Health
Widely prescribed opioid shows minimal pain relief and higher heart risk, study finds
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A widely prescribed opioid painkiller showed limited effectiveness and increased risk of negative effects in a new analysis published in BMJ Evidence-Based Medicine.
The study examined tramadol, a common prescription opioid used to treat chronic pain.
Tramadol has historically been perceived as a safer or less addictive opioid, which has contributed to its widespread use in chronic pain treatment, the study authors noted.
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“Often, we may use tramadol to avoid more addictive drugs like other opioids, though in fact tramadol is a synthetic opioid. It is much milder,” Dr. Marc Siegel, senior medical analyst for Fox News, told Fox News Digital.
In the new analysis, researchers used data from 19 randomized clinical trials involving 6,506 adults with conditions including osteoarthritis, chronic low back pain, neuropathic pain and fibromyalgia. All the studies compared tramadol to a placebo treatment.
The level of pain relief associated with tramadol fell below the threshold typically considered clinically important. (iStock)
Overall, tramadol led to a small decrease in pain, but the amount of relief was less than what is usually considered clinically meaningful, the authors reported.
“It is notable how minimal the pain reduction was and how clearly the study highlighted the elevated risk of serious adverse events, even over relatively short trial durations,” Alopi M. Patel, M.D., pain medicine physician at Icahn School of Medicine at Mt. Sinai in New York City, told Fox News Digital. (Patel was not involved in the study.)
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Participants receiving tramadol experienced a higher risk of adverse events, both serious and non-serious, compared with those receiving a placebo.
Serious adverse events primarily included cardiovascular events, such as chest pain, coronary artery disease and congestive heart failure. The authors concluded that tramadol likely increases the risk of heart-related issues.
Serious adverse events were primarily driven by cardiovascular outcomes, including chest pain, coronary artery disease and congestive heart failure. (iStock)
The authors concluded that the benefits of tramadol for chronic pain are small and that the harms likely outweigh the benefits. The findings call into question the use of tramadol for chronic pain conditions, they stated.
Study limitations
Most of the trials included in the analysis were short, with treatment periods ranging from two to 16 weeks and follow-up periods from three to 15 weeks.
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This limited the ability to assess long-term outcomes, the researchers acknowledged.
The authors reported that many outcomes had a high risk of bias, which may have exaggerated the apparent benefits and minimized the reported harms.
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The trials involved several different types of chronic pain, but the data were not detailed enough to draw conclusions for any specific condition. This makes it “harder to generalize the findings to specific patient populations,” noted Patel.
Most trials were short in duration and compared tramadol only with a placebo — limiting conclusions about long-term effects and comparisons with other treatments. (iStock)
Though the study has value, Siegel said, “looking at slight increased rates of cancer or heart disease among those on the drug is completely misleading, because it is not controlled for other factors and there is no evidence or hint of causation.”
“You would have to first look at underlying characteristics of that group who took the meds.”
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The doctor also pointed out that the study “doesn’t compare [tramadol] with full-on opioids like Percocet.”
Experts emphasize that patients should not stop taking tramadol abruptly, as doing so can lead to withdrawal symptoms. Those looking to change their medication should consult a doctor.
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“I recommend that clinicians and patients engage in transparent, shared decision-making that considers tramadol’s modest benefits alongside its risks,” Patel advised.
Fox News Digital reached out to several manufacturers of tramadol requesting comment.
Health
Could At-Home Brain Stimulation Reduce Psychiatry’s Reliance on S.S.R.I.s?
“Our brains are so pharmaceutically inclined,” he said. “This fits into the model of pills.”
At the same time, tDCS could also challenge the current, pill-centric paradigm, by pushing psychiatrists to go beyond old notions of serotonin deficiencies and chemical imbalances, and to think more broadly about getting the brain unstuck. The two treatments together, research suggests may work together to nudge the brain toward a more plastic, activated state to help people overcome old patterns.
For instance, Dr. Somayya Kajee, a psychiatrist in Norwich, England, has found that tDCS helped some of her patients taper off an antidepressant or avoid having to start on another one. She added she has successfully used Flow to treat her neurodivergent patients who were taking medication for A.D.H.D. or autism, and who did not want to add on an S.S.R.I.
Ms. Davies started tDCS a few weeks after increasing her Prozac dosage. When she first put the headset on for 30 minutes, the recommended interval, she recalled feeling only a slight tingling — a “spicy sensation,” similar to having your hair bleached, as a participant in a clinical trial put it.
But within a few days, something shifted for Ms. Davies. She felt clearer, she said. The harsh voice in her head quieted. It was as if the world was in color again.
She said she could not say for sure what made the difference — the tDCS, delayed effects of the antidepressant, the passage of time or some combination — but “whatever it was helped to make me think, ‘Actually, maybe I can do this,’” she said. For the first time, she looked forward to giving her baby a bath.
Health
Dementia risk rises with common food type millions eat every day, study suggests
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It’s well-known that ultraprocessed foods (UPFs) are not good for overall health — but new research has uncovered further evidence that this diet could negatively impact the brain.
The study, published in the journal Alzheimer’s and Dementia by the Alzheimer’s Association, revealed that UPFs are linked to more than 30 adverse health outcomes, including several dementia risk factors, like cardiovascular disease, type 2 diabetes and obesity.
Researchers from Australia’s Monash University analyzed more than 2,000 dementia-free Australian adults between the ages of 40 and 70, comparing their diets to cognitive function.
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They found that each 10% increase in UPF intake was associated with lower attention scores and higher dementia risk, regardless of whether the adults typically followed a healthy diet, like the Mediterranean diet.
There was no significant link found between UPF consumption and memory.
Each 10% increase in ultraprocessed food intake was associated with lower attention scores and higher dementia risk, the study found. (iStock)
By identifying food processing as a contributor to poorer cognition, the study “supports the need to refine dietary guidelines,” the researchers concluded.
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As the data was self-reported, this could pose a limitation to the strength of the findings, the team noted.
In an interview with Fox News Digital, Dr. Daniel Amen, a California-based psychiatrist and founder of Amen Clinics, discussed how diet has a “powerful impact” on the brain.
“[The brain] uses about 20% of the calories you consume, so the quality of those calories matters,” Dr. Daniel Amen told Fox News Digital. (iStock)
“Your brain is an energy-hungry organ,” he said. “It uses about 20% of the calories you consume, so the quality of those calories matters.”
Food is either “medicine or poison,” according to the doctor, who called out ultraprocessed foods like packaged snacks, soft drinks and ready-made meals that tend to be higher in sugar, unhealthy fats, additives and low-quality ingredients.
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These foods can promote inflammation, insulin resistance, poor blood flow and oxidative stress, all of which are “bad for the brain,” according to Amen.
The brain expert noted that the study revealed even a 10% increase in ultraprocessed food intake – equivalent to roughly a pack of chips per day – was linked to a “measurable drop in attention, even when people had otherwise healthy diets.”
About one package of chips per day can result in cognition changes, according to the study findings. (iStock)
“Attention is the gateway to learning, memory, decision-making and problem-solving,” Amen said. “If you can’t focus, you can’t fully encode information.”
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The “big takeaway,” according to the doctor, is to “love foods that love you back.”
“You may love the taste of chips, cookies and candy, but they don’t love you (or your brain) back,” he said. “Ultraprocessed foods may claim to be sugar-free, low-carb or keto-friendly, but researchers noted that ultraprocessing can destroy the natural structure of food – and can introduce additives or processing chemicals that may affect cognition.”
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Amen suggests sticking to real food that grows on plants or animals, instead of food “made in plants.”
“Build meals around colorful vegetables and fruits, clean protein, healthy fats, nuts, seeds and high-fiber carbohydrates,” he recommended. “Start by replacing one ultraprocessed food per day with a brain-healthy option.”
That might mean swapping out chips for nuts, soda for water or unsweetened green tea, and packaged sweets for berries. “Small choices done consistently can change your brain and your life,” the doctor emphasized.
As UPFs have been shown to worsen several dementia risk factors, Amen stressed that people at risk of cognitive decline should “get serious about prevention as early as possible.”
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“If you have a family history of dementia, memory concerns, diabetes, high blood pressure or weight issues, your diet is not a side issue – it’s a primary brain-health intervention,” Amen said.
“Remember, you’re not stuck with the brain you have. You can make it better, and it starts with the next bite.”
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Fox News Digital reached out to the study researchers for comment.
Health
A Healthy ‘Hyperfixation Meal’ Helps You Lose Weight Faster—Without Dieting
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