uterus, fallopian tubes and ovaries, according to the American Cancer Society.
However, in certain patients with low-grade cancer, such as older people, those with “frailty” and people with major health issues, doctors may recommend deferring surgery, which can pose a high risk.
The American Thyroid Association’s guidelines officially recommend active surveillance for very low-risk microcarcinomas. (iStock)
In cases where the patient has medical comorbidities or wants to preserve fertility, hormone treatment may be used instead of surgery, per the ACS.
“It’s usually also considered for cancer that is lower-grade, low-volume and slow-growing,” the above source stated.
No. 6: Some early kidney cancers
In cases of kidney cancer with small tumors (≤3 cm) or benign lesions, doctors may recommend monitoring them instead of undergoing surgery for removal.
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The American Urological Association confirms that active surveillance is an option for some small renal masses (localized tumors).
“I believe it’s fair to conclude that ‘watch-and-wait’ should remain the standard of care in the era of targeted drugs.”
Deferred treatment is particularly recommended for older patients or those with “significant comorbidities,” research shows.
“Shared decision-making about active surveillance should consider risks of intervention/competing mortality versus potential oncologic benefits of intervention,” the UAU states in its guidance.
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Data from the Delayed Intervention and Surveillance for Small Renal Masses (DISSRM) Registry showed that patients with active surveillance had a 99% or greater cancer-specific survival rate — virtually the same as patients who received immediate treatment.
No. 7: Small papillary thyroid cancers
Papillary thyroid cancer (PTC), the most common type of thyroid cancer, may not warrant treatment for small tumors measuring 1 centimeter (10 mm) or less, which are called microcarcinomas.
A young multiracial female is undergoing a diagnostic medical imaging procedure in a state-of-the-art hospital setting with CT simulator. The image illustrates the use of cutting-edge technology for healthcare and treatment in a modern medical environment. The portrayal highlights precision, care, and the sophistication of contemporary medical practices. (iStock)
Research found that when using active surveillance for 10 to 20 years, less than 10% experienced significant growth, only 5% developed lymph node spread and there were no thyroid-cancer deaths.
The American Thyroid Association’s guidelines officially recommend active surveillance for very low-risk microcarcinomas.
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While many patients with low-risk tumors can safely delay treatment, this does not apply to all cancers or all patients.
As cancer behavior and personal health factors vary widely, patients should consult their doctor to determine the most appropriate course of care based on their individual risk level.
Health
Brain Health Challenge: Test Your Knowledge of Healthy Habits
Welcome to the Brain Health Challenge! I’m Dana Smith, a reporter at The New York Times, and I’ll be your guide.
To live a healthy life, it’s crucial to have a healthy brain. In the short term, it keeps you sharp and firing on all cylinders. In the long term, it can reduce your risk of cognitive decline, dementia and stroke.
Practicing basic healthy behaviors, like eating nutritious food and getting regular exercise, is the best way to enhance your brain power and protect the longevity of your neurons. These types of lifestyle habits can benefit the brain at any age. And while they won’t guarantee that you’ll never develop dementia or another brain disease, several clinical trials have shown that they can improve cognition or slow decline.
Every day this week, you’ll do an activity that’s good for your brain, and we’ll dig into the science behind why it works. Some of these activities can provide a small immediate cognitive benefit, but the bigger reward comes from engaging in them consistently over time. So along with the neuroscience lessons, we’ll include a few tips to help you turn these actions into lasting habits.
To keep you accountable, we’re encouraging you to complete this challenge with a friend. If you don’t have a challenge buddy, no problem: We’re also turning the comments section into one big support group.
There are so many fascinating ways your daily behaviors affect your brain. Take sleep, for example.
Lots of studies have shown that getting a good night’s rest (seven to eight hours) is associated with better memory and other cognitive abilities. That’s because sleep, especially REM sleep, is when your brain transfers short-term memories — things you learned or experienced during the day — into long-term storage.
Sleep is also when your brain does its daily housekeeping. While you rest, the brain’s glymphatic system kicks into high gear, clearing out abnormal proteins and other molecular garbage, including the protein amyloid, which is a major contributor to Alzheimer’s disease. A buildup of amyloid is one reason experts think that people who routinely get less sleep have a higher risk of dementia.
What other behaviors play a big role in brain health? For today’s activity, we’re going to test your knowledge with a quiz. Share your score with your accountability partner and in the comments below — I’ll be in there too, cheering you on.
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