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Novo Nordisk cuts forecasts after replica obesity drugs hit US take-up

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Novo Nordisk cuts forecasts after replica obesity drugs hit US take-up

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Danish pharmaceutical group Novo Nordisk has cut sales and profit forecasts after replica drugs hit take-up of its blockbuster GLP-1 obesity and diabetes medicines Wegovy and Ozempic in the US.

The company beat operating profit forecasts for the first quarter of the year but said it had been hit by compounding — preparations custom-made by pharmacies using the active ingredients of patented drugs.

“In the first quarter of 2025, we delivered 18 per cent sales growth and continued to expand the reach of our innovative GLP-1 treatments,” said Lars Fruergaard Jørgensen, president and chief executive. “However, we have reduced our full-year outlook due to lower-than-planned branded GLP-1 penetration, which is impacted by the rapid expansion of compounding in the US.”

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Novo also said its US operations would no longer have to meet the company’s global gender goals, as President Donald Trump’s administration applies pressure to remove diversity initiatives.

Sales growth for this year is now expected to be 13 to 21 per cent at constant exchange rates, compared with earlier guidance of 16 to 24 per cent. Operating profit growth is forecast at 16 to 24 per cent, compared with a previous range of 19 to 27 per cent.

Sales rose 18 per cent year-on-year to DKr78.1bn ($11.9bn) at constant exchange rates in the first quarter. Operating profits climbed 20 per cent to DKr38.8bn, beating consensus analyst forecasts.

Novo shares rose more than 5 per cent in morning trading.

Compounding began in the US after the Food and Drug Administration regulator declared official shortages in 2022 of Wegovy, Ozempic and Zepbound, which is made by Novo’s rival Eli Lilly. Patients have been able to buy compounded products for as little as $199 a month. List prices for the branded drugs, charged to people without insurance, are $1,000 or more.

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The FDA has now said the shortage is over, meaning pharmacies must stop selling compounded versions of the Novo drugs by May 22. 

Novo said it expects “a step up in the business that used to go to compounders” in the second half of the year, according to chief financial officer Karsten Munk Knudsen. Another potential boost for Wegovy includes deals to sell it at discounted rates at the drugstore chain CVS and via telehealth companies. Novo also plans to speed up its international expansion of Wegovy outside the US, Knudsen said.

“We’ve launched in around 25 markets currently and we see an accelerated launch schedule following increased supplies,” he said.

In a statement alongside its results, the drugmaker said: “While Novo Nordisk maintains our global aspiration of a minimum 45 per cent representation for each gender by the end of 2025, Novo Nordisk’s operations in the US will no longer participate in this global initiative due to evolving legal requirements,” the company said.

Although none have been announced yet, the pharma industry will potentially have to deal with US tariffs on pharmaceutical imports. Tariffs “may have a negative impact on Novo Nordisk and our industry”, the company said on Wednesday.

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Novo has significant production capacity already in the US and exports more from the country than it imports, Jørgensen said. It has announced more than $24bn of investments in the US over the past decade.

Novo was showing “encouraging” signs of “fighting back” in the face of investor worries that it was losing ground to Lilly, said Emily Field, an analyst at Barclays.

“The results and the guidance cut are for the most part in the realm of what people had been expecting,” Field said. “What people really want to hear from them is how confident they are that volumes are going to increase in the second half — because it’s a volume play.”

Novo has also faced investor scrutiny about its planned successor obesity and diabetes drugs, after two sets of worse than expected trial results for its product CagriSema.

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Video: First Batch of Epstein Files Provides Few Revelations

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Video: First Batch of Epstein Files Provides Few Revelations

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First Batch of Epstein Files Provides Few Revelations

The Justice Department, under pressure from Congress to comply with a law signed by President Trump, released more than 13,000 files on Friday arising from investigations into Jeffrey Epstein.

Put out the files and stop redacting names that don’t need to be redacted. It’s just — who are we trying to protect? Are we protecting the survivors? Or are we protecting these elite men that need to be put out there?

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The Justice Department, under pressure from Congress to comply with a law signed by President Trump, released more than 13,000 files on Friday arising from investigations into Jeffrey Epstein.

By McKinnon de Kuyper

December 20, 2025

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Apple, Google tell workers on visas to avoid leaving the U.S. amid Trump immigration crackdown

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Apple, Google tell workers on visas to avoid leaving the U.S. amid Trump immigration crackdown

With reported months-long consulate and embassy delays, Google and Apple say employees on H-1B visas should stay put in the U.S. right now to avoid the risk of getting stranded abroad. The latter tech company’s headquarters campus is seen in Mountain View, Calif.

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Apple and Google are warning some U.S-based employees on visas against traveling outside of the country to avoid the risk of getting stuck coming back, as the Trump administration toughens vetting of visa applicants, according to recent internal memos from the tech companies that were reviewed by NPR.

U.S. consulates and embassies have been reporting lengthy, sometimes months-long delays, for visa appointments following new rules from the Department of Homeland Security requiring travelers to undergo a screening of up to five years’ of their social media history — a move criticized by free speech advocates as a privacy invasion.

For Apple and Google, which together employ more than 300,000 employees and rely heavily on highly-skilled foreign workers, the increased vetting and reports of extended delays were enough for the companies to tell some of their staff to stay in the U.S. if they are able to avoid foreign travel.

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“We recommend avoiding international travel at this time as you risk an extended stay outside of the U.S.,” Berry Appleman & Leiden, a law firm that works with Google, wrote to employees.

The law firm Fragomen, which works with Apple, wrote a similar message: “Given the recent updates and the possibility of unpredictable, extended delays when returning to the U.S., we strongly recommend that employees without a valid H-1B visa stamp avoid international travel for now,” the memo read. “If travel cannot be postponed, employees should connect with Apple Immigration and Fragomen in advance to discuss the risks.”

Apple and Google declined to comment on the advisories, which were first reported by Business Insider.

It’s the latest sign of how the Trump administration’s aggressive immigration policies are affecting the foreign-born workforce in the U.S.

Earlier this year, the White House announced that companies will be subjected to a $100,000 fee for all new H-1B visas, a type of visa popular among tech companies eager to hire highly skilled workers from abroad.

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H-1Bs typically last three years, and applicants have to return to an embassy or consulate in their home country for a renewal, but reports suggest such a routine trip could lead to people being stranded for months as a result of the Trump administration’s new policies.

On Friday, The Washington Post reported that hundreds of visa holders who traveled to India to renew their H-1Bs had their appointments postponed with the State Department explaining that officials needed more time to ensure that no applicants “pose a threat to U.S. national security or public safety.”

At Google, the Alphabet Workers’ Union has been campaigning for additional protections for workers on H-1B visas. Those workers would be particularly vulnerable in the event Google carried out layoffs, since losing employer sponsorship could jeopardize their legal status, said Google software engineer Parul Koul, who leads the union.

The need to support H-1B holders at Google, she said, has “only become more urgent with all the scrutiny and heightened vetting by the Trump administration around the H1B program, and how the administration is coming for all other types of immigrant workers.”

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U.S. launches strikes in Syria targeting Islamic State fighters after American deaths

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U.S. launches strikes in Syria targeting Islamic State fighters after American deaths

President Donald Trump and Defense Secretary Pete Hegseth salute as carry teams move the transfer cases with the remains of Iowa National Guard soldiers Sgt. William Nathaniel Howard, 29, of Marshalltown, Iowa, and Sgt. Edgar Brian Torres-Tovar, 25, of Des Moines, Iowa, and civilian interpreter Ayad Mansoor Sakat, who were killed in an attack in Syria, during a casualty return, Wednesday, Dec. 17, 2025 at Dover Air Force Base, Del.

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WASHINGTON — The Trump administration launched military strikes Friday in Syria to “eliminate” Islamic State group fighters and weapons sites in retaliation for an ambush attack that killed two U.S. troops and an American civilian interpreter almost a week ago.

A U.S. official described it as “a large-scale” strike that hit 70 targets in areas across central Syria that had IS infrastructure and weapons. Another U.S. official, who also spoke on condition of anonymity to discuss sensitive operations, said more strikes should be expected.

“This is not the beginning of a war — it is a declaration of vengeance. The United States of America, under President Trump’s leadership, will never hesitate and never relent to defend our people,” Defense Secretary Pete Hegseth said on social media.

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The new military operation in Syria comes even as the Trump administration has said it’s looking to focus closer to home in the Western Hemisphere, building up an armada in the Caribbean Sea as it targets alleged drug-smuggling boats and vowing to keep seizing sanctioned oil tankers as part of a pressure campaign on Venezuela’s leader. The U.S. has shifted significant resources away from the Middle East to further those goals: Its most advanced aircraft carrier arrived in South American waters last month from the Mediterranean Sea.

Trump vowed retaliation

President Donald Trump pledged “very serious retaliation” after the shooting in the Syrian desert, for which he blamed IS. Those killed were among hundreds of U.S. troops deployed in eastern Syria as part of a coalition fighting the militant group.

During a speech in North Carolina on Friday evening, the president hailed the operation as a “massive strike” that took out the “ISIS thugs in Syria who were trying to regroup.”

Earlier, in his social media post, he reiterated his backing for Syrian President Ahmad al-Sharaa, who Trump said was “fully in support” of the U.S. effort.

Trump also offered an all-caps threat, warning IS against attacking American personnel again.

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“All terrorists who are evil enough to attack Americans are hereby warned — YOU WILL BE HIT HARDER THAN YOU HAVE EVER BEEN HIT BEFORE IF YOU, IN ANY WAY, ATTACK OR THREATEN THE U.S.A.,” the president added.

The attack was conducted using F-15 Eagle jets, A-10 Thunderbolt ground attack aircraft and AH-64 Apache helicopters, the U.S. officials said. F-16 fighter jets from Jordan and HIMARS rocket artillery also were used, one official added.

U.S. Central Command, which oversees the region, said in a social media post that American jets, helicopters and artillery employed more than 100 precision munitions on Syrian targets.

How Syria has responded

The attack was a major test for the warming ties between the United States and Syria since the ouster of autocratic leader Bashar Assad a year ago. Trump has stressed that Syria was fighting alongside U.S. troops and said al-Sharaa was “extremely angry and disturbed by this attack,” which came as the U.S. military is expanding its cooperation with Syrian security forces.

Syria’s foreign ministry in a statement on X following the launch of U.S. strikes said that last week’s attack “underscores the urgent necessity of strengthening international cooperation to combat terrorism in all its forms” and that Syria is committed “to fighting ISIS and ensuring that it has no safe havens on Syrian territory and will continue to intensify military operations against it wherever it poses a threat.”

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Syrian state television reported that the U.S. strikes hit targets in rural areas of Deir ez-Zor and Raqqa provinces and in the Jabal al-Amour area near the historic city of Palmyra. It said they targeted “weapons storage sites and headquarters used by ISIS as launching points for its operations in the region.”

IS has not said it carried out the attack on the U.S. service members, but the group has claimed responsibility for two attacks on Syrian security forces since, one of which killed four Syrian soldiers in Idlib province. The group in its statements described al-Sharaa’s government and army as “apostates.” While al-Sharaa once led a group affiliated with al-Qaida, he has had a long-running enmity with IS.

The Americans who were killed

Trump this week met privately with the families of the slain Americans at Dover Air Force Base in Delaware before he joined top military officials and other dignitaries on the tarmac for the dignified transfer, a solemn and largely silent ritual honoring U.S. service members killed in action.

The guardsmen killed in Syria last Saturday were Sgt. Edgar Brian Torres-Tovar, 25, of Des Moines, and Sgt. William Nathaniel Howard, 29, of Marshalltown. Ayad Mansoor Sakat, of Macomb, Michigan, a U.S. civilian working as an interpreter, also was killed.

The shooting near Palmyra also wounded three other U.S. troops as well as members of Syria’s security forces, and the gunman was killed. The assailant had joined Syria’s internal security forces as a base security guard two months ago and recently was reassigned because of suspicions that he might be affiliated with IS, Interior Ministry spokesperson Nour al-Din al-Baba has said.

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The man stormed a meeting between U.S. and Syrian security officials who were having lunch together and opened fire after clashing with Syrian guards.

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