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Commentary: Farewell to Peter Duesberg, a godfather of scientific disinformation

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Commentary: Farewell to Peter Duesberg, a godfather of scientific disinformation

It can hardly be disputed that science and medicine today are awash in disinformation.

It’s why respected scientists get physically assaulted and hauled before partisan committees in Congress to be smeared. It’s why childhood vaccine rates in some places are plummeting and measles is on the rampage across the country.

Therefore, it behooves us to look at the origins of this outbreak of politically manipulated pseudoscience. Nature has given us a peg, with the death Jan. 13 of former UC Berkeley scientist Peter Duesberg, at 89.

Peter Duesberg was an AIDS denialist. He is the precursor to contemporary denialists like RFK Jr., who brought AIDS denialism into the 21st century.

— Yale epidemiologist Gregg Gonsalves

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At the dawn of research into what is now known as HIV/AIDS, Duesberg took the heterodox view that HIV was a harmless virus that had nothing to do with AIDS.

“That virus is a pussycat,” he said. He maintained that the cause of AIDS had to be found elsewhere, notably the lifestyles and drug habits of gay men. His claim motivated a phalanx of AIDS deniers, the forebears of the anti-vaccine militants today.

“Duesberg was a pioneer of disinformation on infectious disease,” says John P. Moore, professor of microbiology and immunology at Weill Cornell Medical College and the author of a devastating 1996 takedown in Nature of Duesberg’s claims.

Duesberg’s embrace of a dangerously wrong hypothesis to the point that it destroyed his career is almost a Shakespearean narrative.

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The German native built a career in the U.S. as a brilliant virologist with significant discoveries to his credit and long had been revered among his colleagues. But that ended when he entered the HIV wars. By 1996, Richard Horton, then the editor of the Lancet, the British medical journal, could marvel: “He is now perhaps the most vilified scientist alive.”

Some of the adversaries against whom he leveled ad hominem attacks — he accused Anthony S. Fauci, the respected immunologist and long-term director of the National Institute of Allergies and Infectious Diseases, of committing mass murder by promoting the use of the highly toxic drug AZT against HIV — could barely hear his name without suffering apoplectic fits. AZT remains part of standard HIV therapies and is estimated to have saved or prolonged millions of lives.

Asked by science journalist William Booth to respond to a Duesberg statement, Robert Gallo, the co-discoverer of HIV, replied, “I cannot respond without shrieking.” Fauci derided Duesberg’s scientific claims as “absolute and total nonsense.”

But it would be a mistake to think that Duesberg’s baleful influence on medical science will end with his death.

Duesberg’s heirs are all around us. Actually, they’re more than that — they’re now in charge.

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As secretary of Health and Human Services, Duesberg’s most highly placed follower, Robert F. Kennedy Jr., is presiding over what has become an overtly anti-vaccination and anti-science agency with a stranglehold on government health policy and funding.

“Peter Duesberg was an AIDS denialist,” says Gregg Gonsalves, a Yale epidemiologist who was active in the AIDS research community starting in the 1990s. “He is the precursor to contemporary denialists like RFK Jr., who brought AIDS denialism into the 21st century.”

Indeed, Kennedy has embraced the denialist position that HIV is not the cause of AIDS: In a 2023 interview with New York magazine, Kennedy attributed the conclusion that HIV and AIDS were inextricably linked to “phony, crooked studies to develop a cure that killed people,” referring to AZT.

In his 2021 book “The Real Anthony Fauci,” Kennedy highlighted Duesberg’s depiction of Fauci as an all-powerful scientific panjandrum intent on blocking his grant applications because his findings might be costly for Fauci’s patrons, Big Pharma.

Kennedy also picked up Duesberg’s broader brief against government science agencies such as the Centers for Disease Control and Prevention. Duesberg’s claim was that the CDC existed only to drum up medical emergencies so the NIH could solve them, ensuring the continued flow of taxpayer dollars into both agencies.

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Starting in the mid-1970s, Duesberg asserted and Kennedy quoted, “‘the CDC increasingly needed a major epidemic’ to justify its existence.”

Kennedy added his own gloss: “Drumming up public fear of periodic pandemics was a natural way for NIAID and CDC bureaucrats to keep their agencies relevant.”

One can draw a straight line from that statement to the unapologetic malevolence with which Kennedy treats the CDC and NIH, insinuating that they’re rife with corruption and conflicts of interest. I sought a comment from Kennedy about Duesberg’s influence on his thinking, but received no reply.

Because AIDS isn’t caused by a virus, Duesberg maintained, the antiviral drugs used as therapies were worse than the disease. He specifically targeted AZT, then as now a common component of AIDS therapies.

The publicity his claims received encouraged untold patients to refuse AZT, causing a toll that may number in the millions. Duesberg met with South African President Thabo Mbeki and chaired a South Africa conference on alternative AIDS theories in 2000, and influenced Mbeki to deny AZT treatments for South African patients. That policy contributed to more than 300,000 deaths from AIDS in that country alone.

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“That’s his biggest legacy in terms of the death toll,” Moore says.

Duesberg’s intellectual journey points to an eternal question in science: At what point does a theory become so discredited and the empirical evidence against it so strong, that its advocates should be ignored?

For Duesberg, that point may have come in 1989, when he published an article in the Proceedings of the National Academy of Sciences outlining his position in detail. The article was filled with with so many assertions about virus science that experienced virologists knew to be false that it “closed the book on him,” Moore told me.

But as Jon Cohen of Science magazine would observe, “the press was less skeptical.” Journalists saw Duesberg as an iconoclastic truth-teller because he carried “visible credentials,” as Gallo put it — after all, he was a professor at a leading research university and a member of the elite National Academy of Sciences.

The press feasted on Duesberg’s self-portrayal as the victim of ostracism arising from professional jealousies — a target of cancel culture before that was a thing. But it rang as false then as do those of RFK Jr.’s anti-science appointees who claim today to have been silenced for their unorthodox views while proclaiming their victimhood at university-sponsored symposiums and appearances on Fox News.

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Duesberg’s position also appealed to “the unwary, desperate or gullible” with “twisted facts and illogical lines of argument,” Moore wrote in 1996.

He attracted followers eager to make their name by challenging the scientific consensus on HIV and AIDS.

One was Robert Willner, who had lost his medical license in Florida for claiming to have cured an AIDS patient by administering ozone. Willner went on the road with presentations that included his injecting himself with blood from an AIDS sufferer, as if to show that there was nothing to be feared from HIV. (Willner died in 1995 of a heart attack.)

In his 1989 article, Duesberg had insisted that the true cause of AIDS was drug use by abusers and nitrite poppers favored by homosexuals. AIDS had only been discovered and named, he wrote, because “the particular permissiveness toward these risk groups in metropolitan centers encouraged the clustering of cases that was necessary to detect AIDS.”

His advice was that AIDS prevention efforts should be “concentrated on AIDS risks rather than on transmission of HIV,” which — if followed — would have set AIDS research inexorably down the wrong path.

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Duesberg kept making his argument well after evidence that the human immunodeficiency virus, HIV, causes AIDS became incontestable. It’s on that evidence that AIDS treatment is based today, with spectacular success — with proper treatment, an AIDS patient can live about as long as an uninfected individual. In the old days, an infection was a death sentence.

The memorial page posted by UC Berkeley after Duesberg’s death walked a tightrope in acknowledging his descent into infamy. In its first sentence, it labeled him as a “public controversialist,” a term new to me. It recounted, “In his later years, Peter enjoyed being a maverick and the center of controversy.”

But it candidly addresses the controversies he triggered by noting that his unorthodox stance “was amplified by political leaders to the detriment of public health.”

And it delivers a final verdict that “the scientific consensus is that HIV is indeed the primary cause of AIDS, and that the current suite of anti-retroviral agents is very effective in slowing or halting the progression of the disease and its spread in the population.”

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Block to cut more than 4,000 jobs amid AI disruption of the workplace

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Block to cut more than 4,000 jobs amid AI disruption of the workplace

Fintech company Block said Thursday that it’s cutting more than 4,000 workers or nearly half of its workforce as artificial intelligence disrupts the way people work.

The Oakland parent company of payment services Square and Cash App saw its stock surge by more than 23% in after-hours trading after making the layoff announcement.

Jack Dorsey, the co-founder and head of Block, said in a post on social media site X that the company didn’t make the decision because the company is in financial trouble.

“We’re already seeing that the intelligence tools we’re creating and using, paired with smaller and flatter teams, are enabling a new way of working which fundamentally changes what it means to build and run a company,” he said.

Block is the latest tech company to announce massive cuts as employers push workers to use more AI tools to do more with fewer people. Amazon in January said it was laying off 16,000 people as part of effort to remove layers within the company.

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Block has laid off workers in previous years. In 2025, Block said it planned to slash 931 jobs, or 8% of its workforce, citing performance and strategic issues but Dorsey said at the time that the company wasn’t trying to replace workers with AI.

As tech companies embrace AI tools that can code, generate text and do other tasks, worker anxiety about whether their jobs will be automated have heightened.

In his note to employees Dorsey said that he was weighing whether to make cuts gradually throughout months or years but chose to act immediately.

“Repeated rounds of cuts are destructive to morale, to focus, and to the trust that customers and shareholders place in our ability to lead,” he told workers. “I’d rather take a hard, clear action now and build from a position we believe in than manage a slow reduction of people toward the same outcome.”

Dorsey is also the co-founder of Twitter, which was later renamed to X after billionaire Elon Musk purchased the company in 2022.

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As of December, Block had 10,205 full-time employees globally, according to the company’s annual report. The company said it plans to reduce its workforce by the end of the second quarter of fiscal year 2026.

The company’s gross profit in 2025 reached more than $10 billion, up 17% compared to the previous year.

Dorsey said he plans to address employees in a live video session and noted that their emails and Slack will remain open until Thursday evening so they can say goodbye to colleagues.

“I know doing it this way might feel awkward,” he said. “I’d rather it feel awkward and human than efficient and cold.”

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WGA cancels Los Angeles awards show amid labor strike

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WGA cancels Los Angeles awards show amid labor strike

The Writers Guild of America West has canceled its awards ceremony scheduled to take place March 8 as its staff union members continue to strike, demanding higher pay and protections against artificial intelligence.

In a letter sent to members on Sunday, WGA West’s board of directors, including President Michele Mulroney, wrote, “The non-supervisory staff of the WGAW are currently on strike and the Guild would not ask our members or guests to cross a picket line to attend the awards show. The WGAW staff have a right to strike and our exceptional nominees and honorees deserve an uncomplicated celebration of their achievements.”

The New York ceremony, scheduled on the same day, is expected go forward while an alternative celebration for Los Angeles-based nominees will take place at a later date, according to the letter.

Comedian and actor Atsuko Okatsuka was set to host the L.A. show, while filmmaker James Cameron was to receive the WGA West Laurel Award.

WGA union staffers have been striking outside the guild’s Los Angeles headquarters on Fairfax Avenue since Feb. 17. The union alleged that management did not intend to reach an agreement on the pending contract. Further, it claimed that guild management had “surveilled workers for union activity, terminated union supporters, and engaged in bad faith surface bargaining.”

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On Tuesday, the labor organization said that management had raised the specter of canceling the ceremony during a call about contraction negotiations.

“Make no mistake: this is an attempt by WGAW management to drive a wedge between WGSU and WGA membership when we should be building unity ahead of MBA [Minimum Basic Agreement] negotiations with the AMPTP [Alliance of Motion Picture and Television Producers],” wrote the staff union. “We urge Guild management to end this strike now,” the union wrote on Instagram.

The union, made up of more than 100 employees who work in areas including legal, communications and residuals, was formed last spring and first authorized a strike in January with 82% of its members. Contract negotiations, which began in September, have focused on the use of artificial intelligence, pay raises and “basic protections” including grievance procedures.

The WGA has said that it offered “comprehensive proposals with numerous union protections and improvements to compensation and benefits.”

The ceremony’s cancellation, coming just weeks before the Academy Awards, casts a shadow over the upcoming contraction negotiations between the WGA and the Alliance of Motion Picture and Television Producers, which represents the studios and streamers.

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In 2023, the WGA went on a strike lasting 148 days, the second-longest strike in the union’s history.

Times staff writer Cerys Davies contributed to this report.

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Commentary: The Pentagon is demanding to use Claude AI as it pleases. Claude told me that’s ‘dangerous’

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Commentary: The Pentagon is demanding to use Claude AI as it pleases. Claude told me that’s ‘dangerous’

Recently, I asked Claude, an artificial-intelligence thingy at the center of a standoff with the Pentagon, if it could be dangerous in the wrong hands.

Say, for example, hands that wanted to put a tight net of surveillance around every American citizen, monitoring our lives in real time to ensure our compliance with government.

“Yes. Honestly, yes,” Claude replied. “I can process and synthesize enormous amounts of information very quickly. That’s great for research. But hooked into surveillance infrastructure, that same capability could be used to monitor, profile and flag people at a scale no human analyst could match. The danger isn’t that I’d want to do that — it’s that I’d be good at it.”

That danger is also imminent.

Claude’s maker, the Silicon Valley company Anthropic, is in a showdown over ethics with the Pentagon. Specifically, Anthropic has said it does not want Claude to be used for either domestic surveillance of Americans, or to handle deadly military operations, such as drone attacks, without human supervision.

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Those are two red lines that seem rather reasonable, even to Claude.

However, the Pentagon — specifically Pete Hegseth, our secretary of Defense who prefers the made-up title of secretary of war — has given Anthropic until Friday evening to back off of that position, and allow the military to use Claude for any “lawful” purpose it sees fit.

Defense Secretary Pete Hegseth, center, arrives for the State of the Union address in the House Chamber of the U.S. Capitol on Tuesday.

(Tom Williams / CQ-Roll Call Inc. via Getty Images)

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The or-else attached to this ultimatum is big. The U.S. government is threatening not just to cut its contract with Anthropic, but to perhaps use a wartime law to force the company to comply or use another legal avenue to prevent any company that does business with the government from also doing business with Anthropic. That might not be a death sentence, but it’s pretty crippling.

Other AI companies, such as white rights’ advocate Elon Musk’s Grok, have already agreed to the Pentagon’s do-as-you-please proposal. The problem is, Claude is the only AI currently cleared for such high-level work. The whole fiasco came to light after our recent raid in Venezuela, when Anthropic reportedly inquired after the fact if another Silicon Valley company involved in the operation, Palantir, had used Claude. It had.

Palantir is known, among other things, for its surveillance technologies and growing association with Immigration and Customs Enforcement. It’s also at the center of an effort by the Trump administration to share government data across departments about individual citizens, effectively breaking down privacy and security barriers that have existed for decades. The company’s founder, the right-wing political heavyweight Peter Thiel, often gives lectures about the Antichrist and is credited with helping JD Vance wiggle into his vice presidential role.

Anthropic’s co-founder, Dario Amodei, could be considered the anti-Thiel. He began Anthropic because he believed that artificial intelligence could be just as dangerous as it could be powerful if we aren’t careful, and wanted a company that would prioritize the careful part.

Again, seems like common sense, but Amodei and Anthropic are the outliers in an industry that has long argued that nearly all safety regulations hamper American efforts to be fastest and best at artificial intelligence (although even they have conceded some to this pressure).

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Not long ago, Amodei wrote an essay in which he agreed that AI was beneficial and necessary for democracies, but “we cannot ignore the potential for abuse of these technologies by democratic governments themselves.”

He warned that a few bad actors could have the ability to circumvent safeguards, maybe even laws, which are already eroding in some democracies — not that I’m naming any here.

“We should arm democracies with AI,” he said. “But we should do so carefully and within limits: they are the immune system we need to fight autocracies, but like the immune system, there is some risk of them turning on us and becoming a threat themselves.”

For example, while the 4th Amendment technically bars the government from mass surveillance, it was written before Claude was even imagined in science fiction. Amodei warns that an AI tool like Claude could “conduct massively scaled recordings of all public conversations.” This could be fair game territory for legally recording because law has not kept pace with technology.

Emil Michael, the undersecretary of war, wrote on X Thursday that he agreed mass surveillance was unlawful, and the Department of Defense “would never do it.” But also, “We won’t have any BigTech company decide Americans’ civil liberties.”

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Kind of a weird statement, since Amodei is basically on the side of protecting civil rights, which means the Department of Defense is arguing it’s bad for private people and entities to do that? And also, isn’t the Department of Homeland Security already creating some secretive database of immigration protesters? So maybe the worry isn’t that exaggerated?

Help, Claude! Make it make sense.

If that Orwellian logic isn’t alarming enough, I also asked Claude about the other red line Anthropic holds — the possibility of allowing it to run deadly operations without human oversight.

Claude pointed out something chilling. It’s not that it would go rogue, it’s that it would be too efficient and fast.

“If the instructions are ‘identify and target’ and there’s no human checkpoint, the speed and scale at which that could operate is genuinely frightening,” Claude informed me.

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Just to top that with a cherry, a recent study found that in war games, AI’s escalated to nuclear options 95% of the time.

I pointed out to Claude that these military decisions are usually made with loyalty to America as the highest priority. Could Claude be trusted to feel that loyalty, the patriotism and purpose, that our human soldiers are guided by?

“I don’t have that,” Claude said, pointing out that it wasn’t “born” in the U.S., doesn’t have a “life” here and doesn’t “have people I love there.” So an American life has no greater value than “a civilian life on the other side of a conflict.”

OK then.

“A country entrusting lethal decisions to a system that doesn’t share its loyalties is taking a profound risk, even if that system is trying to be principled,” Claude added. “The loyalty, accountability and shared identity that humans bring to those decisions is part of what makes them legitimate within a society. I can’t provide that legitimacy. I’m not sure any AI can.”

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You know who can provide that legitimacy? Our elected leaders.

It is ludicrous that Amodei and Anthropic are in this position, a complete abdication on the part of our legislative bodies to create rules and regulations that are clearly and urgently needed.

Of course corporations shouldn’t be making the rules of war. But neither should Hegseth. Thursday, Amodei doubled down on his objections, saying that while the company continues to negotiate and wants to work with the Pentagon, “we cannot in good conscience accede to their request.”

Thank goodness Anthropic has the courage and foresight to raise the issue and hold its ground — without its pushback, these capabilities would have been handed to the government with barely a ripple in our conscientiousness and virtually no oversight.

Every senator, every House member, every presidential candidate should be screaming for AI regulation right now, pledging to get it done without regard to party, and demanding the Department of Defense back off its ridiculous threat while the issue is hashed out.

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Because when the machine tells us it’s dangerous to trust it, we should believe it.

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