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Parkinson’s risk increases with exposure to common chemical, study suggests

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Parkinson’s risk increases with exposure to common chemical, study suggests

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A pesticide commonly used in America’s food supply has been linked to Parkinson’s disease, new research suggests.

A UCLA study published in the journal Springer Nature Link suggests that exposure to chlorpyrifos could increase the risk of the neurological disease.

The chemical is often used on agricultural products like soybeans, fruit and nut trees, broccoli, cauliflower and other row crops, according to the U.S. Environmental Protection Agency.

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The study compared 829 people with Parkinson’s to 824 people without the disease over a 45-year period, focusing on their proximity to chlorpyrifos.

The researchers also conducted mouse experiments, where mice inhaled the pesticide as humans would for 11 weeks. Experiments were also carried out on zebrafish to study cell-level brain damage.

Chlorpyrifos is often used on agricultural products like soybeans, fruit and nut trees, broccoli, cauliflower and other row crops, according to the U.S. Environmental Protection Agency. (iStock)

In humans, the study revealed that long-term exposure to chlorpyrifos led to more than a 2.5 times higher risk of Parkinson’s.

In mice, exposure to the pesticide caused movement problems similar to Parkinson’s symptoms, loss of dopamine-producing neurons, increased brain inflammation and build-up of harmful proteins.

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Zebrafish suffered brain cell death and damage linked to failure in the cell’s “cleanup system,” according to the study press release.

Dr. Jeff Bronstein, director of the Movement Disorders Program at UCLA and professor of neurology and molecular toxicology, noted that previous human studies also suggested an association between chlorpyrifos exposure and Parkinson’s.

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“[We were] surprised that the mechanism of toxicity was apparent in both mice and zebrafish,” he said. “We rarely find such consistent results in different animal models.”

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A researcher commented that the consistency in results between human and animal subjects is “rare.” (iStock)

The researcher emphasized that the association between pesticide exposure and Parkinson’s was “very strong,” and the longer someone was exposed, the higher the risk became.

“People should avoid exposure to CPF and similar pesticides (organophosphates) by not using them in their home, eating organics, and washing fruits and vegetables before eating them,” Bronstein advised.

Study limitations

The study did have some limitations, the researchers acknowledged, primarily that it was observational, meaning it shows an association but cannot prove causation.

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It also estimated exposure based on participants’ locations, and did not measure diet, indoor exposure or personal lifestyle behaviors. Additionally, the results of the animal models can’t be translated directly to humans.

There was also the possibility that chlorpyrifos was used along with other chemicals, which means it could be difficult to measure its specific impact, the study noted.

Chlorpyrifos is used to control different kinds of pests, like termites, mosquitoes and roundworms, among crops. (iStock)

Industry reaction

Chlorpyrifos is used to control different kinds of pests, like termites, mosquitoes and roundworms, among crops, according to the National Pesticide Information Center (NPIC) at Oregon State University.

People can be exposed to the pesticide by breathing it in or by consuming contaminated food or water.

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In 2021, the EPA banned the use of chlorpyrifos on food crops, but a federal appeals court overturned that decision in 2023, allowing its use to resume on some crops while regulators revisit the rule.

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In January 2026, the EPA issued an update outlining plans to move forward with a rule that would ban most uses of chlorpyrifos.

“Chlorpyrifos is subject to registration review, a process required under FIFRA (the Federal Insecticide, Fungicide, and Rodenticide Act) in which registered pesticides are comprehensively evaluated every 15 years against current safety standards and the latest scientific evidence,” the EPA said in a statement sent to Fox News Digital.

“EPA is currently developing a revised human health risk assessment for chlorpyrifos as part of that review, and will consider this study alongside any other relevant submissions,” the agency said in a statement sent to Fox News Digital. (Getty)

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“EPA is currently developing a revised human health risk assessment for chlorpyrifos as part of that review, and will consider this study alongside any other relevant submissions. Where the science calls for stronger protections or tolerance revocations, EPA will act without hesitation and without delay.”

Fox News Digital reached out to several manufacturers of the chemical for comment.

“People should avoid exposure to CPF and similar pesticides.”

Corteva, an Indiana agrichemical company formed in 2019 through the merger of Dow Chemical and DuPont, announced in 2020 that it would end production of chlorpyrifos within the year, citing declining sales.

In April 2022, the German chemical company BASF requested the cancellation of its pesticide registrations for products containing chlorpyrifos. 

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“BASF does not manufacture chlorpyrifos and does not have any pesticide registrations issued by the U.S. EPA for chlorpyrifos-containing products,” the company told Fox News Digital. 

No products from Corteva or BASF were included in the study linking chlorpyrifos to Parkinson’s disease.

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Dementia risk signals could lie in simple blood pressure readings, researchers say

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Dementia risk signals could lie in simple blood pressure readings, researchers say

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Simple measurements taken during routine blood pressure checks could predict dementia risk years before symptoms appear.

That’s according to new research presented this week at the American College of Cardiology’s Annual Scientific Session in Louisiana.

The findings draw on two studies led by researchers at Georgetown University, which suggest that monitoring how blood vessels age and stiffen over time can provide a window into future cognitive health.

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Data shows rates of dementia and aging-related cognitive decline are expected to increase as populations age, and half of U.S. adults have high blood pressure (hypertension).

Scientists believe that efforts to better address hypertension, a key contributor to heart disease and a risk factor for dementia, could affect both cardiac and brain health.

Data shows rates of dementia and aging-related cognitive decline are expected to increase as populations age. Meanwhile, half of U.S. adults have high blood pressure. (iStock)

“Blood pressure management isn’t just about preventing heart attacks and strokes; it may also be one of the most actionable strategies for preserving cognitive health,” Dr. Newton Nyirenda, the study’s lead author and an epidemiologist at Georgetown University in Washington, said in a press release.

The research focused on two metrics, the pulse pressure-heart rate index and estimated pulse wave velocity. Both were calculated using data collected during standard doctor visits, such as heart rate, age and blood pressure.

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“Blood pressure management isn’t just about preventing heart attacks and strokes; it may also be one of the most actionable strategies for preserving cognitive health.”

Researchers examined five years of data patterns for more than 8,500 people in the SPRINT trial, a large study of adults 50 years and older with hypertension. In the follow-up, 323 of the participants developed probable dementia.

HIDDEN BRAIN CONDITION MAY QUADRUPLE DEMENTIA RISK IN OLDER ADULTS, STUDY SUGGESTS

In one study, the team found the pulse pressure-heart rate index was a strong independent predictor of dementia risk in adults over 50. For participants under 65, every one-unit increase was associated with a 76% higher risk of developing dementia.

For participants under 65, an increase in the pulse pressure-heart rate index was associated with a 76% higher risk of developing dementia. (iStock)

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The second study found that adults with consistently elevated or rapidly increasing pulse wave velocity were more likely to develop dementia than those with stable velocity, even after accounting for factors like smoking, gender and cardiovascular history.

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“Our findings suggest that vascular aging patterns may provide meaningful insight into future dementia risk,” said Nyirenda. “This reinforces the idea that managing vascular health earlier in life may influence long-term brain health.”

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The team emphasized that clinicians should tailor risk assessments and treatment strategies to the individual.

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Further studies are needed to confirm these parameters and determine whether changing vascular aging trajectories reduces dementia risk. (iStock)

“You don’t want to wait until a patient starts manifesting cognitive decline before you act,” said senior study author Sula Mazimba, an associate professor at the University of Virginia.

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Researchers noted the study could not establish causation. Other limitations included the fact that participants already had hypertension and elevated cardiovascular risk, meaning the findings may not apply to people without those conditions.

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Further studies are needed to confirm these findings and to determine whether improving blood vessel health over time could reduce dementia risk.

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Everything You Need To Know About Zepbound for Weight Loss, Including Costs

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Everything You Need To Know About Zepbound for Weight Loss, Including Costs


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What Is Zepbound? Weight-Loss Benefits, Costs and Dosage




















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‘Gas station heroin’ banned in another state amid nationwide crackdowns

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‘Gas station heroin’ banned in another state amid nationwide crackdowns

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A dangerous substance dubbed “gas station heroin” continues to alarm medical professionals, with more states making moves to restrict or ban tianeptine.

Fourteen states have officially classified the tricyclic antidepressant as a Schedule I controlled substance.

Connecticut is the latest state to crack down, officially banning the sale and use of the substance starting on Wednesday.

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Tianeptine, which can produce euphoria in higher doses, can be more potent than morphine and addictive opioids, according to the U.S. Food and Drug Administration.

Some countries have taken steps to restrict how tianeptine is prescribed or dispensed, and have even revised the labels to warn people of its potential addictive qualities.

Tianeptine can be more potent than morphine and addictive opioids. (iStock)

Misuse of tianeptine can cause severe adverse health effects, including respiratory depression, severe sedation and death, according to the Drug Enforcement Administration.

Some companies market the drug as an aid for pain, anxiety and depression, or as a means of improving mental alertness in a pill, powder, salt or liquid form.

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The products are typically sold at convenience stores, gas stations, vape shops and online retailers, and go by names like Tianaa, ZaZa, Neptune’s Fix, Pegasus and TD Red.

Connecticut is the 15th state to classify tianeptine as a Schedule I controlled substance. (Markus Scholz/picture alliance via Getty Images)

Connecticut Lt. Gov. Susan Bysiewicz said in a press release that the schedule change is a necessary step to combat addiction.

“With false marketing that led consumers to believe these are safe products, and with candy-like flavor options, these substances posed a clear threat to those battling substance-use disorder and our youngest residents,” she added.

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The Nutmeg State also added Mitragyna speciosa (kratom), 7-hydroxymitragynine, Bromazolam, Flubromazolam, Nitazenes and Phenibut to the schedule classification.

Earlier this month, FDA Commissioner Martin Makary penned a letter sounding the alarm on what he called a “dangerous and growing health trend.”

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“I am very concerned,” Makary wrote. “I want the public to be especially aware of this dangerous product and the serious and continuing risk it poses to America’s youth.”

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New York-based Robert Schwaner, M.D., vice chair of system clinical affairs at Stony Brook Emergency Medicine, told Fox News Digital that the FDA has never approved tianeptine as a dietary supplement.

“As with heroin and other opioids, significant mu-opioid receptor stimulation ultimately results in a loss of respiratory drive and subsequent cardiac arrest.” (Dekalb County Sheriff’s Office)

“The euphoria at low doses is primarily due to increased serotonergic activity from its serotonin reuptake effects. With increasing doses, the mu-opioid receptor stimulation may become lethal,” said Schwaner. “As with heroin and other opioids, significant mu-opioid receptor stimulation ultimately results in a loss of respiratory drive and subsequent cardiac arrest.”

Schwaner said he believes the substance requires national regulation due to its addictive qualities. 

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“Acting at the same receptor as opioids, tianeptine has the potential for an individual to develop tolerance, subsequent dependence and withdrawal from its use,” he cautioned.

Fox News Digital reached out to the FDA for comment. 

Fox News Digital’s Greg Wehner and Melissa Rudy contributed to this report.

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