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Early Parkinson’s could be detected decades before symptoms with simple blood test

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Early Parkinson’s could be detected decades before symptoms with simple blood test

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A new study from Chalmers University of Technology in Sweden, along with Oslo University Hospital in Norway, may have discovered a way to detect biomarkers of Parkinson’s disease in the blood up to decades earlier.

In the very early stages of the disease, the body goes through changes related to DNA repair and stress in cells. These changes leave detectable clues in the blood before major brain damage occurs, according to a press release for the study.

This could allow for early detection of Parkinson’s, when treatments might have a better chance of slowing or preventing serious damage.

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The processes of DNA repair and cellular stress response can occur for up to 20 years in Parkinson’s patients before motor symptoms fully develop, according to the researchers.

The team used machine learning to discover patterns linked to these processes, which were not found in healthy individuals or patients who were already diagnosed with Parkinson’s.

European researchers discovered a way to detect early Parkinson’s disease via a blood test. (iStock)

Annikka Polster, assistant professor at the Department of Life Sciences at Chalmers who led the study, suggested in a statement that the study has found an “important window of opportunity” in which the disease can be detected “before motor symptoms caused by nerve damage in the brain appear.”

“The fact that these patterns only show at an early stage and are no longer activated when the disease has progressed further also makes it interesting to focus on the mechanisms to find future treatments,” she added.

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Polster confirmed that the study highlighted biomarkers that “likely reflect some of the early biology of the disease,” which “paves the way for broad screening tests via blood samples: a cost-effective, easily accessible method.”

The findings were published in npj Parkinson’s Disease.

Blood tests for early Parkinson’s diagnosis could become more common, researchers predicted. (iStock)

The researchers plan to further develop tools to more easily detect these active mechanisms and understand how they work, according to the university.

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The team predicts that, within five years, blood tests for early Parkinson’s diagnoses could become more common within clinical practice. They are also optimistic about the development of new drugs to prevent or treat the disease.

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“If we can study the mechanisms as they happen, it could provide important keys to understanding how they can be stopped and which drugs might be effective,” Polster said. 

“This may involve new drugs, but also drug repurposing, where we can use drugs developed for diseases other than Parkinson’s because the same gene activities or mechanisms are active.”

More than 10 million people around the world are estimated to be living with Parkinson’s disease. (iStock)

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Study limitations  

The researchers acknowledged that the study had some limitations, including that the gene activity measured in the blood only partly matches what’s happening in the brain.

External factors, such as medication use, may have affected the results, they added.

Also, the study population may not represent all people, so findings may not apply broadly.

By the numbers

More than 10 million people around the world are estimated to be living with Parkinson’s disease, according to the Parkinson’s Foundation. About 90,000 people in the U.S. are diagnosed each year.

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Numbers are expected to continue rising because Parkinson’s is the second-most common neurodegenerative disease after Alzheimer’s.

While research is advancing, there is no cure for the disease, although medications are available to manage symptoms.

Common motor symptoms of Parkinson’s include tremors, slowed movement, muscle stiffness, balance and walking difficulties. (iStock)

Common motor symptoms include tremors, slowed movement, muscle stiffness, balance and walking difficulties, a shuffling gait and freezing episodes. 

Non-motor symptoms include loss of smell, sleep problems, constipation, fatigue, depression or anxiety, speech and swallowing changes, cognitive slowing and reduced facial expression, according to Parkinson’s Foundation and Mayo Clinic.

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Danish Anwer, a doctoral student at the Department of Life Sciences at Chalmers and the study’s first author, detailed in a statement how Parkinson’s affects the brain.

“By the time the motor symptoms of Parkinson’s disease appear, 50% to 80% of the relevant brain cells are often already damaged or gone,” he said. “The study is an important step toward facilitating early identification of the disease and counteracting its progression before it has gone this far.”

“By the time you have actual motor symptoms … a large majority of affected cells have been damaged and destroyed.”

Fox News senior medical analyst Dr. Marc Siegel agreed that Parkinson’s is a “very difficult disease” with an increasing global impact.

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“By the time you have actual motor symptoms affecting gait, tremor, etc., a large majority of affected cells have been damaged and destroyed,” he told Fox News Digital.

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Siegel called the new research “exciting,” suggesting that it “opens the door for earlier and more effective diagnosis and treatment.”

Fox News Digital reached out to the study authors for comment.

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Health

Common nighttime noise exposure may trigger heart problems, study suggests

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Common nighttime noise exposure may trigger heart problems, study suggests

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Living near heavy traffic could negatively impact your heart health.

A European study, published in the journal Environmental Research, found that exposure to nighttime road traffic noise is linked to changes in the blood, leading to worsened cholesterol and cardiovascular risks.

The researchers considered data from the U.K. Biobank, Rotterdam Study, and Northern Finland Birth Cohort 1966, including more than 272,000 adults over the age of 30, according to a press release.

Nighttime road noise exposure was estimated at all participants’ homes based on national noise maps. Researchers also took blood samples to measure the participants’ metabolic biomarkers for disease, then mapped the link between nightly noise levels and existence of biomarkers.

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Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers. (iStock)

The study found that people exposed to louder noise at night — especially sounds above 55 decibels — showed changes in 48 different substances in their blood. Twenty of these associations “remained robust” throughout all cohorts.

Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers, especially LDL “bad” cholesterol, IDL (intermediate-density lipoprotein) and unsaturated fatty acids.

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As noise levels increased, starting at around 50 decibels, cholesterol markers rose steadily, the release stated.

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The authors concluded that this study “provides evidence that nighttime road traffic noise exposure from 50 dB upward is associated with alterations in blood cholesterol and lipid profiles in adults.”

Researchers noted a link between traffic noise and cardiometabolic disease. (iStock)

Study co-author Yiyan He, doctoral researcher at the University of Oulu in Finland, noted that in this type of research, small effect sizes are expected, and environmental exposures such as traffic noise are “typically modest.”

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“Despite this, we observed statistically robust and consistent associations across many biomarkers, especially those related to LDL and IDL lipoproteins,” she told Fox News Digital.

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“We also identified a clear exposure-response pattern starting at around 50 dB, suggesting that metabolic changes become more evident as noise levels increase.”

This aligns with public health guidance, as the World Health Organization recommends lower nighttime noise limits at around 40 to 45 dB, Yiyan He added.

“This finding may clarify the association between traffic noise and cardiometabolic diseases,” the researchers wrote. (iStock)

“The 55 dB level is often used as an interim benchmark associated with substantial noise annoyance and sleep disturbance,” she said. “In our study, we observed associations not only at 55 dB, but also indications of effects emerging at around 50 dB.”

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The strength and consistency of the cholesterol-related associations were surprising, as these changes are usually “subtle.”

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“Instead, we found consistent associations across multiple large European cohorts, which strengthens confidence that the findings may reflect real biological patterns,” Yiyan He went on. “We were also interested to see that effects were minimal below ~50 dB, suggesting a possible threshold-like pattern.”

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The researcher noted that these findings were consistent across genders, education levels and obesity status.

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The study was restricted to White Europeans, which posed a limitation. There was also a lack of information on the fasting status in the UK Biobank.

Changes in cholesterol levels were more severe than researchers expected. (iStock)

“Fasting can influence levels of certain metabolites, particularly fatty acids,” Yiyan He said. “However, based on UK Biobank documentation, fewer than 10% of participants were fasting for at least eight hours, and our main findings focused on cholesterol-related biomarkers, which are generally less sensitive to short-term fasting.”

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The researchers also lacked information on bedroom location, indoor noise exposure and time spent at home.

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“These factors may introduce non-differential exposure misclassification,” Yiyan He said. “Additionally, noise exposure estimates were based on participants’ temporary residential addresses at the time of blood sampling, without considering the duration of residence.”

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“Many of these limitations would tend to bias results toward the null, so the consistent associations we observed remain noteworthy.”

Experts recommend taking measures to limit traffic noise at night. (iStock)

Based on this latest research, Yiyan He noted that nighttime noise is a “health-relevant exposure,” not just “an annoyance.”

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“Our findings suggest that nighttime traffic noise may subtly but consistently affect metabolic health,” she said. “While the changes in cholesterol and lipid levels for any one individual are small, traffic noise affects a very large number of people, which means the potential public health impact could be substantial.”

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The researcher recommends taking measures like improving sound insulation, using noise-reducing strategies and placing bedrooms on the quieter side of the home when possible.

“Because sleep is a key pathway linking noise to health, protecting the nighttime sleep environment is especially important,” she added.

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‘SuperAgers’ stay mentally sharp well past 80, as scientists reveal the reason

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