Health
For Some Measles Patients, Vitamin A Remedy Supported by RFK Jr. Leaves Them More Ill
Doctors in West Texas are seeing measles patients whose illnesses have been complicated by an alternative therapy endorsed by vaccine skeptics including Robert F. Kennedy Jr., the health secretary.
Parents in Gaines County, Texas, the center of a raging measles outbreak, have increasingly turned to supplements and unproven treatments to protect their children, many of whom are unvaccinated, against the virus.
One of those supplements is cod liver oil containing vitamin A, which Mr. Kennedy has promoted as a near miraculous cure for measles. Physicians at Covenant Children’s Hospital in Lubbock, Texas, say they’ve now treated a handful of unvaccinated children who were given so much vitamin A that they had signs of liver damage.
Some of them had received unsafe doses of cod liver oil and other vitamin A supplements for several weeks in an attempt to prevent a measles infection, said Dr. Summer Davies, who cares for acutely ill children at the hospital.
“I had a patient that was only sick a couple of days, four or five days, but had been taking it for like three weeks,” Dr. Davies said.
While doctors sometimes administer high doses of vitamin A in a hospital to manage severe measles, experts do not recommend taking it without physician supervision. Vitamin A is not an effective way to prevent measles; however, two doses of the measles, mumps and rubella vaccine are about 97 percent effective.
At high doses, vitamin A can cause liver damage; dry, peeling skin; hair loss; and, in rare instances, seizures and coma. So far, doctors at West Texas hospitals have said they’ve seen patients with yellowed skin and high levels of liver enzymes in their bloodwork, both signs of a damaged liver.
Many of those patients had been in the hospital for a severe measles infection; doctors discovered the liver damage only after routine lab work.
As of Tuesday, the outbreak, which began in January, had spread to more than 320 people in Texas. Forty patients have been hospitalized, and one child has died.
In neighboring New Mexico counties, the virus has sickened 43 and hospitalized two. Seven confirmed cases in Oklahoma have also been linked to the outbreak.
Local doctors and health officials have become increasingly concerned about the growing popularity of unproven remedies for preventing and treating measles, which they fear is causing people to delay critical medical treatment and to reject vaccination, the only proven way to prevent a measles infection.
In Gaines County, alternative medicine has always been popular. Many in the area’s large Mennonite community, where most cases have been clustered, avoid interacting with the medical system and adhere to a long tradition of natural remedies.
Health officials said the recent popularity of vitamin A use for measles could be traced back to a Fox News interview with Mr. Kennedy, in which he said he had heard of “almost miraculous and instantaneous recovery” with treatments like cod liver oil, which he said was “the safest application of vitamin A.”
In an opinion essay for The Washington Post on Tuesday afternoon, Kevin Griffis, who was until last week the communications director at the Centers for Disease Control and Prevention, wrote that he had resigned in part because of Mr. Kennedy’s handling of the outbreak.
“In my final weeks at the C.D.C., I watched as career infectious-disease experts were tasked with spending precious hours searching medical literature in vain for data to support Kennedy’s preferred treatments,” Mr. Griffis wrote.
In the weeks after the Fox News interview, drugstores in West Texas struggled to keep vitamin A and cod liver oil supplements on their shelves. “I did not hear anything about vitamin A until he said it on television,” said Katherine Wells, the director of public health in Lubbock.
One local doctor — whom Mr. Kennedy named in the Fox News interview as one of the physicians who had told him “what is working on the ground”— opened a makeshift clinic in Gaines County and began doling out various treatments, including vitamin A supplements, to treat active measles cases and to prevent infection.
Dr. Davies said she suspected that a majority of the children she had treated had taken vitamin A supplements at home.
Experts say that vitamin A can play an important role in the “supportive care” that doctors provide to patients with severe measles infections.
It works by replenishing the bodily stores depleted by the virus, which bolsters the immune system, said Dr. William Schaffner, an infectious disease specialist at Vanderbilt University Medical Center.
In the hospital, physicians give only two doses of the vitamin to children with measles, usually over the course of two days, and “very carefully calibrate” the amounts depending on age and weight, he said.
Dr. Schaffner emphasized that it is not a miracle treatment for the virus, and that there is no antiviral medication for measles. And there is no credible evidence that vitamin A helps prevent infection in children in the United States, where vitamin A deficiencies are exceedingly rare.
In fact, giving children repeated, high doses of the vitamin is dangerous. Unlike other vitamins, which are flushed out of the body through urine, excess vitamin A accumulates in fat tissue, making it more likely to reach dangerous levels over time.
“That kind of preventative use I think is especially concerning,” said Dr. Lara Johnson, another doctor at the Lubbock hospital.
“When we have kids taking it for weeks and weeks, then you do potentially have a cumulative impact of the toxicity,” she added.
Dr. Johnson added that local physicians were particularly concerned about parents’ relying on over-the-counter supplements — whose labels don’t always accurately reflect the amount of vitamin they contain — and accepting dosage recommendations from unverified sources.
Health
Aging process could accelerate due to ‘forever chemicals’ exposure, study finds
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A new study suggests that middle-aged men may be more vulnerable to faster biological aging, potentially linked to exposure to “forever chemicals.”
The research, published in the journal Frontiers in Aging, examined how perfluoroalkyl and polyfluoroalkyl substances, more commonly known as PFAS, could impact aging at the cellular level.
PFAS are synthetic chemicals commonly used in nonstick cookware, food packaging, water-resistant fabrics and other consumer products, the study noted.
Their chemical structure makes them highly resistant to breaking down, allowing them to accumulate in water, soil and the human body.
Chinese researchers analyzed blood samples from 326 adults enrolled in the U.S. National Health and Nutrition Examination Survey between 1999 and 2000.
A new study suggests that middle-aged men could face accelerated biological aging at the cellular level due to exposure to PFAS. (iStock)
The researchers measured levels of 11 PFAS compounds in participants’ blood and used DNA-based “epigenetic clocks” — tools that analyze chemical changes to DNA to estimate biological age — to determine how quickly their bodies were aging at the cellular level, the study stated.
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Two compounds, perfluorononanoic acid (PFNA) and perfluorooctanesulfonamide (PFOSA), were detected in 95% of participants.
Higher concentrations of those chemicals were associated with faster biological aging in men of certain age groups, but not in women.
“People should not panic.”
The compounds most strongly linked to accelerated aging were not the PFAS chemicals that typically receive the most public attention, the researchers noted.
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“The associations were strongest in adults aged 50 to 64, particularly in men,” Dr. Xiangwei Li, professor at Shanghai Jiao Tong University School of Medicine and the study’s corresponding author, told Fox News Digital.
“While this does not establish that PFAS cause aging, it suggests that these widely present ‘forever chemicals’ may be linked to molecular changes related to long-term health and aging.”
The study found that two of the compounds were detected in 95% of participants, and higher levels were linked to faster biological aging in men ages 50–64. (iStock)
Midlife may represent a more sensitive biological period, when the body becomes more vulnerable to age-related stressors, according to the researchers.
Lifestyle factors, such as smoking, may influence biological aging markers, potentially increasing vulnerability to environmental pollutants.
While Li said “people should not panic,” she does recommend looking for reasonable ways to reduce exposure.
That might mean checking local drinking water reports, using certified water filters designed to reduce PFAS, and limiting the use of stain- or grease-resistant products when alternatives are available.
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Meaningful reductions in PFAS exposure will likely depend on broader regulatory action and environmental cleanup efforts, Li added.
The researchers noted that midlife could be a particularly sensitive stage, when the body is more susceptible to stressors associated with aging. (iStock)
Study limitations
The researchers outlined several important limitations of the research, including that the findings show an association, but do not prove that PFAS directly causes accelerated aging.
“The study is cross-sectional, meaning exposure and aging markers were measured at the same time, so we cannot determine causality,” Li told Fox News Digital.
The study was also relatively small, limited to 326 adults age 50 or older, which means the findings may not apply to younger people or broader populations.
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Researchers measured PFAS levels using data collected between 1999 and 2000, and today’s exposure patterns may differ.
Li added that while PFAS is known to persist in the environment and the body, these results should be validated through larger, more recent studies that follow participants over time.
Health
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Health
Alzheimer’s prevention breakthrough found in decades-old seizure drug
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A drug that has long been used to treat seizures has shown promise as a potential means of Alzheimer’s prevention, a new study suggests.
The anti-seizure medication, levetiracetam, was first approved by the FDA in November 1999 under the brand name Keppra as a therapy for partial-onset seizures in adults. The approval has since expanded to include children and other types of seizures.
Northwestern University researchers recently found that levetiracetam prevented the formation of toxic amyloid beta peptides, which are small protein fragments in the brain that are commonly seen in Alzheimer’s patients.
The medication was found to prevent the formation of amyloid-beta 42 in both animal models and cultured human neurons, according to the study findings, which were published in Science Translational Medicine.
The effect was also seen in post-mortem human brain tissue obtained from individuals with Down syndrome, who are at high risk for Alzheimer’s disease.
The medication was found to prevent the formation of amyloid-beta 42 in both animal models and cultured human neurons. (iStock)
“While many of the Alzheimer’s drugs currently on the market, such as lecanemab and donanemab, are approved to clear existing amyloid plaques, we’ve identified this mechanism that prevents the production of the amyloid‑beta 42 peptides and amyloid plaques,” said corresponding author Jeffrey Savas, associate professor of behavioral neurology at Northwestern University Feinberg School of Medicine, in a press release.
“Our new results uncovered new biology while also opening doors for new drug targets.”
HIDDEN BRAIN CONDITION MAY QUADRUPLE DEMENTIA RISK IN OLDER ADULTS, STUDY SUGGESTS
The brain is better able to avoid the pathway that produces toxic amyloid‑beta 42 proteins in younger years, but the aging process gradually weakens that ability, Savas noted.
“This is not a statement of disease; this is just a part of aging. But in brains developing Alzheimer’s, too many neurons go astray, and that’s when you get amyloid-beta 42 production,” he said.
The effect was also seen in post-mortem human brain tissue obtained from individuals with Down syndrome, who are at high risk for Alzheimer’s disease. (iStock)
That then leads to tau (“tangles”) — abnormal clumps of protein inside brain neurons — which can kill brain cells, trigger neuroinflammation and lead to dementia.
In order for levetiracetam to function as an Alzheimer’s blocker, high-risk patients would have to start taking it “very, very early,” Savas said — up to 20 years before elevated amyloid-beta 42 levels would be detected.
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“You couldn’t take this when you already have dementia, because the brain has already undergone a number of irreversible changes and a lot of cell death,” the researcher noted.
The researchers also did a deep dive into previous human clinical data to determine whether Alzheimer’s patients who were taking the anti-seizure drug had slower cognitive decline. They reported that the patients in that category had a “significant delay” in the span from cognitive decline to death compared to those not taking the drug.
“This analysis supports the positive effect of levetiracetam to slow the progression of Alzheimer’s pathology,” the researcher said. (iStock)
“Although the magnitude of change was small (on the scale of a few years), this analysis supports the positive effect of levetiracetam to slow the progression of Alzheimer’s pathology,” Savas said.
Looking ahead, the research team aims to find people who have genetic forms of Alzheimer’s to participate in testing, Savas said.
Limitations and caveats
The study had several limitations, including that it relied on animal models and cultured cells, with no human trials conducted.
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Because the study was observational in nature, it can’t prove that the medication caused the prevention of the toxic brain proteins, the researchers acknowledged.
Savas noted that levetiracetam “is not perfect,” cautioning that it breaks down in the body very quickly.
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The team is currently working to create a “better version” that would last longer in the body and “better target the mechanism that prevents the production of the plaques.”
“You couldn’t take this when you already have dementia, because the brain has already undergone a number of irreversible changes and a lot of cell death.”
The medication’s common documented side effects include drowsiness, weakness, dizziness, irritability, headache, loss of appetite and nasal congestion.
It has also been linked to potential mood and behavior changes, including anxiety, depression, agitation and aggression, according to the prescribing information. In rare cases, it could lead to severe allergic reactions, skin reactions, blood disorders and suicidal ideation.
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Funding for the study was provided by the National Institutes of Health and the Cure Alzheimer’s Fund.
Fox News Digital reached out to the drug manufacturer and the researchers for comment.
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