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Common pain medication could reduce cancer spread, study finds

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Common pain medication could reduce cancer spread, study finds

Taking a common over-the-counter pain reliever could help keep certain cancers from spreading.

That’s according to a new study from the University of Cambridge, which found that aspirin could reduce cancer metastatis (spread) by stimulating participants’ immune systems. 

The findings were published in the journal Nature on March 5.

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ASPIRIN MAY BE LINKED TO LOWER RISK OF COLORECTAL CANCER, NEW STUDY SUGGESTS

In mouse models, scientists discovered that a certain protein called ARHGEF1 suppresses T-cells, which are immune cells that can pinpoint and attack individual cancer cells that break away from original tumors, according to a press release.

ARHGEF1 was “switched on” when T cells were exposed to thromboxane A2 (TXA2), a chemical produced by platelets that helps with blood clotting. 

Taking a common over-the-counter pain reliever could help keep certain cancers from spreading, a new study suggests. (iStock)

Too much of TXA2 can increase the risk of heart attacks and strokes.

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That’s where aspirin comes in — it is already known to stop the production of TXA2 and prevent clotting, which is why it may be recommended to prevent cardiac events in some people.

“Aspirin, or other drugs that could target this pathway, have the potential to be less expensive than antibody-based therapies.”

“This new research found that aspirin prevents cancers from spreading by decreasing TXA2 and releasing T cells from suppression,” the press release stated. 

In mice with melanoma, the ones that were given aspirin had less frequent metastases of the cancer compared to those who were not given the medication.

DAILY ASPIRIN AFTER A HEART ATTACK CAN REDUCE THE RISK OF FUTURE EVENTS, STUDY FINDS

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“It was a ‘eureka’ moment when we found TXA2 was the molecular signal that activates this suppressive effect on T cells,” said first author Dr. Jie Yang from the Department of Pathology at the University of Cambridge in the release.

“Before this, we had not been aware of the implication of our findings in understanding the anti-metastatic activity of aspirin,” he went on.

“Aspirin, or other drugs that could target this pathway, have the potential to be less expensive than antibody-based therapies, and therefore more accessible globally.”

Aspirin could reduce cancer metastatis (spread) by stimulating participants’ immune systems, the research found. (iStock)

Previous studies have suggested that daily aspirin treatment is associated with reduced cancer spread in humans with the disease and with reduced cancer mortality in patients without metastasis, noted senior researcher Dr. Rahul Roychoudhuri, professor of cancer immunology at the University of Cambridge.

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In one randomized controlled trial, taking 600 milligrams of aspirin daily for an average of 25 months substantially reduced cancer incidence in carriers of hereditary colorectal cancer.

COMMON CANCER TREATMENT CAN HAVE THIS PAINFUL SIDE EFFECT

Pashtoon Kasi, M.D., medical director of gastrointestinal medical oncology at City of Hope Orange County in California, reiterated that previous research has linked aspirin use with a reduced risk of cancer, particularly gastrointestinal tract cancers.  

“It has been identified in numerous studies with mixed results on reducing the risk of recurrence and/or improving outcomes in patients with metastatic cancer,” Kasi, who was not involved in the research, told Fox News Digital.

“This new study further demonstrates how aspirin and other inhibitors of this pathway could be used in new treatments to prevent the cancer from metastasizing or spreading.”

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Potential risks

Roychoudhuri, the senior researcher, encouraged caution in applying the findings.

While aspirin is low-cost and widely available, its long-term use is not without “significant risks,” he said, including stomach bleeding and hemorrhagic stroke, particularly in older individuals. 

While aspirin is low-cost and widely available, its long-term use is not without “significant risks,” the researcher cautioned. (iStock)

“This is why we emphasize that patients should not start taking aspirin for cancer prevention without specific medical advice from their doctor,” he said in a statement to Fox News Digital.   

“The risk-benefit calculation varies substantially between individuals based on age, comorbidities and concurrent medications,” the doctor noted. 

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“Patients interested in aspirin therapy should discuss it with their oncologist or family practitioner, who can evaluate the potential benefits against the risks.”

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Kasi pointed out the study’s potential limitations, primarily that the research was conducted on mice models rather than humans. 

“The study also did not take into account complications that some people who use aspirin regularly experience, such as bleeding or interactions with other medications,” he noted. 

Experts agree that patients should talk to their doctor to discuss the benefits and health risks associated with regular aspirin use.  (iStock)

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“However, it builds upon the growing body of evidence … and provides mechanistic insights into how this effect might occur from an immune perspective.”

Kasi agreed that patients should talk to their doctor to discuss the benefits and health risks associated with regular aspirin use. 

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“In some cases, low-dose aspirin or other anti-inflammatory drugs are already being considered in clinical use, as well as in additional trials – for example, for individuals born with Lynch syndrome who have a higher predisposition to developing colorectal, endometrial and other cancers,” he noted.

Next steps

The scientists are planning to conduct more research — through the Add-Aspirin clinical trial, which will recruit more than 10,000 patients with early-stage breast, colorectal, gastroesophageal and prostate cancers across the U.K. and India — to determine whether aspirin can stop or delay the recurrence of these cancers.

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“Patients interested in aspirin therapy should discuss it with their oncologist or family practitioner, who can evaluate the potential benefits against the risks.”

“Our research suggests aspirin could potentially be most beneficial for patients with early-stage cancers who have been treated with curative intent but might harbor undetected micrometastases,” Roychoudhuri said.  

“However, further clinical validation is needed before specific recommendations can be made.”

      

The research received funding from the Medical Research Council, the Wellcome Trust and the European Research Council. 

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The Add-Aspirin clinical trial is funded by Cancer Research UK, the National Institute for Health and Care Research, the Medical Research Council and the Tata Memorial Foundation of India.

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Brain Health Challenge: Doctor Appointments for Your Mind and Body

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Brain Health Challenge: Doctor Appointments for Your Mind and Body

Congratulations, you’ve reached the final day of the Brain Health Challenge! Today, we’re asking you to do a few things that might feel a bit out of left field — like getting your blood pressure checked.

No, it isn’t as fun as playing Pips, but experts say it’s one of the most important things you can do for your brain. That’s because heart health and brain health are intrinsically linked.

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High blood pressure, in particular, can damage brain cells, and it’s a significant risk factor for stroke and dementia. When blood pressure is too high, it places stress on the walls of arteries in the brain. Over time, that added stress can cause the blood vessel walls to thicken, obstructing blood flow. In other cases, the increased pressure causes the artery walls to thin and leak blood into the brain.

These changes to the blood vessels can sometimes cause a large stroke to occur. More commonly, the damage leads to micro-strokes and micro-hemorrhages, which cause fewer immediate problems and often go unnoticed. But if someone has hypertension for years or decades, these injuries can build up, and the person may start to experience cognitive impairment.

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High blood pressure “is known as a silent killer for lots of reasons,” said Dr. Shyam Prabhakaran, the chair of neurology at the University of Chicago. “It doesn’t cause you any symptoms until it does.”

Because the damage accumulates over many years, experts say that managing blood pressure in midlife matters most for brain health. Hypertension can be addressed with medication or lifestyle changes, as directed by your doctor. But the first thing you need to do is know your numbers. If your blood pressure comes back higher than 120/80, it’s important to take it seriously, Dr. Prabhakaran said.

While you’re at it, there are a few other aspects of your physical health that you should check on.

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Your eyes and ears are two of them. Hearing and vision loss have both been shown to increase the risk of dementia. Experts think that with less sensory information coming in to stimulate the brain, the regions that process hearing and vision can start to atrophy. What’s more, people with sensory loss often withdraw or are left out of social interactions, further depriving them of cognitive stimulation.

Oral health can also affect your brain health. Research has found a connection between regular flossing and reduced odds of having a stroke. That may be because good oral health can help to reduce inflammation in the body. The bacteria that cause gum disease have also been tied to an increased risk of Alzheimer’s.

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And have you gotten your shingles vaccine? There is mounting evidence that it’s a powerful weapon for protecting against dementia. One study found that it lowered people’s odds of developing the condition by as much as 20 percent.

To wrap up this challenge, we want you to schedule a few medical appointments that benefit your brain, as well as your body.

After five days of feeding, exercising and challenging your brain, you are well on your way to better cognitive health. Thanks for joining me this week, and keep up the good habits!

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Health experts react as Andrew Huberman backs Trump admin’s new food pyramid

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Health experts react as Andrew Huberman backs Trump admin’s new food pyramid

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The Trump administration has taken a new approach to the food pyramid.

The Department of Health and Human Services (HHS) announced new guidelines on Wednesday with an updated, inverted pyramid. The top of the pyramid, which is now the wider part of the structure, is built on meat, fats, fruits and vegetables, while whole grains are at the narrow bottom.

This follows HHS Secretary Robert F. Kennedy Jr.’s mission to “Make America Healthy Again” (MAHA), aimed at addressing chronic disease, childhood illnesses and ultraprocessed foods.

DOCTORS WARN SOME POPULAR FOODS AND DRINKS COULD BE SECRETLY SABOTAGING MEN’S TESTOSTERONE LEVELS

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“The new guidelines recognize that whole, nutrient-dense food is the most effective path to better health and lower health care costs,” Kennedy said during a press briefing in Washington, D.C. 

“Protein and healthy fats are essential, and were wrongly discouraged in prior dietary guidelines. We are ending the war on saturated fats.”

The Trump administration announces the 2025-2030 Dietary Guidelines for Americans, putting “real food” back at the center of health. (realfood.gov)

The HHS secretary rallied against refined carbohydrates, food additives and added sugar, highlighting the health risks associated with sugar-sweetened beverages. 

Kennedy’s main message to Americans was to “eat real food.”

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TRUMP ADMIN’S NEW NUTRITION GUIDELINES TARGET ULTRA-PROCESSED FOODS, EASE UP ON RED MEAT AND SATURATED FATS

The announcement triggered reactions from top health and wellness voices, including Stanford neuroscientist Dr. Andrew Huberman, host of the “Huberman Lab” podcast.

In a post on X, Huberman shared the White House’s graphic of the new pyramid, praising the decisions that were made.

“Oatmeal (and I think that’s rice and sourdough) made the cut!” he commented. “In all seriousness, assuming overall calories are kept in check and people exercise & get sun(day)light, this looks spot on.”

He added, “Maybe up the veggies a bit, add low-sugar fermented foods like sauerkraut & this is great.”

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Huberman said in a thread on the same post that Americans “don’t have to eat all the foods” shown in the diagram.

“You won’t see me drinking milk or eating shrimp,” he said. “Nothing against shrimp, I just don’t like the taste. Aversion to crustaceans.”

“Maybe up the veggies a bit, add low-sugar fermented foods like sauerkraut & this is great,” Huberman commented on X. (Chance Yeh/Getty Images for HubSpot; iStock)

The new guidelines received praise from other major health figures, including former FDA commissioner Dr. David Kessler.

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“There should be broad agreement that eating more whole foods and reducing highly processed carbohydrates is a major advance in how we approach diet and health,” Kessler told The Associated Press.

“Protein and healthy fats are essential, and were wrongly discouraged in prior dietary guidelines.”

Dr. Bobby Mukkamala, president of the American Medical Association, shared in a statement that these guidelines “affirm that food is medicine and offer clear direction patients and physicians can use to improve health.”

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“The American Medical Association applauds the Administration’s new Dietary Guidelines for spotlighting the highly processed foods, sugar-sweetened beverages and excess sodium that fuel heart disease, diabetes, obesity and other chronic illnesses,” Mukkamala wrote.

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The American Medical Association applauded the HHS for its updated nutrition guidelines. (iStock)

But not all feedback was positive.

Some people expressed concern about prioritizing red meat and dairy, while calling for the limitation of saturated fat.

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Neal Barnard, president of the Physicians Committee for Responsible Medicine, shared in a reaction to STAT that while the guidelines “do have one or two good points, emphasizing fruits and vegetables and limiting alcohol,” the guidelines are “for the most part a strong reflection of industry influence.”

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Christopher Gardner, a nutrition expert at Stanford University, also spoke out against the new guidelines, as reported by NPR.

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“I’m very disappointed in the new pyramid that features red meat and saturated fat sources at the very top, as if that’s something to prioritize. It does go against decades and decades of evidence and research,” said Gardner, who was a member of the Dietary Guidelines Advisory Committee.

Fox News Digital’s Rachel Wolf, as well as Alexandria Hoff of Fox News, contributed reporting.

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Matt Damon’s Gluten-Free Diet Helped Him Lose 18 Pounds

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Matt Damon’s Gluten-Free Diet Helped Him Lose 18 Pounds


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Matt Damon’s Weight Loss: Actor Drops 18 Lbs with This Diet | Woman’s World




















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