Health
AI tool scans faces to predict biological age and cancer survival
A simple selfie could hold hidden clues to one’s biological age — and even how long they’ll live.
That’s according to researchers from Mass General Brigham, who developed a deep-learning algorithm called FaceAge.
Using a photo of someone’s face, the artificial intelligence tool generates predictions of the subject’s biological age, which is the rate at which they are aging as opposed to their chronological age.
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FaceAge also predicts survival outcomes for people with cancer, according to a press release from MGB.
A simple selfie could hold hidden clues to one’s biological age — and even how long they’ll live. (iStock)
The AI tool was trained on 58,851 photos of “presumed healthy individuals from public datasets,” the release stated.
To test the tool’s accuracy, the researchers used it to analyze photos of 6,196 cancer patients taken before radiotherapy treatment.
Among the people with cancer, the tool generated a higher biological age that was about five years higher than their chronological age.
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The researchers also tested the tool’s ability to predict the life expectancy of 100 people receiving palliative care based on their photos, then compared it to 10 clinicians’ predictions. FaceAge was found to be more accurate than the clinicians’ predictions.
The researchers’ findings were published in The Lancet Digital Health.
Mass General Brigham developed a deep-learning algorithm called FaceAge, which generates predictions of the subject’s biological age from a photo. (Mass General Brigham)
“We can use artificial intelligence to estimate a person’s biological age from face pictures, and our study shows that information can be clinically meaningful,” said co-senior and corresponding author Hugo Aerts, PhD, director of the Artificial Intelligence in Medicine (AIM) program at Mass General Brigham, in the release.
“This work demonstrates that a photo like a simple selfie contains important information that could help to inform clinical decision-making and care plans for patients and clinicians,” he went on.
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“How old someone looks compared to their chronological age really matters — individuals with FaceAges that are younger than their chronological ages do significantly better after cancer therapy.”
The goal is for the tool to help eliminate any bias that may influence a doctor’s care decisions based on the perception of a patient’s appearance and age.
“While FaceAge may outperform clinicians in some survival predictions, it should augment human judgment, not override it.”
The researchers noted that more research is needed before the tool could be rolled out for clinical use.
Future studies will include different hospitals and cancer patients at various stages of the disease, according to the release. Researchers will also evaluate FaceAge’s ability to predict diseases, general health status and lifespan.
To test the tool’s accuracy, the researchers used it to analyze photos of 6,196 cancer patients taken before radiotherapy treatment. (iStock)
“This opens the door to a whole new realm of biomarker discovery from photographs, and its potential goes far beyond cancer care or predicting age,” said co-senior author Ray Mak, MD, a faculty member in the AIM program at Mass General Brigham, in the release.
“As we increasingly think of different chronic diseases as diseases of aging, it becomes even more important to be able to accurately predict an individual’s aging trajectory. I hope we can ultimately use this technology as an early detection system in a variety of applications, within a strong regulatory and ethical framework, to help save lives.”
ER physician on AI
Dr. Harvey Castro, a board-certified emergency medicine physician and national speaker on artificial intelligence based in Dallas, Texas, was not involved in FaceAge’s development but shared his comments on the tool.
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“As an emergency physician and AI futurist, I see both the promise and peril of AI tools like FaceAge,” he told Fox News Digital.
“What excites me is that FaceAge structures the clinical instinct we call the ‘eyeball test’ — a gut sense of how sick someone looks. Now, machine learning can quantify that assessment with surprising accuracy.”
Among the people with cancer, the tool generated a higher biological age that was about five years higher than their chronological age. (iStock)
Castro predicts that FaceAge could help doctors better personalize treatment plans or prioritize palliative care in oncology — “where resilience matters more than a birthdate.”
The doctor emphasized, however, that caution is key.
“AI models are only as good as the data they’re trained on,” Castro noted. “If the training data lacks diversity, we risk producing biased results.”
“While FaceAge may outperform clinicians in some survival predictions, it should augment human judgment, not override it.”
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Castro also cautioned about potential ethical concerns.
“Who owns the facial data? How is it stored? Do patients understand what’s being analyzed? These questions matter as much as the technology itself,” he said.
“AI can enhance our care — but it cannot replace the empathy, context and humanity that define medicine.” (iStock)
There is also a psychological impact of the tool, Castro noted.
“Being told you ‘look older’ than your age could influence treatment decisions or self-perception in ways we don’t yet fully understand,” he said.
“We need clear consent, data privacy and sensitivity. No one wants to be told they look older without context.”
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The bottom line, according to Castro, is that AI can enhance a doctor’s judgment, but cannot replace it.
“AI can enhance our care — but it cannot replace the empathy, context and humanity that define medicine.”
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As winter weather moves in, cozy essentials like scarves, plush throws and heated bedding become everyday comforts.
But dermatologists caution that these cold-weather favorites can secretly undermine skin health — trapping sweat and bacteria, causing irritation and exposing the skin to excess heat.
Choosing the right materials for wellness — and using them safely — can make a big difference.
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Here are five winter must-haves and gift ideas, with expert tips on how to keep skin healthy and happy while staying warm this season.
Soft scarf, $19.99, Amazon.com
Scarves made of natural fiber, like this one that is 100% cotton, may help if you’re prone to irritation. (Amazon)
A soft scarf is a staple for cold days and an easy way to elevate a winter outfit.
Yet, if breakouts are appearing along the neck, jawline or chest, that favorite accessory may be part of the problem.
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“You should wash your scarf as often as your clothes to prevent breakouts,” Annabelle Taurua, a beauty expert at Fresha, a beauty and wellness booking platform headquartered in London, told Fox News Digital.
Cotton is a better choice than polyester, she also noted, as it’s more breathable and allows sweat to evaporate.
Fluffy blankets, $28.97, Potterybarn.com
Fluffy blankets make for perfect cozy days at home, but their soft fibers can trap sweat, oils and dead skin — which can clog pores and encourage bacteria growth. (Pottery Barn)
Fluffy blankets make for perfect cozy days at home, but their soft fibers can trap sweat, oils and dead skin, which can clog pores and encourage bacteria growth.
Rough textures or infrequent washing can also irritate sensitive skin and worsen breakouts.
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“Regularly wash your blankets, especially those made from synthetic or fluffy materials, to remove built-up oils and dirt,” Taurua advised.
She recommended breathable materials like cotton or linen, as well as hypoallergenic options for anyone prone to irritation.
Good set of sheets, $49.99, Amazon.com
Much like scarves, natural fibers are the way to go for your linens to avoid irritation. (iStock)
Cold weather makes lingering in bed especially tempting, but lying on unwashed bedding can worsen acne.
Pillowcases and sheets quickly collect oil, bacteria and dead skin cells, which transfer directly onto the face.
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“Washing bedding frequently is important,” Taurua said. “You should aim to change and wash your pillowcases every two to three days and your sheets at least once a week.”
Heated blanket, $33.99, Walmart.com
Heated blankets are a great way to stay warm during the winter. (Walmart)
When using a heated blanket, start with the lowest heat setting and limit use, said Taurua.
“Once you’re warm, switch to a regular blanket,” she advised.
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She also said it’s best to avoid direct contact for long periods to reduce irritation.
Hot water bottle, $12.99, Amazon.com
A traditional winter staple, hot water bottles offer quick comfort — but they come with risks similar to heated blankets, including burns, scalding and long-term heat-related skin damage.
Hot water bottles should never be filled with boiling water, experts advise. (Amazon)
“Never fill a hot water bottle with boiling water,” Taurua said.
“Only use hot, not boiling, water, and fill it to a maximum of two-thirds.”
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She recommended wrapping the bottle in a towel or cover to avoid direct skin contact and limiting use to around 20 minutes.
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Comedian Amy Schumer, 44, has recently come clean about her struggle with Cushing’s syndrome, leading to a dramatic weight loss.
Schumer’s transformation has sparked conversation online, to which she responded in a now-deleted Instagram post that shut down speculation about cosmetic enhancements.
“I didn’t lose 30lbs — I lost 50,” she emphasized on social media, adding that she does not get Botox or filler.
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Schumer doubled down that her weight loss was not about her appearance, but about staying alive.
“Not to look hot, which does feel fun and temporary,” she said. “I did it to survive. I had a disease that makes your face extremely puffy that can kill you, but the internet caught it and that disease has cleared.”
Amy Schumer attends Variety’s 2024 Power of Women: New York event on May 2, 2024, in New York City on the left. On the right, Schumer later poses for a photo posted to Instagram after her weight loss. (Marleen Moise/WireImage; Amy Schumer/Instagram)
“Sorry for whatever feeling it’s giving you that I lost that weight,” she added. “I’ve had plastic surgery over the years and I use [Mounjaro]. Sorry to anyone they let down. I’m pain free. I can [play] tag with my son.”
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The actress also addressed her shifting hormones, saying that she’s “happy to share more if anyone has any questions about how I’m looking or feeling or where I am in my perimenopause process.”
“I didn’t lose 30lbs — I lost 50,” Schumer emphasized on social media, adding that she does not get Botox or filler. (Amy Schumer/Instagram)
What is Cushing’s syndrome?
Schumer previously revealed that she had been diagnosed with Cushing’s syndrome, a hormonal disorder that can cause extreme swelling, fatigue and potentially fatal complications.
Dr. Peter Balazs, a hormone and weight loss specialist in New Jersey, provided more details on the condition in an interview with Fox News Digital.
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“Cushing’s syndrome is caused by prolonged, high exposure to cortisol, which is your body’s main stress hormone,” he said. “Usually, the excess cortisol is a result of prolonged steroid use. We see this many times with patients who have some autoimmune disorder.”
Balazs said the “key” to Cushing’s syndrome is not just weight gain, but a “specific redistribution” of fat caused by too much cortisol.
Amy Schumer is photographed during a guest interview on The Tonight Show Starring Jimmy Fallon on Feb. 13, 2024 (left), and later seen walking through midtown New York City on Oct. 28, 2025 (right). (Todd Owyoung/NBC via Getty Images; Raymond Hall/GC Images/Getty Images)
Fat may be driven to the abdomen, chest, upper back (referred to as a “buffalo hump”) or face, sometimes considered “moon face,” the doctor said.
Cortisol also breaks down protein, which leads to a thinning in the arms and legs. “Weight gain can be tough, involuntary and hard to manage,” Balazs added.
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Cortisol stimulates “hunger centers” in the brain, raises blood sugar and promotes fat storage, especially deep belly fat, according to the doctor.
Cushing’s syndrome can also cause high blood pressure, bone loss and sometimes type 2 diabetes, per Mayo Clinic.
In addition to weight gain in certain areas, other symptoms may include pink or purple stretch marks on the stomach, hips, thighs, breasts and underarms, as well as acne, slow wound healing, and thin, frail skin that bruises easily.
With Cushing’s syndrome, fat may accumulate in the abdomen, chest, face or upper back (referred to as a “buffalo hump”). (iStock)
Women with Cushing’s syndrome often experience thick, dark hair on the face and body, as well as irregular periods. Symptoms among men can include a lower sex drive, reduced fertility and erectile dysfunction.
Mayo Clinic listed other potential symptoms, including extreme fatigue, muscle weakness, depression, anxiety, irritability, mood swings, trouble with concentration and memory, headache, sleeplessness, skin darkening and stunted growth in children.
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Those with symptoms should contact their doctor immediately, especially if they are taking steroids to treat health issues like asthma, arthritis or inflammatory bowel disease, as these medications can exacerbate the condition.
The Mayo Clinic has reported that the “sooner treatment starts, the better the chances for recovery.”
“I’ve had plastic surgery over the years and I use [Mounjaro],” Schumer stated in a social media post. (George Frey/Bloomberg)
For patients like Schumer, weight loss is typically not the main goal, Balazs noted, but it is a “critical sign” of successful treatment.
“The primary goal is to normalize your high cortisol levels,” he said. “I believe Amy Schumer got treated first for her underlying problem. Once the cortisol is normalized, which is the most important step, there’s a role to use adjunct medications to decrease weight.”
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Among GLP-1s, Mounjaro is an “excellent choice to decrease deep belly fat and increase insulin sensitivity of cells,” Balazs added.
Fox News Digital’s Stephanie Giang-Paunon contributed to this report.
Fox News Digital reached out to Schumer’s rep requesting comment.
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