Massachusetts
Two Massachusetts scientists receive Nobel Prize in Medicine for discovery of microRNA
Two Massachusetts scientists have been recognized with the Nobel Prize in Physiology or Medicine for their role in the discovery of microRNA — key to the understanding of gene regulation and potential treatments of heart disease, cancer, neurodegenerative diseases and more.
Researchers Victor Ambros, a University of Massachusetts Medical School professor of natural science, and Gary Ruvkun, a Massachusetts General Hospital and Harvard Medical School investigator and professor of genetics, received the Nobel Prize on Monday.
“Gene regulation by microRNA, first revealed by Ambros and Ruvkun, has been at work for hundreds of millions of years,” the Nobel Committee for Physiology or Medicine stated in a release. “This mechanism has enabled the evolution of increasingly complex organisms.”
The committee stated the scientists’ work “revealed an entirely new dimension to gene regulation” that are “proving to be fundamentally important for how organisms develop and function.”
In a press conference at MGH on Monday, Ruvkun called the study of recombinant DNA starting in the 70s a “revolution” and said as a young student and researcher he “just wanted to be part of that.”
In the late 1980s, Ambros and Ruvkun worked as postdoctoral fellows in the laboratory of Robert Horvitz, who was awarded the Nobel Prize in 2002. There they studied the 1 mm long roundworm, C. elegans, narrowing in on a mutation and gene function in the animals.
Ambros and Ruvkun continued the research after the fellowship at respectively at their Harvard University lab and Massachusetts General Hospital and Harvard Medical School lab. The pair compared findings, discovering the existence of microRNA in the worms, and published in 1993 in two articles in the journal Cell.
The discovery was met with “deafening silence from the scientific community,” the Nobel committee wrote, until 2000 when Ruvkun published new findings on microRNA in another gene, demonstrating their presence across the animal kingdom.
In the past two decades, “research into the potential of microRNAs for the diagnosis, prognosis and treatment of disease has expanded from the two original papers published by Ruvkun and Ambros in 1993 to 176,000 papers today,” MGH said in a statement.
The “unexpectedly short” microRNA, Ambros said, help regulate how genes are controlled in cells. The microRNAs “block gene expression by binding to regulatory segments in their target messenger RNAs,” MGH said.
Current research has shown human and most other plant and animal genomes contain “more than 1,000 microRNAs, which control many protein-coding messenger RNAs and may be involved in a broad range of normal- and disease-related activities,” the hospital said.
Researchers are currently conducting clinical trials involving microRNA for medical conditions including heart disease, cancer and neurodegenerative diseases.
Ambros said he was “surprised and delighted” to hear about the Nobel Prize at a press conference in the UMass Chan Medical School in Worcester on Monday and emphasized that studies of laboratory organisms of this kind are “critical and key and fundamental to advancing understanding of biology.”
“I think the unexpectedness of biology is probably the most important principle, perhaps, for people to appreciate,” said Ambros. … “At any given moment, it feels like we know most of what we need to know — that is actually an illusion that we have to consciously disabuse ourselves of and leave ourselves open for the surprises.”
The 2023 Nobel Prize in Physiology or Medicine was awarded to two researchers, Katalin Karikó and Drew Weissman, who helped develop mRNA vaccines to combat the COVID-19 pandemic.
Nobel prize announcements will continue with the physics prize on Tuesday, chemistry on Wednesday, literature on Thursday, Peace Prize on Friday and the Memorial Prize in Economic Sciences on Oct. 14.

Massachusetts
Another shark species off Massachusetts is taking striped bass from fishermen
It’s not just great white sharks that are taking stripers from fishermen these days.
Porbeagle sharks — which stick around the Bay State all year — have been spotted several times in the last week chomping on striped bass that fishermen caught.
Those on a recent whale watch off the Cape even got a front-row seat to the action.
“We hope you lunge after your Fourth of July hot dog like this porbeagle going after a striped bass on our Provincetown whale watch yesterday!” Captain John Boats posted.
“It was incredible to see this top predator in its element in this National Geographic moment,” Captain John Boats added. “Our naturalist said it may have even been his favorite whale watch he has ever been on… Thanks to MA Sharks for your support and for showing us how to ID different shark species!”
MA Sharks is run by shark researcher John Chisholm, who on the day before July 4th received four different reports of porbeagle sharks taking striped bass.
“It was a busy day for porbeagle shark sightings yesterday,” Chisholm posted. “This is one of four reports we received yesterday of them taking striped bass from the N Shore to Nantucket. If you have an encounter like this, please let me know.”
Meanwhile over the holiday weekend, great white sharks were spotted all across the region.
In Cape Cod Bay, an 8-foot white shark was seen about two miles west of Wellfleet’s Jeremy Point.
On the South Shore, a dead seal with shark bites was found along Rexhame Beach in Marshfield.
And up on the North Shore, a small white shark was spotted about five miles off Marblehead.
Then much farther north, a beach was closed to swimming in Maine after a report of two sharks near Reid State Park.
“Swimming areas currently have been cleared,” the Maine town of Georgetown posted Sunday morning. “Be safe, stay alert, and enjoy Georgetown.”
A couple hours later, the swimming area at Reid was reopened.
“If you are in or on the water, please stay alert,” the town added.
White sharks come to the region every summer and fall to hunt for seals close to shore.
Before heading into the water, Chisholm urges people to review shark safety guidelines, including: be aware that sharks hunt for seals in shallow water; stay close to shore where rescuers can reach you; don’t isolate yourself; avoid areas where seals are present; avoid areas where schools of fish are visible; avoid murky or low-visibility water; limit splashing; and follow all signage and flag warnings at beaches and instructions of the lifeguards.
Chisholm also encourages beachgoers to use the Atlantic White Shark Conservancy’s Sharktivity app to view shark activity, get shark alerts and report sightings.
Massachusetts
Wrong-way driving is becoming more common and deadly in Mass. The state is racing to prevent it. – The Boston Globe
In each of the last two years, the state issued more than 500 citations to drivers on state highways, the Massachusetts Turnpike, and the Boston Harbor tunnels, a Globe analysis of state data found. And 2026 is on track to outpace those figures, with the state already logging nearly 270 citations by late June.
Wrong-way crashes tend to be at least 12 times deadlier than other car accidents, studies show, and their causes are frustratingly difficult to pin down to a single source.
Now state officials are rushing to implement a new $75 million program that includes a constellation of cameras, new road signs, and infrastructure improvements designed to prevent wrong-way collisions.
Massachusetts supercharged the effort after the death of state Trooper Kevin Trainor spurred calls for stronger action, including from Governor Maura Healey, said Jonathan Gulliver, a state undersecretary of transportation.
Gulliver said the Massachusetts Department of Transportation now expects to mount 430 detection cameras by the end of 2027. The system notifies wrong-way drivers with an audible alarm, flashing signs, and a spotlight, then pings law enforcement if a driver does not turn around.
The installation underway builds off a smaller pilot program at 16 Massachusetts locations that flagged roughly 300 wrong-way incidents since 2022.
“I’m not sure that [wrong-way crashes] happened more or less years ago, but I am certain we didn’t hear about them as much when they did,” Gulliver said.
In all, wrong-way crashes are among the “most preventable” roadway accidents but difficult to eliminate because they cannot be tracked cleanly to one source, said AAA spokesperson Mark Schieldrop.
Persistent speeding, distracting and impaired driving, and an aging population of drivers confused behind the wheel are the leading contributors to wrong-way citations, experts said. Nationally, six in 10 wrong-way crashes involve an alcohol-impaired driver.
And the dark of night can’t take all the blame, either: nearly 45 percent of crashes in Massachusetts occurred during daylight hours.
And though a wrong-way incident can be as simple as sliding into the unintended lane on a ramp, a single mistake against the flow of traffic is often dangerous.
In Massachusetts, at least 135 people have died in 5,506 wrong-way crashes on Massachusetts roads since 2018, according to AAA. That includes 22 deaths in 2025, the most in a single year during that time frame.
State officials here are focusing first on divided highways, where high-speed crashes can be especially deadly. MassDOT has identified 100 high-risk spots for wrong-way detection cameras, which include crash-prone intersections already equipped with cameras in Danvers, Auburn, Braintree, Fall River, and Wheatley.
Roughly 70 other roads at risk for wrong-way crashes may require larger reconstruction projects down the line, Gulliver said.
State leaders also intend to install clearer “wrong way” and “do not enter” signage, improved pavement markings, directional arrows, and better lighting at highway ramps and interchanges.
Legislation tucked into the state’s $63 billion budget plan, sent to the governor’s desk Wednesday, also proposes a study to improve roadway safety for drivers over 70, an expansion of law enforcement training, and completion of an analysis of documented incidents of wrong-way driving.
At a press conference following a vote on the budget amendment, Nicole Dailey lauded the efforts to address the issue after her son Christopher Dailey, an 18‑year‑old Gloucester High School graduate and hockey team captain, died in a wrong-way crash on Route 128 last summer.
“I don’t want any other community to have to go through this,” said Dailey. “It’s . . . senseless.”
Across the country, fatal wrong-way crashes doubled in the decade after 2014. Recent crashes in Massachusetts have involved drivers under the influence or allegedly fleeing the State Police, but many incidents can be traced back to disorientation and poor signage. Winding roads and complicated overpasses — specific to the older infrastructure and circuitous traffic patterns in Massachusetts — can add to the problem, Gulliver said.
In response, state officials sourced detection technology from TAPCO, a Wisconsin-based transportation product company. The cameras, mounted on street light signals, use artificial intelligence and heat detection to identify wrong-way drivers and differentiate them from pedestrians, birds, and other hazards, Gulliver said.
The software-based system costs $20,000 per camera to install, less than half the $70,000 price tag associated with cameras in the previous state pilot program. Those cameras use “loop detection” to manually identify wrong-way drivers, using wiring in the roads that recognizes passing vehicles above.
An average of two wrong-way cameras are installed each week. Some have proved to be fruitful immediately.
At the intersection of Routes 128 and 35 in Danvers, where officials connected a camera on June 16, “the same day we activated it, we caught a wrong-way driver,” Gulliver said.
In the next few years, state officials also hope to have a system that automatically pings roadside message boards and GPS systems to notify drivers about wrong-way vehicles.
Still, Massachusetts is moving more slowly than other states.
Rhode Island — a “leader” in wrong-way crash detection, Gulliver said — did not have a single wrong-way driving death in the decade after it began its analysis of collision hotspots at 200 ramps statewide in 2015. Ultimately, additional wrong-way signs, lower to the ground and with flashing lights, worked in tandem with other low-cost measures to warn over 1,000 vehicles that they need to turn around, state data show.
Eva Zymaris, a spokesperson for the Connecticut Department of Transportation, said the installation of cameras bore similar results in that state, with 237 out of 400 planned locations operational to date.
Illuminated wrong-way signs flash when a driver is going the wrong way and pings two highway operations centers. That avoids the need for 911 calls that can otherwise pour in after an accident has already happened, Zymaris said.
In 2022, before the $81 million system was installed, 23 people died from wrong-way crashes in Connecticut. Preliminary data show there were four deaths in 2025.
“Seconds count here,” Zymaris said. “To be able to expedite that response time is huge to prevent crashes and fatalities.”
Now Vermont and Maine are also ramping up prevention efforts, after the number of wrong-way deaths rose in both states. And nationwide, states such as Ohio and Florida implemented detection technology roughly a decade ago. Nevada adopted harsher penalties for wrong-way driving in 2025.
Wrong-way crashes, typically the fault of an individual driver, can rarely be solved otherwise, said Peter Savolainen, a Michigan State University professor who studies road user behavior.
“A lot of times drivers don’t know until it’s too late that they’re going the wrong way,” he said. “So all states can do — and are doing — is try to make it more difficult for people to make that incorrect decision.”
Samantha J. Gross of the Globe staff contributed to this report.
Diti Kohli can be reached at diti.kohli@globe.com. Follow her @ditikohli_. Scooty Nickerson can be reached at scooty.nickerson@globe.com.
Massachusetts
Motorcyclist flown to hospital after crash in Groton on Fourth of July
A motorcyclist was seriously hurt in a crash with another vehicle on July Fourth in Groton, Massachusetts.
The Groton Fire Department says the collision occurred around 8:34 a.m. Saturday in the area of Old Ayer Road and Boston Road (Route 119).
The motorcyclist, a man in his 40s, suffered a significant lower-body injury. He was taken by ambulance to a landing zone at the fire station on Farmers Row, then flown by a medical helicopter to UMass Memorial Medical Center in Worcester. His condition wasn’t immediately available.
The driver of the passenger vehicle reported no injuries, officials added.
It’s unclear what caused the crash. An investigation by the Groton Police Department is ongoing.
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