Health
What is ‘brain rot’? The science behind what too much scrolling does to our brains
Oxford University Press has chosen “brain rot” as its word of the year.
The word is defined as “supposed deterioration of a person’s mental or intellectual state, especially viewed as a result of overconsumption of material (now particularly online content) considered to be trivial or unchallenging. Also: something characterized as likely to lead to such deterioration.”
Some experts believe that constant, endless scrolling of social media and other online content is doing exactly that – rotting our brains.
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Behavioral neuroscientist Dr. Kyra Bobinet, author of “Unstoppable Brain,” told Fox News Digital that there is a growing awareness of brain rot and its consequences.
Oxford University Press choosing “brain rot” as the word of the year is “pinpointing the issues,” according to one expert. (iStock)
“It’s in the zeitgeist that people have difficulty with their attention span. They feel brain foggy, they [have] less concentration … They can’t do deep work,” said California-based Bobinet.
“And then there’s also this epidemic of loneliness that has been kind of sitting on the heels of this, because we can’t really focus on anything, including relationship-building.”
Stuck in a scroll
A certain part of the brain, called the habenula, is responsible for getting stuck in endless scrolling, according to Bobinet.
The habenula is a central part of the brain that’s involved in various important functions, including motivation and decision-making. But when activated, this area can also “kill our motivation to try,” she noted.
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“It’s the heart of when you know you should be doing something, and you do this other thing instead, like ‘doom-scrolling,’” she said.
“This is the area of our brain that when it’s on, we feel depressed. We feel out of control, we feel impulsive, we feel addicted,” one neurologist said about the habenula. (iStock)
Scrolling on social media is also a way to “disassociate” and give the brain a rest after a long day, Bobinet said. This is an “avoidance behavior,” which the habenula controls.
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“Anytime you’re avoiding something, you know this area of the brain is on,” she said.
This is how social media addictions can form, Bobinet warned, as this part of the brain can make it “very painful” to stop scrolling.
“There’s this epidemic of loneliness that has been kind of sitting on the heels of this, because we can’t really focus on anything, including relationship-building,” one expert said. (iStock)
This can result in a “dangerous” loss of motivation, the neuroscientist warned.
“We all need motivation to live our lives and to feel proud of ourselves and to feel confident and to get what we want,” she told Fox News Digital.
How to avoid brain rot
There isn’t a one-size-fits-all solution for avoiding brain rot, according to Bobinet.
The key is learning what works best for the individual, she said, which involves “tweaking and tinkering and adjusting as you go,” she said.
“Humans are very resilient,” she added. “Once we know the truth about our bodies, then we can do something about it.”
Scrolling on social media is a way to “disassociate” and give the brain a rest after a long day, which is an “avoidance behavior,” one neuroscientist said. (iStock)
Dr. Don Grant, national adviser of healthy device management at Newport Healthcare in Los Angeles, called out device makers and content producers for keeping users hooked to their devices.
“They’re very clever, these creators who created these algorithms and also leverage our limbic system – the same [way] the people who created slot machines did,” he told Fox News Digital. “Pull the handle … You never know what you’re going to get.”
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Grant said he’s concerned about “the death of some things,” including imagination.
“We don’t have to imagine anything anymore,” he said. “We pick up our devices every time. I’m worried about memory. I’m worried about education.”
Grant said he often hears from kids that they spend eight hours on any given night scrolling and watching videos, which “disrupts their sleep hygiene.”
One expert said he often hears from kids that they spend eight hours on any given night scrolling and watching videos, which “disrupts their sleep hygiene.” (iStock)
“And I say, ‘OK, can you tell me one video you remember?’ I have yet to have one kid really be able to remember anything they saw.”
“Our brain matter is diminishing, our memories are diminishing [and] our attention spans are diminishing,” Grant warned.
“I’m worried about memory. I’m worried about education.”
The expert offered some tips to avoid getting stuck in a “doom scroll” of “endless, bottomless” content, especially for children.
Since the internet is “archived forever,” Grant noted that “FOMO,” or fear of missing out, is not a valid reason to stay online.
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“Maybe phone a friend or FaceTime your grandma for the holidays,” he suggested.
Grant also urges people to be more strategic about spending time online, splitting it up into 80% “meaningful, legitimate” content and 20% entertainment.
One expert urges people to be more strategic about spending time online, splitting it up into 80% “meaningful, legitimate” content and 20% entertainment. (iStock)
“For digital hygiene and well-being, you can set limits, you can block access,” said Grant. “Set tech-free times and zones in your home, especially for families.”
“Get outside, move a muscle … play memory games, intellectually challenging or educational games.”
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The expert also encourages people to ask themselves a few questions after scrolling to help gauge the quality of time spent.
These might include: “Could you tell me how much time you were online? Did you spend more time than you wanted to? Did you feel better?”
Grant added, “There’s a perceived danger of virtual life and how we’re using our free time – at the end of it, are you really feeling good about yourself?”
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A new injectable therapy is showing positive results in reducing melanoma throughout a five-year period.
The personalized mRNA cancer therapy, called intismeran autogene, combined with the cancer immunotherapy drug KEYTRUDA (pembrolizumab), is a collaboration between Merck and Moderna.
The results from the phase 2b KEYNOTE-942 study were presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago on May 27.
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After about a five-year follow-up, the combo drug was found to reduce the risk of melanoma recurrence or death by 49% compared to pembrolizumab alone.
The researchers analyzed data from 157 patients with high-risk stage 3 and 4 melanoma whose cancer had been removed via surgery. The participants were split into two groups — one received the combo therapy and the other only received pembrolizumab, according to a press release.
The therapy was found to reduce the risk of melanoma recurrence or death by 49% compared to pembrolizumab alone after a five-year follow-up. (iStock)
The findings revealed that the combination group saw benefits that were “sustained and durable over time.”
Intismeran autogene is designed using mutations identified in a patient’s own tumor, with the intention of teaching the immune system what the cancer looks like so that it can recognize and attack it.
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According to the researchers, intismeran is “well-tolerated” with a “manageable” safety profile.
The most commonly cited side effects of the personalized mRNA vaccine plus KEYTRUDA were fatigue, injection-site pain, chills, fever and headache. The researchers reported no new long-term safety concerns and no severe vaccine-related adverse events.
The combination therapy is currently being evaluated in a phase 3 study — the final confirmation stage.
Patients with late-stage melanoma have a “significant risk” of cancer recurrence, according to an expert. (iStock)
In a Merck press release from January, Kyle Holen, MD, Moderna’s senior vice president and head of development, oncology and therapeutics, noted that this data highlights the “potential of a prolonged benefit … in patients with resected high-risk melanoma.”
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“We continue to invest in our platform in oncology because of encouraging outcomes like these, which illustrate mRNA’s potential in cancer care,” he said.
Dr. Marjorie Green, senior vice president and head of oncology, global clinical development at Merck Research Laboratories, also commented that for many patients with stage 3 or 4 melanoma, there is a “significant risk of recurrence following surgery.”
Researchers confirmed that the combination therapy is currently being evaluated in a phase 3 study. (iStock)
“As such, demonstrating the longer-term potential of intismeran autogene and KEYTRUDA to reduce the risk of recurrence for certain patients with melanoma is a meaningful milestone,” she said.
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The company cited encouraging five-year follow-up data and pointed to upcoming late-stage INTerpath trial results with Moderna in several hard-to-treat cancers.
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An accidental lab discovery has opened the door to entirely new ways of preventing the flu.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells, SWNS reported.
By targeting the specific molecules the viruses rely on, scientists found that they could block them from entering new cells and halt their replication altogether.
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Researchers say these “fundamental insights” into seasonal influenza highlight a clear path toward developing better preventive medications.
“The hope is that fundamental, curiosity-based research like this helps to pave the way for novel strategies to treat and prevent influenza infections,” principal investigator Dr. Emily Bruce, from the University of Vermont’s Larner College of Medicine, said in the SWNS report.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells. (iStock)
While several flu strains cause illness, H1N1 and H3N2 influenza A viruses are the most common. However, current flu tests cannot differentiate between them, and clinical treatments are identical for both.
Although vaccines and antivirals are available, Bruce noted a “dire” need for better medications to stop the virus from spreading cell to xxcell.
“You don’t get sick when a virus is in one cell,” he noted. “You get sick because a virus replicates itself and goes into many more cells.”
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The study, which was published in The Journal of Virology, originally aimed to map how viral RNA segments are transported within cells to create new viral particles.
The team used H1N1 and H3N2 viruses isolated from the nasal passages of positive patients in 2022.
Clinical treatments remain identical for both primary strains of the flu virus. (iStock)
During the investigation, the team unexpectedly stumbled upon a cellular pathway that blocked the virus from entering lung cells, SWNS reported.
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The data revealed that when a specific human protein called Rab11B was depleted, H3N2 viruses failed to enter human lung cells. H1N1 viruses were completely unaffected.
Using reverse genetics, the team mapped this defect and uncovered a brand-new, H3N2-specific role for Rab11B during viral entry.
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This discovery challenged the scientific assumption that all flu viruses enter cells the same way.
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“Viruses are like pirates from different countries hijacking someone’s ship,” Bruce said. “Different viruses, like different types of pirates, use different methods to get onboard.”
This discovery challenged the scientific assumption that all flu viruses enter cells the same way. (iStock)
“We had previously thought that all flu viruses used the same way to get into a cell, but we discovered that this is not true,” she went on. “H1N1 and H3N2 need different proteins to get in, and if you get rid of the right protein, a specific virus can’t get in.”
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While these findings identify a critical cellular pathway for viral entry, the study was conducted using isolated cells, the researchers acknowledged.
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Further research is needed to determine whether blocking the protein is safe and effective within a live, complex human respiratory system.
Bruce and the team hope to conduct further research to determine whether this Rab11B-dependency is a fundamental property of H3N2, or if it’s a trait unique to currently circulating flu strains.
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Eating processed meat like ham, sausage and bacon may be linked to a higher risk of certain types of cancer, according to new research.
While health organizations have already confirmed that processed meat can contribute to colon cancer, this study looked closer at cancers in the upper digestive tract, where the link has historically been less clear.
To understand these connections, researchers from the European Prospective Investigation into Cancer and Nutrition (EPIC), one of the world’s largest long-term nutrition and cancer cohorts, tracked the health and diets of 450,112 people across Europe for an average of 14 years.
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The study group included 131,426 men and 318,686 women, according to the study’s press release.
During the follow-up period, 876 people developed stomach cancer and 215 people developed esophageal adenocarcinoma, which is cancer of the tube connecting the mouth to the stomach.
For female participants, eating both processed meat and white meat was linked to an increased risk of developing the disease. (iStock)
Researchers tracked where the stomach cancers grew, separating them into the upper part of the stomach near the throat and the lower part of the stomach.
The researchers also sorted the tumors into two categories based on how the cancer cells appeared under a microscope: intestinal, which forms more organized structures, and diffuse, in which the cells are more scattered throughout the tissue.
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After adjusting for other lifestyle factors, the researchers found that for every extra 30 grams of processed meat a person ate per day, their overall risk of stomach cancer went up by 9%. Eating that same extra 30 grams a day was also linked to a 13% higher risk of esophageal adenocarcinoma.
A standard single slice of regular deli-sliced ham or lunch meat averages around 28 grams, according to USDA data and nutritional tracking databases.
An extra 20 grams of white meat, such as chicken and turkey, was linked to a 12% higher risk of cancer in the main body of the stomach. (iStock)
An extra 20 grams of white meat, such as chicken or turkey, was linked to a 12% higher risk of cancer in the main body of the stomach, the researchers noted.
The study also revealed differences between men and women. For male participants, only processed meat showed a clear, statistically significant link to a higher risk of stomach cancer. For female participants, however, eating both processed meat and white meat was linked to an increased risk.
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These findings align with global health benchmarks, particularly those established by the World Health Organization’s International Agency for Research on Cancer.
The agency has long classified processed meat as a known human carcinogen, primarily due to its strong, well-documented links to colorectal cancer.
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However, health organizations have also consistently pointed to a potential, yet less definitive, relationship between these meats and cancers of the stomach.
Eating 30 grams of processed meat a day, or the equivalent to one slice of ham, was linked to a 13% higher risk of esophageal adenocarcinoma. (iStock)
Further scientific investigation is needed to confirm the findings and to account for other underlying risk factors, such as certain stomach infections, which could interact with dietary habits.
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A key limitation of the study is its reliance on self-reported diets, which can sometimes lead to inaccuracies in how participants recall their meat consumption over time, the researchers noted.
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The findings were published in the International Journal of Cancer.
Fox News Digital reached out to the researchers requesting comment.
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