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New class of antibiotics discovered for first time in decades

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New class of antibiotics discovered for first time in decades

For the first time in three decades, researchers believe they have identified a new class of antibiotics.

Teams at McMaster University in Ontario, Canada and the University of Illinois, Chicago — led by researcher Gerry Wright — collaborated in the discovery of lariocidin, which was found to be effective against drug-resistant bacteria.

The results were published this week in the journal Nature.

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Lariocidin is a lasso peptide, a string of amino acids in a lasso shape that attacks bacteria and keeps it from growing and surviving, according to a McMaster press release.

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For the first time in three decades, researchers believe they have identified a new class of antibiotics (not pictured). (iStock)

It is produced by a type of bacteria called Paenibacillus, which the researchers retrieved from a local backyard soil sample and cultivated in a lab for one year.

Paenibacillus was found to produce a new substance that attacks antibiotic-resistant bacteria.

“Lariocidine is not susceptible to many of the mechanisms that make disease-causing bacteria resistant to the available antibiotics,” the researchers told Fox News Digital.

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The molecule has a unique structure of a “knotted lasso or a pretzel.”

“Lariocidin binds to the molecular machine, the ribosome, that makes all the cellular proteins, which is one of the most vital processes in the cells,” the researchers said. 

The finding is significant in light of growing antimicrobial resistance, which the World Health Organization has described as a global public health threat. (iStock)

“It binds to a specific site in the ribosome to which none of the known antibiotics bind, and stops the ribosome from making proteins.”

Another key benefit of lariocidin is that it’s not toxic to human cells, the researchers noted.

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The finding is significant in light of growing antimicrobial resistance, which the World Health Organization has described as a global public health threat that kills more than 4.5 million people worldwide each year.

 

“The antibiotic resistance crisis that we’re currently facing represents a major threat to how we practice medicine,” the researchers told Fox News Digital.

“We need to prevent and treat infection if we are to continue to have unfettered access to surgeries, hip replacements, cancer chemotherapy, the treatment of premature infants, etc. — consequently, we need new antibiotic drugs to do this over the long term.”

“The antibiotic resistance crisis that we’re currently facing represents a major threat to how we practice medicine.”

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Dr. Marc Siegel, clinical professor of medicine at NYU Langone Health and Fox News senior medical analyst, applauded the discovery.

“Artificial intelligence promises to improve new drug targets, including for antibiotics — and in the meantime, research at McMaster in Canada has found a new class of antibiotics,” he told Fox News Digital.

Dr. Marc Siegel reiterated that a new class of antibiotics hasn’t emerged in decades — “in part because they aren’t that profitable, as you only need them when sick.” (iStock/Fox News)

“This new kind of antibiotic — lariocidin — works by interfering with protein synthesis that many bacteria need to survive.”

Siegel reiterated that a new class of antibiotics hasn’t emerged in decades — “in part because they aren’t that profitable, as you only need them when sick.”

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Dr. Stephen Vogel, a family medicine physician with PlushCare, a virtual health platform with primary care, therapy and weight management options, said this discovery represents a “promising answer” to tackle infections caused by drug-resistant bacteria. 

“Because this microbe can kill bacteria in a way that it can’t evolve to evade, due to its protein production system called the ribosome, it has the potential to be a durable and lasting choice for a large variety of deadly bacterial infections,” the North Carolina-based doctor told Fox News Digital.

“Garden soil may seem mundane, but it’s in fact its own universe of microbes, fungi and bacteria, which can lead to key innovations like the promise that this discovery brings,” one expert said. (iStock)

If this microbe were brought to market as an antibiotic, it would mean millions fewer deaths from bacterial infections each year, according to Vogel.

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“Garden soil may seem mundane, but it’s in fact its own universe of microbes, fungi and bacteria, which can lead to key innovations like the promise that this discovery brings,” he added.

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Looking ahead, the McMaster researchers will investigate ways to modify and produce the newly discovered molecule for use in clinical settings, a process that will require significant time and resources.

“This discovery is just the starting point of a long process of developing this molecule into a drug,” the researchers told Fox News Digital.  (iStock)

“This discovery is just the starting point of a long process of developing this molecule into a drug,” the researchers told Fox News Digital. 

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“What we have to do next is to test whether lariocidin, which can cure animals, is effective for the treatment of a variety of infections in humans.”

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The researchers added that science is sometimes “serendipitous.”

“You often have to shovel a lot of dirt before you find a gem, which lariocidin certainly is. Therefore, funding ‘dirt shoveling’ is critical for finding new gems.”

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Common nighttime noise exposure may trigger heart problems, study suggests

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Common nighttime noise exposure may trigger heart problems, study suggests

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Living near heavy traffic could negatively impact your heart health.

A European study, published in the journal Environmental Research, found that exposure to nighttime road traffic noise is linked to changes in the blood, leading to worsened cholesterol and cardiovascular risks.

The researchers considered data from the U.K. Biobank, Rotterdam Study, and Northern Finland Birth Cohort 1966, including more than 272,000 adults over the age of 30, according to a press release.

Nighttime road noise exposure was estimated at all participants’ homes based on national noise maps. Researchers also took blood samples to measure the participants’ metabolic biomarkers for disease, then mapped the link between nightly noise levels and existence of biomarkers.

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Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers. (iStock)

The study found that people exposed to louder noise at night — especially sounds above 55 decibels — showed changes in 48 different substances in their blood. Twenty of these associations “remained robust” throughout all cohorts.

Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers, especially LDL “bad” cholesterol, IDL (intermediate-density lipoprotein) and unsaturated fatty acids.

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As noise levels increased, starting at around 50 decibels, cholesterol markers rose steadily, the release stated.

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The authors concluded that this study “provides evidence that nighttime road traffic noise exposure from 50 dB upward is associated with alterations in blood cholesterol and lipid profiles in adults.”

Researchers noted a link between traffic noise and cardiometabolic disease. (iStock)

Study co-author Yiyan He, doctoral researcher at the University of Oulu in Finland, noted that in this type of research, small effect sizes are expected, and environmental exposures such as traffic noise are “typically modest.”

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“Despite this, we observed statistically robust and consistent associations across many biomarkers, especially those related to LDL and IDL lipoproteins,” she told Fox News Digital.

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“We also identified a clear exposure-response pattern starting at around 50 dB, suggesting that metabolic changes become more evident as noise levels increase.”

This aligns with public health guidance, as the World Health Organization recommends lower nighttime noise limits at around 40 to 45 dB, Yiyan He added.

“This finding may clarify the association between traffic noise and cardiometabolic diseases,” the researchers wrote. (iStock)

“The 55 dB level is often used as an interim benchmark associated with substantial noise annoyance and sleep disturbance,” she said. “In our study, we observed associations not only at 55 dB, but also indications of effects emerging at around 50 dB.”

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The strength and consistency of the cholesterol-related associations were surprising, as these changes are usually “subtle.”

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“Instead, we found consistent associations across multiple large European cohorts, which strengthens confidence that the findings may reflect real biological patterns,” Yiyan He went on. “We were also interested to see that effects were minimal below ~50 dB, suggesting a possible threshold-like pattern.”

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The researcher noted that these findings were consistent across genders, education levels and obesity status.

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The study was restricted to White Europeans, which posed a limitation. There was also a lack of information on the fasting status in the UK Biobank.

Changes in cholesterol levels were more severe than researchers expected. (iStock)

“Fasting can influence levels of certain metabolites, particularly fatty acids,” Yiyan He said. “However, based on UK Biobank documentation, fewer than 10% of participants were fasting for at least eight hours, and our main findings focused on cholesterol-related biomarkers, which are generally less sensitive to short-term fasting.”

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The researchers also lacked information on bedroom location, indoor noise exposure and time spent at home.

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“These factors may introduce non-differential exposure misclassification,” Yiyan He said. “Additionally, noise exposure estimates were based on participants’ temporary residential addresses at the time of blood sampling, without considering the duration of residence.”

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“Many of these limitations would tend to bias results toward the null, so the consistent associations we observed remain noteworthy.”

Experts recommend taking measures to limit traffic noise at night. (iStock)

Based on this latest research, Yiyan He noted that nighttime noise is a “health-relevant exposure,” not just “an annoyance.”

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“Our findings suggest that nighttime traffic noise may subtly but consistently affect metabolic health,” she said. “While the changes in cholesterol and lipid levels for any one individual are small, traffic noise affects a very large number of people, which means the potential public health impact could be substantial.”

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The researcher recommends taking measures like improving sound insulation, using noise-reducing strategies and placing bedrooms on the quieter side of the home when possible.

“Because sleep is a key pathway linking noise to health, protecting the nighttime sleep environment is especially important,” she added.

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The Best Time To Drink Coffee for Weight Loss and a Faster Metabolism

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The Best Time To Drink Coffee for Weight Loss and a Faster Metabolism


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‘SuperAgers’ stay mentally sharp well past 80, as scientists reveal the reason

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‘SuperAgers’ stay mentally sharp well past 80, as scientists reveal the reason

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→ Some 80-year-olds still have razor-sharp brains — and now scientists know why

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→ 5 ways to preserve vision as you age, according to an ophthalmologist

SuperAger Ralph Rehbock sits with his wife in his home.  (Shane Collins, Northwestern University)

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More than 59% of women may have high blood pressure by 2050, according to a new report from the American Heart Association.

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