Health
Parkinson's patients who take 'magic mushrooms' see key benefits, study finds
As Parkinson’s cases continue to rise, the race is on for therapies to combat the effects of the disease — and researchers have pinpointed an unlikely source of relief.
Psilocybin, a psychedelic compound found in some mushrooms, has been found to improve mood, cognition and motor symptoms in Parkinson’s patients, according to a new study from the University of California San Francisco (UCSF).
The substance, often referred to as “magic mushrooms,” has previously been shown to alleviate depression and anxiety, which prompted the researchers to explore its potential for Parkinson’s.
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People with the neurological movement disorder often suffer from “debilitating mood dysfunction” and don’t tend to respond well to traditional antidepressants, according to a UCSF press release.
Psilocybin, a psychedelic compound found in some mushrooms, has been found to improve mood, cognition and motor symptoms in Parkinson’s patients. (iStock)
“Many people don’t realize this, but mood symptoms in Parkinson’s are linked to a faster physical decline,” said lead study author Ellen Bradley, M.D., assistant professor and associate director of UCSF’s Translational Psychedelic Research Program, in the release.
“And they are actually a stronger predictor of patients’ quality of life with Parkinson’s than their motor symptoms.”
The small study included 12 people with mild to moderate Parkinson’s disease. They ranged in age from 40 to 75. All had depression and/or anxiety.
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They all received a 10 mg-dose of psilocybin, then a 25 mg-dose two weeks later. To measure the effects, the participants met with a licensed therapist before and after receiving the medication.
At the one-week and one-month follow-ups, the patients reported “clinically significant improvements” not only in mood and cognition, but also motor function.
“Many people don’t realize this, but mood symptoms in Parkinson’s are linked to a faster physical decline.”
“These results are really encouraging,” Bradley told Fox News Digital. “Depression and anxiety, which debilitate so many people with Parkinson’s, improved significantly — and those improvements lasted for at least three months after patients took the drug.”
Amir Inamdar, a pharmaceutical physician in the U.K. and chief medical officer at Cybin, noted that the improvement in motor symptoms was somewhat surprising.
“As the authors note, this could be because of the modulation of dopamine via psilocybin’s effect on several serotonin receptor types.” (Inamdar was not involved in the study.)
The most common side effects of psilocybin were anxiety, nausea, headache and elevated blood pressure, but none were serious enough to require medical care, according to the researchers.
People with the neurological movement disorder often suffer from “debilitating mood dysfunction” and don’t tend to respond well to traditional antidepressants. (iStock)
“Despite the reports of challenging experiences in a couple of participants, psilocybin seemed to be well-tolerated,” Inamdar noted. “The side effects were consistent with what has been seen in other studies, with no precipitation/ exacerbation of psychotic symptoms.”
The study, which was published in Neuropsychopharmacology, a Nature publication, was funded by an anonymous donor.
Limitations and further research
This was the first study to measure the effects of a psychedelic substance on patients with a neurodegenerative disease, according to USCF.
While this study was an “important first step,” Bradley noted that the researchers can’t draw conclusions from it, as it was a small pilot without a control group.
“We’ve now started a much larger trial designed to rigorously test if psilocybin is effective in Parkison’s,” she told Fox News Digital.
“We’re also collecting multimodal biological data to understand how psilocybin works. That’s critical not just for optimizing psilocybin treatments, but also for guiding development of next-generation psychedelics that are in the pipeline now and could be promising for people with Parkinson’s.”
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Bradley still recommends that Parkinson’s patients approach psilocybin and other psychedelics with “a lot of caution.”
“I wouldn’t recommend to my patients with Parkinson’s that they start using psilocybin,” she clarified. “We’re very, very early in this research, and we don’t think these drugs will be safe for everyone with the illness.”
This was the first study to measure the effects of a psychedelic substance on patients with a neurodegenerative disease, according to USCF. (iStock)
“I hope that people continue to advocate for research so we can speed this process of identifying the right psychedelic treatment for the right patient at the right time.”
Inamadar agreed that while the results are encouraging, the study was based on a small and limited sample.
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“The study was also open-label, which lends itself to higher expectancy effects, though the improvements in mood and anxiety symptoms were still seen at three months,” he added.
“Overall, [the] quite encouraging results warrant further investigation, certainly in trying to understand the mechanism behind improvement in motor symptoms.”
Health
Common nighttime noise exposure may trigger heart problems, study suggests
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Living near heavy traffic could negatively impact your heart health.
A European study, published in the journal Environmental Research, found that exposure to nighttime road traffic noise is linked to changes in the blood, leading to worsened cholesterol and cardiovascular risks.
The researchers considered data from the U.K. Biobank, Rotterdam Study, and Northern Finland Birth Cohort 1966, including more than 272,000 adults over the age of 30, according to a press release.
Nighttime road noise exposure was estimated at all participants’ homes based on national noise maps. Researchers also took blood samples to measure the participants’ metabolic biomarkers for disease, then mapped the link between nightly noise levels and existence of biomarkers.
Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers. (iStock)
The study found that people exposed to louder noise at night — especially sounds above 55 decibels — showed changes in 48 different substances in their blood. Twenty of these associations “remained robust” throughout all cohorts.
Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers, especially LDL “bad” cholesterol, IDL (intermediate-density lipoprotein) and unsaturated fatty acids.
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As noise levels increased, starting at around 50 decibels, cholesterol markers rose steadily, the release stated.
The authors concluded that this study “provides evidence that nighttime road traffic noise exposure from 50 dB upward is associated with alterations in blood cholesterol and lipid profiles in adults.”
Researchers noted a link between traffic noise and cardiometabolic disease. (iStock)
Study co-author Yiyan He, doctoral researcher at the University of Oulu in Finland, noted that in this type of research, small effect sizes are expected, and environmental exposures such as traffic noise are “typically modest.”
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“Despite this, we observed statistically robust and consistent associations across many biomarkers, especially those related to LDL and IDL lipoproteins,” she told Fox News Digital.
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“We also identified a clear exposure-response pattern starting at around 50 dB, suggesting that metabolic changes become more evident as noise levels increase.”
This aligns with public health guidance, as the World Health Organization recommends lower nighttime noise limits at around 40 to 45 dB, Yiyan He added.
“This finding may clarify the association between traffic noise and cardiometabolic diseases,” the researchers wrote. (iStock)
“The 55 dB level is often used as an interim benchmark associated with substantial noise annoyance and sleep disturbance,” she said. “In our study, we observed associations not only at 55 dB, but also indications of effects emerging at around 50 dB.”
The strength and consistency of the cholesterol-related associations were surprising, as these changes are usually “subtle.”
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“Instead, we found consistent associations across multiple large European cohorts, which strengthens confidence that the findings may reflect real biological patterns,” Yiyan He went on. “We were also interested to see that effects were minimal below ~50 dB, suggesting a possible threshold-like pattern.”
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The researcher noted that these findings were consistent across genders, education levels and obesity status.
The study was restricted to White Europeans, which posed a limitation. There was also a lack of information on the fasting status in the UK Biobank.
Changes in cholesterol levels were more severe than researchers expected. (iStock)
“Fasting can influence levels of certain metabolites, particularly fatty acids,” Yiyan He said. “However, based on UK Biobank documentation, fewer than 10% of participants were fasting for at least eight hours, and our main findings focused on cholesterol-related biomarkers, which are generally less sensitive to short-term fasting.”
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The researchers also lacked information on bedroom location, indoor noise exposure and time spent at home.
“These factors may introduce non-differential exposure misclassification,” Yiyan He said. “Additionally, noise exposure estimates were based on participants’ temporary residential addresses at the time of blood sampling, without considering the duration of residence.”
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“Many of these limitations would tend to bias results toward the null, so the consistent associations we observed remain noteworthy.”
Experts recommend taking measures to limit traffic noise at night. (iStock)
Based on this latest research, Yiyan He noted that nighttime noise is a “health-relevant exposure,” not just “an annoyance.”
“Our findings suggest that nighttime traffic noise may subtly but consistently affect metabolic health,” she said. “While the changes in cholesterol and lipid levels for any one individual are small, traffic noise affects a very large number of people, which means the potential public health impact could be substantial.”
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The researcher recommends taking measures like improving sound insulation, using noise-reducing strategies and placing bedrooms on the quieter side of the home when possible.
“Because sleep is a key pathway linking noise to health, protecting the nighttime sleep environment is especially important,” she added.
Health
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Health
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