CHAPEL HILL, N.C. — The white powder, deposited in a small tube, arrived one morning by FedEx in a basement workplace on the campus of the College of North Carolina at Chapel Hill.

“Fast OD, half bag, weirdly torpid after,” the nameless drug person from Wilmington, N.C., wrote on a slip of paper the scale of an index card, which got here with the tube. The person had a hunch that there was fentanyl within the powder however feared the presence of xylazine, a harmful animal tranquilizer that may depart oozing wounds on limbs.

Erin Tracy, a chemist on the college who focuses on testing medication, started trying to find the reply. She distributed the pattern right into a small vial, then loaded it right into a $600,000 refrigerator-size gadget referred to as a fuel chromatograph-mass spectrometer, which is often utilized in educational chemistry laboratories. A close-by pc displayed the leads to a line graph with a dramatic peak — the sign for fentanyl.

There was solely a hint of xylazine, the machine confirmed. In a state more and more besieged by the drug on the street provide, the outcomes from the check, carried out in September, amounted to a partial aid.

The work on the North Carolina lab is a part of a technique referred to as hurt discount, which goals to not lead customers to abstinence however to present them the instruments to make use of medication safely, maintaining them from infections, accidents and dying. President Biden is the primary president to endorse the technique, lending it a federal imprimatur that well being consultants say may rework how the USA contends with drug use.

The testing of drug samples on the lab and in a rising variety of cities throughout the nation is delivering new perception to researchers and drug customers about what’s within the native drug provide. Drug customers can be taught what’s in a substance earlier than they use it, alert different customers to doable risks within the provide or discover out why a drug led to an overdose or another response. The Chapel Hill group has additionally examined samples of medicine that triggered deadly overdoses after which relayed the outcomes to hurt discount teams.

The testing work in North Carolina and elsewhere, referred to as drug checking, has change into particularly important to recognizing fentanyl, an artificial opioid and a chief offender in lots of overdose deaths lately. Different medication, similar to cocaine and heroin, are sometimes blended with fentanyl.

However the U.S. drug provide is more and more being contaminated by different substances as nicely, similar to xylazine. The risky and increasing medley has intensified calls from public well being consultants and a few federal officers to put money into extra refined types of drug checking.

Dr. Nora D. Volkow, the director of the Nationwide Institute on Drug Abuse, a division of the Nationwide Institutes of Well being, famous that individuals who have been fatally overdosing from medication weren’t simply dying from fentanyl, but in addition from different contaminants.

“We have to perceive that, and we want know-how that may provide the data,” she mentioned.

Drug coverage consultants say that whereas the precise quantity is troublesome to find out, there are dozens of well being departments, educational laboratories or hurt discount teams utilizing machines for drug checking across the nation, together with in cities similar to New York and Chicago. However the work wants extra funding, consultants say, partly due to how troublesome it’s to scale. Whereas check strips that may verify for the presence of fentanyl in a pattern usually value $1, drug checking machines have a price ticket within the tens and even tons of of 1000’s of {dollars}.

The Biden administration’s 2022 nationwide drug technique goals to extend drug checking companies at hurt discount applications by 25 p.c inside three years, a feat that coverage consultants say would require extra funds to be directed to teams that usually function on shoestring budgets.

Drug checking has lengthy been a function of hurt discount efforts in Canada, Australia and Europe, together with in social settings similar to nightclubs and music festivals. However the observe has picked up in the USA solely lately, a mirrored image of the nation’s gradual adoption of hurt discount measures. In additional than a dozen states, even the essential instruments of drug checking, similar to fentanyl check strips, are outlawed as drug paraphernalia; conservatives criticize the observe as permissive of drug use.

Because the opioid provide has surged in latest a long time, drug checking has usually been carried out by crime laboratories or the Drug Enforcement Administration, which study the contents of drug seizures. Regulation enforcement businesses have lengthy been hesitant to share the outcomes shortly or publicly for the needs of serving to drug customers know extra concerning the native provide.

Customers are sometimes left to intuit what they take primarily based on a tablet or powder’s scent or look, similar to its lightness or darkness. Samples from the identical drug seller can comprise completely different quantities of fentanyl, with different substances blended in which may differ from dose to dose. And the consequences of medicine can differ from batch to batch, which might have hint quantities of gear that generally trigger odd and stunning sensations.

Drug checking instruments are wanted partly, consultants say, due to the restricted worth of fentanyl check strips — one of many core elements of the Biden administration’s drug management technique. Not like some drug checking machines, the strips don’t inform a person the range or quantity of fentanyl in a pattern — solely whether or not it accommodates the drug. And since fentanyl is so widespread, customers usually ingest substances figuring out they comprise the drug.

Some hurt discount teams now have cheaper, toaster-size machines that conduct much less complete checks than the Chapel Hill gadget however are extremely moveable. These machines permit well being staff in cities like New York, Chicago, San Francisco and Boston to check drug samples out of vans or small rooms, with outcomes reported again to customers in minutes.

“We’ve regulars that come again week after week, people that get a provide and don’t need to use it till they arrive to the drug testing service,” mentioned Ro Giuliano, who directs syringe trade applications on the San Francisco AIDS Basis, which checks medication utilizing the smaller machines.

The Chapel Hill group has developed what some drug coverage consultants see as essentially the most bold mannequin. Its mail-in program, which started final yr, permits the work to stretch past a single group or group, together with to states the place drug checking is perhaps thought-about unlawful.

This system doesn’t know the identities of the customers who submit medication for testing; the samples are usually routed via hurt discount organizations, which have relationships with the drug customers and may talk outcomes to them. The outcomes are additionally posted on-line. The researchers have to date examined medication from 18 states and 51 clinics and applications.

To gather samples, the Chapel Hill group supplies drug customers with kits that embrace a small vial with a chemical resolution that successfully neutralizes the substance. Nabarun Dasgupta, the scientist who oversees this system, mentioned that step helps to fend off doable skepticism concerning the legality of the work.

Drug checking has already benefited customers in states with drug paraphernalia legal guidelines that make it harder to check medication, mentioned Aaron Ferguson, a pacesetter of the City Survivors Union, a bunch that represents hurt discount organizations and drug customers. In latest months, he has gathered dozens of heroin samples from cities in Texas, the place drug checking instruments are outlawed, to ship to Dr. Dasgupta’s group, suspecting they comprise fentanyl.

Instruments for drug checking “create an early warning system that merely isn’t going to occur from D.E.A. drug seizures in a criminalized drug provide,” Mr. Ferguson mentioned. “Even the folks dealing the medication don’t know what’s in them in most cases.”

Among the many roughly 600 samples the group has run to date, Dr. Dasgupta and his group have discovered over 100 substances. Solely a small quantity have been what he known as the “supposed” medication, similar to THC, cocaine, heroin, ketamine, MDMA and methamphetamine. Many samples have contained dizzying combos of a dozen or extra substances.

Dr. Dasgupta recalled a pattern submitted by a hurt discount group in western North Carolina, which had obtained it from a drug person simply throughout the border in Tennessee. Hurt discount teams within the space had been unaware of a probably harmful opioid, metonitazene, that surfaced within the pattern, he mentioned. Weeks later, the Facilities for Illness Management and Prevention issued a report concerning the substance, a sign of how drug checking can provide well timed warnings for customers.

In two different instances, the researchers found xylazine in a pattern from a person who had been mistakenly recognized with a bacterial abscess, which might generally name for an amputation. Some early xylazine wounds can as an alternative be handled extra like a burn, Dr. Dasgupta mentioned, avoiding the necessity for extra dramatic intervention. A minimum of a type of customers was spared an amputation after the presence of xylazine was confirmed, he mentioned.

Drug coverage consultants say that drug checking is already leaving an imprint on well being officers and members of legislation enforcement. Traci C. Inexperienced, an epidemiologist at Brandeis College who leads a drug checking program in Massachusetts that collects samples from hurt discount teams and legislation enforcement businesses, mentioned that when authorities businesses and drug customers communicated about what was within the drug provide, native authorities have been much less prone to caricature drug use.

The drug provide is “not this huge, deadly, heaving beast,” Dr. Inexperienced mentioned. “It’s one thing that we’re coexisting with.”